Molecular Switches
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4 |
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F V
F V
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hν |
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S |
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Biomaterial |
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S' |
+ |
Biomaterial |
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Caged Biomaterial |
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Free Biomaterial |
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A |
B |
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A |
B |
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A) |
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hν1 |
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hν2 |
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A |
Active Site |
B |
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"ON"-State |
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"OFF"-State |
A S
B) |
A |
hν1 |
hν2
P
A
"ON"-State
A
In
C)
B
In
B
X |
S |
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B
B
"OFF"-State
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X |
S |
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A |
Inactive |
In |
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biomaterial |
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hν1 
hν2
S
Active biomaterial
P
F V
F V
M
M
M M
M M
M
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CH2OH |
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CH2OH |
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H |
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O |
H |
H |
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O |
H |
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H |
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H |
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OH |
HO |
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OH |
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H |
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HO |
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OH |
HO |
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OH |
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H |
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H |
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H |
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OH |
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(1) |
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(2) |
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O O O
S |
N |
O N |
Concanavalin A |
( Con. A) |
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+ |
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Lys |
NH2 |
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O |
O |
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O |
O |
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N |
N |
Lys |
Con. A |
S |
H |
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O |
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300nm < λ < 400nm |
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λ > 475nm |
S |
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O |
O |
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N |
HN |
Lys |
Con. A |
O |
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(3a)-Con. A |
(3b)-Con. A |
N |
O |
+ |
Concanavalin A |
( Con. A) |
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NO2 |
Lys |
NH2 |
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H2C |
O |
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C |
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O N |
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O |
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O |
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300nm < λ < 400nm |
N (CH2)2 C N Lys Con. A |
+ |
N (CH2)2 C N Lys Con. A |
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H |
H |
O |
λ > 475nm |
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OH |
NO2 |
O2N |
(4a)-Con. A |
(4b)-Con. A |
M M
M
M M
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M |
M |
M |
M |
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M M
M M