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X
- •Preface
- •Acknowledgments
- •Contents
- •Contributors
- •Introduction
- •Conclusion
- •References
- •1860s–Early1900s
- •1940s–1970s
- •1980s–1990s
- •2000–2010
- •Best Practice Guidelines
- •Future Directions
- •Conclusions
- •References
- •3: Enhanced Recovery Pathways: Is It Laparoscopy or Is It Everything Else?
- •Introduction
- •Introduction
- •Basic Scientific Principles
- •Improving Postoperative Recovery
- •Late Recovery
- •Summary
- •References
- •White-Light Endoscopy
- •Chromoendoscopy
- •Narrow Band Imaging
- •Conclusions
- •References
- •Introduction
- •Dysplasia Not Endoscopically Detected (“Endoscopically Invisible”)
- •Surveillance Intervals
- •Chemoprevention
- •Additional Considerations
- •Conclusion
- •References
- •Introduction
- •Endoscopic Mucosal Resection (EMR)
- •Preparation
- •Resection Criteria
- •Resection Techniques
- •Endoscopic Submucosal Dissection (ESD)
- •Resection Criteria
- •Technique
- •Combined Endoscopic Laparoscopic Surgery (CELS)
- •ESD Versus EMR
- •ESD Versus Minimally Invasive Surgery
- •Conclusion
- •References
- •7: Transanal Endoscopic Surgery (TES)
- •Introduction
- •Indications
- •Technique
- •Complications
- •Results
- •Beyond Endoluminal Resection
- •References
- •Introduction
- •Patient Selection
- •Preparation
- •Specific Applications
- •Diverticular Perforation
- •Obstructing Cancers
- •Inflammatory Bowel Disease
- •Colonoscopic Perforations
- •Small Bowel Obstruction
- •Conclusions
- •References
- •Introduction
- •Pathophysiology
- •Clinical Manifestation
- •Diagnosis
- •Management
- •Conclusion
- •References
- •10: Fulminant Clostridium difficile Colitis: Colon-Preserving Therapies
- •Introduction
- •Operative Interventions
- •Turnbull “Blowhole” Procedure
- •Non-Operative Interventions
- •Nasojejunal Lavage
- •Fecal Microbiota Therapy
- •Conclusion
- •References
- •Introduction
- •Conclusions
- •References
- •Introduction
- •Classification
- •Historic Management
- •Technical Considerations
- •Hartmann’s Vs. Primary Anastomosis
- •Microperforation
- •Macroperforation
- •Conclusion
- •References
- •13: Perforated Diverticulitis: When Is Interval Resection Really Indicated?
- •Introduction
- •Interval Colectomy
- •Immune Compromise
- •Recurrent Episodes
- •Perforated Diverticulitis
- •Conclusion
- •References
- •Introduction
- •Pelvic Floor Testing
- •Anal Manometry
- •Balloon Expulsion Testing
- •Electromyography (EMG)
- •Anal Endosonography
- •Defecography
- •Pudendal Nerve Terminal Motor Latency
- •Normal Physiology
- •Fecal Incontinence
- •Functional Constipation
- •Conclusion
- •References
- •Introduction
- •Perineal Procto-(recto)-sigmoidectomy
- •Delorme Procedure
- •Conclusion
- •References
- •Introduction
- •Definitions
- •Aetiology
- •Symptoms
- •Patient Assessment
- •Surgical Options
- •Access
- •Mobilisation
- •Fixation
- •Resection
- •Conclusion
- •References
- •17: Obstructed Defecation: When Is Surgery Indicated?
- •Introduction
- •Testing
- •Anatomic Defects
- •Rectocele
- •Transvaginal Approach
- •Transanal Approach
- •Enterocele
- •Sigmoidocele
- •Ventral Rectopexy
- •STARR
- •Descending Perineum Syndrome
- •Functional Etiology
- •Pelvic Floor Dyssynergia
- •Rectal Hyposensitivity
- •Fecal Diversion
- •References
- •Introduction
- •Alternative Therapies
- •Sphincteroplasty
- •Radiofrequency Energy Delivery
- •Magnetic Sphincter Augmentation
- •Conclusion
- •References
- •Introduction
- •Conclusions
- •References
- •Definitions
- •Introduction
- •Intracorporeal Resection
- •Anastomosis
- •Special Considerations
- •Enterotomy Closure
- •Results
- •Conclusion
- •References
- •Introduction
- •Background
- •Indications
- •Technical Aspects
- •Discussion
- •Conclusion
- •References
- •Introduction
- •Definition
- •Incidence
- •Risk Factors
- •Recurrence After Repair is High
- •Parastomal Hernia Prevention
- •Stoma Placement
- •Stoma Creation Technique
- •Conclusions
- •References
- •Introduction
- •Diagnosis
- •Treatment
- •Conservative Treatment
- •Surgical Treatment
- •Local Suture Repair
- •Laparoscopic Repair
- •Open Repair
- •Conclusion
- •References
- •Introduction
- •Low Advanced Rectal Cancer: APE or ELAPE?
