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    -
      
     

       
      
       
 
      
-
      
s

     
       
         
 .
    
-
         
       
        
      

      
        
       
       
https://t.me/med1917
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FibroTest, Steato Test, Acti Test, Nash Test, Ash Test. ( 
- 

   
         


 
F1          
    
        
          
77  

).


CAP).
 
 BioPredictive.
     
  
       

      
        
29].
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 , 
  
        
 -
       -
 
       
78, 140, 149].
        
      
       ,
        
4. 
       

4 -  29]

           
FibroTest


ActiTest

0.75-1.00
F4
0.73-0.74
F3-F4
0.64-1.00
A3
0.59-0.72
F3
0.61-0.63
A2-A3
0.49-0.58
F2
0.53-0.60
A2
0.32-0.48
F1-F2
0.37-0.52
A1-A2
0.28-0.31
F1
0.30-0.36
A1
0.22-0.27
F0-F1
0.18-0.29
A0-A1
0.00-0.21
F0
0.00-0.17
A0
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       

     
Fibroscan 502 touch.     

          
       
       
          
METAVIR       
      
        
   -       -   
   -          
.
     


  
13
-  
13
-
     IRIS   

       
       

       
13

2
   
   CYP450
1A2 [146, 167, 178].
https://t.me/med1917
45

13
- .
 
     
67].
     
 -    
13
-
      

         -
 
13

2
.
 
13
-      
      
     

13

2
.
      
157].
 
       

       

       IRIS
()
         
69, 157].
  
13
-   
 [13, 69, 147, 162].

13
-5-8.
https://t.me/med1917
46
 5 -    
13
   -
 [162]
6 
13
-69, 147]
7 -  [13]


(-)
0

0,00
0,00
10

2,38
4,04
20

4,99
10,16
30

5,96
15,85
40

8,49
20,81
50

9,97
23,26
60

11,76
26,93
80

15,07
27,99
% 

31.0 (25.9 38.7)

13.6 (5.7 22.3)
- A
3.1 (1.1 16.5)
-B
0.6 (-1.1 3.5)
-C


 -120
>30%

-20-

-20
P<0.001)
-60
 (P<0.001)
-20
28.6 (P<0.001)
https://t.me/med1917
47
Продолжение таблицы 7


(-)
100
23,481,15
15,76
31,75
120
28,161,55
17,03
36,37
8 -  
(DOB) [13]


(-)
0

0,00
0,00
10
11,050,51
7,87
14,56
20
20,841,11
14,29
30,23
30
17,620,88
13,15
21,68
40
15,240,82
8,56
20,10
50
14,130,64
8,67
17,99
60
12,940,52
7,99
15,84
80
8,930,43
6,96
13,10
100
7,760,38
4,63
11,08
120
6,970,38
3,98
9,24
      
     PDR    


13
-     
       DOB   
(dose/h       
13
  
       dose/h  
         
(DOB). 
13
-
https://t.me/med1917
48
9. 
         
       
         

13
-     -

 9 -  
13
-     
[147]
  10 
 AUC
(95% CI)




VPP*
VNP**
F1
0.822
29.75
85.7%
76.7%
64.29%
91.67%
F2
0.910
19.00
90.3%
81.1%
82.35%
90.00%
F3
0.923
16.40
92.9%
86.4%
92.86%
86.36%
F4
0.965
11.95
96.2%
91.7%
98.04%
84.62%
  60 min
 AUC
(95% CI)




VPP*
VNP**
F1
0.824
18.4
85.7%
74.4%
62.07%
91.43%
F2
0.900
15.25
91.1%
81.8%
82.46%
90.11%
F3
0.936
13.40
91.9%
84.4%
92.95%
87.26%
F4
0.973
10.55
92.3%
91.7%
97.96%
73.33%
          
CUM 
13
C 
 *VPP     **VNP

https://t.me/med1917
49

      
 [39].
     
     c 
  STATISTICA for Windows   
BXXR310F964808FA-V    
        
     -
2
 
      
  ,   
     
     
2
,
2

6, 54, 63]. 
   Chi-Square  
7, p=0.25).
   p>0,05.   
   -    
         
 0,05 [54, 63].
   
      
       
       
 [54, 63].
     
    -  -
ANOVA [6, 54, 63].
https://t.me/med1917
50
 
13
-

   
13
-  
      


     

     


    
        
 
       
      
     
  
 -       
 

      
       

   

OR        
      
https://t.me/med1917