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Файл:БХ - Презентации / Разные / 1.Энзимология и БО / 06-07-БО-1 (ЛФ).ppt
Monooxygenase System (Microsomal
Oxidation)
The substrate can be oxidized by incorporation of one atom of O2.
The enzymes are monooxygenases or cytochrome P450 - also mixed function oxidase.
The enzymes are associated with the smooth endoplasmic reticulum, preparated as microsomes.
RH + O2 + NADPH + H+ R-OH + H2O + NADP+
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Functioning of Microsomal
Respiratory Chain
|
e- |
e- |
|
FMN |
Cyt b5 |
O2 |
|
Cyt P450 |
|||
|
H2O
NADP + H+ |
NADP+ |
RH |
R-OH |
|
NADP + H+ |
|
|
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Microsomal Oxidation and Cytochrome P450
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