The genetics of dogs
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Table 8.1. Continued.
Gene symbol |
Gene name |
Gene class |
Gene effect |
Comments |
NTRK1 |
Neurotrophic Tyrosine |
Tyrosine kinase receptor |
Oncogene |
On neurotrophin binding, phosphorylates itself |
|
Kinase Receptor, Type 1 |
|
|
and members of the MAPK pathway |
|
- aka TRKA |
|
|
|
P13K |
Phosphoinositide-3-Kinase |
Pi3k protein is heterodimer |
Oncogene |
Catalytic proteins may be one of four: PI3KCA, |
|
|
of catalytic and adaptor |
|
CB, CG or CD; PI3KCA is most strongly |
|
|
proteins |
|
associated with cancer |
PMAIPI |
Phorbol-12-Myristate-13- |
BH3-only BCL-2 family |
Tumour suppressor gene |
Pro-apoptotic transcriptional target of p53 |
|
Acetate-Induced Protein 1 |
member |
|
|
|
- aka NOXA |
|
|
|
PTEN |
Phosphatase and Tensin |
Protein tyrosine |
Tumour suppressor gene |
Preferentially dephosphorylates phospho- |
|
Homologue |
phosphatase |
|
inositide substrates |
PTHLH |
Parathyroid Hormone-Like |
Parathyroid hormone family |
Causative of humoral |
Regulates endochondral bone development and |
|
Hormone - aka PTHrP |
|
hypercalcaemia of |
epithelial-mesenchymal interactions during |
|
|
|
malignancy |
the formation of mammary glands and teeth |
RAD51 |
RAD51 Homologue |
RAD51 protein family |
Loss causes genomic |
Highly similar to Escherichia coli DNA recombi- |
|
(S. cerevisiae) |
|
instability |
nase A; interacts with Brca1 and Brca2 |
|
|
|
|
proteins |
RAF1 |
V-Raf-1 Murine Leukaemia |
Serine/threonine protein |
Oncogene |
A MAP kinase kinase kinase (MAP3K) that |
|
Viral Oncogene |
kinase |
|
functions downstream of ras proteins |
|
Homologue 1 |
|
|
|
RB1 |
Retinoblastoma 1 |
Chromatin component |
Tumour suppressor gene |
Negative regulator of the cell cycle; active form is |
|
|
|
|
hypophosphorylated |
SATB1 |
Special AT-Rich Sequence- |
Homeobox gene |
Oncogene - promotes |
Protein binds nuclear matrix and scaffold as well |
|
Binding Protein 1 |
|
metastasis |
as DNA-chromatin remodelling for |
|
|
|
|
transcription |
SHC1 |
Src Homology 2 Domain |
Redox protein |
Longest isoform is tumour |
Three isoforms, adapter proteins in signal |
|
Containing Transforming |
|
suppressor |
transduction pathways |
|
Protein 1 |
|
|
|
SLC2A1 |
Solute Carrier Family 2 |
Solute carrier 2 family |
Facilitates cell nutrition |
Major glucose transporter in blood-brain barrier |
|
Member 1 - aka GLUT1 |
member |
|
|
SLIT2 |
Slit Homologue 2 |
Chemorepulsive factor |
Tumour suppressor gene |
Inhibits chemotaxic migration of various types |
|
(Drosophila) |
|
|
of cells |