- •Summary
- •References
- •The Technical Steps
- •Oncological Outcomes
- •References
- •Introduction
- •Assessing Tumor Response
- •Special Consideration: Residual Adenoma
- •Radiological Imaging
- •Follow-Up
- •Outcomes
- •References
- •Introduction
- •APR Vs Sphincter-Preserving Surgery
- •Preoperative Planning
- •TATA Procedure
- •Complications
- •Postoperative Management
- •Results
- •Functional Outcomes: ISR Vs APR
- •Conclusion
- •References
- •Introduction
- •Outcomes: Which Coloanal Anastomotic Technique is Best?
- •CJP Vs SCAA
- •CJP Vs ETS
- •CJP Vs Transverse Coloplasty
- •Conclusion
- •References
- •Background
- •Historical Perspective
- •Short-Course Vs Long-Course Direct Comparison
- •Alternative Approaches
- •Summary/Patient Selection
- •References
- •Introduction
- •Surgical Technique
- •Abdominal Dissection First
- •Perineal Dissection First
- •Oncological Results
- •Functional Results
- •Conclusion
- •References
- •Introduction
- •Air-Leak Test
- •Indocyanine Green-Based Microperfusion Assessments
- •Conclusion
- •References
- •Introduction
- •Operative Principles
- •Trials
- •Oncologic Outcomes
- •Short-Term Outcomes
- •Functional Outcomes
- •Robotic Proctectomy
- •Transanal TME
- •Conclusions
- •References
- •Index

376
preservation particularly for low- and mid-rectal lesions [35]. Outcomes are also
collected in the taTME registry hosted by the OSTRiCh (Optimizing Surgical
Treatment of Rectal Cancer) national clinical collaborative [36].
J. Fleshman and K. Wells
National Accreditation Program forRectal Cancer (NAPRC)
Whatever the advances in operative techniques for rectal cancer surgery, complete
TME remains the goal. Dening operative benchmarks and establishing accreditation of complex/high-risk operations to specialized centers is the way to standardize
a high level of quality via real-time auditing. Through OSTRiCh recommendations
to the ACS Commission on Cancer (CoC), the National Accreditation Program for
Rectal Cancer (NAPRC) was developed to employ a multidisciplinary, evidencebased approach to guide the processes of rectal cancer care [37].
Part of this process includes designation of high-risk procedures, including TME,
to specialized centers with high-volume surgeons to ensure that surgical standards
are consistently achieved. This is controversial as the absolute number of cases
needed to overcome the learning curve for prociency remains unclear. Historically,
high-volume surgeons (>20 cases) had fewer complications and need for postprocedural interventions compared to lower-volume surgeons [38]. A more recent
database analysis supports that surgeons with a cumulative 5-year experience of >25
rectal resections had signicantly lower rates of major events (OR=0.82) and surgical complications (OR 0.71) [39]. There are very few reports on the learning curve
for laparoscopic resection of the rectum. In the randomized controlled trials outlined
above, high volume was a requirement for participation. Z6051 required that surgeons be credentialed for laparoscopic and open TME rectal resection and submit 20
operative and path reports as well as an unedited recording of a laparoscopic pelvic
dissection for review. ROLARR required 30 rectal cancer resections per surgeon
prior to credentialing. Certainly the excellent results reported in recent literature have
become the expectation for clinical practice, and colorectal surgeons who intend to
manage rectal cancer should, therefore, undergo the same degree of scrutiny.
