- •Запорожець т.М., ткаченко о.В.
- •Content module 1: introduction to physiology lesson 1 Physiology subject and tasks. Physiological investigations methods. Excitability. Excitement. Irritation laws.
- •Importance of Chronaxie
- •Materials for auditory self-work.
- •Task 2. To prepare nervous-muscular preparation.
- •Task 3. Nerve and muscle excitability measurement.
- •Task 4. Muscles contractions dependence on single irritations force.
- •Task 5. Draw and analize the curve “force-time”.
- •Literature recommended:
- •Materials for self-control: Control questions:
- •Content module 2: “excitable tissues physiology” lesson 2 Nervous and muscular fibers resting potential and action potential.
- •1. The topic studied actuality.
- •Electrical changes during muscular contraction
- •Resting membrane potential
- •Action potential
- •Repolarization
- •Action potential curve
- •Latent Period
- •Importance of intracellular potassium ions:
- •Action Potential
- •Refractory period
- •Excitability changings (figure of action potentials phases and excitability changings correlation)
- •4.Materials for auditory self-work.
- •Task 1. Galwani’s first experiment.
- •Task 2. Galwani’s second experiment (contraction without metal).
- •Task 3. K.Matteuchi’s experiment.
- •5. Literature recommended:
- •6. Materials for self-control:
- •Lesson 3 Nervous and muscular fibers electrical irritation mechanisms investigation. Electromyography.
- •1. The topic studied actuality.
- •III. Fibrillation and denervation hypersensitivity
- •IV. Myasthenia gravis
- •Emg application in dentistry different branches
- •Emg application in therapeutical dentistry.
- •Emg application in surgical dentistry.
- •Emg application in orthopedical dentistry.
- •Emg application in children dentistry and orthodonthia.
- •3.2. Topic content.
- •Materials for auditory self-work.
- •5. Literature recommended:
- •6. Materials for self-control:
- •Lesson 4 Skeletal muscles contraction mechanisms investigation
- •1. The topic studied actuality.
- •Skeletal Muscle
- •Sarcomere
- •Composition of muscle
- •In Skeletal Muscle
- •Tongue, lips muscles and masticatory muscles contractive types and regimes at conversation.
- •Contractive types and regimens at mastication.
- •Masticatory muscles physiological properties. Masticatory musculature force and work.
- •The new in the world of masticatory muscles physiology and functional anatomy
- •4. Materials for auditory self-work.
- •Task 1. Skeletal muscle contractions curves registration
- •Task 2. Dynamometry
- •Literature recommended:
- •Materials for self-control:
- •Lesson 5 Skeletal and smooth muscles comparative characteristics.
- •Skeletal and smooth muscles comparative characteristics
- •Further events (common for skeletal and smooth muscles) –
- •4.Materials for auditory self-work.
- •4.1. List of study practical tasks necessary to perform at the practical class.
- •Task 1. Frog’s stomach smooth muscles contractions registration
- •Task 2. To compare frog skeletal and smooth muscle to chemicals
- •5. Literature recommended:
- •6.Materials for self-control:
- •Lesson 6 Excitation transmission investigation through nervous fibers and nervous-muscular synapses
- •1. The topic studied actuality.
- •3.2.Topic content.
- •Neuronal theory.
- •Electrical theory.
- •Chemical theory
- •2 Main types:
- •Functions:
- •Functions:
- •Functions:
- •Functions of Myelin Sheath
- •Neurilemma
- •Mechanism of Saltatory Conduction
- •Nervous fibers properties
- •Synapses physiology
- •4 Main mediators groups:
- •Functions of synapse
- •Electrical Synapse or Ephapse
- •Chemical Synapse
- •Mechanism of Development of epsp
- •Properties of epsp
- •Significance of epsp
- •1. Postsynaptic Inhibition
- •Action of gaba—ipsp
- •2.Presynaptic Inhibition
- •3.Renshaw Cell Inhibition
- •Materials for auditory self-work.
- •4.1.List of study practical tasks necessary to perform at the practical class.
