Добавил:
Sekretar
kiopkiopkiop18@yandex.ru
t.me/Prokururor I Вовсе не секретарь, но почту проверяю
Опубликованный материал нарушает ваши авторские права? Сообщите нам.
Вуз:
Предмет:
Файл:Ординатура / Хирургия / Библиотека им академика М.И. Перельмана / Книга_5976_Библиотеки_им_академика_М_И_Перельмана
.pdf
is utilized to make nanoparticles needs to be leachable impurity-free, nontoxic, and chemi-
cally inert. The drug is dissolved, trapped, encapsulated, or connected to nanoparticles dur-
ing the preparation, and depending on the preparation technique, nanoparticles,
nanospheres, or nanocapsules can be produced. Based on the origin, natural polymer
(collagen, chitosan, gelatin, silk fibroin, zein, soy protein, and cellulose) and biodegradable
synthetic polymer (PEO, PVA, PGA, PCL, and PLGA) are used [68]. Besides, the availability
of integrin binding sites, mechanical properties, physicochemical properties and biodegrada-
tion behavior of polymer can be considered for the selection of polymer during the prepara-
tion of nanoparticles [69].
5.1.2 Metal nanoparticles
Metal nanoparticles (MNPs) are tiny metal particles which possess dimensions of a few
nanometers, i.e., 1e100 nm. In comparison to bulk equivalents, MNP has a greater surface
area to volume ratio, a higher surface transitioning energy between the molecular and
metallic states, a unique electronic structure, plasmon excitation, quantum size, short-range
order, and an increased number of curves as imperfections. MNPs have characteristic phys-
ical, chemical, electronic, electrical, mechanical, magnetic, thermal, dielectric, optical, and bio-
logical properties [70]. The production of monodispersed nanoparticles of diverse sizes and
shapes has also proved to be challenging. MNPs can be synthesized via two distinct routes:
TABLE 6.1 Literature instances pertaining to use of nanocarriers for efficient delivery of bioactives.dcont’d
S. No
Name of the active
component Drug delivery system Inference Reference
19. Armoracia rusticana EtOH
Ext.
Liposomes Antioxidant, antimicrobial,
chemopreventive,
antiinflammatory,
gastroprotective, and
hypocholesterolaemic
effects
[59]
20. Berberine Surface engineered
dendrimer
Higher drug pay load, improved
pharmacokinetics and reduced
dosing
[60]
21. Malloapelta B Surface engineered
dendrimer
Improved water solubility and
efficacy
[61]
22. Thymoquinone Ethosome Antimicrobial enhanced efficacy [62]
23. Carvacrol Nanoemulsion Enhanced anticancer and
antioxidant therapeutic effect
[63]
24. Silymarin Lyophilized nanosuspension
tablets
Enhancement in the solubility
and permeability
[64]
25. Quercetin in green tea Single-walled carbon
nanotube
Confirmed antioxidant capacity
in tea samples with high
selectivity
[65]
6. Impact of nanotechnology on herbal bioactives: an overview148
https://t.me/med1917
the first is a physical approach involving evaporation/condensation and laser ablation, and
the second is a chemical approach involving the reduction of metal ions in solution under
conditions endorsing the eventual formation of small metallic nanoparticles or aggregates
[71]. Silver nanoparticles, gold nanoparticles, iron oxide nanoparticles, and mesoporous silica
nanoparticles are all variants of MNPs [72].
5.1.3 Lipid nanoparticles
Advanced nano-colloidal carrier systems, solid lipid nanoparticles (SLNs) combine the ad-
vantages of conventional colloidal systems (emulsions, liposomes, and polymeric nanopar-
ticles) with the advantages of lipid nanoparticles for controlled and targeted delivery
[73,74]. SLNs are more physicochemically stable against dreadful conditions in the external
environment during storage, provide greater defense against labile drug degradation,
improved bioavailability, and are easy to manufacture on a large scale. Besides, in NLCs, par-
tial liquid lipid is used in place of solid lipid to create an imperfect matrix. NLCs exhibit high
drug-loading capability with minimum drug expulsion during storage [75]. In comparison to
SLNs, NLCs shows high drug loading capacity, alteration in drug release profile, low drug
leakage, and better option for desired dosage forms [39].
5.1.4 Self-assembled nanosystems
Self-assembled nanosystems are defined as self-aggregates of amphiphilic products pre-
pared to employ nanotechnology [76]. Due to the low water solubility of some pharmacolog-
ical compounds, a solubilizing delivery strategy is often used to guarantee adequate drug
bioavailability and/or aid clinical or even preclinical research and development efforts.
Along with enhanced solubilization, self-assembled drug delivery systems (SADDS) provide
several other benefits, such as regulated drug release, susceptibility to drug hydrolysis and
chemical or enzymatic degradation, decreased toxicity, and increased drug availability
[77]. Some of the self-assembled systems include cubosomes, self-nanoemulsifying drug de-
livery systems, and hydrogels. However, limited content is available to know about the for-
mation princi ples of self-assembled nanosystems and the self-assembly of amphiphilic
prodrugs [78].