Conclusions
Total mesorectal excision through a minimally invasive approach is feasible in the
hands of the experienced surgeon. Currently short-term outcomes through minimally invasive techniques approach those of open resection; however, we await
oncologic outcomes and meta-analysis of the most recent randomized controlled
trials. Until then, laparoscopic TME should be used judiciously. Emerging technologies including robotic surgery and taTME offer alternative strategies for achieving the goal of a high-quality oncologic resection. As the landscape of rectal cancer
surgery evolves, the necessary constant needs to be multidisciplinary oversight with
rectal cancer surgery limited to a body of surgeons and surgical centers experienced
in this high-risk procedure.

32 Laparoscopic TME: Is There aVerdict?
377
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J. Fleshman and K. Wells

Index
A
Abdominal compartment syndrome (ACS), 115
Abdominoperineal excision (APE)
AR, 267
CRM, 265
local recurrence, 267, 271
pelvic dissection, 266
perineal dissection, 265
rectal cancer, 264
Abdominoperineal resection (APR), 318, 341
functional outcomes, 310
vs. ISR, 309
low rectal cancers, 301
vs. SPS, 302, 303
ACS Commission on Cancer (CoC), 376
Acute diverticulitis
DILALA, 123
emergency surgery, 121
end colostomy/HP, 122
generalized peritonitis, 121
gram-negative and anaerobic bacteria, 122
laparoscopic lavage and drainage, 124–126
LHP, 122
LLD, 122
LOLA and DIVA groups, 123
non-operative treatment, patients, 124
prevalence of, 121
primary anastomosis, 124
PubMed, 122
RCTs, 123
readmission rate, 123
sigmoidectomy, 123
three-stage operation, 121
Adenoma-associated lesion or mass (ALM), 44
Altemeier procedure, 163, 166–168
American Society of Colon and Rectal
Surgeons (ASCRS), 137, 194
Anal endosonography, 155, 156, 158
Anal manometry, 158
Anastomotic leak
assessments, 357
biomarker
disruption and luminal bacteria, 364
intestinal inammation, 363
intestinal ischemia, 362
categorization, 356
focal/segmental ischemia, 356
ghost ileostomy, 356
integrity, 355
intraoperative assessment, perfusion
assessing anastomotic
perfusion, 361, 362
ICG, 360, 361
local vascular insufciency/splanchnic
vasoconstriction, 356
mechanical completeness
air-leak tests, 358, 359
doughnuts, 357
intraoperative endoscopic
assessment, 359, 360
mechanisms, 356
meta-analysis, 358
microperfusion, 364
multifactorial, 355
perioperative morbidity, 355
rectal cancer, 355
Argon plasma coagulation (APC), 59
Articial bowel sphincter (ABS), 198, 199
Australian Laparoscopic Compared with open
Low Anterior Resection Trial
(ALaCaRT), 372
Autouorescence imaging (AFI), 40
B
Balloon expulsion test, 160
Balloon expulsion testing, 155
‘Bottom-up’ or transanal approach, 275
© Springer International Publishing AG 2018
C.M. Schlachta, P. Sylla (eds.), Current Common Dilemmas in Colorectal Surgery,
https://doi.org/10.1007/978-3-319-70117-2
379

380
Index
Bowel preparation
and antisepsis, 11
antimicrobial therapy, 12
bulking agents, 12
CFU, 11
combined mechanical, oral and parenteral
preparation, 11
evidence-based practices, 11
history of
1860s–early1900s, 12, 13
1940s–1970s, 13
1980s–1990s, 13–14
2000–2010, 14, 15
National Surgical Quality Improvement
Project, 16
nonabsorbable enteral antibiotic use, 16
nonabsorbable sulfonamides, 12
NSQIP, 15
parenteral antibiotic prophylaxis, 15
postoperative infections, 11
prolonged ileus, 15
single-agent therapies, 12
Bowel resection, 178
C
C. difcile infection (CDI)
accurate and quick diagnosis, 108
antibiotic consumption, 108
community-acquired, 108
dened, 108
endoscopic conrmation, 109
indications, 110
loop ileostomy, 110
moderate, 108
nonoperative and operative approaches, 110
radiological tests, 109
surgery riming and role, 110
total colectomy with end ileostomy, 110
