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11 High-Resolution Ultrasound Imaging System 267
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Table 11.6 Connection scheme between FPGA and computer
Interface Data throughput Features
USB3.0 >300 MB/s USB devices can be connected and disconnected at
PCIE3.0 X1 984.6 MB/s Physical PCI Express links may contain from one to
X16 15.8 GB/s
any time
32 lanes
Data Process
Previous sections introduce key parts in an imaging circuit for the IVUS application. They are crucial for data acquisition to ensure a low noise level RF data. When the data are transferred to the data process unit, such as FPGA, digital signal processing is required to get an ultrasound image. There are several methods to deal with the algorithms. Usually, the processing algorithms can be divided into two steps: The first step is achieved by local field processing unit, and the second step is programmed in a computer. Generally, the signal processing algorithms before the image do not require large size data storage, which is suitable to be achievedon a FPGA. In contrast, post-image processing algorithms require more data storage, which are suitable to be achieved in a computer.The strategy of the implementation of the imaging algorithms is determined by the designer. Here in this section, the algorithms which are suitable for the implementation in FPGA will be introduced.
As the core processor, the implemented algorithms in FPGA greatly influence the performance of the imaging system. Figure 11.5 shows the structure of the imple­mented algorithms for real-time grayscale IVUS imaging (Qiu et al. 2012). Digital band-pass filter (BPF), envelope detection, digital scan conversion, and other algo­rithms can be implemented (Hu et al. 2006;Xuetal.2008; Zhang et al. 2010). Hardware interface in the FPGA enables the connection of high-speed ADC. The data were filtered first by BPF to remove the noise outside the spectrum. The enve­lope was then extracted by a detector and then followed by a digital scan converter (DSC) and logarithmic compression. The DSC was employed to convert the polar data to Cartesian coordinates. Finally, image data will be transferred to the computer by high-speed PCIE or USB interface. Other algorithms including digital time gain compensation (DTGC) and data smoothing may also be applicable in the FPGA. DTGC provides that the data are digitally amplified by configurable coefficients to compensate for ultrasound attenuation in the tissue. The following sections give more details on the individual algorithms implemented in the FPGA.
Digital Filter
The echo signal received by the FPGA may contain some noises from electronics, cable, etc., which degrades the signal-to-noise ratio (SNR) of the images. Although an
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RAM
RAM
Interface
Echo
signal
Fig. 11.5 The algorithms implemented in FPGA for real-time IVUS imaging
Data
Interface
Digital
Filter
Envelope
Detector
Scan
Conve rter
Log
Compress or
Computer
Interface
PCIE
USB
analog filter has been applied before the ADC, there are still some noises left that get into the digital circuits. A digital filter in the FPGA would eliminate the undesirable noises and improve the SNR further. The easiest way in FPGA for the filter is FIR filter (Qiu et al. 2012). Since FPGA is competent for multiplication and addition, it is very suitable for the FIR calculation. Moreover, the FIR filter coefficients are symmetric; therefore, the number of multipliers can be reduced by half, which saves resources in the FPGA. Some advanced functions such as DSP block in the FPGA can be used to achieve fast processing. Although high order FIR provides better noise suppression, it results in elongated ripples which degraded the imaging resolution. Therefore, it is a trade-off for the selection of SNR improvement and unwanted ripples. Figure 11.6 shows a representative signal processed by a digital 31-tap FIR band-pass filter. More than 40 dB additional noise suppression can be attained with this setting. FPGA also supports high-speed process, which the FIR filter can run in a clock higher than 240 MHz. The coefficients of the digital filter are flexible and reconfigurable during the imaging process.
Envelope Detection
Grayscale B-mode imaging is usually used for the IVUS imaging to represent the backscattering of the ultrasound from the vessel. It requires a positive data for the display. Usually, the envelope is extracted from the filtered ultrasound data. Since ultrasound echo signals are broadband in frequency spectrum, the Hilbert transform could be used to extract the envelope. An architectural example of the envelope detection method is shown in Fig. 11.7. The in-phase (I) and quadrature (Q) signal could be obtained by the Hilbert transform. The modulus of I/Q signals is calculated for the acquisition of envelope by removing the carrier frequency. To fit for FPGA architecture, cordic algorithm could be employed for this action by an iterative pro­cess using a series of adders and shifters (Qiu et al. 2012). Simulation with cordic algorithm in the FPGA shows that it can run at a 250 MHz clock, which supports a high throughput process for modulus calculation.
