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Endoscopic Surgical Pain Management in the Aging Spine
Anthony T. Yeung, Christopher A. Yeung, and Christopher Meredith
64
k e y p o i n t s
e foraminal endoscopic surgical approach avoids the surgical morbidity of
stripping the multifidus muscle.
e foraminal approach is capable of intradiscal and epidural decompression
under clear endoscopic visualization.
e foraminal approach can be used to treat chronic common low back pain
by denervating the nerves innervating the disc as well as the dorsal spinal column.
Variations in foraminal normal anatomy and pathoanatomy, poorly
understood by traditional surgeons, plays major role in chronic lumbar pain syndrome.
Use of specialized miniaturized surgical tools, including the use of bipolar
radiofrequency and laser, is an important and integral part of the endoscopic procedure.

INTRODUCTION

The aging spine typically begins with disc degeneration and annular dehis­cence, followed by transfer of loads from the anterior spinal column to the facets. This may produce discogenic pain and axial back pain, resulting in segmental instability with resultant deformity. If the condition becomes painful, and nonsurgical treatment is not effective, traditional surgical treat­ment has been limited to diskectomy and fusion. Though diskectomy has been shown to be beneficial by the SPORT effectiveness of fusion is questioned. Traditional spine surgery to treat painful degenerative disc disease such as with herniated discs, spondylo­listhesis, central spinal stenosis, and neuroforaminal stenosis encompasses many different techniques. Surgical treatment, however, often results in a “failed back surgery syndrome” (FBSS) with limited success for subsequent salvage procedures. Newer minimally invasive techniques, in skilled and experienced hands, when approaching the pathology along natural muscle and tissue planes opens the door to earlier and a greater number of mini­mally invasive surgical options for the painful, aging spine without excessive concern about the paradoxical effects of surgery. The concept of “endoscopic surgical pain management” is addressed in this chapter, based on the senior author’s (ATY) 20-year experience using his percutaneous endoscopic transforaminal surgical technique described as the YESS (Yeung Endo­scopic Spine Surgery) procedure.
The YESS procedure eliminates the pain generator causing the pain syndrome, not just “masking” the pain with therapeutic injections. The approach accomplishes disc decompression by “selectively” removing degen­erative nucleus, sealing and closing annular tears, decompressing spinal nerves, ablating nerves and inflammatory tissue contributing to discogenic and axial back pain, and surgically removing a wide spectrum of disc her­niations. In more advanced stages, lumbar spondylolysis and isthmic and
1
study, the long-term cost-
degenerative spondylolisthesis can also be addressed surgically. This brief overview provides examples of conditions that the senior author has treated endoscopically with minimal surgical morbidity, in contrast with the much more invasive traditional option. The reader is directed to the pub­lished references for more detailed information on the evolution of this new minimally invasive and innovative technique.
Traditional surgical correction in the aging spine usually involves open decompression, fixation, and fusion techniques. The percentage of fusion surgeries for these conditions as a whole has increased dramatically in the United States over the past few decades. Between 1990 and 2001, lumbar fusion surgery increased 220%.
17
leagues, for degenerative spondylolisthesis surgery (decompression and fusion) is not a cost-effective procedure, when examined over a 2-year period. The importance of this data is that it emphasizes the need to better identify the source of back pain and sciatica, possibly earlier treatment, and more thor­ough study of the complex innervations of the spine in the foramen (Fig-
ure 64-1A-C). This area, known as the “hidden zone” of MacNab, holds
the answer to the effectiveness of foraminal decompression and ablation of foraminal nerves in the treatment of discogenic and facet pain. It may have an impact on health care reform that seeks to reduce the cost of care, because over 100 billion dollars a year is spent on back pain in the United States, most of it being spent on nonsurgical treatment such as physical therapy, interventional pain management, and over-the-counter and prescription drugs. We also need to reduce the need for fusion as a surgical solution for pain. This can be accomplished if we are able to not only demonstrate the efficacy and cost-effectiveness of endoscopic surgical pain management, but help establish a new subspecialty in endoscopic surgical pain management, because it requires special training to acquire proficiency.
understanding common lumbar pain. Cadaver microdissection of the nerves in the foramen reveals an extensive network of nerves arising from the spinal cord, splitting into the dorsal and ventral rami before exiting the foramen as the spinal nerve. A ramus communicans connects with the sinuvertebral nerves innervating the annulus. When there is an inflamma­tory response to annular tears with the development of an inflammatory membrane, the subsequent neo-neurogenesis and angiogenesis response contributes to pain that is not detected by imaging studies currently avail­able. Better soft tissue imaging and imaging of chemical changes in the spine may help. We traditionally only grossly see the traversing and exiting spinal nerves as surgeons, and routinely fail to recognize and miss the rela­tively common furcal nerve, or the dorsal ramus and its medial and lateral branches that emanate from each spinal nerve. This network of nerves from the dorsal ramus contributes greatly to chronic discogenic and axial back pain not responsive to nonsurgical treatment. It is undetected by MRI or CT scan, but can be visualized endoscopically and confirmed by metic­ulous cadaver dissection (Figure 64-1B, C). Rational treatment calls for the appropriate and effective use of diagnostic and therapeutic diagnos­tic procedures such as diskography, selective nerve root blocks, foraminal