C. difcile-associated diarrhea (CDAD), 107
Chemoprevention, 51
Chemoradiation, 302, 303
Chemotherapy, 296
Chromoendoscopy (CE), 37–39
Circumferential radial margin (CRM), 333
Circumferential resection margin
(CRM), 265, 342
Clostridium difcile infection
antibiotic consumption, 108
CDAD and CDI, 107
CDI (see C. difcile infection (CDI))
clinical symptoms, 108
complicated/fulminant CDI, 108
description, 107
diagnosis, 108–109
endoscopic conrmation, 109
exotoxins, 108
morbidity and mortality, 107
radiological tests, 109
spores, 107
Colectomy
benign conditions, 207
extracorporeal anastomosis, 211
ileocolic anastomosis, 210
minimally invasive laparoscopic, 212
NSQIP, 213
perioperative outcomes, 212
Coloanal anastomosis (CAA)
anastomotic leak, 320
functional outcomes, 320
HCAA, 318
ISR, 319
QOL, 322
splenic exure, 313
SPS, 313
TC, 322
transverse coloplasty, 316
Coloanal reconstruction, 322
Colon surgery, 5, 207, 214
Colonic J-pouch (CJP), 314, 315, 319–323
Colonic lavage, 115–119
Colonic mucosal lesions
Kudo pit pattern classication, 58
Colonoscopic perforations, 101, 102
Colony-forming units (CFU), 11
Colorectal neoplasms
Paris classication, 58
Colorectal surgery
anastomotic leak rates after, 7
elective, 3, 14
enteral and parenteral antibiotics, 15
gut decontamination with oral
nonabsorbable antibiotics, 8
Nichols preparation, 16
parenteral antibiotics, 13
patients management, 21
rectal resections, 5
safe anastomosis without mechanical
preparation, 14
SSI, 5
Combined endoscopic laparoscopic surgery
(CELS), 70, 74
Complete clinical response (cCR)
MRI, 293, 295
nCRT, 292
WW, 293, 294
Complete pathological response (cPR), 289
Constipation

Index
381
anus and puborectalis, 160
clinicians, 159
colon transit study, 184
defecography, 160
digital rectal exam, 159
dyssynergia and obstructive defecation, 159
gastrointestinal complaints, 159
low-ber diet and promotility agents, 185
non-relaxing puborectalis/external anal
sphincter, 160
obstructive defecation, 160
Rome III criteria, 159
STARR and VR, 188
Covered perforations, 144
CRM, see Circumferential resection margin
(CRM)
Crohn’s colitis, 43, 50, 207
D
Damage control surgery (DCS), 122, 136, 137
Defecography
anatomic barriers identication, 156
defecation, 156
small bowel and colon opacication, 156
Delorme procedure, 166–168
Denonvilliers’ fascia, 371
Descending perineum syndrome, 189
Diarrhea
antibiotic-associated, 107
high-risk communities, 109
toxic megacolon and perforation, 108
Digital rectal examination (DRE), 290, 303
Distal resection margins (DRM), 280
Diverticular perforation, 98–101
Diverticulitis-laparoscopic lavage vs. resection
(DILALA), 98
Dutch Diverticular Disease (3D) Collaborative
Study, 134
Dysplasia
and colorectal cancer, 33
and neoplastic lesions, 34
personal history, 33
surveillance in IBD, 33
WLE exam, 39
Dysplasia management
chemoprevention, 51
CRN and CRC, 43
DALM and ALM, 44
detection, 44
disease-specic factors, 46
endoscopically invisible, 49, 50
high-resolution methods, 44
interval colonoscopic exams, 43
patient, disease and histologic
characteristics, 52
polypoid lesions, 44
pseudopolyps and scars, 44–46
risk factors, 46, 47
stricture, presence of, 46
surveillance intervals, 50, 51
surveillance program, 43
visible dysplasia, 44
visible lesions, 46–49
Dysplasia-associated lesion
or mass (DALM), 44
Dyssynergic defecation, 189
E
Early and intermediate recovery
ERPs, 25, 26
EHS classication, 252
Electromyography (EMG), 155
Emergency colectomy, 98
Emergency laparoscopic bowel surgery
anaesthetic consultation and strategic plan
discussion, 98
applications, 98–103
cholecystectomy and anti-reux
surgery, 97
colonoscopic perforations, 101, 102
diverticular perforation, 98–101
hand ports, 97
inammatory bowel disease, 101
obstructing right colon cancer, 99, 100
patient selection, 97, 98
small bowel obstruction, 102, 103