5.1.5 Cubosomes
Cubosomes, which resemble honeycombs but are hollow within, split an enormous inter-
facial space into two internal water channels. Major interest is being paid to the use of cubo-
somes as a viable delivery system for herbal medicines [79]. When stuffed with different
medications, their internal cubic structure and chemical make-up becomes apparent. Cubo-
somes have great potential in drug nanoformulation because of their many advantageous
properties, such as their high drug payloads due to their high internal surface area and cubic
crystalline structures, their ease of preparation, the biodegradability of lipids, their ability to
encapsulate hydrophobic, hydrophilic, and amphiphilic substances, their targeting, and their
controlled release of bioactive agents [80]. In preparation, monoglyceride and a polymer are
simply emulsified, then homogenised and sonicated. Top-down and bottom-up methods are
commonly used for the preparation of cubosomes [81].
5. Nanophytomedicines: Nanostru ctured drug delivery systems for bioactive 149
https://t.me/med1917
5.1.6 Self-nanoemulsifying drug delivery systems (SNEDDS)
SNEDDS, which are mixtures of oils, lipids, synthetic oils, surfactants, hydrophilic sol-
vent(s), and cosolvents, form oil-in-water (o/w) microemulsions when they are stirred gently
and then diluted further with water [82]. To increase oral bioavailability, lipid suspensions,
solutions, and emulsions have all been employed, but more recently, the effectiveness of
self-nanoemulsifying (SNEDDS) drug delivery systems has come into focus [83]. SNEDDS
readily move to the gastrointestinal tract, and the required agitation is provided by the peri-
staltic movements of the stomach and the intestine for self-emulsification [84]. SNEDDS tends
to protect the sensitive drug substances, aid in selective targetability, improve bioavailability,
high drug loading capacity, easy storage because of its thermodynamics stable system and in
contrast to oily solutions, fine oil droplets provide high interfacial area for partitioning of the
drug between oil and water, SNEDDS pass quickly, thus facilitating distribution of the drug
throughout the GIT [85].
5.1.7 Hydrogels
Hydrogels are networks of water-soluble polymers that are linked together in three dimen-
sions having different che mical makeups and bulk physical properties. After drug delivery,
hydrogels can store the drug in a depot from which it is slowly released, keeping the drug
at a constant concentration in the tissues for a long time. Hydrogels have several potential
uses in tissue engineering and regenerative medicine, both in the clinic and in the lab [86]
diagnostics cellular immobilization, cell separation, and barrier materials to control biological
adhesions [87].
5.1.8 Human serum albumin
Albumin, a common plasma protein produced in the liver helps carry hormones and fatty
acids around the body and helps keep the body’s osmotic pressure stable. It is biodegradable,
nontoxic, nonimmunogenic, easy to cleanse, and soluble in water [88]. Albumin has hydro-
phobic pocketlike domains, where it binds hydrophobic molecules (like vitamins, hormones,
and other plasma constituents). As it has cell-carrying receptors, it acts as a good carrier for
targeted drug delivery. It also facilitates endothelial transcytosis of plasma components into
the extravascular space. The result is that HSA nanovectors are well tolerated and have no
negative side effects [89].
5.1.9 Nanofiber
Due to their physicochemical properties, nanofibers offer innovative potential drug deliv-
ery systems for use in therapeutics [90]. Outstanding high specific surface area-to-volume ra-
tio and highly porous mesh structure, mimic the structure of the extracellular matrix [91].
Natural polymers are recommended over synthetic because of their biocompatible, biode-
gradable, and resemblance to extracellular proteins [92]. Herbal bioactive substances derived
from natural sources have attracted particular attention owing to their pronounced therapeu-
tic characteristics in healthcare [93]. Nanofiber’s properties enable the delivery of various
6. Impact of nanotechnology on herbal bioactives: an overview150
https://t.me/med1917
bioactive compound carriers with antimicrobial, antiinflammatory, antioxidant, antiseptic,
antiviral, and other properties [91]. Electrospinning (E-Spinning), centrifugal spinning (Force
spinning TM Solution Blow Spinning), and carbon dioxide (CO
2
) Laser Supersonic Drawing
are some common techniques used for the preparation of Nanofibers [91].
5.1.10 Micelles
Micelles, a type of colloidal dispersion, are created immediately at critical micelle concentra-
tion (CMC) and temperature, with particle sizes ranging from 5 to 100 nm. Micelles occur when
hydrophobic fragmentsare separated from the continuousphase, lowering thesystem’s free en-
ergy and allowing the hydrogen bond network in water to rebuild [94]. Micelles also gain en-
ergy by the creation of Van der Waals bonds between hydrophobic blocks at their core [95].
Micelles have a hydrophobic core made up of fragments of amphiphilic molecules, and hydro-
philic shells made up of fragments of amphiphilic molecules. MC has great stability, is ideal for
biocompatibility, and has the ability to solubilize a wide variety of medications that are not
easily soluble [96]. Pluronic,poly(ethylene glycol), poly(D,
L-lactide-co-glycolide), andpolycap-
rolactone are a few examples of amphiphilic agents that have the ability to produce MC [97].