- •Task 1. Isolated impulse conducting law (through nervous fibers).
- •Task 2. Two-sized conduction law.
- •Task 3. Physiological integrity law.
- •Task 4. To study fatigue (tiredness) ability in synapse.
- •Literature recommended:
- •Materials for self-control:
- •Control questions:
- •Lesson 7 Practical experience management on content credit 1,2: “Excitable tissues physiology”
- •Content credit 3: “organism functions nervous regulation” lesson 8 Reflex arc investigation. Receptors physiology.
- •1.The topic studied actuality.
- •3.2. Topic content.
- •1. Somatic Nervous System
- •2. Autonomic Nervous System
- •V.According to receptors localization:
- •VI.According to biological significance:
- •VIII.According to ending result:
- •2. Visceroreceptors:
- •Facial-mandibular region receptors
- •Classification:
- •Significance of Receptor Potential
- •Mechanism of Development of Receptor Potential and Generation of Action Potential in the Nerve Fiber
- •4.Materials for auditory self-work.
- •4.1. List of study practical tasks necessary to perform at the practical class.
- •Task 1. Receptive field definition.
- •Task 2. Reflex arc analysis.
- •Task 3. Gustatory receptors functional mobility determining (before and after eating).
- •5. Literature recommended:
- •6.Materials for self-control:
- •Lesson 9 Excitement processes investigation in cns. Inhibition processes investigation in cns.
- •1. The topic studied actuality.
- •3.2.Topic content.
- •Inhibiting in cns
- •4.Materials for auditory self-work.
- •Task 1. Temporary excitement summation.
- •Task 2. Excitement summation.
- •5. Literature recommended:
- •6.Materials for self-control:
- •Lesson 10 Reflex activity co-ordination mechanisms investigation.
- •1.The topic studied actuality.
- •3.2.Topic content.
- •4.Materials for auditory self-work.
- •4.1.List of study practical tasks necessary to perform at the practical class.
- •Task 1. Excitement irradiation in central nervous system.
- •5.Literature recommended:
- •Materials for self-control:
- •Control questions:
- •Content module 4: “cns role in motor functions regulation”
- •Lesson 11 Spinal cord physiology. Spinal cord role investigation in motor organism functions regulation
- •1.Topic studied actuality:
- •2. Study aims:
- •3.2. Topic content.
- •Internal structures of spinal cord
- •Neurons in Anterior Gray Horn
- •Neurons in Lateral Gray Horn
- •Neurons in Posterior Gray Horn
- •Spinal proper functions:
- •Spine vegetative functions:
- •Spine afferent ways:
- •Efferent ways:
- •Pyramidal tracts
- •Termination
- •Function
- •Effects of Lesion
- •Materials for auditory self-work.
- •Task 1. To investigate muscular tone in human being
- •Task 3. Deep (prophound) spinal reflexes investigation
- •5. Literature recommended:
- •Materials for self-control:
- •Lesson 12 Somato-sensor system investigation (skin and proprioceptive sensitivity, nociceptive sensitivity)
- •1.Topic studied actuality.
- •2 Main reasons:
- •Injured organ oxygen consumption inhibiting
- •Insufficiency in it
- •Pain classification:
- •Conductive ways
- •Visceral pain
- •Referred pain
- •3 Variants of pain theory:
- •Situation
- •Termination
- •Function
- •Situation
- •Termination
- •Function
- •Situation
- •Termination
- •Functions
- •Ascending tracts of spinal cord
- •Descending tracts of spinal cord
- •Sensory pathways
- •Pain projective zones at different teeth diseases
- •Dental pain conductive tracts and central mechanisms
- •4. Materials for auditory self-work.
- •4.1.List of study practical tasks necessary to perform at the practical class.
- •Task 1. To investigate hands and face skin pain sensitivity
- •Task 2. Temperature sensitivity investigation on hand
- •Task 3. Muscular-articular sensitivity investigation
- •Task 4. Pressure and weight sense investigation (Weber-Fechner’s law)
- •Task 5. Complicated sensitivity types investigation.
