The genetics of dogs

Gene symbol

Gene name

Gene class

Gene effect

Comments

BIRC5

Baculoviral IAP Repeat

Inhibitor of apoptosis (IAP)

Oncogene

Gene normally expressed in fetal development

Containing 5 - aka

gene family

Survivin

BRAF

V-Raf Murine Sarcoma Viral

raf/mil family of serine/

Oncogene

Mutations associated with many human and

Oncogene Homologue B1

threonine protein kinases

murine cancers

BRCA1

Breast Cancer 1

Nuclear phosphoprotein

Tumour suppressor gene

Mutation responsible for approximately 40% of

involved in maintenance

human inherited breast cancers

of genome stability

BRCA2

Breast Cancer 2

DNA binding and histone

Tumour suppressor gene

Mutation responsible for many human inherited

acetylase

breast cancers

CADM1

Cell Adhesion Molecule 1

Immunoglobulin

Pro-apoptotic/tumour

Nectin-like molecule localized at cell-cell

- aka ISGF4, TSLC1

superfamily

suppressor

contacts; associates with an actin binding

protein

CCND1

Cyclin D1

Cyclin family

Oncogene

Regulatory subunit of CDK4 or CDK6, whose

activity is required for cell cycle G1/S

transition; interacts with tumour suppressor

protein Rb

CDK4

Cyclin Dependent Kinase 4

Serine/threonine protein

Oncogene

Phosphorylates RBI, activity required for cell

kinase

cycle G1/S transition

CDKNIA

Cyclin Dependent Kinase

Inhibitor of CDK2 and 4

Tumour suppressor gene

Functions as regulator of cell cycle progression

Inhibitor 1Aaka

at G1

Wild-Type P53-Activated

Fragment 1, WAF1

CDKN2A

Cyclin Dependent Kinase

Inhibitor of CD4 kinase

Tumour suppressor gene

Encodes p16(Ink4a) and p19(ARF) which

Inhibitor 2A

stabilize p53 and inactivate cell cycle

CDKN2B

Cyclin Dependent Kinase

Inhibitor of CD4 and CD6

Tumour suppressor gene

Encodes p15(Ink4b) which inactivates cell cycle

Inhibitor 2B

kinases

COX2

Cyclooxygenase 2 - aka

Cyclooxygenase

Oncogene

Prostaglandin synthase involved in inflammation

PTGS2

and mitogenesis

CTNNBI

Beta-Catenin

Cadherin-associated

Tumour suppressor gene

Anchors actin cytoskeleton; may be responsible

protein

for transmitting the contact inhibition signal

CXCR4

Chemokine (C-X-C Motif)

Seven transmembrane

Oncogene

Alpha-chemokine receptor specific for stromal-

Receptor 4

region receptor

derived-factor-1 (SDF1)