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    -
      
         -
       


      

 
         
       
     
9, 10, 35, 40, 50, 53, 140].
        

       
        
 
   .       
       
 [10, 53]. 
. 
     
13
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
     
         

     
      
https://t.me/med1917
92
        
       
       
       

13
-
       

13
-
 

  
F1, F
13
C-


        

      F   -40 (p=0,019), DOB-80
(p=0,020), DOB-100 (p=0,028).
F
FF

13
C-p -
p=0,025),
-FF4

13
C-       

-80, DOB-120   F
 F       
13
C-
p<0.01).
FFp
F
13
-
https://t.me/med1917
93
           
(dose/h) - -20
        

         

13
-

[28, 93].       
      
      F    

     
13
- 

        

        
24.
       
        
       
      

       

       
     
  
13
-   
          
   
13
-    
https://t.me/med1917
94


13
-
4.  

13
-
  
13
-   
        
        

13
-        
        

13
-      













13





13
C-

https://t.me/med1917
95
 
     
13
-  
       
      
       

https://t.me/med1917
96

1. -
   p       - 
     
F0 - 7,7%, F1 -13%, F2 - 13%, F3 - 33%,
F4 - p
F0-FF3-F4).
2.          
        
- 
x10
9
- 
3. 
13
-
F
F

  74%.
4.       F0-F  
F3-Fp
   
13
C- 

13
C- F0, F1, F2

https://t.me/med1917
97

1.      

13
-
 
2.   -   
    


  
13
- 
      
13
- 
      
         

https://t.me/med1917
98

       
        
  

13
- 
   

https://t.me/med1917
99

 
 
 
 
 
 
 
 
 - 

 
 
 
 
 
 
13
-
13
- 
 
 
 
 
 
 
 
 -
 
 
https://t.me/med1917
100
 
dose/h 
CUM 
DOB delta over base 
PDR 
RW 
HBsAg 
ntiHCV  

https://t.me/med1917