Добавил:
Sekretar
kiopkiopkiop18@yandex.ru
t.me/Prokururor I Вовсе не секретарь, но почту проверяю
Опубликованный материал нарушает ваши авторские права? Сообщите нам.
Вуз:
Предмет:
Файл:Ординатура / Хирургия / Библиотека им академика М.И. Перельмана / Книга_232_библиотеки_им_акад_М_И_Перельмана
.pdf
2. Complications in G
y
necological Oncolog
y
13
r
e
d
uce
d
e
ff
ect on t
h
e
g
ut moti
l
it
y
postoperative
ly
, an
d
re
d
uce
d
th
rom
b
osis ris
k
, as we
ll
as exce
ll
ent postoperative ana
lg
esi
a
Good postoperative care, with access to correctl
y
staffed hi
g
h-
d
ependenc
y
and/or intensive care
In t
h
e
gy
neco
l
o
g
ica
l
onco
l
o
gy
center, t
h
e anest
h
etist is an inte
g
ra
l
part o
f
t
h
e
mu
l
ti
d
iscip
l
inar
y
team
.
Infecti
o
n
I
n gyneco
l
ogica
l
onco
l
ogy, patients are at ris
k
o
f
in
f
ection in t
h
e c
h
est, in
t
h
e pe
l
vis/intraa
bd
omina
l
region, in t
h
e urinary tract, at t
h
e woun
d
site, an
d
at sites o
f
intravenous an
d
arteria
l
l
ines. Any prop
h
y
l
actic regime is e
ff
ective
in re
d
ucing postoperative in
f
ective comp
l
ications [7]. It is important t
h
at t
h
e
regime
b
e given at t
h
e appropriate time. We
h
ave use
d
a nurse-
b
ase
d
“patient
group
d
irective” to ensure t
h
at a
ll
women un
d
ergoing surgery, w
h
et
h
er e
l
ec
-
tive or emergency, are covere
d
b
y anti
b
iotic prop
h
y
l
axis. As t
h
e majority o
f
our patients are more t
h
an 60 years o
ld
, we avoi
d
t
h
e use o
f
cep
h
a
l
osporins,
as t
h
is can pre
d
ispose towar
d
pseu
d
omem
b
ranous co
l
itis [8]. Our patients
receive metroni
d
azo
l
e (500 mg IV), gentamicin (120 mg IV), an
d
b
enzy
l
peni-
ci
ll
in (1.2 g IV) wit
h
in
d
uction o
f
anest
h
esia. We omit t
h
e penici
ll
in i
f
t
h
e
patient is a
ll
ergic. We see very
f
ew cases o
f
c
h
est in
f
ection in our group
d
ue to t
h
e use o
f
regiona
l
anest
h
esia an
d
active pre- an
d
postoperative
p
h
ysiot
h
erapy
.
hrombos
i
s
P
atients with
gy
necolo
g
ical cancer are at increased risk of thrombosis
resultin
g
from the mali
g
nanc
y
and the effects of pelvic sur
g
er
y
. Man
y
patients
have had decreased mobilit
y
prior to sur
g
er
y
as a result of massive ascites. The
ascites, combined with a
p
elvic mass, which can com
p
ress the venous return
from the le
g
s, causes the woman with
gy
necolo
g
ical cancer to present a special
risk for thromboembolism. In addition, man
y
women with
gy
necolo
g
ical
cancer have a morbidl
y
increased bod
y
mass index and thus are at risk of
embolism. Followin
g
gy
necolo
g
ical oncolo
gy
sur
g
er
y
, the incidence of deep
vein thrombosis without proph
y
laxis is in excess of 40% [9]
.
T
herapeuticall
y
, a number of
gy
necolo
g
ical oncolo
gy
patients are takin
g
a
g
ents that lead to an increased risk of thromboembolism. While conventional
hormone replacement therap
y
(HRT) is well known to predispose to throm
-
boembolism, patients taking tamoxifen have a greater risk of thrombosis
and are therefore advised to stop takin
g
it 2 weeks before sur
g
er
y
. This
p
oint is im
p
ortant, as there is an increased number of breast cancer
p
atients
who opt for sur
g
ical ablation of their ovaries as part of their breast cancer
mana
g
ement
.
https://t.me/med1917

4 R
.
A
.
F
.
Cr
a
wf
o
r
d
W
e use
l
ow-mo
l
ecu
l
ar-wei
gh
t
h
eparin (40 m
g
su
b
cutaneous
ly
) on a
d
ai
ly
b
asis. T
h
is re
g
imen is
g
iven at 18:00
h
ours on a
d
mission an
d
so wi
ll
not inter
-
f
ere i
f
an epi
d
ura
l
is use
d
t
h
e
f
o
ll
owin
g
mornin
g
. In a
dd
ition, patients wear
g
ra
d
uate
d
stoc
k
ings an
d
are we
ll
h
y
d
rate
d
. We pre
f
er to use regiona
l
anest
h
e
-
sia in addition to the general anesthesia, as this has the positive benefi
t o
f
r
e
d
ucin
g
t
h
rom
b
osis. Ca
lf
stimu
l
ation is a
l
so use
d
in t
h
e operatin
g
t
h
eater,
although the evidence for this procedure’s benefi
t is not conc
l
usive. We con-
t
inue t
h
e
l
ow-mo
l
ecu
l
ar-weig
h
t
h
eparin unti
l
t
h
e patient is
d
isc
h
arge
d
f
rom
th
e
h
os
p
ita
l
.
