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- •Preface
- •Foreword
- •Contents
- •Anaesthetic Protocols
- •Surgical Technique
- •Surgical Incisions
- •Multimodal Pain Relief
- •Promoting Early Oral Intake
- •Early Mobilisation
- •Contributors
- •Introduction
- •Principles of an ER Protocol
- •Key Elements of an ER Protocol
- •Preadmission Information and Counselling
- •Preoperative Fasting and Metabolic Conditioning
- •Discharge Criteria
- •Outcomes
- •References
- •Introduction
- •Pre-assessment Clinics
- •Treating Co-morbidity Before Surgery
- •Cardiovascular Risk
- •Assessing Cardiac Risk and Need for Cardiology Assessment
- •What Investigations Should Be Considered?
- •12 Lead Resting ECG
- •Non-invasive Stress Testing
- •Pulmonary Risk
- •Anaemia
- •Nutrition
- •Obesity
- •Hypertension
- •Diabetes
- •Smoking and Alcohol Intake
- •Patient Education and Conditioning of Expectations
- •Summary
- •Conclusions
- •References
- •The Metabolic Response to Injury
- •Insulin Resistance and Complications After Surgery
- •Some Special Risk Groups
- •Preoperative Nutritional Support
- •Physiological Effects of Bowel Preparation
- •Preoperative Carbohydrates Instead of Overnight Fasting
- •Epidural Anaesthesia and Analgesia
- •Postoperative Nutrition and Metabolism
- •How to Ensure Optimal Metabolism in Clinical Practice
- •References
- •Introduction
- •The Role of the Anaesthetist
- •Risk Factors for Major Surgery
- •Functional Capacity
- •Cardiac Risk Index in Non-cardiac Surgery: The Lee Index
- •Optimisation of Pre-existing Disease
- •Cardiovascular Risk Reduction
- •Day of Surgery
- •Admission to Hospital and Preoperative Preparation
- •Conduct of Anaesthesia
- •Nasogastric Tubes in GI Surgery
- •Anti-microbial Prophylaxis
- •Urinary Drainage
- •Avoiding Peri-operative Hypothermia
- •Prevention of Postoperative Nausea and Vomiting (PONV)
- •Monitoring and Vascular Access During Surgery
- •Arterial Pressure Monitoring
- •Central Venous Lines and Monitoring
- •Avoid Fluid Shifts
- •Individualised Goal-Directed Fluids
- •Postoperative Fluids
- •Stroke Volume Optimisation
- •Technique of Fluid Optimisation
- •Timing of Stroke Volume Optimisation
- •Monitoring Cardiac Output and Oxygen Delivery
- •Oxygen Delivery and Goal-Directed Therapy
- •References
- •Which Fluids?
- •Analgesia
- •Modulation of the Stress Response
- •Intraoperative Issues for the Anaesthetist
- •Comparing Open and Laparoscopic Surgery
- •Positioning of the Patient on the Operating Table
- •Open Surgery
- •Laparoscopic Surgery
- •Physiological Consequences of Surgery
- •Open Surgery
- •Laparoscopic Surgery
- •Cardiovascular Effects
- •Pulmonary Effects
- •Renal Effects
- •Ventilation Strategy During Surgery
- •Open Surgery
- •Laparoscopic Surgery
- •Summary
- •Postoperative Care
- •Preventing Secondary Complications
- •Reducing the Risk of Postoperative Chest Infection
- •During Surgery
- •Postoperatively
- •Preventing Venous Thromboembolism
- •Prevention
- •Reducing the Risk of Wound Infection
- •Introduction
- •Pathophysiology of Inappropriate Fluid Balance
- •Types of Fluids
- •Fluid Therapy in Colorectal Surgery
- •Restrictive/Standard/Liberal Regimens
- •Cardiovascular Monitoring
- •Goal-Directed Therapy
- •Fluid Therapy Within an ERAS Protocol
- •Preoperative
- •No Pre-medication
- •Mechanical Bowel Preparation
- •Preoperative Fasting
- •Intraoperative
- •Fluid Optimisation
- •Mid-thoracic Epidural Analgesia
- •Treatment of Postoperative Nausea and Vomiting (PONV)
- •Avoid Nasogastric Tubes
- •Postoperative
- •Encourage Early Postoperative Oral Intake
- •Avoid Fluid Overload
- •Conclusion
- •References
- •Introduction
- •Analgesic Drugs
- •Routes of Administration
- •Classical Approach to Analgesia for Colorectal Surgery
- •Epidural Analgesia (Extradural)
- •Other Approaches to Pain Control
- •Spinal Anaesthesia (Subarachnoid or Intrathecal)
- •Other Local Anaesthetic Blocks
- •Transversus Abdominis Plane (TAP) Block
- •Local Anaesthetic into Incision
- •Opioids
- •Strong Opioids
- •Weaker Opioids
- •Paracetamol
- •Alternative Approaches
- •Lidocaine Infusions
- •Ketamine
- •Magnesium
- •Pregabalin
- •Others
- •Summary
- •References
- •Introduction
- •No Mechanical Bowel Preparation
- •Stoma Training
- •Goal-Directed Perioperative Fluid Administration
- •Maintenance of Normothermia
- •Epidural Analgesia
- •Patient Positioning
- •Laparoscopic Surgery or Transverse Incisions
- •Avoidance of Nasogastric Tubes
- •Avoidance of Drains
- •Use of Postoperative Laxatives
- •Early Removal of Bladder Catheter
- •Enhanced Recovery in Rectal Cancer
- •Single-Port Surgery
- •Nausea and Vomiting
- •Postoperative Ileus
- •Anastomotic Leak
- •Conclusions
- •References
- •Introduction
- •Principles of Change Management
- •Forming a Steering Group
- •Writing a Business Case
- •Creation of a Care Pathway and Associated Literature
- •Education
- •Embedding the New Care Pathway
- •Overcoming Barriers and Troubleshooting
- •Summary
- •References
- •Introduction
- •Developing the Role
- •Getting Started
- •Managing Care
- •Outpatient Clinic
- •Preadmission Clinic
- •Day of Surgery Admission
- •Surgery
- •Recovery
- •Postoperative Recovery
- •Data Collection
- •Evaluation of the ER Programme
- •Title
- •Grade
- •Key Relationships
- •Job Summary
- •Main Duties and Responsibilities
- •Clinical Practice and Practice Development
- •Service Development and Management
- •Research and Audit
- •Professional/Education and Training Role
- •Financial Responsibility
- •Risk Management
- •Note
- •Appendix 9.2: Sample Flow Charts and Protocols
- •References
- •Introduction
- •Measuring Success and Failure in ER
- •Outcome Measures in ER
- •Functional Recovery and Patient Satisfaction in ER
- •Compliance in ER
- •Deviations in the Post-operative Enhanced Recovery Pathway
- •Causes of Deviation in ER
- •Prediction of Deviations in Enhanced Recovery
- •Signs of Early Deviation from ER
- •Late Deviation from ER
- •Failure in Enhanced Recovery
- •Physiological Factors
- •Surgical Factors
- •Anaesthetic Factors
- •Implementation Factors
- •References
- •References
- •Index