5.1.11 Phospholipid complex
In recent years, lipidic complexes of herbal drugs have come to be regarded as novel drug
delivery systems, in particular for the purpose of increasing bioavailability. This is due to the
key benefits that lipidic complexes offer, such as an easy method of preparation, high encap-
sulation efficiency, high stability, and the ease with which they can be scaled up on an indus-
trial level [98]. Phospholipids are utilized because they are biocompatible physiological lipids.
These phospholipids form molecular complexes with medication molecules through the uti-
lization of weak chemical interactions [99e101]. Phospholipids are responsible for transport-
ing the medication molecules into the blood circulation directly rather than going through
first-pass metabolism. This allows for the drug to be more effective [99e101].
5.1.12 Dendrimer
Dendrimers are hyperbranched artificial macromolecules that have novel three-
dimensional, spheroid monodisperse nanobiopolymeric treelike structure which make it an
unsuitable candidate for designing a targeted drug delivery system to overcome the bioche m-
ical barriers and deliver drugs across the desired site [102]. Dendrimers consist of (A) core
(point of attachment called as G0 phase) (B) inner shells and (C) outer surface sites of reactive
groups and the succeeding layers are called as “generations.” Based, on the generation, num-
ber of branching points are generated that also influence the toxicity of the dendrimer [8].
5.1.13 Carbon nanotube
Carbon nanotube, also known as buckytube, identified as cylindrically shaped, nanoscale
hollow tubes. Owing to their physical, chemical, and electromechanical, and optical property
they are widely used in different areas. Based on the synthesis, these are basically classified as
single-walled (SWCNT) and multi-walled (MWCNT) [103].
5. Nanophytomedicines: Nanostru ctured drug delivery systems for bioactive 151
https://t.me/med1917
6. Understanding herbal nanoparticles
Nanomedicine is the advanced version of Ayurveda. In Ayurveda “Bhasma” are used in
therapeutics applications [104]. Bhasma (ash) is prepared via “Bhasmikarana,” where the
active components are metal ion-nanoparticles. These oxidative metal states are more absorb-
able, stable, and human-compatible. Bhasma with various phytoconst ituents can improve ab-
sorption and site-specific targeting. SEM and TEM demonstrated that Bhasma were 5e50 nm
metallic particles during bhasmikaran [105], and from that, it can be concluded that modern
nanomedicine is a model for its use.
7. Conclusions
The abundance of plant bioactives offers enormous opportunities for research in order to
convert these traditional herbs into novel delivery systems, thereby achieving their efficacious
delivery. The nanotechnologies have further been implemented to augment their efficacy,
site-specific delivery, and to minimize any associated toxic effects. Several nanocarrier sys-
tems have been employed for their incorporation and effective delivery. The major concern
to be addressed in future will be toxicity and stability issues. Owing to nanosiz ed particles,
delivery systems are able to go beyond all the available biological barriers, thus leading to
higher chances of toxicity. The need of the hour is to put in efforts for research studies to un-
derstand toxicity and safety issues associated with nanophytomedicines prior to their com-
mercial use.
References
[1] Lavelli V, Kerr W. 10. Applications of recovered bioactive compounds in food products. 2017.
[2] Newman DJ, Cragg GM. Natural products as sources of new drugs from 1981 to 2014. Journal of Natural Prod-
ucts 2016;79(3):629e61. https://doi.org/10.1021/acs.jnatprod.5b01055.
[3] Samtiya M, Aluko RE, Dhewa T, Moreno-Rojas JM. Potential health benefits of plant food-derived bioactive
components: an overview. Foods 2021;10(4). https://doi.org/10.3390/foods10040839.
[4] Mukherjee PK, Harwansh RK, Bhattacharyya S. Bioavailability of herbal products. Elsevier BV; 2015.
p. 217e45. https://doi.org/10.1016/b978-0-12-800874-4.00010-6.
[5] Salehi B, Machin L, Monzote L, Sharifi-Rad J, Ezzat SM, Salem MA, et al. Therapeutic potential of quercetin:
new insights and perspectives for human health. ACS Omega 2020;5(20):11849e72. https://doi.org/
10.1021/acsomega.0c01818.
[6] Sezgin-Bayindir Z, Losada-Barreiro S, Bravo-Díaz C, Sova M, Kristl J, Saso L. Nanotechnology-based drug de-
livery to improve the therapeutic benefits of NRF2 modulators in cancer therapy. Antioxidants 2021;10(5).
https://doi.org/10.3390/antiox10050685.
[7] Chavda VP, Patel AB, Mistry KJ, Suthar SF, Wu ZX, Chen ZS, et al. Nano-drug delivery systems entrapping
natural bioactive compounds for cancer: recent progress and future challenges. Frontiers in Oncology
2022;12. https://doi.org/10.3389/fonc.2022.867655.
[8] Patra JK, Das G, Fraceto LF, Campos EVR, Rodriguez-Torres M del P, Acosta-Torres LS, et al. Nano based drug
delivery systems: recent developments and future prospects. Journal of Nanobiotechnology 2018;16(1).
https://doi.org/10.1186/s12951-018-0392-8.
[9] Kurutas EB. The importance of antioxidants which play the role in cellular response against oxidative/nitro-
sative stress: current state. Nutrition Journal 2016;15(1). https://doi.org/10.1186/s12937-016-0186-5.