In patients with signifi
cant deep vein thrombosis, we also consider using
an inferior vena caval umbrella fi
lter inserted under radiological control. Its
u
se great
l
y re
d
uces t
h
e ris
k
o
f
f
ata
l
pu
l
monary em
b
o
l
us, w
h
ic
h
is especia
ll
y
m
ar
k
e
d
w
h
en t
h
ere is
b
i
l
atera
l
i
l
iac venous t
h
rom
b
osis associate
d
wit
h
a pe
l
vic
m
ass.
H
emorrha
g
e and Transfusio
n
During extensive surgery for advanced malignancy, patients are at signifi
-
c
ant ris
k
f
or intraoperative or primary
bl
oo
d
l
oss. We routine
l
y crossmatc
h
4
u
nits o
f
bl
oo
d
f
or patients un
d
ergoing ovarian cancer surgery. Wit
h
patients
u
n
d
ergoing interva
l
d
e
b
u
lk
ing surgery, we o
f
ten anticipate an anemia
d
ue to
th
e cancer an
d
t
h
e e
ff
ect o
f
c
h
emot
h
erapy. Patients wi
ll
o
f
ten
b
e trans
f
use
d
as
th
e operation starts. Our anest
h
etic team pre
f
ers t
h
is to trans
f
usion on t
h
e
d
ay
p
rior to t
h
e operation. As t
h
ese patients are operate
d
on in t
h
e win
d
ow
b
etween
c
yc
l
es o
f
c
h
emot
h
erapy, we
d
o not
d
e
l
ay t
h
e patient as one mig
h
t
d
o ot
h
er
p
atients wit
h
anemia
f
or a
b
enign operative in
d
ication. Secon
d
ary
h
emorr
h
age
o
ccurs rare
l
y an
d
is usua
ll
y associate
d
wit
h
a s
l
ippe
d
l
igature or unrecognize
d
bl
ee
d
ing point. O
f
ten t
h
ere is a
l
arge raw area
f
o
ll
owing tumor resection, an
d
we fi
nd that lavage with hot (30˚C–40˚C) water (not saline) allows identifi
ca-
t
ion o
f
bl
ee
d
ing points
.
U
n
f
ortunate
l
y, we
d
o not
h
ave easy access to eryt
h
ropoietin
f
or our c
h
e-
m
ot
h
erapy patients in t
h
e NHS. T
h
is su
b
cutaneous treatment can
b
e use
f
u
l
to
m
aintain t
h
e
h
emog
l
o
b
in
d
uring c
h
emot
h
erapy an
d
re
d
uce t
h
e nee
d
f
or trans
-
f
usion prior to interva
l
d
e
b
u
lk
ing surgery.
Dama
g
e to Or
g
an
s
R
adical
gy
necolo
g
ical sur
g
er
y
aims to remove as much of the disease as
r
equired, including a margin of normal tissue. In cervical cancer surgery, this
l
eads to Wertheim’s approach, whereb
y
the ureter, bladder, and bowel are
dissected free from the cervical cancer. The incidence of fi
stula rate is reported
a
s between 1% and 6% for this surgery. During lymphadenectomy, there is a
r
isk of major vessel damage. Vascular injury associated with lymphadenec-
https://t.me/med1917

2. Complications in G
y
necological Oncolog
y
15
tom
y
in en
d
ometria
l
cancer occurre
d
in 0.7% o
f
t
h
e cases;
h
owever, t
h
is was
s
atis
f
actori
ly
mana
g
e
d
t
h
rou
gh
a
d
equate sur
g
ica
l
trainin
g
an
d
experience o
f
s
ta
ff
wit
h
in t
h
e unit [10]. Durin
g
ovarian sur
g
er
y
, t
h
e
d
isease is usua
lly
con-
fi
ned to the peritoneal cavity, and signifi
cant remova
l
o
f
d
isease can
b
e ac
h
ieve
d
by
peritonea
l
strippin
g
. Recta
l
resection wit
h
primar
y
anastomosis
f
or c
l
ear
-
ance o
f
pe
l
vic
d
isease is a
d
vocate
d
by
some. T
h
e accepta
bl
e
l
eve
l
f
or anasto
-
motic
l
ea
k
s
h
ou
ld
b
e equiva
l
ent to t
h
at
f
or recta
l
surgery. In t
h
e cancer center,
we
h
ave access to many specia
l
ists w
h
o can provi
d
e intraoperative a
d
vice
re
g
ar
d
in
g
or
g
an in
j
ur
y
. T
h
is is ver
y
h
e
l
p
f
u
l
w
h
en consi
d
erin
g
in
j
uries, w
h
ic
h
f
ortunate
l
y are very rare
.
W
oun
d
d
e
h
iscence an
d
h
ernias are re
l
ative
l
y uncommon
b
ut are associ
-
ate
d
wit
h
cancer cac
h
exia an
d
mi
dl
ine incisions
.