- •5. Literature recommended:
- •6. Materials for self- control:
- •Lesson 13 Posterior brain physiology. Posterior brain role investigation in motor and sensor functions regulation
- •1. The topic studied actuality.
- •2. Study aims:
- •3.1.Basic knowledge, skills, experiences, necessary for study the topic:
- •3.2. Topic content.
- •Medulla oblongata functions:
- •Pons cerebri
- •4. Materials for auditory self-work.
- •Task 1. Trigeminal nerve (V-th pair investigation)
- •Task 2. Facial nerve (VII-th pair) investigation
- •Task 3. Glossopharyngeal nerve (IX-th pair) investigation
- •Task 4. Accessory nerve (XI-th pair) investigation
- •Task 5. Hypoglossal nerve (XII-th pair) investigation
- •5. Literature recommended:
- •6. Materials for self- control:
- •Lesson 14 Midbrain physiology. Midbrain role investigation in motor and sensor functions regulation
- •1. The topic studied actuality.
- •3.2. Topic content.
- •Superior Colliculus
- •Red Nucleus
- •Connections of Red Nucleus
- •Task 2. Stato-kinetic human reflexes.
- •Task 3. Investigate static and stato-kinetic reflexes in guinea pig.
- •5. Literature recommended:
- •Control questions:
- •Lesson 15 Cerebellum, diencephalon, subcortex nuclei physiology, their role in organism motor functions regulation
- •1. The topic studied actuality.
- •Structural organization of a cerebellum.
- •Functions of cerebellum
- •Cerebellum and its connections
- •Signs of a cerebellum lesion
- •Signs of a pallidum lesion.
- •Signs of a striate body lesion. Striatic syndrome.
- •2. Study aims:
- •3.2.Topic content.
- •Intermediate brain physiology
- •Functions:
- •Functions
- •1. Secretion of posterior pituitary hormones
- •2. Control of anterior pituitary
- •3. Control of adrenal cortex
- •4. Control of adrenal medulla
- •5. Regulation of body temperature
- •10. Regulation of water balance
- •11. Regulation of sleep and wakefulness
- •12. Role in behavior and emotional changes
- •13. Regulation of sexual function
- •14. Regulation of response to smell
- •15. Role in circadian rhythm
- •Cerebellum physiology
- •Interneuronal activity in cerebellum
- •Components and connections of functional divisions of cerebellum
- •Corticocerebellum (neocerebellum)
- •Functions of cerebellum
- •Connections of basal ganglia
- •1. Control of voluntary motor activity
- •2. Control of muscle tone
- •3. Control of reflex muscular activity
- •4. Control of automatic associated movements
- •5. Role in arousal (excitive) mechanism
- •4.Materials for auditory self-work.
- •4.1.List of study practical tasks necessary to perform at the practical class.
- •Task 1. To investigate movement co-ordination
- •Task 2. Asynergy investigation
- •Task 3. Dynamic ataxy investigation
- •Task 4. To put the attention to:
- •1. Literature recommended:
- •Materials for self-control:
- •Lesson 16 Practical experiences management on content credit 4: “cns role in motor functions regulation”
- •1. The topic studied actuality.
- •2. Study aims:
- •Topic content.
- •Ans is divided into 3 main parts:
- •Vegetative and somatic nervous system comparative characteristics
- •Ans mediator mechanisms
- •Organs with monosympathetic innervation:
- •Organs with monoparasympathetic innervation:
- •Vegetative ganglii features:
- •Effects of autonomic nervous system of selected organs
- •Metasympathetic nervous system (mns)
- •Mns functions:
- •2. Materials for auditory self-work.
- •Task 1. To perform pupils investigation
- •Task 2. Reflex to eyes convergence
- •Task 3. Vasomotor skin functions investigation
- •Task 4. Dermographism
- •Task 5. Erben’s reflex
- •Task 6. Abrams’ reflex
- •Literature recommended:
- •Materials for self-control:
- •Control questions:
- •Hormones synthesis, secretion and releasing. Hormones classification (according to their chemical structure):
- •Interrelations between nervous and humoral mechanisms in physiological functions regulation.
