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Blood isolates of Staphylococcus

aureus

at a U.S. Hospital, 1993-2004

%RIS and histograms:

Pseudomonas aeruginosa

pneumoniae

Amikacin vs. Gentamicin

Scatterplot: Klebsiella pneumoniae

Third-Generation cephalosporins

United

andStates ESBL

hospital

South

America

hospital

pneumoniae

Multi-resistant clone beginning in July 1991

S.аureus Total and by

Resistance Profile

BacTrack Expert System

Isolate alerts

WHONET-SaTScan Clusters - by Species

Clusters

RI

Start date

End date

observed

expecte

observe

expecte

 

 

 

 

Initial

Initial

Total

Total

 

 

 

 

 

d

d

d

A. baumanii

250

10/18/200

12/9/200

6

0.76

20

8.15

 

 

4

4

 

 

 

 

S.

500

8/19/2004

8/25/200

8

1.09

10

1.57

marcescens

 

 

4

 

 

 

 

B. cepacia

>1,00

3/30/2005

5/29/200

5

0.31

16

4.15

 

0

 

5

 

 

 

 

SaTScan space-time permutation Jan 2004 - Dec 2005 outbreaks Range of Cluster Length - 1 to 100d

Total Hospitals - all organisms, first per patient “Nosocomial” isolates (>= Hospital Day 3) Limit to clusters >= 4 isolates

Acinetobacter baumanii isolates 2003-2005

Start date: 10/18/04

End date: 12/9/04

clusters

by Antimicrobial resistance

Cluster

RI

Start

End

Initial

Initial

Total

Total

s

 

date

date

observe

expecte

observe

expecte

 

profile

d

d

d

 

 

 

 

d

ACFLN

160

6/2/2005

6/26/2005

2

0.12

2

0.12

ACFLNG

>1,00

10/2/200

12/29/200

6

1.62

16

8.16

T

0

4

4

 

 

 

 

A=Ampicillin, C=Cefotaxime, F=Ceftazidime, L=Levofloxacin, N=Nitrofurantoin, G=Gentamicin, T=Trimethoprim/Sulfamethoxazole

ACFLN = Non-susceptible to 5 antimicrobials ACFLNGT = Non-susceptible to 7 antimicrobials

SaTScan space-time permutation Jan 2004 - Dec 2005 outbreaks Range of Cluster Length - 1 to 100d

“Nosocomial isolates” (>= Hospital Day 3) Cluster Size - 1 to 100d