P
sycholog
i
cal Compl
i
cat
i
on
s
T
he patient dia
g
nosed with
gy
necolo
g
ical cancer often responds b
y
wantin
g
ever
y
thin
g
possible done to remove the cancer. While a postmeno
-
pausal woman, who has completed her reproductive life, ma
y
view a h
y
s
-
terectom
y
as the removal of an or
g
an that has “turned bad,” a
y
oun
g
woman
ma
y
have a ver
y
different viewpoint. This is especiall
y
marked for those
women whose dia
g
nosis is made throu
g
h screenin
g
. The woman dia
g
nosed
throu
g
h screenin
g
has never had an
y
s
y
mptom or si
g
n of the disease and
relies on the medical service for makin
g
the dia
g
nosis as well as treatin
g
the cancer. The patient then has to live throu
g
h the life-threatenin
g
illness,
with major surgery and recovery, never having been “sick” in the fi
r
st
p
lace.
A
lthou
g
h the ma
j
orit
y
of women with
gy
necolo
g
ical cancer have alread
y
completed their families or are postmenopausal, a small
g
roup of
y
oun
g
er
gy
necolo
g
ical cancer patients still have fertilit
y
needs. This situation is also
pertinent for those patients with breast cancer. Preservation of fertilit
y
poten
-
tial can pose a signifi
cant
p
roblem. Germ cell ovarian cancer can be treated
with conservative sur
g
er
y
, as this disease needs treatment with chemotherap
y
.
Reco
g
nition of the potential of this condition is imperative, as
g
erm cell
ovarian cancer is associated with a
y
oun
g
a
g
e
g
roup and an overall better
s
urvival rate. As there has been a tremendous increase in cervical intrae
p
ithe
-
lial neoplasia (CIN), a number of
y
oun
g
women are requirin
g
man
y
cervical
treatments. Excisional treatments to the cervix lead to earlier deliver
y
. Con
-
s
ideration must be
g
iven to assisted fertilit
y
techniques for collection of
ooc
y
tes or embr
y
os for these
y
oun
g
women, althou
g
h there is often limited
t
im
e
f
o
r
t
hi
s
t
r
eat
m
e
n
t.
R
adical vulval sur
g
er
y
is associated with severe chan
g
es to bod
y
ima
g
e.
This has prompted the move to the triple incision, with which we tr
y
to reduce
the morbidit
y
of the traditional radical en bloc vulvectom
y
. We aim to perform
a wide local excision with a 2 cm macroscopicall
y
clear mar
g
in from the tumor.
This reliabl
y
leaves an 8 mm patholo
g
icall
y
clear mar
g
in, which is associated
https://t.me/med1917

R
.
A
.
F
.
Cr
a
wf
o
r
d
w
it
h
minima
l
ris
k
o
f
l
oca
l
recurrence. T
h
e in
g
uino-
f
emora
l
ly
mp
h
a
d
enectom
y
results in a signifi
cant risk of lymphedema, which is ugly and has its associated
c
omor
b
i
d
it
y
. In t
h
e ear
ly
postoperative perio
d
, woun
d
h
ea
l
in
g
is compro-
m
ise
d
by
in
f
ection an
d
/or
f
ormation o
f
ly
mp
h
oc
y
sts in 20%–30% o
f
patients,
wh
i
l
e in t
h
e
l
on
g
term,
ly
mp
h
e
d
ema o
f
t
h
e
l
e
g
s wit
h
increase
d
ris
k
f
or ce
ll
u
l
itis
i
s re
p
orted in 10%–70% of
p
atients
.
S
exua
l
dy
s
f
unction
h
as
b
een measure
d
in up to 80% o
f
women un
d
er
g
oin
g
gy
neco
l
o
g
ica
l
cancer sur
g
er
y
[11]
.
ow to Reduce Compl
i
cat
i
ons Furthe
r
C
omplications associated with
gy
necolo
g
ical cancer sur
g
er
y
can be reduced
by
addressin
g
several areas of practice, startin
g
with the patient and leadin
g
t
hrou
g
h aspects of the disease, operation, sur
g
eon and his or her team, and
t
herap
y
.
T
hrou
g
h education, patients can be advised about disease-reduction activ-
i
t
y
. In
gy
necolo
g
ical cancer, this is the use of the oral contraceptive pill for
5
y
ears, which leads to a 50% reduction in ovarian cancer risk, albeit with an
increased risk of cervical cancer. The use of tamoxifen leads to a signifi
ca
n
t
reduction in breast cancer, but its long-term usage is associated with a signifi
ca
n
t
in
c
r
eased
ri
s
k
o
f
e
n
do
m
et
ri
a
l
ca
n
ce
r
.