6. Impact of nanotechnology on herbal bioactives: an overview152
https://t.me/med1917
[10] Khurana RK, Jain A, Jain A, Sharma T, Singh B, Kesharwani P. Administration of antioxidants in cancer: debate
of the decade. Drug Discovery Today 2018;23(4):763e70. https://doi.org/10.1016/j.drudis.2018.01.021.
[11] Singh V, Kumar A. Antioxidant potential of Glycyrrhiza glabra L. Roots: in-vitro evidences. Journal of Phar-
maceutical Technology, Research and Management 2020;8(1):9e13. https://doi.org/10.15415/
jptrm.2020.81002.
[12] Lakey-Beitia J, Burillo AM, La Penna G, Hegde ML, Rao KS. Polyphenols as potential metal chelation com-
pounds against Alzheimer’s disease. Journal of Alzheimers Disease 2021:8.
[13] Dhalaria R, Verma R, Kumar D, Puri S, Tapwal A, Kumar V, et al. Bioactive compounds of edible fruits with
their anti-aging properties: a comprehensive review to prolong human life. Antioxidants 2020;9:1123.
[14] Stagos D. Antioxidant activity of polyphenolic plant extracts. Antioxidants 2020;9(1). https://doi.org/10.3390/
antiox9010019.
[15] Khurana S, Venkataraman K, Hollingsworth A, Piche M, Tai TC. Polyphenols: benefits to the cardiovascular
system in health and in aging. Nutrients 2013;5(10):3779e827. https://doi.org/10.3390/nu5103779.
[16] Jain A, Kesharwani P, Garg NK, Jain A, Nirbhavane P, Dwivedi N, et al. Nano-constructed carriers loaded with
antioxidant: boon for cardiovascular system. Current Pharmaceutical Design 2015;21(30):4456e64. https://
doi.org/10.2174/1381612821666150803152033.
[17] Kozł owska A, Szostak-Wegierek D. Targeting cardiovascular diseases by flavonols: an update. Nutrients
2022;14(7). https://doi.org/10.3390/nu14071439.
[18] Snopek L, Mlcek J, Sochorova L, Baron M, Hlavacova I, Jurikova T, et al. Contribution of red wine consumption
to human health protection. Molecules 2018;23(7):1684. https://doi.org/10.3390/molecules23071684.
[19] Anand P, Kunnumakara AB, Sundaram C, Harikumar KB, Tharakan ST, Lai OS, et al. Cancer is a preventable
disease that requires major lifestyle changes. Pharmaceutical Research 2008;25(9):2097e116. https://doi.org/
10.1007/s11095-008-9661-9.
[20] Niedzwiecki A, Roomi MW, Kalinovsky T, Rath M. Anticancer efficacy of polyphenols and their combinations.
Nutrients 2016;8(9). https://doi.org/10.3390/nu8090552.
[21] Cháirez-Ramírez MH, de la Cruz-López KG, García-Carrancá A. Polyphenols as antitumor agents targeting
key players in cancer-driving signaling pathways. Frontiers in Pharmacology 2021;12. https://doi.org/
10.3389/fphar.2021.710304.
[22] Batra P, Sharma AK. Anti-cancer potential of flavonoids: recent trends and future perspectives. 3 Biotech
2013;3(6):439e59. https://doi.org/10.1007/s13205-013-0117-5.
[23] Chang H, Lei L, Zhou Y, Ye F, Zhao G. Dietary flavonoids and the risk of colorectal cancer: an updated meta-
analysis of epidemiological studies. Nutrients 2018;10(7). https://doi.org/10.3390/nu10070950.
[24] Wyss-Coray T. Ageing, neurodegeneration and brain rejuvenation. Nature 2016;539(7628):180e6. https://
doi.org/10.1038/nature20411.
[25] Uttara B, Singh AV, Zamboni P, Mahajan RT. Oxidative stress and neurodegenerative diseases: a review of up-
stream and downstream antioxidant therapeutic options. Current Neuropharmacology 2009;7(1):65e74.
https://doi.org/10.2174/157015909787602823.
[26] Jellinger KA. Basic mechanisms of neurodegeneration: a critical update. Journal of Cellular and Molecular Med-
icine 2010;14(3):457e87. https://doi.org/10.1111/j.1582-4934.2010.01010.x.
[27] Na HK, Surh YJ. Modulation of Nrf2-mediated antioxidant and detoxifying enzyme induction by the green tea
polyphenol EGCG. Food and Chemical Toxicology 2008;46(4):1271e8. https://doi.org/10.1016/
j.fct.2007.10.006.
[28] Ashkar F, Bhullar KS, Wu J. The effect of polyphenols on kidney disease: targeting mitochondria. Nutrients
2022;14(15). https://doi.org/10.3390/nu14153115.
[29] Fakhri S, Abbaszadeh F, Moradi SZ, Cao H, Khan H, Xiao J. Effects of polyphenols on oxidative stress, inflam-
mation, and interconnected pathways during spinal cord injury. Oxidative Medicine and Cellular Longevity
2022;2022. https://doi.org/10.1155/2022/8100195.