Manual of Fast Track Recovery
for Colorectal Surgery


Nader Francis • Robin H. Kennedy
Olle Ljungqvist • Monty G. Mythen
Editors
Manual of Fast Track
Recovery for Colorectal
Surgery

Editors
Nader Francis, MBChB, FRCS, PhD
Consultant Colorectal Surgeon
Department of Surgery
Yeovil District Hospital
Yeovil, Somerset
United Kingdom
Olle Ljungqvist, MD, PhD
Professor of Surgery
Department of Surgery
Örebro University Hospital
Örebro, Sweden
Robin H. Kennedy, MS, FRCS, MBBS
Consultant Colorectal Surgeon
St. Mark’s Hospital
Harrow, United Kingdom
Monty G. Mythen, MBBS, FRCA,
FFICM, MD
Professor of Anaesthesia and Critical Care
Centre for Anaesthesia
University College of London
London, United Kingdom
ISBN 978-0-85729-952-9 e-ISBN 978-0-85729-953-6
DOI 10.1007/978-0-85729-953-6
Springer London Dordrecht Heidelberg New York
British Library Cataloguing in Publication Data
A catalogue record for this book is available from the British Library
Library of Congress Control Number: 2011944270
© Springer-Verlag London Limited 2012
Whilst we have made considerable efforts to contact all holders of copyright material contained in this
book, we may have failed to locate some of them. Should holders wish to contact the Publisher, we will
be happy to come to some arrangement with them.
Apart from any fair dealing for the purposes of research or private study, or criticism or review, as
permitted under the Copyright, Designs and Patents Act 1988, this publication may only be reproduced,
stored or transmitted, in any form or by any means, with the prior permission in writing of the publishers,
or in the case of reprographic reproduction in accordance with the terms of licenses issued by the
Copyright Licensing Agency. Enquiries concerning reproduction outside those terms should be sent to
the publishers.
The use of registered names, trademarks, etc., in this publication does not imply, even in the absence of
a specifi c statement, that such names are exempt from the relevant laws and regulations and therefore free
for general use.
Product liability: The publisher can give no guarantee for information about drug dosage and application
thereof contained in this book. In every individual case the respective user must check its accuracy by
consulting other pharmaceutical literature.
Printed on acid-free paper
Springer is part of Springer Science+Business Media (www.springer.com)