Th
e
m
o
v
e
to
t
h
e
a
r
o
m
atase
inhi
b
i
to
r
s
f
or breast cancer will lead to much less endometrial disease. U
p
take of a
pp
ro
p
ri
-
a
te screenin
g
methods that have been validated is important. We have seen a
signifi
cant reduction in cervical cancer since the active call/recall system for
c
ervical screenin
g
b
y
primar
y
care was introduced in 1988. Cervical cancer has
b
ecome a rare cancer in the last decade in the United Kin
g
dom, a situation that
h
as not
b
een mirrore
d
in t
h
e rest o
f
Western Euro
p
e. T
h
e ro
l
e o
f
l
a
p
arosco
p
ic
p
roph
y
lactic bilateral oophorectom
y
for patients at hi
g
h risk of
g
eneticall
y
c
arried ovarian cancer is im
p
ortant. The use of
p
readmission assessment is vital
t
o allow the anesthetist to have access to the
p
atient several weeks
p
rior to the
o
peration. The patient’s ph
y
sical state can be optimized before sur
g
er
y.
The approach to the disease can be modifi
ed in several ways. The use of
b
etter ima
g
in
g
allows the sur
g
eon to be full
y
aware of the extent of the disease.
T
his ma
y
lead to anticipation of and preparation for bowel sur
g
er
y
b
y
both
t
he sur
g
eon and the patient. It ma
y
modif
y
the need to operate, as, if more
e
xtensive
d
isease is
d
iscovere
d
on ima
g
in
g
, we ma
y
consi
d
er ra
d
iot
h
erap
y
f
or
c
ervical cancer or neoad
j
uvant chemotherap
y
for patients with extensive
o
varian cancer. T
h
e use o
f
t
h
e “ris
k
-o
f
-ma
l
i
g
nanc
y
in
d
ex” [12]
h
as
b
een
va
li
dated
as
a
m
et
h
od
to
r
e
f
e
r
cases
o
f
o
v
a
ri
a
n
ca
n
ce
r
to
a
ce
n
te
r wh
e
r
e
t
h
e
r
e
i
s a survival advanta
g
e for the patient. We use a cutoff of 200 for the risk-of-
m
ali
g
nanc
y
index and have found it to be ver
y
effective. Neoad
j
uvant chemo-
t
herap
y
ma
y
separate out those patients who are chemotherapeuticall
y
r
esistant, and therefore we operate onl
y
on those patients who have chemo-
s
ensitive disease. This a
g
ain allows for the patient’s condition to be optimized.
W
ith the effect of chemotherap
y
, the ascites disappears and the cachexia often
i
mproves. We have active input from dieticians, and patients who are havin
g
https://t.me/med1917

2. Complications in G
y
necological Oncolog
y
17
diffi
culties with nutrition are given early support, which may include paren-
te
r
al
n
ut
ri
t
i
o
n
fo
r
so
m
e.
N
ot operatin
g
is per
h
aps t
h
e
b
est wa
y
o
f
re
d
ucin
g
operative comp
l
ications.
We screen our patients wit
h
postmenopausa
l
bl
ee
d
in
g
wit
h
transva
g
ina
l
u
l
tra
-
s
oun
d
. T
h
ose patients wit
h
t
h
in re
g
u
l
ar en
d
ometrium
d
o not un
d
er
g
o an
y
further investi
g
ation. This population amounts to more than 40% of the
patient
g
roup, an
d
we avoi
d
t
h
e ris
k
o
f
operative intervention (re
l
atin
g
to
outpatient
hy
steroscop
y
)
f
or t
h
ese patients. T
h
e
l
i
k
e
l
i
h
oo
d
o
f
a misse
d
cancer
is ver
y
sma
ll
<<1%. T
h
e ro
l
e o
f
ly
mp
h
a
d
enectom
y
in en
d
ometria
l
cancer is
b
ein
g
a
dd
resse
d
by
t
h
e Me
d
ica
l
Researc
h
Counci
l
, a stu
dy
in t
h
e treatment o
f
en
d
ometria
l
cancer (MRC ASTEC). T
h
is ran
d
omize
d
stu
dy
h
as
b
een reporte
d
in abstract form, suggesting that there is no benefi
t from extended surgery.
T
h
e use o
f
a secon
d
-
l
oo
k
proce
d
ure in ovarian cancer is not genera
ll
y recom-
mended, as the results of this operation do not infl
uence t
h
e surviva
l
[
13
]
. A
re
d
uce
d
rate o
f
b
owe
l
resection is seen wit
h
primar
y
ovarian cancer sur
g
er
y
,
as it does not appear to give any survival benefi
t. This theory, however, has
not
b
een su
bj
ect to a contro
ll
e
d
tria
l
. Wit
h
t
h
e increase in more ear
ly
-sta
g
e
cervica
l
cancer seen as a resu
l
t o
f
t
h
e screenin
g
pro
g
ram, we can per
f
orm
l
ess
radical surgery. Typically, the Rutledge type 2 radical hysterectomy is suffi
cient
f
or treatment rat
h
er t
h
an t
h
e type 3. T
h
e type 2 proce
d
ure gives a simi
l
ar
s
uccess rate wit
h
a
l
ower comp
l
ication rate. T
h
e use o
f
f
erti
l
ity-sparing surger
y
(ra
d
ica
l
trac
h
e
l
ectom
y
) is more appropriate wit
h
sma
ll
er-vo
l
ume cancers. T
h
e
ro
l
e o
f
sentine
l
-no
d
e
d
issection is o
f
interest
f
or patients wit
h
vu
l
va
l
cancer.
