The genetics of dogs
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Table 6.8. DLAa associations with canine autoimmune condition.
DLA association
|
|
|
|
|
|
Level of risk (odds |
|
Condition |
DRB1" |
DQA1" |
DQB1" |
Comment |
Breeds |
ratio) |
References |
Canine diabetes mellitus |
009:01 |
001:01 |
008:02 |
|
Range of breeds; |
2.1 |
Catchpole et al. |
|
|
|
|
|
|
|
(2005) |
|
015:01 |
006:01 |
023:01 |
|
Samoyed, Cairn |
1.5 |
Kennedy et al. |
|
|
|
|
|
and |
|
(2006c) |
|
002:01 |
009:01 |
001:01 |
|
Tibetan Terriers |
1.5 |
Kennedy et al. |
|
|
|
|
|
|
|
(2007d) |
Addison's disease |
015:02 |
006:01 |
023:01 |
|
Nova Scotia Duck |
6.7 for |
Hughes et al. |
|
|
|
|
|
Tolling Retriever |
homozygotes |
(2010) |
Primary immune-mediated haemolytic |
006:01 |
005:01:1 |
007:01 |
|
Range of breeds |
1.8 |
Kennedy et al. |
anaemia |
015:01 |
006:01 |
003:01 |
|
|
2.6 |
(2006d) |
|
001:01 |
|
|
|
|
|
|
SLEb-related immune-mediated |
006:01 |
005:01:1 |
007:01 |
Rheumatoid |
Nova Scotia Duck |
4.9 for IMRD; 7.2 |
Wilbe et al. (2009) |
rheumatic disease |
|
|
|
arthritis (RA) |
Tolling Retriever |
for ANA positive |
|
|
|
|
|
shared epitope |
|
|
|
|
|
|
|
(RARAA) |
|
|
|
Chronic inflammatory hepatitis |
006:01 |
004:01 |
013:03 |
|
Dobermann |
14.9 for |
Dyggve et al. |
|
|
|
|
|
|
homozygotes |
(2011) |
Canine polyarthritis |
002:01 |
|
|
RA-shared |
Range |
2.4 |
Oilier et al. (2001) |
|
009:01 |
|
|
epitope (QRRAA, |
of breeds |
4.3 |
|
|
018:01 |
|
|
RKRAA) |
|
3.5 |
|
Symmetrical lupoid onychodystrophy |
018:01 |
001:01 |
008:02 |
|
Gordon Setter |
2.1; |
Wilbe et al. (2010b) |
|
018:01 |
001:01 |
008:02 |
|
Bearded Collie |
5.4 for |
|
|
|
|
|
|
|
homozygotes |
|
|
018:01 |
001:01 |
002:01 |
|
Bearded Collie |
|
|
|
001:01 |
001:01 |
002:01 |
|
Giant Schnauzer |
|
|
Autoimmune lymphocytic thyroiditis |
|
001:01 |
|
|
Range of breeds |
2.3 |
Kennedy et al. |
|
|
|
|
|
|
|
(2006b) |
|
|
001:01 |
|
|
Range of breeds |
1.7 |
Kennedy et al. |
|
|
|
|
|
|
|
(2007d) |
|
|
|
|
|
|
|
Continued |
Table 6.8. Continued.
DLA association
|
|
|
|
|
|
Level of risk (odds |
|
Condition |
DRB1" |
DQA1" |
DQB1" |
Comment |
Breeds |
ratio) |
References |
|
012:01 |
001:01 |
002:01 |
|
Doberman |
2.4 |
Kennedy et al. |
|
|
|
|
|
|
|
(2006a) |
|
012:01 |
001:01 |
002:01 |
|
Giant Schnauzer |
6.5 |
Wilbe et al. (2010a) |
Anal furunculosis |
001:01 |
001:01 |
002:01 |
|
German Shepherd 5.1 |
Kennedy et al. |
|
|
|
|
|
|
Dog |
|
(2008a), Barnes |
|
|
|
|
|
|
|
et al. (2009) |
Necrotizing (MSc-like) |
010:01:1 |
002:01 |
015:01 |
|
Pug Dog |
12.7 for |
Greer et al. (2010) |
meningoencephalitis |
|
|
|
|
|
homozygotes |
|
Uveodermatologic (VKHd-like) |
|
002:01 |
|
|
Akita |
15.9 |
Angles et al. (2005) |
syndrome |
|
|
|
|
|
|
|
Canine chronic superficial keratitis |
015:01 |
006:01 |
003:01 |
|
German Shepherd 8.5 for |
Jokinen et al. |
|
|
|
|
|
|
Dog |
homozygotes |
(2011) |
Meningoencephalitis |
018:02 |
001:01 |
008:02 |
|
Greyhound |
4.7 |
R. Shiel, personal |
|
|
|
|
|
|
|
communication |
DLA, dog leucocyte antigen.
l'SLE, systemic lupus erythematosus. 'MS, multiple sclerosis.
Vogt-Koyanagi-Harada-like.