examining the data from the SPORT trial, concluded that even
Understanding chronic, surgically treatable back pain begins with
16
A recent article by Tosteson and col-
2-15
427
428
P A R T V I I I     The Future of the Aging Spine
A
F IG UR E 6 4- 1 A, Fresh cadaver dissection of dorsal and foraminal anatomy showing the relationship of the disc annulus, spinal nerves, facets, and lamina 
dictating surgical access. Normal  left foraminal anatomy L2-S1. Blue:  hubbed needles are inserted into  the disc space in the  foramen accessing the posterolateral  quadrant of  the disk. Note  the furcal nerve  branch at L4-L5.  The epidural space  can be  reached  with  a far lateral  trajectory and/or by  removing the ventral  facet  with trephines, lasers, or endoscopic high-speed diamond burrs. All soft tissue has been stripped  from the transverse processes, including dorsal ramus innervation  of the dorsal column. The intertransverse ligament covering the exiting nerves in the foramen has  been stripped away. B, Facet innervation and the relationship of  the transverse process, the interspinous ligament, and the exiting nerve in the foramen. The right exiting nerve at L3-L4 exhibits a furcal nerve branch traversing the  foramen in the far lateral quadrant of the L3-L4 disc annulus. Furcal nerves are the myelinated branches of normal spinal nerves (usually the exiting nerve), commonly  seen endoscopically in the foramen. When stimulated or cut, these nerves can cause dysesthesia and react like the parent spinal  nerve. It does not respond like the  main nerve because it is usually too small to be  detected by continuous intraoperative electromyography or radicular pain reported by the patient. The endoscopic  surgeon should take care to recognize and not injure these furcal nerves if they  are more than 1 mm in diameter, but they cannot always be avoided. Dysesthesia,  immediately postoperative or delayed, is readily treated by transforaminal epidural blocks combined with sympathetic blocks. Furcal nerves can be responsible  for  sciatica that is seemingly out of proportion to what is suggested by relatively normal MRI appearance, and may be part of the sciatica reported preoperatively. Note  also the proximity of the intermediate and lateral branches of the dorsal ramus on the cephalic edge of the transverse process at L3. The dorsal ramus sends a medial  branch that crosses the transverse process on the way to innervate the facet joint above and below the disc level. Irritation of the lateral branch, when irritated, can  cause muscle spasm and  an involuntary list. C, Dorsal  ramus innovation of L3, L4,  and L5 facets. The dorsal  ramus emanating from the origin  of the spinal nerve  sends off medial, intermediate, and lateral branches to  innervate the facets and the dorsal muscle column. The interspinous ligament has been removed to expose  the dorsal ramus. It is found just ventral to the intertransverse ligament and can irritate the exiting nerve and its dorsal root ganglion. This poorly studied nerve can  be responsible for severe chronic axial back pain associated with a degenerating disc exhibiting grade IV and V far lateral  annular tears. Back pain, not just sciatica,  caused  by  disc  protrusions  and  annular  tears  can  be  explained  by  irritation of the dorsal ramus, not just  the  spinal  nerves.  Selective  endoscopic  diskectomy  and  thermal annuloplasty can reduce axial back pain and sciatica, and Intradiscal Electrothermic Therapy (IDET) cannot reach these nerves! Endoscopic rhizotomy of the  branches of the dorsal ramus has shown to be a very effective means of decreasing chronic severe axial back pain.
epidural steroid blocks, facet and medial branch blocks, and sympathetic nerve blocks. Research studies, such as those by Caragee18, that empha­size the risks and the difficulty of interpretation of diagnostic tests such as diskography without balancing the indications and usefulness of the disk­ography, does a disfavor to endoscopic minimally invasive surgeons who
B
pathoanatomy and the interventionalist’s experience. It is not unusual to find pathoanatomy, such as chronic granulation and inflammatory tissue in the disc or furcal nerves in the foramen, that is not apparent on preoperative imaging studies, but is clearly visualized endoscopically during foraminal endoscopic surgery.
C
are able to look at pathoanatomy and are skilled at spinal endoscopy. This skill affords endoscopic surgeons the opportunity to treat lumbar pain and sciatica without fusion.
The politics and social-economic pressures of medicine create even more controversy as poorly qualified “experts” provide personal opinion on “stan­dard of care” in medical-legal and insurance coverage disputes.
The information obtained from these diagnostic and therapeutic injec­tion procedures allows the surgeon to more selectively pinpoint the pain source and to determine how to mitigate the source of pain.