Wit
h
on
l
y 10%–20% o
f
t
h
e patients wit
h
apparent stage 1/2
d
isease
h
aving
positive nodes, the sentinel-node technique reduces the signifi
cant morbidity
f
or t
h
ose wit
h
no
d
e-ne
g
ative
d
isease. In a
dd
ition, t
h
is proce
d
ure
g
reat
ly
re
d
uces t
h
e
l
en
g
t
h
o
f
operation an
d
h
ospita
l
sta
y
, two parameters t
h
at are
important
f
or t
h
e e
ld
er
l
y patient
.
Th
e va
l
ue o
f
t
h
e mu
l
ti
d
iscip
l
inary meeting cannot
b
e overemp
h
asize
d
in
t
h
e mana
g
ement o
f
re
d
ucin
g
comp
l
ications. An important ro
l
e in t
h
e meetin
g
is t
h
at o
f
t
h
e specia
l
ist pat
h
o
l
ogist, w
h
o provi
d
es in
f
ormation
l
ea
d
ing to eit
h
er
more or
l
ess extensive surgery. As we
ll
as in
f
orming t
h
e team a
b
out t
h
e
s
urgery, t
h
e pat
h
o
l
ogica
l
opinion may a
d
vise wit
h
respect to t
h
e nee
d
f
or
a
d
juvant t
h
erapy or o
b
servation a
l
one wit
h
out
f
urt
h
er t
h
erapy.
L
aparoscopic sur
g
er
y
h
as not
b
een use
d
wi
d
e
ly
by
onco
l
o
gy
centers in t
h
e
Unite
d
Kin
gd
om. Our experience is t
h
at
f
or en
d
ometria
l
an
d
cervica
l
cancer,
there are quite considerable benefi
ts for minimal-access techniques relating to
d
iagnosis an
d
recovery wit
h
no a
d
verse e
ff
ects
.
R
e
p
air o
f
t
h
e mi
dl
ine a
bd
omina
l
incision s
h
ou
ld
use a mass-c
l
osure tec
h-
nique wit
h
a
l
ong-
l
asting a
b
sor
b
a
bl
e or nona
b
sor
b
a
bl
e
l
oope
d
suture. Less
pain is associate
d
wit
h
a
l
ong-
l
asting a
b
sor
b
a
bl
e suture. Repair o
f
incisiona
l
h
ernia is
b
est ac
h
ieve
d
wit
h
mes
h
[14]
.
H
aving t
h
e rig
h
t surgeon
f
or t
h
e operation is very important. T
h
e success
o
f
t
h
e operation is
b
etter in centers wit
h
a
h
ig
h
er
f
requency o
f
proce
d
ure.
Surgery in t
h
is setting a
ll
ows t
h
e uti
l
ization o
f
a surgeon w
h
ose is appropri
-
ate
l
y traine
d
, anot
h
er
f
actor
l
ea
d
ing to
b
etter outcomes. Junor et a
l
. [15]
d
emonstrate
d
t
h
at an operation
f
or ovarian cancer per
f
orme
d
b
y a gyneco
l
ogi
-
ca
l
onco
l
o
g
ist was associate
d
wit
h
a 25%
b
etter outcome
f
or a
d
vance
d
d
isease
https://t.me/med1917

R
.
A
.
F
.
Cr
a
wf
o
r
d
than an operation performed by the generalist; this translates into a signifi
can
t
survival advantage. This fi
nding is in addition to the patient being managed
by
t
h
e mu
l
ti
d
iscip
l
inar
y
team an
d
receivin
g
t
h
e appropriate c
h
emot
h
erap
y.
Th
e use o
f
ps
y
c
h
osexua
l
support usua
lly
via a specia
l
ist nurse w
h
o
h
as
a
ccess to a
dd
itiona
l
expertise is ver
y
h
e
l
p
f
u
l
in a
ll
eviatin
g
patients’ ps
y
c
h
o
l
o
g
i
-
ca
l
d
i
st
r
ess.
Return to theater is a problem that occurs but is diffi
cult to quantify. Early
r
eturn to t
h
eater
f
or an appropriate reason can
b
e
l
i
f
e savin
g
. It is essentia
l
,
th
ere
f
ore, t
h
at t
h
e postoperative care
f
or t
h
e patient is o
f
h
i
gh
qua
l
it
y
.
I
n t
h
e West An
gl
ia Cancer Networ
k
, we are usin
g
vi
d
eocon
f
erencin
g
,
wh
ic
h
a
ll
ows
f
or t
h
e interaction o
f
t
h
e
l
oca
l
unit–
l
eve
l
team wit
h
t
h
e s
p
ecia
l
ist
m
u
l
ti
d
iscip
l
inary team at t
h
e center. T
h
is
l
ea
d
s to
b
etter
d
iscussion an
d
man
-
a
gement
f
or patients wit
h
cancer an
d
precancer wit
h
out requiring t
h
at patients
o
r c
l
inicians trave
l
to t
h
e center
.
