The mechanism by which DEN induce HCC in mice is by the generation of electrophilic ethyldiazo­nium ions upon metabolic activation of the carcinogen. These highly reactive ions interact with DNA, proteins and lipids causing a chain reaction leading to increasing ROS pool. Accumulation of ROS leads to oxidative stress and hepatocyte death and eventually compensatory proliferation involving many signal­ling cascades. The ability of these plants to reduce the effect of DEN and subsequently HCC was thought to be due to their ability to scavenge ROS generated thereby reducing the load and/or sources of ROS. Phenolics and flavonoids are known to have excellent antioxidant activity, while terpenoids, alkaloids have shown to have moderate antioxidant activity (Kasote et al., 2015). Phenolics and flavonoids like Caffeoylquinic acid, Kaempferol, apigenin dimethyl ether, as well as other compounds like Aristolone, Magnoflorine, N-Trans-Feruloyldopamine, β-sitosterol and Stigmasterol present in A. tagala (Hadem & Sen 2018a; 2018b) and known to have antioxidant property may have contributed to the antioxidant property of A. tagala (Yoshida & Niki 2003; Hung et al., 2007; Wang 2010; Li et al., 2014; Krishna et al., 2015; Dizdar 2018). Besides phenolics and flavonoids present in C. caesia, terpenoids may be an important contributing factor to their antioxidant property. Ar-turmerone, Borneol, 1,8-cineole, Linalool