DESCRIPTION OF THE DEVICE

The design of the endoscope and endoscopic system is an important fac-
tor for endoscopic surgeons to consider. Techniques of endoscopic decom­pression vary depending on the endoscope design, the available surgical instruments, and surgical techniques practiced by the developer of the system. Not all endoscopic systems are designed for or amenable to the technique described here, but techniques and endoscopic systems continue to evolve. This chapter specifically describes the YESS transforaminal

INDICATIONS AND CONTRAINDICATIONS

A widely accepted indication for foraminal endoscopic disc surgery is cur-
rently a foraminal or extraforaminal lumbar disc herniation. All sizes and types of herniations, however, are possible in the hands of a skilled and experienced endoscopic surgeon. Indications rely heavily on the skill and experience of the surgeon, as well as the patient’s anatomy relative to the
“inside-out-technique,” utilizing the YESS foraminoscope ( Figure 64-2) and the instruments designed for the system and technique. Not only is it important to have the necessary instruments, but specially configured can­nulas are designed to expose the pathoanatomy to be surgically treated but, in the process, also protect vital anatomy such as the nerve and dura. Other systems are also evolving, so that in time, there will be similarities evolved
and copied from the YESS transforaminal technique illustrated here. location of the herniation and the ability to access the herniation. Indica­tions may also depend on injection and imaging studies to identify a painful condition of the disc. The painful condition is currently identified by pre­operative diagnostic and therapeutic injections such as evocative chromo­diskography, foraminal epidurography, therapeutic foraminal blocks, or selective nerve root blocks. Small disc herniations with sciatica, herniations with predominant back pain from the herniation, and annular tears that cause chemical sciatica that may be considered relative contraindications for traditional surgery because of the surgical risk-benefit ratio of the proce­dure, but may be an indication for foraminal endoscopic surgery. Any con­dition that obviously benefits from intradiscal therapy such as intradiscal debridement of diskitis is best performed percutaneous transforaminally. Contraindications are relative, dependent on percutaneous access to the
BACKGROUND OF SCIENTIFIC TESTING
AND CLINICAL OUTCOMES
Peer-reviewed literature for disc herniation, first reported by Mayer and
19
Brock
in 19933 then by Hermantin2 in a prospective randomized study, has concluded that the results with transforaminal endoscopic (coined “arthroscopic” by Kambin similar to those with open diskectomy, but with significantly less surgical morbidity and quicker recovery (Table 64-1). The YESS technique evolved from the original Kambin technique as Yeung originally learned from Kam­bin. The procedure, done on an outpatient basis, utilizes local anesthesia with sedation. Patients are usually discharged an hour after surgery. Results show
20
) diskectomy in the lumbar spine are generally
PARTIAL INSTRUMENT SET FOR SELECTIVE ENDOSCOPIC DISCECTOMY (NOT TO SCALE)
Stylet
(used in needle)
Needle
C H A P T E R   6 4     Endoscopic Surgical Pain Management in the Aging Spine
Cannula
Obturator
(blunt end, 2-hole; side
hole allows delivery
of anesthetic)
Trephine Rongeur
expanded visualization of surgical field
(working channel
for all tools not used
w/needle; beveled edge allows
429
Exploded view of scope tip w/tool in working channel
Tool
V
i d e o
f
i e
l d
Tool
F IG UR E 6 4- 2   Richard Wolf YESS Multichannel Operative Endoscope. The spinal endoscope is designed with an operative channel, multichannel irrigation 
for improved visualization, and a cannula system configured to enhance surgical access to pathoanatomy  while protecting sensitive anatomy such as spinal nerves. 
(Reprinted from Yeung CA, Hayes VM, Siddiqi FN, Yeung AT. Lumbar endoscopic posterolateral (transforaminal) approach. In Motion pre servation surgery of the spine. Yue JJ, Bertagnoli R, McAfee PC, An HS (eds). Philadelphia, Saunders/Elsevier, 2008.)
Working
channel
Video CCD
pickup
Irrigation
channel
Cannula
Scope tip and tool within cannula
YESS
DISCOSCOPE
Yeung Endoscopic Spine Surgery system
for selective endoscopic discectomy
Light cable
Irrigation port
Suction
hose
Tool
and spinal endoscopy
Video cable
Cannula
Tool
Cannula
Tissue
Video display from discoscope
the goal established for endoscopic surgeons wishing to take up the proce-
TA BL E 64 -1 Mic rodi skec tomy versus Endo scop ic
Diskec tomy
Level II-III Evidence
Satisfactory outcome 97% 93%
“Very satisfied” 73% 67%
Disability
Narcotic use 7 days 25 days
Hospital stay 0 day 1 day
From F.U. Hermantin ,T. Peters, L. Quartararo, et al. A prospective randomized study compar­ing the results of open discectomy with those of video-assisted arthroscopic microdiscectomy.  Journal of Bone and Joint Surgery 81A ( 1999 ) 958 – 965.