Co
ncl
u
s
io
n
Gy
neco
l
o
g
ica
l
cancer sur
g
er
y
is associate
d
wit
h
comp
l
ications, some o
f
wh
ic
h
are avoi
d
a
bl
e
by
se
l
ectin
g
t
h
e correct operation, sur
g
eon, an
d
h
ospita
l
f
or t
h
e proce
d
ure. Ot
h
er comp
l
ications may
b
e re
d
uce
d
b
y optimizing t
h
e
p
atient’s con
d
ition
b
e
f
ore sur
g
er
y
an
d
mana
g
in
g
t
h
e patient in specia
l
ist
u
n
its.
e
f
erences
1. NHS Execut
i
ve. Improving Outcomes in Gynaecological Cancers—The Manual.
L
ondon: NHS Executive; Jul
y
1999
.
2. Bristow RE, Tomacruz RS, Armstron
g
DK, Trimble EL, Montz F
J
. Survival effect of
m
axima
l
c
y
tore
d
uctive sur
g
er
y
f
or a
d
vance
d
ovarian carcinoma
d
urin
g
t
h
e p
l
ati
-
num era: a meta-ana
ly
sis.
J
C
l
in Onco
l
.
2002
;
20
:
12
4
8
–
12
5
9.
3. S
h
ep
h
er
d
JH. Revise
d
FIGO staging
f
or gynaeco
l
ogica
l
cancer. Br J O
b
stet G
y
naeco
l
.
1989
;
9
6
:889–892.
4. Shepherd JH, Ngan HY, Neven P, Fryatt I, Woodhouse CR, Hendry WF. Multivariate
analysis of factors affecting survival in pelvic exenteration.
I
nt J Gynecol Cancer.
1994
;6
:3
6
1–370
.
5. Wi
g
ht R, Baldock M.
R
eport from the Working Party on Co-Morbidity Assessment
n Cancer—Its Role in the National Core Cancer Dataset
.
Exeter, En
g
land: NHS
Information Authorit
y
; 2001
.
6. Arbous MS, Grobbee DE, van Kleef JW, et al. Mortalit
y
associated with anaesthesia:
a qua
l
itative ana
ly
sis to i
d
enti
fy
ris
k
f
actors. Anaest
h
esia. 2001;56:1141–1153.
7. Guasc
h
ino S, De Santo D, De Seta F. New perspectives in anti
b
iotic prop
hyl
axis
f
or o
b
stetric an
d
gynaeco
l
ogica
l
surgery. J Hosp In
f
ect. 2002;50(supp
l
A):S13–S16.
https://t.me/med1917

2. Complications in G
y
necological Oncolog
y
19
8. Al-Eidan FA, McElnay JC, Scott MG, Kearney MP. Clostridium diffi
c
il
e
–
assoc
i
ated
d
iarr
h
oea in
h
ospita
l
ise
d
patients.
J
C
l
in P
h
arm T
h
er.
2000
;
2
5:
101
–
109.
9. Cran
d
on AJ, Koutts J. Inci
d
ence o
f
post-operative
d
eep vein t
h
rom
b
osis in
gy
nae
-
c
o
l
ogica
l
onco
l
ogy. Aust N Z J O
b
stet G
y
naeco
l
. 1983
;
23:21
6
–219.
10. Nunns D, Wi
ll
iamson K, Swaney L, Davy M. T
h
e mor
b
i
d
ity o
f
surgery an
d
a
d
juvant
ra
d
iot
h
erapy in t
h
e management o
f
en
d
ometria
l
carcinoma. Int J G
y
neco
l
Cancer.
2000;10
:
233
–
238
.
11. Andersen BL
,
v
an Der Does J. Surviving gynecologic cancer and coping with sexual
m
orbidit
y
: an international problem.
I
nt J Gynecol Cancer.
994;4:225–241
.
12. Tin
g
ulstad S, Ha
g
en B, Sk
j
eldestad FE, Halvorsen T, Nustad K, Onsrud M. The risk-
o
f-mali
g
nanc
y
index to evaluate potential ovarian cancers in local hospitals. Obstet
G
y
neco
l
.
999;93:448–452
.
u
-
e
nce surviva
l
in epit
h
e
l
ia
l
ovarian cancer.
L
ancet.
988;8611:599–603
.
14. Luijen
d
ij
k
RW, Hop WC, van
d
en To
l
MP, et a
l
. A comparison o
f
suture repair wit
h
mes
h
re
p
air
f
or incisiona
l
h
ernia. N Eng
l
J Me
d
.
2000;3
4
3
:
392
–
398.
15. Junor EJ, Hole DJ, McNulty L, Mason
M
,
Young J. Specia
l
ist gynaeco
l
ogists an
d
surviva
l
outcome in ovarian cancer: a Scottis
h
nationa
l
stu
d
y o
f
1866 patients. Br J
bstet Gynaecol
.