[30] Bhullar KS, Rupasinghe HPV. Polyphenols: multipotent therapeutic agents in neurodegenerative diseases.
Oxidative Medicine and Cellular Longevity 2013;2013. https://doi.org/10.1155/2013/891748.
[31] Yang F, Lim GP, Begum AN, Ubeda OJ, Simmons MR, Ambegaokar SS, et al. Curcumin inhibits formation of
amyloid b oligomers and fibrils, binds plaques, and reduces amyloid in vivo. Journal of Biological Chemistry
2005;280(7):5892e901. https://doi.org/10.1074/jbc.M404751200.
References 153
https://t.me/med1917
[32] Yang B, Dong Y, Wang F, Zhang Y. Nanoformulations to enhance the bioavailability and physiological func-
tions of polyphenols. Molecules 2020;25(20). https://doi.org/10.3390/molecules25204613.
[33] Rein MJ, Renouf M, Cruz-Hernandez C, Actis-Goretta L, Thakkar SK, da Silva Pinto M. Bioavailability of bioac-
tive food compounds: a challenging journey to bioefficacy. British Journal of Clinical Pharmacology
2013;75(3):588e602. https://doi.org/10.1111/j.1365-2125.2012.04425.x.
[34] Aqil F, Munagala R, Jeyabalan J, Vadhanam MV. Bioavailability of phytochemicals and its enhancement by
drug delivery systems. Cancer Letters 2013;334(1):133e41. https://doi.org/10.1016/j.canlet.2013.02.032.
[35] Kyriakoudi A, Spanidi E, Mourtzinos I, Gardikis K. Innovative delivery systems loaded with plant bioactive
ingredients: formulation approaches and applications. Plants 2021;10(6):1238. https://doi.org/10.3390/
plants10061238.
[36] Sharma T, Katare OP, Jain A, Jain S, Chaudhari D, Borges B, et al. QbD-steered development of biotin-
conjugated nanostructured lipid carriers for oral delivery of chrysin: role of surface modification for improving
biopharmaceutical performance. Colloids and Surfaces B: Biointerfaces 2021;197. https://doi.org/10.1016/
j.colsurfb.2020.111429.
[37] Ansari SH, Islam F, Sameem M. Influence of nanotechnology on herbal drugs: a review. Journal of Advanced
Pharmaceutical Technology and Research 2012;3(3):142e6.
[38] Gunasekaran T, Haile T, Nigusse T, Dhanaraju MD. Nanotechnology: an effective tool for enhancing bioavail-
ability and bioactivity of phytomedicine. Asian Pacific Journal of Tropical Biomedicine 2014;4:S1e7. https://
doi.org/10.12980/APJTB.4.2014C980.
[39] Jain A, Sharma T, Saini S, Katare OP, Soni V, Singh B. Nanocargos: a burgeoning quest in cancer management.
Current Nanomedicine 2020;10(2):149e63. https://doi.org/10.2174/2468187309666190823160241.
[40] Sindhu RK, Gupta R, Wadhera G, Kumar P. Modern herbal nanogels: formulation, delivery methods, and ap-
plications. Gels 2022;8(2):97.
[41] Battogtokh G, Ko YT. Self-assembled chitosan-ceramide nanoparticle for enhanced oral delivery of paclitaxel.
Pharmaceutical Research 2014;31(11):3019e30.
[42] Joseph A, Wood T, et al. Curcumin-loaded polymeric nanoparticles for neuroprotection in neonatal rats with
hypoxic-ischemic encephalopathy. Nano Research 2018;11(10):5670e88.
[43] Ren T, Hu M, et al. Piperine-loaded nanoparticles with enhanced dissolution and oral bioavailability for epi-
lepsy control. European Journal of Pharmaceutical Sciences 2019;137:104988.
[44] Simonetti G, Palocci C, et al. Anti-Candida biofilm activity of pterostilbene or crude extract from non-
fermented grape pomace entrapped in biopolymeric nanoparticles. Molecules 2019;24(11):2070.
[45] Santiago TR, Bonatto CC, et al. Green synthesis of silver nanoparticles using tomato leaf extract and their
entrapment in chitosan nanoparticles to control bacterial wilt. Journal of the Science of Food and Agriculture
2019;99(9):4248e59.
[46] Graverini G, Piazzini V, et al. Solid lipid nanoparticles for delivery of andrographolide across the blood-brain
barrier: in vitro and in vivo evaluation. Journal of Colloids Surfaces B: Biointerfaces 2018;161:302e13.
[47] Sadegh Malvajerd S, Azadi A, et al. Brain delivery of curcumin using solid lipid nanoparticles and nanostruc-
tured lipid carriers: preparation, optimization, and pharmacokinetic evaluation. ACS Chemical Neuroscience
2018;10(1):728e39.
[48] Gumireddy A, Christman R, et al. Preparation, characterization, and in vitro evaluation of curcumin-and
resveratrol-loaded solid lipid nanoparticles. AAPS PharmSciTech 2019;20(4):1e14.