*
Sixty patients randomized, 30 per group.
Group 1: Arthro scopic Microdiskectomy
27 days 49 days
*
SURGICAL OUTCOME
Group 2: Microscopic Diskectomy
dure. The results for all types of herniated nucleus pulposus (HNP), through 2008, as reported in the literature are summarized in Table 64-2.
The YESS endoscopic transforaminal approach, described in this chap­ter, also addresses a wide spectrum of painful degenerative conditions of the lumbar spine. The results of highly selected patients for these painful conditions have been reported at national and international spine meetings, but the clinical results of endoscopic treatment contained and noncontained HNP studies were last reported in 2004. Over 3,000 cases recorded on an excel database ranging from 1- to 10-year follow-up using clinical standard­ized measurements such as visual analog scale (VAS), Oswestry Disability Index (ODI), SF 12 (lifestyle disability scale), and MacNab criteria are cur­rently being collated independently for peer-reviewed publication.
The endoscopic foraminal approach, differentiated from the posterior approach, emphasizes the dilation along tissue planes without damage to normal anatomy. The foraminal approach for disc herniation utilizing the “inside-out-technique” provides easy access for central, paracentral, and subligamentous foraminal and extraforaminal disc herniations through natural tissue planes between the longissimus and psoas muscles (Figure
64-3). For foraminal and large paracentral herniations, it is easy to visualize
the lateral edge of the traversing nerve (Figure 64-4) once the herniation
that patients use less postoperative pain medication and return to work within 1 to 6 weeks. It is not unusual for individual patients to return to work in a matter of days. Long-term follow-up has demonstrated decreased recur­rence (6%), less postlaminectomy syndrome, and greater patient satisfaction overall. Morganstern, a student of Yeung
21
, has reported6 that after a learning curve of approximately 70 patients utilizing the YESS technique for a wide spectrum of disc herniation types, a 90% overall good/excellent result by MacNab and modified MacNab criteria is achievable. The 90% standard was
is removed. If the fragment is large and extruded, it comes out as an intact collagenized fragment. Prodromal symptoms of disc herniation in the aging spine usually arise from annular tears, which cause recurrent back pain and sciatica before the disc herniates. The opportunity to study and treat pain­ful annular tears endoscopically that do not heal naturally provides infor­mation on validating the theory of electrothermal therapy but also sheds light on the reasons why the usefulness of blind radiographic methods will always be limited. Identification of granulation tissue and nucleus material
430
P A R T V I I I     The Future of the Aging Spine
TA BL E 64 -2 Resul ts of Arth roscop ic Di skec tomy* versu s Mic rodi skec tomy
Author(s)
Mayer   (1993)
Kambin   (1999)
Yeung   (2000)
Lew/Mehalic 
Number of Patients
20 Contained HNP  
60 Small protrusion  
500 All patient groups 42  
49 Far lateral HNP NR NR 85%
Type of Treatment (Indications)
Small protrusion Single
Contained/extruded HNP
Mean Age (range)
Mean Follow-up (range)
Results MacNab Good/Excellent
NR NR 80%
NR NR 97%
NR 86%
25-69
(2001)
Yeung   (2001)
Tsou/Yeung 
307 HNP—all types  
All patient groups
NR   18-72
23   NR
219 HNP with neurologic deficit NR NR 93%
(2002)
Ruetten  
463 All HNP NR NR 81%
(2005)
Choi/Lee   (2007)
Ruetten   (2008)
Hoogland  
41 Extraforaminal HNP 58.7  
32-74
178 All HNP 43  
20-68
34.1   NR
NR   1-24 mo
262 Recurrent HNP NR NR 86%
(2008)
*Term coined by Kambin; later used generically to denote endoscopic foraminal diskectomy. ( P. Kambin, Arthroscopic microdiskectomy. Mt Sinai J Med  58(2) (1991) 159-64).
MacNab criteria: Good—occasional back or leg pain not interfering with normal work or recreation; Excellent—no pain, no restriction of activity.
84%
92%
82%
F IG UR E 6 4- 3   Basic  “Inside-Out-Technique”  for  Endoscopic  Disc 
Decompression. Uniportal technique for selective endoscopic diskectomy. After  introduction of a beveled cannula, endoscopic microrongeurs are used for visu­alized fragmentectomy. This  is followed by use of specialized hinged rongeurs  and straight  and flexible shavers  to remove the  soft nucleus from  the annular  herniation defect. (Reprinted from Yeung CA, Hayes VM, Siddiqi FN, Yeung AT.
Lumbar endoscopic posterolateral (transforaminal) approach. In Motion pres­ervation surgery of the spine. Yue JJ, Bertagnoli R, McAfee PC, An HS (eds). Philadelphia, Saunders/Elsevier, 2008.)
in the annular layers (Figure 64-5A) provides a good prognosis for those tears treated with thermal annuloplasty. The nucleus material that weakens the annulus must be removed before the annulus is cauterized to close the tear. Using a biportal approach and a 70-degree scope, cauterization and confirmation of successful thermal annuloplasty under direct endoscopic