- •6. Materials for self-control:
- •Control questions:
- •Lesson 19 Hormones role in psychical and physical development, linear body growth, adaptation, homeostasis regulation.
- •1. The topic studied actuality.
- •2.Study aims:
- •Corticotropine main effects:
- •Thyreotropine main effects:
- •Gonadotropines main effects:
- •Oxytocine main effects:
- •Vasopressine main effects:
- •Glucocorticoids effects-1
- •Glucocorticoids effects-2
- •Glucocorticoids effects-3
- •Vascular effects:
- •Glucocorticoids metabolic effects
- •Mineralocorticoids main effects:
- •Adrenaline main effects:
- •Adrenaline metabolic effects;
- •Somatotropine main effects:
- •Prolactine main effects:
- •Male sexual hormones
- •Inhibine
- •Progesterone functions:
- •Stress, general adaptation syndrome.
- •General adaptational syndrome morphological features.
- •Stress-inducing and stress-limiting systems. Diseases of adaptation
- •Stress-triggers or stressors:
- •4. Materials for auditory self-work.
- •Task 1. To investigate adrenaline influence on pupil width
- •Task 2. To observe pituitrine action to melanoforme cells
- •Task 3. To observe insuline action on white mice
- •Task 4. Spermatozoid reaction of Gally-Maininy
- •5. Literature recommended:
- •6. Materials for self-control:
- •Credit control on module 1: “general physiology”. Questions list for credit module control module 1
- •Content module 5. Autonomic nervous system role in visceral functions regulation.
- •Content module 6.
- •Visceral functions humoral regulation and endocrine glands role in regulation.
- •Tests for self-control:
- •Tasks for self-control
- •1. Introduction.
- •3. Ending aims of studying the subject “Normal Physiology”.
- •4. Module 1: General physiology
- •4.3. The student self-work types
- •4.4. Individual tasks list:
- •4.5. Credit modules assessment methodics.
- •4.6. Theoretical questions list for students preparing to credit module control
- •4.7. Practical tasks and works list to the credit module control Module 1: General Physiology Practical skills on excitive structures physiology.
- •Practical skills on organism functions nervous regulation physiology and cns role in motor functions regulation.
- •4.8. Literature recommended on the subject “Normal Physiology”.
- •Literature recommended
Міністерство охорони здоров’я України
Вищий державний навчальний заклад України
“УКРАЇНСЬКА МЕДИЧНА СТОМАТОЛОГІЧНА АКАДЕМІЯ”
Кафедра нормальної фізіології
Запорожець т.М., ткаченко о.В.
НОРМАЛЬНА ФІЗІОЛОГІЯ
НАВЧАЛЬНИЙ ПОСІБНИК ДЛЯ СТУДЕНТІВ МЕДИЧНОГО ТА СТОМАТОЛОГІЧНОГО ФАКУЛЬТЕТІВ
МОДУЛЬ 1: “ЗАГАЛЬНА ФІЗІОЛОГІЯ”
ПОЛТАВА 2008
Approved by
the Central methodical comission
the protocol N.1. from 20.09.2007.
It was composed by: Zaporozhets T.N., d.med.sci., prof., Tkachenko E.V., assistant
Reviewers:
The doctor of medical sciences, professor Kostenko V.A., the head of pathological physiology department of the highest state educational institution of Ukraine “Ukrainian Medical Dental Academy”, Poltava.
Cand. Phil. Sci. Znamenskaya I.V., the higgher lecturer of foreign languages department of the highest state educational institution of Ukraine “Ukrainian Medical Dental Academy”, Poltava.
In a given manual materials of English and American authors such as I.S.Fox, W.Ganong, Guyton were represented in an origin. The manual contains theoretical material and material for practical classes, questions for students’ self-preparing as well as tests and tasks (with answers) for preparing to Krok-1. It is illustrated by figures and tables.
