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Файл:ECHO 2013 / Cancer Treatment Related Cardiotoxicity
.pdf
Gaps in Knowledge (3)
Q: With prophylactic heart failure therapy, can cardiotoxicity be prevented?
A: ACE Inhibitors and carvedilol have been shown to reduce anthracycline induced cardiotoxicity in selected population.
Chemoprevention: Ongoing trials in HER2+ Breast Cancer
Thank You
Gaps in Knowledge (4)
Q: What are the long-term and late cardiac effects of HER2 targeted agents in breast cancer survivors?
A: Uncertain….
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NSABP B-31: |
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Population-based observational |
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cardiac death or CHF 4.0% |
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study : CM or CHF 20% |
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Tissue Doppler
S’ = 7.7 cm/sec |
S’ = 5.7 cm/sec |
E’ = 9.6 cm/sec |
E’ = 4.6 cm/sec |
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