F IG UR E 6 4- 4   Traversing Nerve after Removal of a Extruded Foraminal 
HNP. Indigo carmine dye stains the degenerative nucleus blue, helping the sur­geon to  selectively remove not  only the extruded, sequestered disc herniation,  but also the loose degenerative disc material, which could become the source of  a recurrent herniation.  Here, the  decompressed traversing nerve is clearly visu­alized to  confirm  complete decompression of the herniation.  Intraoperative or  postoperative CT scan or MRI is not needed to confirm complete decompression  of the spinal nerve when visual confirmation confirms successful removal of the  herniation. The real-time extraction of the herniation fragment, followed by direct  visualization of the decompressed nerve, confirmed by the conscious patient pro­viding immediate feedback reporting immediate relief of leg pain, precludes the  need for traditional evidence based medicine calling for a double-blind, random­ized study to validate the selective endoscopic diskectomy technique or any visu­alized endoscopic technique designed to address the pathoanatomy.
visualization provide confirmation that the tear is closed and sealed (Figure 64-5B).
The technique for endoscopic foraminoplasty in more advanced disc degeneration and foraminal narrowing is associated with central and foraminal stenosis, not only for lateral recess stenosis but also for foraminal
C H A P T E R   6 4     Endoscopic Surgical Pain Management in the Aging Spine
Grade IV
tear
431
A
F IG UR E 6 4 -5   Endoscopic Thermal Annuloplasty of Annular Tears. A, Painful annular tear identified endoscopically after intraoperative chromo-diskography 
confirms the  presence  of a grade IV  annular  tear  with disc tissue  embedded  in  the annular fibers. Tears  that  don’t heal have imbedded  disc  material preventing   the tear from healing naturally. The nucleus material must be removed from the annular layers before the results of thermal annuloplasty is predictable. This is the  reason the surgical results of  IDET is  not predictable. Selective endoscopic diskectomy removes degenerative disc material as well as the nucleus  embedded  in the  annulus. Endoscopic  thermal annuloplasty follows. Tears  vary  in size, location,  and  type. One or  two  quadrant posterior and  posterolateral  tears in patients  with  20% to 25% remaining annular thickness have good long-term results following endoscopic thermal annuloplasty. More extensive tears will also heal, but can tear  again. Painful annular tears are best diagnosed with Evocative Chromo-Discography and confirmed by endoscopic  visualization of the tear. Diskography performed  by the surgeon evokes the pain, while the indigo carmine dye helps locate the tear. Granulation and inflammatory tissue are often found adjacent to the tear, and  visual documentation of tear closure provides evidence of endoscopic thermal annuloplasty in the treatment of painful annular tears as a source of pain in the aging  spine. B, Illustration of selective endoscopic diskectomy and thermal annuloplasty technique for a grade IV Tear. C, Grade III-IV annular tear cauterized and closed  with bipolar radiofrequency thermal annuloplasty as viewed through  a  70-degree scope. The prognosis for this tear is good because the tear is completely closed,  and 20% to 24% of the annulus is still preserved after closing the tear.
decompression of the ventral facet in tall discs to gain “inside-out” access to sequestered herniations in the epidural space. A foraminoplasty cannula exposes the ventral aspect of the superior facet for endoscopic decompres-
B
C
or implants such as spinal cord stimulators. Preoperative evaluation incor­porates correlation of the findings on imaging studies such as MRI, CT
scan, diskography, and CT/diskography. sion (Figure 64-6A), which helps strip the capsule and define the under­surface of the facet to be removed with trephines and burrs (Figure 64-6B). Degenerative spondylolisthesis is often associated with disc protru­sions and lateral stenosis, whereas sciatica from isthmic spondylolisthesis, due to the mechanical compression of the axilla and subarticular recess (Figure 64-6C), is effectively treated by endoscopic foraminal decompres­sion in selected patients. These patients usually improve temporarily with foraminal diagnostic and therapeutic injections. Endoscopic decompres­sion of the foramen can provide enough relief that the patient will avoid fusion. Failed back surgery syndrome (FBSS) patients with lateral recess stenosis and recurrent disc herniation also respond well. When the sup­port is shifted posteriorly to the facet joints, synovitis and facet cysts may form. These cysts may impinge on the spinal nerves. Pedunculated cysts are sometimes visualized endoscopically, especially if the cyst wall is stained by

