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Файл:Ординатура / Хирургия / Библиотека им академика М.И. Перельмана / Книга_2866_Библиотеки_им_академика_М_И_Перельмана.pdf
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- •Preface
- •Contents
- •Introduction
- •Prevention
- •Harm Reduction
- •Decision-Making/Differential Diagnosis
- •Screening
- •Health Maintenance
- •References
- •Physical Exam
- •Vaccinations
- •Introduction
- •Symptoms
- •Other History
- •Physical Exam
- •Lab Tests
- •Differential Diagnosis
- •Treatment
- •Prevention
- •Long Covid
- •References
- •Introduction
- •Provider Perspectives
- •Portable Medical Summary
- •Education
- •Employment
- •Specialist-Dominated Care
- •Internist-Dominated Care
- •Condition-Specific Medical Knowledge
- •Medication Reconciliation/Polypharmacy
- •Secondary Medical Conditions
- •Behavioral Health
- •Health Maintenance
- •Sexual Health
- •Sexual Abuse
- •Contraception
- •Cervical Cancer Screening
- •Health Disparities
- •Ethical Considerations
- •Conclusion
- •References
- •Introduction
- •Outpatient Assessment
- •Social History
- •Medications
- •Functional Assessment
- •Geriatric Syndromes
- •Delirium
- •Confusion Assessment Method (CAM): Short version [14]
- •Delirium Evaluation
- •Depression
- •Medication Management
- •Preventing Future Falls
- •Polypharmacy
- •Sensory Loss
- •Vision
- •Hearing Loss
- •Osteoporosis
- •Sleep Disorders
- •Advanced Care Planning
- •Home Care
- •References
- •History
- •Palliative Care/Hospice Care
- •Constipation
- •Nausea/Vomiting
- •Pain
- •Conclusion
- •References
- •Introduction
- •Definitions
- •Decision-Making
- •Identification
- •Key History
- •Workup
- •Management
- •Risky or Unhealthy Alcohol Use
- •Risky Opioid Use or OUD
- •References
- •Introduction
- •History
- •Physical Exam
- •Type 1 Diabetes
- •Type 2 Diabetes
- •Lifestyle Changes
- •Metformin
- •GLP-1 Receptor Agonists (Exenatide, Liraglutide, Dulaglutide, Lixisenatide)
- •DPP-4 Inhibitors (Sitagliptin, Saxagliptin, Linagliptin, Alogliptin)
- •SGLT-2 Inhibitors (Canagliflozin, Dapagliflozin, Empagliflozin, Ertugliflozin)
- •Thiazolidinediones (Pioglitazone)
- •Alpha-Glucosidase Inhibitors (AGIs) (Acarbose, Miglitol)
- •Insulin
- •References
- •Subclinical Hypothyroidism
- •Treatment Challenges
- •Hyperthyroidism
- •Brief Introduction
- •Key H&P
- •Decision-Making/Differential Diagnosis
- •Treatment
- •Graves’ Disease
- •Hypothyroidism
- •Brief Introduction
- •Key H&P
- •Decision-Making/Diagnosis
- •Treatment
- •Overt Hypothyroidism
- •Radioactive Iodine (RAI)
- •Surgery
- •Treatment: Subclinical Hyperthyroidism
- •Thyroid Nodules
- •Brief Introduction
- •Key H&P
- •Decision-Making/Differential Diagnosis
- •Treatment
- •References
- •Introduction
- •History
- •Medical History
- •Family History
- •Social History
- •Physical Exam
- •Decision-Making/Differential Diagnosis
- •Screening Population
- •Testing Lipid Levels: Fasting vs. Non-fasting
- •Treatment
- •Treatment Strategies
- •Lifestyle Modification
- •Statins
- •Fibrates
- •Fish Oil
- •Other Non-statin Medications
- •Monitoring After Initiating Therapy
- •References
- •Introduction
- •History
- •Who Should Lose Weight?