1999
;
10
6
:1130–113
6
.
https://t.me/med1917

. Laparoscopic Entr
y
T
echni
q
ues: Consensus
avita Lalchandan
i
Kevin Phillips
Once relatively confi
ned to obstetrics and gynecology, laparoscopic proce-
d
ures t
h
at
h
ave
b
een
d
eve
l
ope
d
f
or a
ll
k
in
d
s o
f
surgery wit
h
in t
h
e a
bd
omen
h
ave increased dramatically over the past decade. The attraction of laparos
-
c
opy, as opposed to the “open” operational equivalent, to the gynecologist and
g
eneral sur
g
eon is the reduced trauma of access. Several ver
y
small incisions
a
re utilized rather than one large laparotomy incision. There is clear evidence
that laparoscopic surgery provides signifi
cant benefi
ts compared with lapa-
rotomy for patients, providers, and surgeons. Potential benefi
ts for patients
include reduced total operative trauma, reduced incidence of major wound
an
d
a
dh
esive comp
l
ications, more rapi
d
conva
l
escence, an
d
a
f
aster return to
work or usual activities. The benefi
ts for healthcare providers include shorter
hospital stay with consequent hospital costs and social costs. The benefi
ts for
s
urgeons include an almost-closed and no-touch operative approach with
reduced risk of infection, better display of anatomy and pathology, more
precise removal of diseased tissue, and more accurate tissue repair [1–4]. As
with an
y
sur
g
ical procedure, the laparoscopic approach is associated with
complications, which must be offset against the expected clinical benefi
ts.
Th
e
larger medical and surgical community is still evaluating the safety and effec-
tiveness of these laparoscopic procedures in comparison to the traditional
open surgical procedures [2,5–7]
.
George Kelling has been credited with the fi
rst laparoscopy as we know it
today. In 1901 he used a Fiedler puncture needle to introduce fi
l
te
r
ed
a
ir in
to
the peritoneal cavity (pneumoperitoneum) of a live canine that was locall
y
anesthetized. Kelling then inserted a trocar into the abdomen and used the
trocar to advance a Nitze c
y
stoscope (used as an earl
y
laparoscope) to visuall
y
inspect the canine abdominal cavit
y
[8,9]
.
Until recently, laparoscopic surgery was conducted primarily in the fi
eld
of gynecology. Laparoscopic tubal sterilization was fi
rst described in the 1930s
and 1940s, but it was not until the late 1970s that operative endoscopic tech-
niques were used to treat endometriosis and infertility [10,11]. Progress in the
development of new instruments, optics, lasers, and electrosurgery enabled
t
h
e per
f
ormance o
f
h
ig
hl
y comp
l
ex an
d
sop
h
isticate
d
l
aparoscopic surger
y
8,10,12
]
.
https://t.me/med1917

3. Laparoscopic Entr
y
Techniques: Consensus 2
1
I
t was on
ly
a
f
ter t
h
e
d
eve
l
opment o
f
computer-c
h
ip vi
d
eo/te
l
evision
camera that in 1985 the fi
rst laparoscopic cholecystectomy in a human was
per
f
orme
d
in German
y
, succee
d
e
d
by
its in
d
epen
d
ent intro
d
uction in France
in 1987 [9]. T
h
ese a
d
vances were
f
o
ll
owe
d
by
t
h
e rapi
d
expansion o
f
l
aparos
-
cop
y
into a
ll
areas o
f
g
enera
l
sur
g
er
y
. As Ste
ll
ato writes, “It can
b
e sai
d
wit
h
out
exa
gg
eration that almost an
y
abdominal or retro peritoneal operation per
-
f
orme
d
‘open’
h
as
b
een attempte
d
l
aparoscopica
lly
” [8].
I
n t
h
e Unite
d
States, 310,756
l
aparoscopic c
h
o
l
ec
y
stectomies were per
-
f
orme
d
in 1997. Dia
g
nostic
l
aparoscop
y
was estimate
d
to
h
ave occurre
d
in
91,170 cases, an
d
l
a
p
arosco
p
ic steri
l
ization was estimate
d
to
h
ave occurre
d
in
3
17,961 women [13]. In Austra
l
ian
h
ospita
l
s
b
etween Ju
ly
1999 an
d
June 2000,
more t
h
an 5.5 mi
ll
ion surgica
l
proce
d
ures were un
d
erta
k
en. O
f
t
h
ese, near
ly
3
% were estimate
d
to
h
ave occurre
d
l
aparoscopica
ll
y—a tota
l
o
f
151,501
l
apa
-
roscopic procedures. These fi
gures suggest that even with small complication
rates,
l
ar
g
e num
b
ers o
f
patients wi
ll
su
ff
er a comp
l
ication.
aparoscop
i
c Entr
y
Techn
i
que
T
he ma
j
orit
y
of complications associated with laparoscopic sur
g
er
y
occur
during access and the creation of artifi
cial
p
neumo
p
eritoneum [14–18]. The
umbilical area is the thinnest
p
ortion of the abdominal wall and is therefore
the preferred access site [12]. However, immediatel
y
below this point are the
aortic bifurcation, the bowel, and the omentum. Access-related in
j
uries can
occur to these or
g
ans as well as to the inferior vena cava, liver, portal vein,
c
y
stic arter
y
, ureter, bladder, iliac arter
y
, and epi
g
astric arter
y
[12,19]. Ma
j
or
vascular injuries are rare [11], but once they are infl
icted
,
between 9% and 13%
of patients will die, often as a consequence of hemorrha
g
e or
g
as embolism
[20,21]. Access-related bowel or visceral in
j
uries are more common. Reports
indicate that between 50% and 66% of bowel or visceral in
j
uries are undia
g-
nosed at the time of primar
y
sur
g
er
y
and can lead to ma
j
or complications such
as se
p
sis or
p
eritonitis [11].