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Fig. 11.6 a Unprocessed echo waveform and b processed waveform with a 31-tap digital filter in the FPGA
I
Quadrant
Q
Pipeline
computing
Compensation
To DSC
Cordic
Echo signal
Algorithm
Delay
Hilbert
Filter
Hilbert
Fig. 11.7 Hilbert transform and cordic algorithm based envelope detector
Digital Scan Convertor
A single element transducer is usually employed for IVUS imaging, which requires a mechanical rotation of the transducer to acquire a sectional image. Therefore, the ultrasound signals are obtained at different angles (~500 angles), which restores as a polar coordinate. On the other hand, the screen for the imaging is presented with Cartesian coordinates. So that, a conversion named as digital scan convertor (DSC) is required to transform the polar coordinate’s data to Cartesian coordinate’s data (Chang et al. 2008; Levesque and Sawan 2009). Figure 11.8 demonstrates the principle of DSC. C-R represents the Cartesian coordinate and P represents the Polar coordinate. The value in pixel S can be calculated by relevant P interpolation can be achieved in the FPGA (Qiu et al. 2012).
and Pyi. Linear
xi
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Table 11.7 Evaluation items and reference value
Articles Referred value
Axial resolution ~50 µm
Lateral resolution ~150 µm
Dynamic range >50 dB
CNR >5
Imaging frame rate >20
Penetration depth >5 mm
Imaging Evaluation
Imaging evaluation should be done before the in vivo study, which is useful for the improvement of the imaging performance. Table 11.7 shows the imaging parameters and referred value. There are several methods to evaluate the performance including wire phantom imaging and tissue phantom imaging. Tungsten wires with 12.5 µm diameter (California Fine Wire Co., CA, USA) are usually employed to evaluate the imaging resolution at different points for IVUS imaging. They are placed at specific positions, showing the imaging resolution at those points. Quantitative measurements of the axial and lateral resolution can be achieved by measuring the full width at half maximum (FWHM) of the wire targets (Brown and Lockwood 2005; Ketterling et al.
2006).
A tissue mimicking phantom could be fabricated to further evaluate the IVUS image quality. There are several methods to fabricate the phantom (Madsen et al.
2010). It may contain a mixture of deionized water, high-grade agarose, preservative,
propylene glycol, filtered bovine milk, and glass-bead to generate tissue mimicking attenuation and backscattering. This phantom provides tissue mimicking attenuation of about −32 dB/cm for 40 MHz ultrasound and backscattering to test the imaging
Fig. 11.8 Block diagram of digital scan converter implemented in FPGA with linear interpolation
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Fig. 11.9 Phantom evaluation of the ultrasound system a Tungsten wire phantom image, b Image of tissue mimicking phantom
resolution and penetration depth. Some anechoic holes are made inside the phan­tom to evaluate the value of contrast-to-noise ratio (CNR), which offers an indirect characterization of spatial resolution in all directions simultaneously (Mamou et al.
2009; Lediju et al. 2011). The CNR was calculated as:
CNR =
|
mean
t
sta
− mean
2
+ sta
t
|
n
2
n
where meantand meannrepresent the mean backscatter amplitude of the phantom and the anechoic hole. sta
and stanrepresent the corresponding standard deviations.
t
Figure 11.9a shows the wire phantom image. The axial and lateral resolutions in the third wire are 57.8 and 181.6 µm, respectively. The dynamic range of the images is set to 50 dB. Figure 11.9b presents the tissue phantom image. High-resolution ultrasound can provide a certain imaging depth.
Summary
This chapter provides a basic introduction to the IVUS system. Some essential parts including pulse generation, echo receiver, and image processing algorithms are intro­duced. In addition, the evaluation method is also introduced in the l ast session. The contents in this chapter can be useful for designing a system for IVUS application.
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