team composition, 97
trans-anal stapling, 98
ultrasonic and bipolar energy
sources, 97
Emergency surgery, 121
Endoluminal resection, 91
Endoscopic detection, see Inammatory bowel
disease (IBD)
Endoscopic mucosal resection (EMR)
technique
efcacy and adverse events, 61
vs. ESD, 70, 74, 90, 91
Kudo pit pattern classication, 57, 58
laterally spreading polyps, 56
Paris classication, 57, 58
polyps, 57
preparation, 56, 57
resection techniques, 59–61
smooth “nongranular” type, 57
Endoscopic resection, 47, 48, 50

382
Index
Endoscopic submucosal dissection
(ESD), 48, 91
adenomas resection, 62
adoption, 62
advanced histology, 62
careful examination, specimens, 62
efcacy and complications, 70
electrosurgical knives, 62
endoscopic hemoclip placement, 68
endoscopic suturing device, 68
ESGE and JGES, 63
high-frequency EUS probes, 66
knives and hemostatic accessories, 66, 67
Kudo pit pattern classication, 63
magnication chromoendoscopy, 63
minimally invasive surgery, 74–77
morbid gastrectomy and
lymphadenectomy, 62
mucosal incision, 67
pediatric colonoscope, 66
recurrence after piecemeal lesions, 62
Sano capillary pattern, 65
steps in, 68, 69
submucosal dissection, 67
vessel coagulation, 67
virtual chromoendoscopy, 63
End-to-side (ETS), 315, 316, 321, 323
Enhanced recovery after surgery (ERAS)
pathway, 165
Enhanced recovery pathways (ERPs)
antibiotic prophylaxis and
thromboprophylaxis, 22
components, 22, 23
description, 22
early and intermediate recovery, 25, 26
initial randomized trials, 22, 23
late recovery, 27
perioperative interventions, 21, 22
perioperative period, 21
postoperative recovery, 23–25
Enterocele, 186, 187
Enterotomies, 222
Enterotomy closure, 224, 225
ETAP-GRECCAR 11 trial, 282, 375
European Association of Endoscopic Surgeons
(EAES), 137
European Organisation for Research and
Treatment of Cancer (EORTC), 27
European Society of Gastrointestinal
Endoscopy (ESGE), 63
External rectal prolapse (ERP)
LVR, 186
STARR, 188
Extralevator abdominoperineal excision
(ELAPE)
abdominal part, 268
CRM, 270
external sphincter, 271
local recurrence, 271
mesorectum, 270
neurovascular bundles, 269
pelvic dissection, 268
perineal dissection, 268, 269
F
Fecal diversion, 190
Fecal incontinence (FI)
anal endosonography, 158
biofeedback, 158
defecography, 159
dened, 193
etiologies, 157, 193
maintenance of, 157
management strategies, 193
medical therapy, 157
physical exam, 157
SNS (see Sacral nerve stimulation (SNS))
solid/liquid feces loss, 157
validated surveys, 157
Fecal microbiota therapy (FMT)
mortality associated with FCDC, 119
recurrent CDI, 118
severity score, 118
FENIX magnetic sphincter augmentation
(MSA) system, 198, 200
Fermentable oligo-, di-, monosaccharides, and
polyols (FODMAP), 185
5-Fluorouracil (5-FU), 330
FOLFOX chemotherapy, 336
Foreign body reinforcement, 246–248
Free perforations, 144
French Jackson-Pratt drains, 124
Fuji Intelligent Chromoendoscopy (FICE), 40
Full-thickness local excision (FTLE), 301
Fulminant Clostridium difcile colitis (FCDC)
colonic ischemia and perforation, 113
description, 113
low gastrointestinal restoration rates, 113
medical management, 113
minimally invasive procedure, 114, 116
non-operative interventions, 118
FMT (see Fecal microbiota therapy
(FMT))
nasojejunal lavage (see Nasojejunal
lavage)

Index
383
operative and non-operative colon-
preserving options, 114
operative interventions, 115–117
loop ileostomy (see Loop ileostomy)
Turnbull “Blowhole” procedure, 117, 118
surgical interventions, 114
G
Gastrointestinal Quality of Life Index
(GIQLI), 27
Grading of Recommendations, Assessment,
Development, and Evaluation
(GRADE) system, 148
H
Hand-assisted laparoscopic surgery (HALS)
benign conditions, 207
colon and rectum, 209
colorectal surgery, 211–214
cost-conscious medical industry, 207
exposure, 209
GI tract continuity, 210