Class
i
f
i
cat
i
on of Laparoscop
i
c In
j
ur
i
e
s
Laparoscopic entry-related injuries can be classifi
ed
in
to
t
w
o
m
a
in
groups:
Ty
pe 1 in
j
urie
s
—dama
g
e b
y
Verres needle or trocar to normall
y
located
b
l
ood
v
esse
l
s
a
n
d
bo
w
el
Ty
pe 2 in
j
uries
—
dama
g
e b
y
Verres needle or trocar to bowel adherent
to
t
h
e
abdo
min
a
l w
a
l
l
It is recognized that when bowel is fi
rmly adherent to the anterior abdominal
wall at the point of entr
y
into the cavit
y
, then bowel dama
g
e ma
y
occur
https://t.me/med1917

2
2 S. Lalchandani and K. Philli
p
s
wh
et
h
er t
h
e mo
d
e o
f
access is
by
l
aparotom
y
(open) or
l
aparoscop
y
c
l
ose
d)
.
D
espite t
h
e rapi
d
evo
l
ution in an
d
a
d
option o
f
l
aparoscopic sur
g
er
y
in t
h
e
p
ast
d
eca
d
e
by
g
enera
l
sur
g
eons, most case reports an
d
l
ar
g
e series reportin
g
th
ese in
j
uries are
d
erive
d
f
rom o
ld
er
gy
neco
l
o
g
ic
l
iterature. Even wit
h
newer
i
nstrumentation and knowled
g
e, these in
j
uries still occur with
g
reat frequenc
y
.
I
n part t
h
is ma
y
re
l
ate to a
l
earnin
g
curve associate
d
wit
h
t
h
e a
d
option o
f
l
aparoscopic sur
g
er
y
,
b
ut a
dd
itiona
l
f
actors inc
l
u
d
e a
l
ac
k
o
f
un
d
erstan
d
in
g
of
t
h
e mec
h
anisms invo
l
ve
d
in creatin
g
t
h
ese in
j
uries an
d
a
l
ac
k
o
f
apprecia-
t
ion
f
or t
h
e proximit
y
o
f
important viscera
l
structures to t
h
e anterior a
bd
omi-
nal
w
all.
There are fi
ve access methods in three major categories. There is consider-
abl
e
d
e
b
ate as to w
h
ic
h
o
f
t
h
ese access met
h
o
d
s is t
h
e sa
f
est an
d
/or most
eff
ective.
. B
l
in
d/
c
l
ose
d
met
h
o
d
s
Needle (Verres or other) insertion into peritoneum, followed b
y
gas insuffl
ation, insertion of trocar, and insertion of la
p
aro
-
sco
p
e. Both insertions are conducted in a blind fashion in closed
laparoscop
y
, usuall
y
at an infraumbilical site or in the pit
o
f
t
h
e
u
m
b
ili
cus.
Thi
s
i
s
t
h
e
m
ost
co
mm
o
n
access
m
et
h
od
in
gy
necolo
gy
.
Direct trocar insertion into peritoneum, followed b
y
g
as insuf
-
ation and insertion of laparoscope. The rationale for the devel-
opment of this approach was the diffi
culty associated with
g
raspin
g
the wall of an abdomen distended b
y
pneumoperito-
neum, alon
g
with the safet
y
issues related to the concomitant
increase in force required to insert the primar
y
trocar [22]. A
further benefi
t of this method was the ability to inspect the
trocar insertion site for both position of the trocar and dama
g
e
to internal or
g
ans prior to introducin
g
pneumoperitoneum
[13]. The Z technique for dia
g
nostic laparoscop
y
is a variation
on the direct trocar techni
q
ue [12].
2
. Visual/o
p
en method
Hasson technique, includin
g
peritoneal cutdown followed b
y
insertion of Hasson trocar under direct visualization
,
secured
with a purse-string suture or stay suture, and then insuffl
at
i
o
n
with carbon dioxide
[
11,12,23,24
].
3. H
y
brid visual/closed method
s
Optical trocar to gain access, followed by gas insuffl
at
i
o
n
a
n
d
insertion of la
p
arosco
p
e
.
Optical needle to gain access, followed by gas insuffl
ation
,
inser
-
tion of trocar, and insertion of laparoscope.
Pneumoperitoneum is desi
g
ned to facilitate better visualization of the abdomi-
nal cavit
y
durin
g
laparoscopic sur
g
er
y
. It is formed when carbon dioxide
g
as
is introduced into the peritoneum through controlled, automatic insuffl
at
i
o
n
.
A lar
g
e pocket of
g
as is produced in the
g
reater peritoneal sac, enablin
g
sur
g
i-
cal instruments to be advanced without dama
g
in
g
the viscera and vascular
s
tructures
[
12
]
.
https://t.me/med1917
Соседние файлы в папке Библиотека им академика М.И. Перельмана