OPERATIVE TECHNIQUE(S)

Anesthesia
The procedure is carried out in an operating room. Local anesthesia using
0.5% to 1% lidocaine, supported by an anesthesiologist using fentanyl and
midazolam (Versed), is all the anesthesia needed. Some surgeons and
anesthesiologists are more comfortable with general anesthesia, and it is an
acceptable standard of care to use general anesthesia, but there is greater
chance of nerve injury from anatomic variations of the position of the exit-
ing nerve and with anomalous nerves in the foramen, such as the furcal
nerves. The patient’s ability to feel pain during the procedure provides an
additional safety factor for foraminal surgery. indigo carmine or is visualized in the course of a diskectomy for chronic sciatica (Figure 64-7). Degenerative and isthmic spondylolisthesis (Figure
64-8A-D) can also be treated endoscopically with proper interventional
injection workup. Impingement from the disc or superior facet of the infe­rior vertebra can be sorted out with diagnostic and therapeutic injections. If evocative diskography evokes concordant back pain and/or sciatica, and foraminal epiduralgrams and therapeutic injections provide information of the pathoanatomy, then careful preoperative planning will provide informa­tion on the likely outcome of foraminal decompression.
Position
The prone position is preferred because it provides a more intuitive for the
surgeon and lends greater flexibility when using a biportal approach work-
ing inside the disc space. The biportal approach provides greater visual
control of the flexible shavers and larger surgical instruments. A six-step
protocol in standardizing optimal needle and instrument placement is
extensively published, and not within the scope of this chapter.

CLINICAL PRESENTATION AND EVALUATION

The clinical presentation and evaluation for endoscopic decompression are the same as for the techniques used for traditional transcanal surgery. FBSS patients, however, represent a large and diverse group of spine surgery patients who have previously undergone spine surgery to treat back pain, yet they continue to suffer from back pain and sciatica after one or more spine surgeries. FBSS can be the result of an initial failure to recognize all of the pain generators, failure of the initial surgery (inadequate disc removal), recurrence of the original pathology (recurrent disc herniation), or progres­sion of the underlying condition (lumbar spondylosis and facet arthrosis). The endoscopic applications outlined in this chapter are applicable to all of these conditions and often obviate the need for large instrumented fusions
Procedure
The procedure and technique described are those preferred by the author.
In every instance, diskography is an integral part of the technique. The
diagnostic value of the subjective provocative response is valuable for con-
firming the disc as the source of the pain. Not only is evocative Chromo-
Discography a clinical confirmatory test that links the suspected painful
disc to the patient’s subjective pain complaints, but the blue staining of the
degenerated nucleus pulposus and annular defects, using the vital dye indigo
carmine in 10% concentration, visually identifies normal and degenerative
portions of the disc and annulus in contained or uncontained herniations.
Contiguous disc fragments in the epidural space, disc tissue embedded in
the annular defects, and herniation tracts are stained by the dye for targeted
432
ENDOSCOPIC FORAMINAL-PLASTY
P A R T V I I I     The Future of the Aging Spine
Lateral stenosis
Superior view
A
B
F IG UR E 6 4 -6 A, Endoscopic foraminal decompression. In more advanced aging, foraminal stenosis and osteophytosis can cause impingement of the spinal 
nerves. A specially configured cannula is placed under the facet for foraminal decompression. A side-firing laser is useful to strip the capsule from the facet; then a tre­phine and high-speed diamond burr are used to decompress the ventral portion of the facet to enlarge the foramen and elevate the foraminal window to gain access  to the epidural space. The exiting nerve is then followed into the epidural space to decompress the axilla between the traversing and the exiting nerve. Decompression  continues until the lateral edge of the traversing nerve is visualized or until fat is seen in the foramen. B, Foraminal decompression may be performed in conjunction  with disc decompression or as a stand-alone procedure. Here, the illustration demonstrates the use of the holmium:yttrium-aluminum-garnet side-firing laser to strip  the capsule from the ventral facet. More extensive decompression may be further performed with trephines, endoscopic Kerrison rongeurs, high-speed endoscopic  burrs, or rasps. C, Decompressed exiting nerve for lateral recess stenosis. A high-speed diamond burr was used to complete the superior facet decompression to free  the exiting nerve by stripping the facet capsule and removing 4 mm from the ventral surface of superior facet.
