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- •Anemia
- •Syndromes in anemia
- •Definition of anemia
- •Risk factors for anemia
- •Classification of anemia
- •Classification of anemia
- •Classification by severity
- •Symptoms and signs of anemia
- •Initial investigations in anemia
- •Iron deficiency anemia
- •Causes of iron-deficiency anemia
- •Syndromes in IDA
- •Symptoms of iron deficiency
- •Clinical presentation of IDA
- •Diagnostics of IDA
- •Poikilocytosis
- •Iron metabolism parameters and CBC changes in iron deficiency
- •Bone marrow in iron deficiency
- •Additional tests for differential diagnostics in IDA
- •Management of IDA
- •Megaloblastic anemia
- •Daily need in B12 and folic acid
- •Vitamin B12 absorption and transport.
- •Classification Of The Megaloblastic Anemias
- •Classification Of The Megaloblastic Anemias
- •B12 deficiency: pathogenesis of symptoms
- •Clinical presentation of megaloblastic anemia
- •Funicular myelosis
- •Diagnostics
- •Peripheral blood smear in megaloblastic anemia
- •Treatment
- •Response to therapy with B12 – reticulocytosis within 7-10 days
- •Hemolytic anemia
- •Pathogenesis of hemolytic anemia
- •Classification of hemolytic anemia
- •Mechanisms of different types of hemolysis
- •Classification Of Disorders Due To Hemoglobin Abnormalities
- •Hemolysis Due To Antibodies
- •Drugs Causing Hemolysis In Subjects
- •Clinical presentation
- •Diagnostics
- •Principles of treatment
- •Aplastic anemia
- •Clinical presentation of aplastic anemia
- •Pancytopenia
- •Aplastic anemia treatment
Pancytopenia
Bone marrow in total aplasia (may be associated with drugs, radiation, toxins
Aplastic anemia treatment
1.Bone marrow transplantation in all patients >30 years old
2.Immunosupression
3.Androgens intake
4.Transfusion of RBC and platelets
5.Stimulation of leukopoiesis
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