hand-assisted laparoscopic
port placement, 210, 211
ileocolic anastomosis, 210
intra-abdominal operations, 207
malignancy, 210
minilaparotomy incision, 211
minimally invasive operations, 208
multi-quadrant colorectal surgery, 207
non-colorectal laparoscopic operations, 208
operations, 210
operative time and conversion rates, 210
Hand-sewn coloanal anastomosis
(HCAA), 314, 318
Hand-sewn straight coloanal anastomosis, 317
Hartmann’s procedure (HP), 122
Hartmann’s vs. primary anastomosis, 133–136
Hemicolectomy, see Ileocolic/right
hemicolectomy
High-denition (HD) colonoscopy
technologies, 36
High-grade dysplasia (HGD), 50
High-resolution magnetic
resonance imaging, 343
Hinchey classication system, 130
Hypofractionation, 332
I
Ileocecal interposition (ICI), 318
Ileocolic/right hemicolectomy
anatomy, 220–222
Crohn’s disease, 223
guidelines and positioned supine, 220
intracorporeal resection, 221, 222
isoperistaltic anastomosis, 222
trocar placement, 221
Indocyanine green (ICG), 360, 361
Indocyanine green uorescence angiography
(ICG-FA), 360
Inferior mesenteric artery (IMA), 132
Inammatory bowel disease (IBD)
colitis histology, 33
colon cancer and dysplasia surveillance,
34–36
dysplasia and colorectal cancer, 33
endoscopic removal, dysplastic
lesions, 33
histologic inammatory activity, 33
patients’ risk factors, 34
surveillance examination, 33
WLE (see White-light
endoscopy (WLE))
Injectable bulking agents, 194, 199
Internal rectal prolapse (IRP)
LVR, 186
STARR, 188
Intersphincteric resection (ISR)
abdominal dissection, 345, 346
advantages, 348
chemoradiotherapy, sphincter-preserving
surgery, 344, 345
feasibility and morbidity, 349
functional results, 350
oncological results, 349
perineal dissection, 346–348
perineal transanal approach, 350
rectal cancer
classication, 343, 344
management, 341
oncological rules, 341, 342
surgical management, 342, 343
Interval colectomy, 143–147
Interval resection, 144, 145, 147
Intestinal antisepsis, 11
Intracorporeal anastomosis (IC)
demographics, 218
disadvantages, 220
intraoperative, 218, 219
Pfannenstiel, 219
postoperative, 218, 219
Intraluminal microdialysis catheter, 362
Intraoperative bowel perforation, 270
Intussusception, 186
Isoperistaltic anastomosis, 222

384
Index
J
Japanese Gastrointestinal Endoscopy Society
(JGES), 63
K
Kaunas University of Medicine, 335
Keyhole technique, 253, 257, 258
L
Laparoscopic colectomy, 137
Laparoscopic colorectal surgery, 227, 228, 235
Laparoscopic Hartmann resection, 99
Laparoscopic Hartmann’s procedure (LHP), 122
Laparoscopic ileocolic, see Ileocolic/right
hemicolectomy
Laparoscopic intracorporeal
anastomosis (IC), 217
Laparoscopic lavage and drainage (LLD), 122,
124–126
Laparoscopic ventral mesh rectopexy
(LVMR), 171, 174
Laparoscopic ventral rectopexy (LVR), 187, 188
Laparoscopic-assisted colorectal surgery, 74
Laparoscopic-assisted extracorporeal
anastomosis (EC), 217
Laparoscopy
functional outcomes, 374
oncologic outcomes, 372, 373
principles, 369–372
short-term outcomes, 373
TME, 369
Large colon polyps, 56
Laser Doppler owmetry (LDF), 362
Late recovery
ERPs, 27
Lavage
laparoscopic, 147
surgical re-intervention, 147
Local recurrence (LR), 302
Loop ileostomy
ACS, 116
Foley catheter, 115
historical TAC and experimental groups, 115
indications, 115
laparotomy/diagnostic laparoscopy, 117
with lavage technique, 115
prospective national Canadian registry, 116
vs. total abdominal colectomy, 116
Low anterior resection (LAR), 342
Low anterior resection syndrome, 318, 350
Low rectal cancers, 341–348, 350
Low-grade dysplasia (LGD), 50
Lysozyme, 363
M
Macroperforation, 146–148
Mesorectum, 370
Microbiome
human health and disease, 16
Microperforation
ACPGBI and WSES guidelines, 146
adverse outcomes, 146
description, 145
interval colectomy recommendations, 146
mesocolic abscesses, 146