Specialized cannula isolates facet,
protects nerve root
C
removal. Nonionic Isovue 300 contrast is used for radiographic visualiza­tion of the injectate. It is mixed with indigo carmine in a 10:1 ratio. In a nondegenerated disc, the roentgenographic contrast permeates the nucleus pulposus and forms a compact oval or bilobular nucleogram. There is no dye penetration into the substance of the normal impermeable annular col­lagen layers. Therefore the absence of an annulogram represents a normal annulus. In degenerated conditions, clefts, crevices, tears, and migrated frag­ments of nucleus will be filled with contrast both inside the disc and along the herniation tract.
A syringe is attached to the needle via an extension tube and the surgeon correlates the patient’s response to the application of the injectate. Manual pressure, graded light, moderate, and high, is accurate enough to correlate the patient’s response to the injection, thereby correctly used here the pain generated by the diskography process with the volume and pressure of the manual injection. This must also be correlated with the diskogram pat­tern. The literature promotes the use of a transducer to record the intra­discal pressures during the diskogram process. Surgeons who perform their own diskography, however, rapidly learn to correlate the findings with the
endoscopic pathoanatomy and become more proficient at patient selection. For patients with ambiguous clinical complaints, a preoperative diskography may help clarify the nature of the spinal problem. However, intraoperative diskography has the advantage of outlining the disc herniation as identified on the preoperative MRI study and assists the surgeon in removal of the disc. Ultimately the herniated disc material is extracted under endoscopic visualization.
The endoscopic approach uses a posterolateral approach, located typically 10 to 12 cm from the midline of the spine in a 160- to 180-pound patient, and uses an access cannula with 6- to 7-mm inner diameter and 7- to 8-mm outer diameter. It allows for the use of foramimal endoscopes with 2.8-, 3.1-, and 4.0-mm working channels that provide excellent, clear visualization of and access to the foraminal structures containing the disc and annulus, the epidural space, and ventral surface of the facet joint, including the pedicle and vertebral body. A combination of trephines, Kerrison rongeurs, high­speed drills, articulating graspers, flexible pituitary graspers, and various laser delivery systems can be used to ablate nerves, enlarge the neural foramen, remove facet and foraminal osteophytes, and decompress the spinal canal
C H A P T E R   6 4     Endoscopic Surgical Pain Management in the Aging Spine
433
compressing neural structures without any destruction of the posterior spinal structures. Foraminal decompression is capable of treating a treating a wide variety of the pathologies discussed here. Its application potential in the elderly is virtually limitless, as it allows for outpatient and minimally invasive treatment of many spine disorders currently managed with either large, open surgeries or
F IG UR E 6 4 -7   Pedunculated  Synovial  Cysts.  Pedunculated  cysts  may 
be difficult to see on MRI because they may vary in size and are sometimes seen  incidentally during  foraminal  surgery.  It does not have  to  be  located adjacent  to the facet joint,  because the  cyst may be medial or  lateral  to  the joint. Here  the cyst,  accompanied  by  a  plexus of  blood  vessels,  is  found in  the  foramen  compressing the exiting nerve. Usually a cyst is suspected from the finding of a  bright signal adjacent to the facet capsule.
pain medications alone. The emergence of foraminal spinal endoscopy offers a bridge for treating many spinal ailments in patients who might not fare well with large open surgeries yet need something more than pain management.