[49] Singh RP, Gangadharappa H, et al. Phytosome complexed with chitosan for gingerol delivery in the treatment
of respiratory infection: in vitro and in vivo evaluation. European Journal of Pharmaceutical Sciences
2018;122:214e29.
[50] Patil S, Ayara P. Carica papaya: formulation and evaluation of new dosage form design. IJPSR
2019;10:1677e85.
[51] Pishva SP, Mousavi E, et al. The effect of berberine nanomicelles on hepatic cirrhosis in bile duct-ligated rats.
Nanomedicine Journal 2018;5(4):199e209.
[52] El-Far M, Salah N, et al. Silymarin nanoformulation as potential anticancer agent in experimental Ehrlich asci-
tes carcinoma-bearing animals. Nanomedicine 2018;13(15). 1865-1858.
[53] Jakab G, Fülöp V, et al. Optimization of quality attributes and atomic force microscopy imaging of reconsti-
tuted nanodroplets in baicalin loaded self-nanoemulsifying formulations. Pharmaceutics 2018;10(4):275.
6. Impact of nanotechnology on herbal bioactives: an overview154
https://t.me/med1917
[54] Setiawan SD, Ramadhani CC, et al. Study of self nano-emulsifying drug delivery system (SNEDDS) loaded red
fruit oil (Pandanus conoideus Lamk.) as an eliminated cancer cell MCF-7. International Journal of Drug Deliv-
ery Technology 2018;8(4):229e32.
[55] Yang B-Y, Hu C-H, et al. Effects of bilayer nanofibrous scaffolds containing curcumin/lithospermi radix extract
on wound healing in streptozotocin-induced diabetic rats. Polymers 2019;11(11):1745.
[56] Ramalingam R, Dhand C,et al. Poly-ε-caprolactone/gelatinhybrid electrospun composite nanofibrous mats con-
tainingultrasound assisted herbal extract: antimicrobial and cellproliferationstudy.Nanomaterials2019;9(3):462.
[57] Tokudome Y, Oku N, et al. Antitumor activity of vincristine encapsulated in glucuronide-modified long-
circulating liposomes in mice bearing Meth A sarcoma. Biochimica et Biophysica Acta (BBA) - Biomembranes
1996;1279(1):70e4.
[58] Wang F, Ye X, et al. Time interval of two injections and first-dose dependent of accelerated blood clearance
phenomenon induced by PEGylated liposomal gambogenic acid: the contribution of PEG-specific IgM. Journal
of Pharmaceutical Sciences 2019;108(1):641e51.
[59] Pavaloiu R-D, Sha’at F, et al. Design and evaluation of a delivery system based on liposomes for armoracia
rusticana extract. Revista de Chimie 2019;70(7):2347e9.
[60] Gupta L, Sharma AK, et al. Dendrimer encapsulated and conjugated delivery of berberine: a novel approach
mitigating toxicity and improving in vivo pharmacokinetics. International Journal of Pharmaceutics
2017;528(1e2):88e99.
[61] Le PN, Pham DC, et al. Poly (N-isopropylacrylamide)-functionalized dendrimer as a thermosensitive nanoplat-
form for delivering malloapelta B against HepG2 cancer cell proliferation. Advances in Natural Sciences: Nano-
science and Nanotechnology 2017;8(2):025014.
[62] Nasri S, Ebrahimi-Hosseinzadeh B, et al. Thymoquinone-loaded ethosome with breast cancer potential: optimi-
zation, in vitro and biological assessment. Journal of Nanostructure in Chemistry 2020;10(1):19e31.
[63] Khan I, Bahuguna A, et al. Carvacrol nanoemulsion evokes cell cycle arrest, apoptosis induction and autophagy
inhibition in doxorubicin resistant-A549 cell line. Artificial Cells, Nanomedicine, and Biotechnology
2018;46(Suppl. 1):664e75.
[64] Ibrahim AH, Rosqvist E, et al. Formulation and optimization of lyophilized nanosuspension tablets to improve
the physicochemical properties and provide immediate release of silymarin. International Journal of Pharma-
ceutics 2019;563:217e27.
[65] Kuyumcu Savan E. Square wave voltammetric (SWV) determination of quercetin in tea samples at a single-
walled carbon nanotube (SWCNT) modified glassy carbon electrode (GCE). Journal of Analytical Letters
2020;53(6):858e72.
[66] Pyykkö I, Zou J, Zhang Y, Zhang W, Feng H, Kinnunen P. Nanoparticle based inner ear therapy. World Journal
of Otorhinolaryngology 2013;3(4):114e33.
[67] Kumari A, Yadav SK, Yadav SC. Biodegradable polymeric nanoparticles based drug delivery systems. Colloids
and Surfaces B: Biointerfaces 2010;75(1):1e18. https://doi.org/10.1016/j.colsurfb.2009.09.001.
[68] Srivastava A, Yadav T, Sharma S, Nayak A, Akanksha Kumari A, Mishra N. Polymers in drug delivery. Journal
of Biosciences and Medicines 2016;04(01):69e84. https://doi.org/10.4236/jbm.2016.41009.
[69] Guterres SS, Alves MP. Polymeric nanoparticles, nanospheres and nanocapsules, for cutaneous applications.
Drug Target Insights 2007;2.