v
Preface
Enhanced Recovery After Surgery (ERAS) has transformed perioperative care in
modern surgical practice by emphasising the patients’ optimal return to normal
function after major surgery. The term ERAS was coined in 2001 by a group of
academic clinicians (the ERAS Group) to replace the expression of ‘Fast Track’
surgery, and to emphasise the quality of the patients’ recovery, rather than the speed
of discharge. Subsequently, this group formed the ERAS Society for perioperative
care ( www.erassociety.org ), which is facilitating the creation of this ERAS series,
together with the British section of the society (ERAS-UK, www.enhancedrecov-
eryhub.org ) .
This book is long overdue. The most immediate didactic value resides in helping
an entire multi-disciplinary ERAS team to understand the fundamental concepts
and to deal with common problems in order to maintain success in ERAS. The
manual hence focuses on practicalities, although it also contains chapters with more
basic scientifi c content on the anaesthetic contribution, nutrition and metabolic
response as well as audit and data collection for ERAS. The book thus fi lls an obvi-
ous need as a major bibliographical tool designed to facilitate the initial and ongo-
ing practice of ERAS.
As ERAS originated in colorectal surgery, it is natural that the fi rst manual in the
series concerns this surgical discipline. However, much of the content will be equally
applicable to other surgical specialties. As the ERAS methodology spreads, and
more information and experience emerge, further manuals in the series will be
published.

vi
Preface
We are pleased to have several internationally renowned ERAS experts contrib-
uting to this book. The authors can be confi dent that there will be many grateful
readers who will have gained a broader and scientifi c prospective on ERAS as a
result of their efforts.
Olle Ljungqvist, Chairman
Ken Fearon, General Secretary
The Enhanced Recovery After Surgery (ERAS) Society for Perioperative Care.

vii
Foreword
Enhanced recovery programmes have the potential to transform the experience
of care for large numbers of patients undergoing surgery. Pioneered in Denmark,
enhanced recovery is now becoming fi rmly established across a range of disciplines
within the UK, including colorectal, musculoskeletal, gynaecological and urologi-
cal surgery. The benefi ts both to patients in terms of quicker recovery and to the
health service in terms of effi cient use of resources are clear cut.
Over the past 2 years I have had the pleasure and privilege of working with many
champions and early adopters of enhanced recovery. I have been impressed by their
commitment to spread the benefi ts of enhanced recovery as widely as possible and
as quickly as possible. It is also clear that successful implementation requires close
collaboration between surgeons, anaesthetists, nurses, dietitians and experts in
rehabilitation.
Enhanced recovery involves multiple changes to practice both before, during and
after surgery. I strongly commend this manual, which is authored by acknowledged
experts in the fi eld. They have set out the evidence base underlying enhanced recov-
ery and combined this with practical advice on implementation.
Our challenge now is to ensure maximum benefi t for patients within as short a
timescale as is reasonably possible. This manual will help us all to meet this
challenge.
Professor Sir Mike Richards
National Cancer Director


ix
Contents
1 Overview: Key Elements and the Impact
of Enhanced Recovery Care . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1
Kenneth C.H. Fearon
2 Preoperative Optimisation and Conditioning
of Expectations . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 15
John T. Jenkins and Jennie L. Burch
3 The Metabolic Stress Response and Enhanced Recovery . . . . . . . . 37
Olle Ljungqvist
4 Anaesthetic Contributions in Enhanced Recovery. . . . . . . . . . . . . . 49
Monty G. Mythen and Michael Scott
5 Perioperative Fluid Management in Enhanced Recovery . . . . . . . . 73
Krishna K. Varadhan and Dileep N. Lobo
6 Pain Control After Surgery. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 95
William J. Fawcett
7 Colorectal Surgery and Enhanced Recovery. . . . . . . . . . . . . . . . . . . 111
Matthew G. Tutton, N. Julian H. Sturt, and Alan F. Horgan
8 Setting Up an Enhanced Recovery Programme . . . . . . . . . . . . . . . . 131
Fiona Carter and Robin H. Kennedy
9 The Role of the Enhanced Recovery Facilitator . . . . . . . . . . . . . . . . 143
Jane P. Bradley Hendricks and Fiona Carter
10 Success and Failure in Colorectal Enhanced Recovery . . . . . . . . . . 159
Nader Francis, Andrew Allison, and Jonathan Ockrim
11 Data Collection and Audit. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 171
Jonas O.M. Nygren and Olle Ljungqvist
Index . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 177
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