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12. Read this text and translate it. Medical biotechnology

Medical biotechnology is the use of living cell materials to research and produce pharmaceutical and diagnostic products that help to treat and prevent humane diseases. Most medical biotechnologists work in academic of industrial settings.

Medical and pharmaceutical biotechnology can speed diagnosis, prevention, and certain therapies. Biotech medicine includes the creation of new vaccines, neutraceuticals, cosmetics with active biological ingredients, and medicines from transgenic animals and plants.

Due to the new basis, lack of experience and ignorance, the implementation of results of some areas of biotechnology (such as about stem cells, genetic enhancement, cell cloning, testing of new drugs in developing nations, controls of transgenic crops, and

international regulation and enforcement) met severe resistance of society. Recombinant DNA and hybridoma technologies have been applied long time ago for manufacturing of rare and unique drugs (mainly protein) for human and veterinary medicine.

Presently more than 150 recombinant proteins are approved or are in clinical trials for medical use.

Biotechnology met new challenges after the year 2000 when the human genome was sequenced. Although the function of 95% of the human 31 000 genes is still obscure, they all are of potential interest for the pharmaceutical biotechnology. The sequencing of human genome laid the foundations of a new branch of biotechnology called “genomic technologies”. They include not only sequencing of new genes and genomes but also development of molecular(DNA and RNA) markers and microarray chips

for detecting mutant genes and methods for specific gene silencing (suppression) and/or repair of defective genes for the purposes of gene therapy.

The fields of application of modern biotechnology techniques are medicines, vaccines, diagnostics, gene therapy, bioactive therapeutic, clinical and contract research and neutraceuticals.

13. Give Russian equivalents for the following words:

powerful techniques, recombinant DNA, hybridoma technologies, fermentation technologies, natural materials, achievements of genetic and cell engineering, medical and pharmaceutical biotechnology, diagnosis, prevention, biotech medicine, creation of new vaccines, active biological ingredients, transgenic animals and plants, stem cells, genetic enhancement, cell cloning, veterinary medicine, recombinant proteins, human genome, pharmaceutical biotechnology, genomic technologies, development of molecular markers and microarray chips, gene therapy, bioactive therapeutic.

14. Translate the sentences into English.

1) Трансгенный организм — живой организм, в геном которого искусственно введенген другого организма.

2) Пациенту была назначена музыкальная терапия.

3) Ему поставили диагноз– менингит.

4) В клинических исследованиях принимают участие ведущие медики страны.

5) Ученые должны ускорить темп работы, если они хотят закончить к условленному сроку.

6) Рекомбинантная ДНК - составлена из фрагментов разного происхождения.

7) Рекомбинантные белки - это белки, ДНК которых была создана искусственно.

15. Give detailed answers to the questions.

1) What does biotech medicine include?

2) Why did some areas of biotechnology meet severe resistance of society?

3) How were recombinant DNA and hybridoma technologies used?

4) How many recombinant proteins are approved in clinics?

5) When did biotechnology meet new challenges?

6) What is “genomic technologies”?

7) List the fields of application of modern biotechnology techniques.

16. Speak on the new facts you found in the text. What wondered you or what information was new for you? Can you add some other information about the

biotechnology?

17. Discover the difference in the sense of the following words:

Medicine, drug, tablets, medication, remedy, cure, medicament, preparation, physic, therapeutic, doctor's stuff.

18. Make sentences showing the difference of these words.

19. Read the text again and make questions to each paragraph.

20. Give a summary of this text. Check if all ideas from this text were used.

22. Give a detailed answer or write an essay on the following questions:

• The future of biotechnology.

• What scientist will I be? And how will I help humanity?

• What color of biotechnology is necessary to add?

UNIT 13

Genetic Engineering

What areas of biotechnology do you know? What does genetic engineering deal with?

Where can biotechnologists apply the products of genetic engineering?

Comment the joke on the picture. How do you understand it?

1. Read this text and translate.

The scope of genetic engineering

Genetic engineering is the area of biotechnology concerned with the directed alteration of genetic material.

Biotechnology has already had countless applications in industry, agriculture, and medicine. It is a hotbed* of research. The finishing of the human genome project – a “rough draft” of the entire human genome was published in the year 2000 – was a scientific milestone** by anyone’s standards. Research is now shifting to decoding the functions and interapplications based on this information. The potential medical benefits are too many to list; researchers are working on every common disease, with varying degrees of success. Progress takes place not only in the development of drugs and diagnostics but also in the creation of better tools and research methodologies, which in turn accelerates progress.

When considering what developments are likely over the long term, such improvements in the research process itself must be factored in***. The human genome project was completed ahead of schedule (it usually takes ten years to get from proof-of-concept to

successful commercialization).

Genetic therapies are of two sorts: somatic and germ-line. In somatic gene therapy, a virus is typically used as a vector to insert genetic material into the cells of the recipient's body. The effects of such interventions do not carry over into the next generation. Germ-line genetic therapy is performed on sperm or egg cells, or on the early zygote, and can be inheritable. Embryo screening, in which embryos are tested for genetic defects or other traits and then selectively implanted, can also count as a kind of germ-line intervention. Human gene therapy, except for some forms of embryo screening, is still experimental. Nonetheless, it holds promise for the prevention and treatment of many diseases, as well as for uses in enhancement medicine.

The potential scope of genetic medicine is vast: virtually all disease and all human traits – intelligence, extroversion, conscientiousness, physical appearance, etc. – involve genetic predispositions. Single-gene disorders, such as cystic fibrosis, sickle cell anemia, and Huntington's disease are likely to be among the first targets for genetic intervention. Polygenic traits and disorders, in which more than one gene is implicated, may follow later, although even polygenic conditions can sometimes be influenced in a beneficial direction by targeting a single gene.

Notes

*hotbed – a place where a lot of particular kind of activity happens.

**milestone – a very important event in the development of smth.

***to factor in – to include a particular thing in your calculations about how long something will take, how much it will cost etc.

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