[70] Mody V, Siwale R, Singh A, Mody H. Introduction to metallic nanoparticles. Journal of Pharmacy and Bio-
Allied Sciences 2010;2(4):282. https://doi.org/10.4103/0975-7406.72127.
[71] Siegel J, Kvítek O, Ulbrich P, Kolská Z, Slepi
cka P,
Svor
cík V. Progressive approach for metal nanoparticle syn-
thesis. Materials Letters 2012;89:47e50. https://doi.org/10.1016/j.matlet.2012.08.048.
[72] Iriarte-Mesa C, López YC, Matos-Peralta Y, de la Vega-Hernández K, Antuch M. Gold, silver and iron oxide
nanoparticles: synthesis and bionanoconjugation strategies aimed at electrochemical applications. Topics in
Current Chemistry 2020;378(1). https://doi.org/10.1007/s41061-019-0275-y.
[73] Dhiman N, Awasthi R, Sharma B, Kharkwal H, Kulkarni GT. Lipid nanoparticles as carriers for bioactive de-
livery. Frontiers of Chemistry 2021;9. https://doi.org/10.3389/fchem.2021.580118.
[74] Jain A, Sharma T, Kumar R, Katare OP, Singh B. Raloxifene-loaded SLNs with enhanced biopharmaceutical
potential: QbD-steered development, in vitro evaluation, in vivo pharmacokinetics, and IVIVC. Drug Delivery
and Translational Research 2022;12(5):1136e60. https://doi.org/10.1007/s13346-021-00990-x.
References 155
https://t.me/med1917
[75] Ghasemiyeh P, Mohammadi-Samani S. Solid lipid nanoparticles and nanostructured lipid carriers as novel
drug delivery systems: applications, advantages and disadvantages. Research in Pharmaceutical Sciences
2018;13(4):288e303. https://doi.org/10.4103/1735-5362.235156.
[76] Yadav S, Sharma AK, Kumar P. Nanoscale self-assembly for therapeutic delivery. Frontiers in Bioengineering
and Biotechnology 2020;8. https://doi.org/10.3389/fbioe.2020.00127.
[77] Wen H, Jung H, Li X. Drug delivery approaches in addressing clinical pharmacology-related issues: opportu-
nities and challenges. The AAPS Journal 2015;17(6):1327e40. https://doi.org/10.1208/s12248-015-9814-9.
[78] Gonçalves C, Pereira P, Gama M. Self-assembled hydrogel nanoparticles for drug delivery applications. Mate-
rials 2010;3(2):1420e60. https://doi.org/10.3390/ma3021420.
[79] Bhosale RR, Osmani RA. Cubosomes: the inimitable nanoparticulate drug carriers. Scholars Academic Journal
of Pharmacy 2013;2(6):481e6.
[80] Dhadwal A, Sharma DR, Pandit V, Ashawat MS, Kumar P. Cubosomes: a novel carrier for transdermal drug
delivery. Journal of Drug Delivery and Therapeutics 2020;10(1):123e30. https://doi.org/10.22270/
jddt.v10i1.3814.
[81] Singhal K, Kaushik N, Kumar A. Cubosomes: versatile nanosized formulation for efficient delivery of therapeu-
tics. Current Drug Delivery 2022;19(6):644e57. https://doi.org/10.2174/1567201818666210708123855.
[82] Sharma T, Jain A, Kaur R, Saini S, Katare OP, Singh B. Supersaturated LFCS type III self-emulsifying delivery
systems of sorafenib tosylate with improved biopharmaceutical performance: QbD-enabled development and
evaluation. Drug Delivery and Translational Research 2020;10(4):839e61. https://doi.org/10.1007/s13346-020-
00772-x.
[83] Jain A, Kaur R, Beg S, Kushwah V, Jain S, Singh B. Novel cationic supersaturable nanomicellar systems of ral-
oxifene hydrochloride with enhanced biopharmaceutical attributes. Drug Delivery and Translational Research
2018;8(3):670e92. https://doi.org/10.1007/s13346-018-0514-8.
[84] Nasr A, Gardouh A, Ghorab M. Novel solid self-nanoemulsifying drug delivery system (S-SNEDDS) for oral
delivery of olmesartan medoxomil: design, formulation, pharmacokinetic and bioavailability evaluation. Phar-
maceutics 2016;8(3). https://doi.org/10.3390/pharmaceutics8030020.
[85] Singh B, Bandopadhyay S, Kapil R, Singh R, Katare OP. Self-emulsifying drug delivery systems (SEDDS):
formulation development, characterization, and applications. Critical Reviews in Therapeutic Drug Carrier
Systems 2009;26(5):427e521. https://doi.org/10.1615/critrevtherdrugcarriersyst.v26.i5.10.
[86] Li J, Mooney DJ. Designing hydrogels for controlled drug delivery. Nature Reviews Materials 2016;1(12).
https://doi.org/10.1038/natrevmats.2016.71.
[87] Bennett SL, Melanson DA, Torchiana DF, Wiseman DM, Sawhney AS. Next-generation HydroGel films as tis-
sue sealants and adhesion barriers. Journal of Cardiac Surgery 2003;18(6):494e9. https://doi.org/10.1046/
j.0886-0440.2003.00303.x.