Miles operation, 263
Minimally invasive approach, 376
Molecular imaging, 294
Mucosectomy, 314
Multi-agent systemic chemotherapy, 330
Multidimensional Fatigue Inventory 20
(MFI-20), 27
N
Narrow band imaging (NBI), 39, 40
Narrow-band imaging International Colorectal
Endoscopic (NICE), 66
Nasojejunal lavage
early intervention, 118
feasibility randomized trial, 118
National Accreditation Program for Rectal
Cancer (NAPRC), 376
National Cancer Database (NCDB), 374
National Comprehensive Cancer Network
Guidelines, 329
National Surgical Quality Improvement
Program (NSQIP), 7, 212
National Surgical Quality Improvement
Project (NSQIP), 15
Natural orice specimen extraction (NOSE)
colectomy
advantages and disadvantages, 232
bowel anastomosis, 227
conventional medial-to-lateral approach, 229
description, 227
difculties and complications, 232, 233
heterogeneity and bias, 228
indications, 228, 229
proximal colotomy, 230
sigmoid resection with transrectal
extraction, 228
Natural orice transluminal endoscopic
surgical (NOTES) procedures, 228,
275, 302

Index
385
Neoadjuvant chemoradiotherapy (nCRT), 289,
292, 295, 302
Neoplasia
colorectal, 43
dened, 51
dysplasia surveillance, 43
metachronous development, 50
Nonabsorbable antibiotics, 12, 13, 16
Nonpolypoid lesions, 47, 48
O
Obstructed defecation syndrome (ODS)
abnormal function, 183
balloon expulsion, 184
blood testing, 184
conservative treatments, 185
dened, 183
descending perineum syndrome, 189
enterocele, 186, 187
fecal diversion, 190
uoroscopic defecography during the
evacuation phase, 184
history and examination, 183–185
pelvic oor dyssynergia, 189
rectal hyposensitivity, 190
rectocele (see Rectocele)
screening colonoscopy, 184
sigmoidocele, 186
Obstructing right colon cancer, 99, 100
Obstructive defecation, 159, 160
Obstructive defecation syndrome (ODS), 159
Oligometastatic disease, 337
Oral mechanical bowel preparation (OMBP)
elective colorectal surgery, 3
vs. enema/no preparation, 3–6
European and Canadian surgical societies, 3
GRECCAR III randomized trial, 5
gut decontamination with oral
nonabsorbable antibiotics, 8
laparoscopic resection, 5
Mayo Clinic group, 5
NSQIP, 7
oral antibiotics, 7
SSI rates, 3
Veterans Affairs (VA), 7
with/without enema vs. enema/no
preparation, 5, 6
OSTRiCh, 376
P
Parastomal hernia (PSH)
conservative treatment, 252
denition, 242
EHS classication, 252
foreign body reinforcement, 246–248
healthcare utilization, 242
incidence, 242
intestinal stoma creation, 241
laparoscopy, 253
local repair with mesh, 253, 255
local suture repair, 252, 253
on patients, 243
physical examination, 251
recurrence repair of, 244
risk factors, 243–244
stoma creation technique, 245, 246
stoma formation, 251
stoma placement, 244
sugarbaker technique, 253, 255, 258
surgical strategy, 252, 258
symptoms, 251
Parenteral antibiotics
colorectal surgery, 13, 14
enteral and, 15
oral antibiotics, 14
Partial mesorectal excision (PME), 342
Pathologic complete response (pCR), 333
Patient-controlled analgesia (PCA), 307
Pelvic oor dyssynergia, 189
Pelvic organ prolapse (POP) disorders, 172
Perforated diverticulitis
adjacent organs/omentum, 129
ASN, DSS and EAES guidelines, 148
cancer risk, 148, 149
classication, 130
colo-colonic anastomosis, 132
CT imaging, 131
DCS, 136, 137
emergency surgery, 133
end-colostomy/primary anastomosis, 144
generalized peritonitis, 131
historic management, 131, 132
IMA and SRA, 132
immunosuppressed patients, 129, 137, 138
indications, 129
interval colectomy, 144
laparoscopic colectomy, 137
laparoscopic lavage, 131
limitations, 131
macroperforation, 146–148
microperforation, 145, 146
microscopic and macroscopic, 144
optimal/cutoff number, recurrences, 145
“prophylactic” colectomy, 145
proximal and distal margins, 132
sigmoid colon, 129
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