POSTOPERATIVE CARE

A postoperative lumbar corset will make the patient feel more comfortable. Before removal of the access cannula, routine use of depomedrol 80 mg delivered with 0.5% bupivacaine (Marcaine) (1-2 ml) will provide immediate postoperative analgesia; there have been no instances of infection from the use of steroids. The patient should be instructed to avoid bending, lifting, and twisting for 4 to 6 weeks to allow the annulus to heal and to reduce the incidence of recurrent disc herniation from the foraminal access portal and from an annular defect produced by the disc herniation. Physical therapy is not required but can be considered on an individual basis. Patients are instructed to use their pain as a guide to activity after the 6-week period.

COMPLICATIONS AND AVOIDANCE

The risk of serious complications or injury is low—approximately 1% or less in the authors’ experience. As with any surgery, there are the usual risks of infection, nerve injury, dural tears, bleeding, and scar tissue formation. Transient dysesthesia, the most common postoperative complaint, occurs in approximately 5% to 15% of cases and is almost always transient. Its cause remains incompletely understood, but a detailed study of foraminal anatomy reveals an extensive network of nerves that can be surgically irritated, even with the most careful use of surgical instruments. Dysesthesia may also be related to nerve recovery, operating adjacent to the dorsal root ganglion of the exiting nerve, or a small hematoma adjacent to the ganglion of the exiting nerve, because it can occur days or even weeks after surgery. There are also anomalous nerve fibers in the annular tissue, which may be furcal nerves or
A
C
FI G U RE 6 4 -8   Both isthmic and degenerative forms of spondylolisthesis are treatable endoscopically if the pain gen-
erator can be demonstrated to come from the disc or foramen. A, Lateral MRI demonstrates a degenerative spondylo listhesis  with a disc protrusion contributing to central stenosis. The disc can be decompressed endoscopically, but the risk of instability  with further slippage is increased. B, There is foraminal stenosis causing sciatica. This patient had right sciatica, not left; good  relief was obtained with a foraminal epidural block on the right. C, Endoscopic foraminoplasty identified impingement of the  exiting nerve by the tip of the superior facet of the inferior vertebra. D, A furcal nerve was found in the foramen, possibly also  contributing to the patient’s sciatica. His sciatica resolved following foraminal endoscopic decompression.
B
D
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P A R T V I I I     The Future of the Aging Spine
ADVANTAGES AND DISADVANTAGES
e visualization of conjoined nerves, furcal nerve branches, and anomalous  anatomy such as sympathetic nerves may shed light on why current imaging  studies cannot fully explain the reason(s) that some patients with identical  imaging studies have debilitating pain and others do not. e advantages of  endoscopic visualization of dorsal and foraminal pathoanatomy provide greater  opportunity for surgical treatment. When the degenerative process creates con­ditions that are demonstrated to produce pain, ablation of nerves responsible  for pain is a viable surgical procedure that causes very little surgical morbidity  as compared to the traditional techniques such as fusion. ese variations in  normal anatomy and anomalous nerves in the foramen also present a new set  of surgical risks to the endoscopic surgeon. Irritation or surgical injury to these  sensitive nerves, often unavoidable, is considered a risk that is fortunately very  small compared with the benefit of pain relief.
nerves growing into an inflammatory membrane in the area of the foramen that is not the traversing or exiting nerve. It could show up in the surgical specimen without permanent effect on the patient, but may cause temporary dysesthesia. Using blunt techniques to dilate the annular fibers has limited surgical morbidity and the excisional biopsy of tissues (anomalous nerves) caused by neo-neurogenesis and angiogenesis from the surgical specimen, but dysesthesia cannot be avoided completely, because it has occurred even when there were no adverse intraoperative events and in cases in which the continu­ous electromyography (EMG) and somatosensory evoked potentials (SEP) did not show any nerve irritation. The symptoms are sometimes so minimal that most endoscopic surgeons do not report it as a “complication.” The more severe dysesthetic symptoms are similar to a variant of complex regional pain syndrome, but usually less severe, and without the skin changes. Postopera­tive dysesthesia is treated with transforaminal epidurals, sympathetic blocks, and the off-label use of pregabalin 150 mg/day or gabapentin titrated to as much as 1800 to 3200 mg/day. Gabapentin is approved by the U.S. Food and Drug Administration (FDA) for postherpetic neuralgia, but is effective in the treatment of neuropathic pain. The close proximity of sympathetic nerves and their role in disc innervation is still poorly understood, but treatment of dysesthesia by blocking the sympathetic trunk has produced dramatic results, especially when provided early in the course of postoperative dysesthesia.
Avoidance of complications is enhanced by the ability to visualize nor­mal and pathoanatomy clearly, as well as through the use of local anesthesia and conscious sedation rather than general or spinal anesthesia. Adopting the “inside-out-technique” will give the surgeon more leeway in planning the surgical approach, since direct targeting to the herniation based on imaging studies may provide some “surprises” when visualization is not as clear as anticipated because of bleeding, and the herniation turns out to be more than a simple herniation not appreciated by the imaging study. Staying inside the disc space or returning to the disc space when visualization is obscured to reorient the surgeon is an important factor to consider. In expe­rienced hands, some surgeons have safely utilized general anesthesia when circumstances make it safer for the patient. With use of a local anesthetic, the patient usually remains comfortable during the entire procedure, with the exception of periods such as during Evocative Chromo-Discography annular fenestration, or when instruments are manipulated past the exit­ing nerve. Local anesthesia of 0.50% lidocaine permits generous use of this diluted anesthetic for pain control but allows the patient to feel pain when the nerve root is manipulated. Nerves can also be adherent to the annulus or nucleus. Pain experienced by the patient is very helpful to the surgeon when probing or operating in the foramen, as it permits documentation or release of these adhesions before removing the herniation.

CONCLUSIONS AND DISCUSSION

In summary, endoscopic posterolateral lumbar diskectomy and forami­nal decompression provides a visualized method for minimal access to the disc and epidural space that avoids surgical morbidity to the dorsal muscle column. This endoscopic approach also allows for the visualiza­tion of foraminal and intradiscal pathology that is not appreciated by the traditional approach. Inflammation pays a major role in pain production.
The correlation of these conditions and findings with pain generation may open the door to a better understanding of the degenerative process caus­ing lumbar disc herniations, and our concept of surgical intervention that encourages patient selection for earlier intervention may evolve as well. Fol­lowing foraminal diskectomy and decompression, the traversing nerve, exit­ing nerve, axilla, and epidural space are all able to be probed and visualized. It is not always necessary to directly visualize all structures if there is good indirect evidence that the painful structure is being appropriately addressed; an example is decompression of a central disc herniation by visualizing the annulus and annular tears with an intradiscal view of the annulus. Patients can also provide confirmation that their leg pain is gone when undergoing surgery under conscious sedation. A closer study of posterior column and facet innervation will also open the door for endoscopic nerve ablation tech­niques that can be used for axial back pain.
In this area of health care reform, identifying the pain generator early, and treating it with a minimally invasive technique with surgical pain man­agement, may lead to cost savings by decreasing our dependence on drug usage for chronic pain, and large expensive destructive surgery spine surgery such as fusion. Any technology to help surgeons attain proficiency through surgical training simulators or improved imaging capability, preoperatively or intraoperatively, should be part of the equation in health care reform.

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