[88] Conte R, Luca ID, Luise AD, Petillo O, Calarco A, Peluso G. New therapeutic potentials of nanosized phyto-
medicine. Journal of Nanoscience and Nanotechnology 2016;16(8):8176e87. https://doi.org/10.1166/
jnn.2016.12809.
[89] Raoufinia R, Mota A, Keyhanvar N, Safari F, Shamekhi S, Abdolalizadeh J. Overview of albumin and its purifi-
cation methods. Advanced Pharmaceutical Bulletin 2016;6(4):495e507. https://doi.org/10.15171/apb.2016.063.
[90] Rasouli R, Barhoum A, Bechelany M, Dufresne A. Nanofibers for biomedical and healthcare applications.
Macromolecular Bioscience 2019;19(2). https://doi.org/10.1002/mabi.201800256.
[91] Huesca-Urióstegui K, García-Valderrama EJ, Gutierrez-Uribe JA, Antunes-Ricardo M, Guajardo-Flores D.
Nano
fiber systems as herbal bioactive compounds carriers: current applications in healthcare. Pharmaceutics
2022;14(1). https://doi.org/10.3390/pharmaceutics14010191.
[92] Reddy MSB, Ponnamma D, Choudhary R, Sadasivuni KK. A comparative review of natural and synthetic
biopolymer composite scaffolds. Polymers 2021;13(7). https://doi.org/10.3390/polym13071105.
[93] Cragg GM, Newman DJ. Natural products: a continuing source of novel drug leads. Biochimica et Biophysica
Acta (BBA) - General Subjects 2013;1830(6):3670e95. https://doi.org/10.1016/j.bbagen.2013.02.008.
[94] Hanafy N, El-Kemary M, Leporatti S. Micelles structure development as a strategy to improve smart cancer
therapy. Cancers 2018;10(7):238. https://doi.org/10.3390/cancers10070238.
[95] Torchilin VP. Micellar nanocarriers: pharmaceutical perspectives. Pharmaceutical Research 2007;24(1):1e16.
https://doi.org/10.1007/s11095-006-9132-0.
6. Impact of nanotechnology on herbal bioactives: an overview156
https://t.me/med1917
[96] Hwang D, Ramsey JD, Kabanov AV. Polymeric micelles for the delivery of poorly soluble drugs: from nano-
formulation to clinical approval. Advanced Drug Delivery Reviews 2020;156:80e118. https://doi.org/
10.1016/j.addr.2020.09.009.
[97] Branco MC, Schneider JP. Self-assembling materials for therapeutic delivery. Acta Biomaterialia
2009;5(3):817e31. https://doi.org/10.1016/j.actbio.2008.09.018.
[98] Jain A, Saini S, Kumar R, Sharma T, Swami R, Katare OP, et al. Phospholipid-based complex of raloxifene with
enhanced biopharmaceutical potential: synthesis, characterization and preclinical assessment. International
Journal of Pharmaceutics 2019;571:118698. https://doi.org/10.1016/j.ijpharm.2019.118698.
[99] Peng Q, Zhang ZR, Sun X, Zuo J, Zhao D, Gong T. Mechanisms of phospholipid complex loaded nanoparticles
enhancing the oral bioavailability. Molecular Pharmaceutics 2010;7(2):565e75. https://doi.org/10.1021/
mp900274u.
[100] Beg S, Raza K, Kumar R, Chadha R, Katare OP, Singh B. Improved intestinal lymphatic drug targeting via
phospholipid complex-loaded nanolipospheres of rosuvastatin calcium. RSC Advances 2016;6(10):8173e87.
https://doi.org/10.1039/c5ra24278a.
[101] Gnananath K, Nataraj KS, Rao BG. Phospholipid complex technique for superior bioavailability of phytocon-
stituents. Advanced Pharmaceutical Bulletin 2017;7(1):35e42. https://doi.org/10.15171/apb.2017.005.
[102] Tunki L, Kulhari H, Sistla R, Pooja D. Dendrimer-based targeted drug delivery. In: Pharmaceutical applications
of dendrimers. Elsevier; 2019. p. 107e29. https://doi.org/10.1016/B978-0-12-814527-2.00005-6.
[103] He H, Pham-Huy LA, Dramou P, Xiao D, Zuo P, Pham-Huy C. Carbon nanotubes: applications in pharmacy
and medicine. BioMed Research International 2013;2013. https://doi.org/10.1155/2013/578290.
[104] Arvizo R, Bhattacharyya S, Kudgus R, Giri K, Bhattacharya R, Mukherjee P. ChemInform abstract: intrinsic
therapeutic applications of noble metal nanoparticles: past, present and future. Chemical Society Reviews
2012;41:2943e70.
[105] Pal D, Sahu CK, Haldar A. Bhasma : The ancient Indian nanomedicine. Journal of Advanced Pharmaceutical
Technology & Research 2014;5(1):4e12. https://doi.org/10.4103/2231-4040.126980.
References 157
https://t.me/med1917
Соседние файлы в папке Библиотека им академика М.И. Перельмана