Затверджено Центральною
методичною комісією
Протокол №1 від 20.09.2007 р.
Склали: Запорожець Т.М., д.мед.н., професор, Ткаченко О.В., асистент
Рецензенти:
Доктор медичних наук, професор Костенко В.О., завідувач кафедри патологічної фізіології вищого державного навчального закладу України «Українська медична стоматологічна академія», м.Полтава.
Кандидат філологічних наук Знаменська І.В., старший викладач кафедри іноземних мов вищого державного навчального закладу України «Українська медична стоматологічна академія», м.Полтава.
У навчально-методичному посібнику були використані матеріали англійських та американських підручників під редакцією I.S.Fox, W.Ganong, Guyton. Автори зберегли мову оригіналів. Посібник містить теоретичний матеріал та практичні завдання, питання до самопідготовки студентів, а також учбові тести та задачі (з відповідями) для підготовки до ліцензійного іспиту з “Крок-1”. Посібник вдало ілюстрований тематичними малюнками і таблицями.
contents
CONTENT MODULE 1: INTRODUCTION TO PHYSIOLOGY 5
LESSON 1 Physiology subject and tasks. Physiological investigations methods. Excitability. Excitement. Irritation laws. 5
CONTENT MODULE 2: “EXCITABLE TISSUES PHYSIOLOGY” 11
LESSON 2 Nervous and muscular fibers resting potential and action potential. 11
LESSON 3 Nervous and muscular fibers electrical irritation mechanisms investigation. Electromyography. 21
LESSON 4 Skeletal muscles contraction mechanisms investigation 29
LESSON 5 Skeletal and smooth muscles comparative characteristics. 40
LESSON 6 Excitation transmission investigation through nervous fibers and nervous-muscular synapses 44
LESSON 7 Practical experience management on content credit 1,2: “Excitable tissues physiology” 64
CONTENT CREDIT 3: “ORGANISM FUNCTIONS NERVOUS REGULATION” 65
LESSON 8 Reflex arc investigation. Receptors physiology. 65
LESSON 9 Excitement processes investigation in CNS. Inhibition processes investigation in CNS. 76
LESSON 10 Reflex activity co-ordination mechanisms investigation. 81
CONTENT MODULE 4: “CNS ROLE IN MOTOR FUNCTIONS REGULATION” 84
LESSON 11 Spinal cord physiology. Spinal cord role investigation in motor organism functions regulation 86
LESSON 12 Somato-sensor system investigation (skin and proprioceptive sensitivity, nociceptive sensitivity) 98
LESSON 13 Posterior brain physiology. Posterior brain role investigation in motor and sensor functions regulation 118
LESSON 14 Midbrain physiology. Midbrain role investigation in motor and sensor functions regulation 122
LESSON 15 Cerebellum, diencephalon, subcortex nuclei physiology, their role in organism motor functions regulation 130
LESSON 16 Practical experiences management on content credit 4: “CNS role in motor functions regulation” 160
CONTENT MODULE 5: “AUTONOMIC NERVOUS SYSTEM ROLE IN VISCERAL FUNCTIONS REGULATION” 160
LESSON 17 Autonomic nervous system structural-functional organization, its role in visceral functions regulation. Autonomic reflexes structural distinguishing features. Autonomical nervous system integrative centers 160
CONTENT MODULE 6: “HUMORAL REGULATION AND ENDOCRINE GLANDS IN VISCERAL FUNCTIONS REGULATION” 168
LESSON 18 Humoral regulation, its factors, hormones action mechanism to the target cells, hormonal secretion regulation. Hypothalamic-hypophyseal system. 168
LESSON 19 Hormones role in psychical and physical development, linear body growth, adaptation, homeostasis regulation. 177
CREDIT CONTROL ON MODULE 1: “GENERAL PHYSIOLOGY”. QUESTIONS LIST FOR CREDIT MODULE CONTROL MODULE 1 188
TESTS FOR SELF-CONTROL: 189
TASKS FOR SELF-CONTROL 198