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AgaSyedSameer
MujeebZafarBanday
SaniyaNissarEditors
Genetic
Polymorphism
and Cancer
Susceptibility
Genetic Polymorphism and Cancer
Susceptibility
Aga Syed Sameer
•
Mujeeb Zafar Banday
•
Saniya Nissar
Editors
Genetic Polymorphism
and Cancer Susceptibility
Editors
Aga Syed Sameer
Basic Medical Sciences, College of
Medicine
King Saud bin Abdulaziz University for
Health Sciences (KSAU-HS)
Jeddah, Saudi Arabia
King Abdullah International Medical
Research Centre (KAIMRC), National
Guard Health Affairs (NGHA)
Jeddah, Saudi Arabia
Mujeeb Zafar Banday
Department of Biochemistry
Government Medical College
Karan Nagar, Srinagar, Jammu and Kashmir,
India
Saniya Nissar
Department of Biochemistry
Government Medical College
Karan Nagar, Srinagar, Jammu and Kashmir,
India
ISBN 978-981-33-6698-5 ISBN 978-981-33-6699-2 (eBook)
https://doi.org/10.1007/978-981-33-6699-2
# The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Singapore
Pte Ltd. 2021
This work is subject to copyright. All rights are solely and exclusively licensed by the Publisher, whether
the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of
illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and
transmission or information storage and retrieval, electronic adaptation, computer software, or by
similar or dissimilar methodology now known or hereafter developed.
The use of general descriptive names, registered names, trademarks, service marks, etc. in this
publication does not imply, even in the absence of a specific statement, that such names are exempt
from the relevant protective laws and regulations and therefore free for general use.
The publisher, the authors, and the editors are safe to assume that the advice and information in this book
are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the
editors give a warranty, expressed or implied, with respect to the material contained herein or for any
errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional
claims in published maps and institutional affiliations.
This Springer imprint is published by the registered company Springer Nature Singapore Pte Ltd.
The registered company address is: 152 Beach Road, #21-01/04 Gateway East, Singapore 189721,
Singapore
Our Ever-Lasting Friends and Family
without whom this feat was impossible
https://t.me/medicina_free
Foreword 1
It gives me extreme pleasure and honor to write a foreword for the book entitled
“Genetic Polymorphisms and Cancer Susceptibility ” which has been edited by one
of my colleagues, Dr Syed Sameer Aga. This book focuses on genetic
polymorphisms and their role in modulating the risk of developing various cancers.
The book contains various chapters focusing on the role played by various
important genes and their specific polymorphisms in different cancers. The first
chapter of this book “Mutations and Polymorphisms” lays the foundat ion of the
book in discussing the basic differences between polymorphisms and mutations of
the genome.
There are dedicated chapters discussing specific cancers and the genes and the
polymorphisms involved in their carcinogenesis. Chapter 3, microRNAs and breast
cancer focuses on the role played by various miR SNPs in cancer susceptibility as
well as cancer prognosis. Chapter 4 of the book discusses various SNPs in the
inflammatory pathway genes and their role in gastric cancer risk. Chapter 7 written
by editors themselves provi des us an in-depth insight on the role played by viruses
via inflammatory pathway genes and the associated genes in cervical carcinogenesis.
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I wish the editors of this book a huge success and expect the trio of editors will
continue to publish similar books in future benefitting the scientific community with
their expertise in this field.
Basic Medical Sciences, College of Medicine-Jeddah
King Saud bin Abdulaziz University for Health Sciences,
King Abdulaziz Medical City, National Guard Health Affairs
Jeddah, Kingdom of Saudi Arabia
Sheikh A. Saeed
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Foreword 2
Dr. Aga Syed Sameer has been a prolific writer and a passionate researcher since his
starting days of career at Sher-i-Kashmir Institute of Medical Sciences, Srinagar,
India. As a research fellow, Sameer impressed one and all in the system by his
commitment, humility, scientific aptitude, and passion towards research. His quality
research publications in high impact scientific international journals impressed one
and all. All clinical departments loved to get associated with the department of
immunology in general and with Sameer in particular to get into some form of high
impact credible research. His love for writing never faded and, wherever, he worked,
it gave him an identity at all places of work.
Today, I really feel honored, happy, and humbled to write a foreword on his
extraordinary beautifully written Springer publication on “Genetic Polymorphisms
and Cancer Susceptibility.” I found this book a masterpiece, deliberating in a
detailed and an analytical way on polymorphisms playing their role in human
cancers. I am sure that all students, teachers, and clinicians dealing with cancer
research on human beings in any form will find this beautiful manuscript interesting
and of great help in planning and executing their research on human cancers. I
sincerely recommend this book to all oncologists and basic scientists.
The book is evidence based and supported with credible and high impact
references throughout its content. I congratulate Dr. Sameer and his team for putting
in so much of hard work to bring out this great manuscript to light for our better
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understanding of role of polymorphisms in human carcinogenesis. I am sure Sameer
will continue to grow, prosper, and contribute more and more quality work to the
research world.
Colorectal Division,
Department of General and Minimal Surgery
Sher-i-Kashmir Institute of Medical Sciences
Srinagar, J&K, India
Fazl Q. Parray
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Foreword 3
It gives me an immense pleasure to write a foreword for this book entitled “Genetic
Polymorphisms and Cancer Susceptibility” edited by Dr Syed Sameer Aga and his
team whom I know very well and have been associated with them for various
research projects. I am delighted to know that they have undertaken this scientific
project, which I am sure is going to be a great contribution to the scientific literature.
They have the potential, knowledge, and dedication to accomplish even very
difficult goals. The title of the book itself conveys the importance of the subject.
In fact, innumerable work has been published on gene polymorphisms across the
globe. The book has encompassed all the important aspects of gene polymorphisms
and their relevance in various human cancers. The chapters have been well written
by a galaxy of authors recognized in the field. Dr. Sameer has been associ ated with
cancer research right from the time he joined our institute. He did not look back and
worked quite hard to publish his work in reputed national and international journals
and in the form of books with well-known publishing houses.
The book is going to describe the role of gene polymorphisms in the genesi s of
various cancers and thereby guide and facilitate the management of this dreadful
group of diseases. Many researchers, cancer biologists, doctors, related
academicians, and finally the patients are going to be benefited by this book.
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