The genetics of dogs

Table 7.5. Summary table of loci putatively linked or associated with canine hip dysplasia. Canine chromosome number (CFA no.) is shown in column 1. The LOD score (logarithm of the odds, an estimate of how closely two loci are linked) is followed by map location in Mb in parentheses forlinkage studies on 159 Labrador Retriever/Greyhound crossbreeds (Todhunter et al., 2005) using MSS1 (Minimal Screening Set 1) and MSS2. The same statistics for linkage analysis on Labrador Retrievers are summarized for MSS1 and MSS2 (Phavaphutanon et al., 2009). Statistics are from linkage analysis on 100 Labrador Retriever/ Greyhound crossbreeds genotyped at 21,455 single nucleotide polymorphisms (SNPs) (Zhou et al., 2010) and measured for four hip dysplasia phenotypes (the distraction index, DI; the dorsolateral subluxation score, DLS; the Norberg angle, NA; and the Orthopedic Foundation for Animals (OFA) hip score - or EHR, extended hip joint radiograph) and their principal components (PCs) for the left (L) and right (R) hips of these measurements. The results of the complete genome-wide association study (GWAS) reported in Zhou et al. (2010) are tabulated using Pvalues instead of LOD scores. Statistics for multi-point linkage mapping for the principal components of the DI, DLS and NA on CFA11 and 29 used the same SNP genotypes and dogs reported in Zhuet al. (2008). The two right-hand columns summarize linkage analysis statistics reported by Chase et al. (2004, 2005) for the NA and acetabular osteophytes (OA) in Portuguese Water Dogs, and by Marschall and Distl (2007) in German Shepherd Dogs for a hip score.

3(17)0FAL

2.5(17)0AR

3.3(35)PC7

Table 7.5. Continued.