Биоинженерия / Биомеханика_микрофлюидные_устройства / статьи / 20_BIOMGB-000005-032006_1

CONCLUSIONS

In summary, we developed an in vitro cell culture model of atherosclerosis where realistic replication of mechanical stresses seen in regions of disturbed flow are accurately replicated. Proof of concept studies clear demonstrate structural and functional differences in HAECs cultured under normal and disturbed flow conditions confirming the ability of this system to accurately mimic the in vivo mechanical loading environment.

ACKNOWLEDGMENTS

This work was supported in part by the National Science Foundation under Grant No. 0814194 and American Heart Association National Scientist Development Grant No. 0730319N. R.E. was partially supported by the Department of Bioengineering via Research Incentive Funds.

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