- •Treatment
- •Diet
- •Physical Activity
- •Pharmacotherapy
- •Long-Term Follow-Up After Uncomplicated Bariatric Surgery
- •References
- •Brief Introduction
- •Decision-Making/Differential Diagnosis
- •Acute Cough
- •Subacute Cough
- •Chronic Cough
- •Evaluation/Investigation
- •Disease-Specific Features
- •Acute Cough
- •Subacute Cough
- •Chronic Cough
- •Treatment
- •References
- •Introduction
- •Sudden-Onset Dyspnea
- •Acute-Onset Dyspnea
- •Episodic Dyspnea
- •Chronic Dyspnea
- •Treatment
- •References
- •Introduction
- •Acute Sinusitis
- •Chronic/Recurrent Sinusitis
- •Physical Findings
- •Diagnosis
- •Diagnostic Tests
- •Additional Evaluation
- •References
- •Introduction
- •Decision-Making/Differential Diagnosis
- •Key H&P
- •Rapid Antigen Detection Tests
- •Treatment
- •Symptomatic Treatment
- •References
- •Introduction
- •ICSD3 Classifies Sleep Disorders into Seven Major Categories [4]
- •Prevalence
- •Sleep History
- •STOP-Bang Questionnaire
- •Understanding ESS Score
- •Focused Physical Exam
- •Definition
- •Risk Factors
- •Pathophysiology
- •Diagnosis
- •Treatment: OSAHS/SDB (Usual Therapy)
- •References
- •Brief Introduction
- •Decision-Making/Differential Diagnoses
- •Physical Examination
- •Measuring Blood Pressure
- •Diagnostic Studies
- •Clinical Quality Measure
- •Assessment
- •Treatment
- •Lifestyle Management
- •Pharmacological Interventions
- •Refractory or Resistant Hypertension
- •References
- •Chest Pain
- •History
- •Physical Exam
- •Differential Diagnosis
- •Potentially Life-Threatening
- •Acute Coronary Syndromes
- •Aortic Dissection
- •Pulmonary Embolism
- •Pneumothorax
- •Non-Life-Threatening Causes
- •Gastroesophageal Reflux Disease
- •Pleuritic Chest Pain
- •Cervical Angina
- •Pericarditis
- •Chronic Angina
- •Herpes Zoster
- •Muscular Pain
- •Rib Fracture
- •Costochondritis
- •Esophageal Spasm
- •Diagnostic Testing
- •Electrocardiogram
- •Blood Testing
- •Imaging
- •Chest X-Ray
- •X-Ray C-Spine
- •Transthoracic Echocardiogram
- •References
- •Introduction
- •Laboratory Evaluation
- •Hypoproliferative Anemias
- •Microcytic Anemia
- •Differential Diagnosis
- •Iron Deficiency Anemia
- •Epidemiology
- •Pathophysiology
- •Key History
- •Physical Exam
- •Laboratory Evaluation
- •Diagnosis
- •Treatment
- •Normocytic Anemia
- •Differential Diagnosis [6]
- •Epidemiology
- •Pathophysiology
- •Laboratory Evaluation
- •Diagnosis
- •Treatment
- •Macrocytic Anemia
- •Differential Diagnosis [2]
- •Megaloblastic Anemia
- •Vitamin B12 Deficiency
- •Epidemiology
- •Pathophysiology
- •Laboratory Evaluation
- •Diagnosis
- •Folic Acid Deficiency
- •Hyperproliferative Anemia
- •Hemolytic Anemia
- •Intrinsic Hemolytic Anemia
- •Sickle Cell Anemia
- •Epidemiology
- •Pathophysiology
- •Laboratory Evaluation
- •Diagnosis
- •Treatment
- •Thalassemia
- •Epidemiology
- •Pathophysiology
- •Laboratory Evaluation
- •Hereditary Spherocytosis (HS)
- •Epidemiology
- •Pathophysiology
- •Laboratory Evaluation
- •Glucose-6-Phosphate Dehydrogenase Deficiency (G6PD Deficiency)
- •Epidemiology
- •Pathophysiology
- •History Physical Exam
- •Laboratory Evaluation
- •Extrinsic Hemolytic Anemia
- •Autoimmune Hemolytic Anemia
- •Warm Autoimmune Hemolytic Anemia (WAHA)
- •Epidemiology
- •Pathophysiology
- •Laboratory Evaluation
- •Cold Autoimmune Hemolytic Anemia
- •Epidemiology
- •Pathophysiology
- •Laboratory Assessment
- •Conclusion
- •References
- •Introduction
- •Differential Diagnosis
- •Decision-Making/Treatment
- •References
- •Introduction
- •Decision-Making/Differential Diagnosis
- •Papulosquamous
- •Psoriasiform
- •Pityriasiform
- •Lichenoid
- •Erythroderma
- •Eczematous
- •Dermal
- •Vascular
- •Vesiculobullous
- •Infectious
- •Autoimmune, Intraepidermal
- •Autoimmune, Subepidermal
- •Noninflammatory
- •References
- •Introduction
- •Decision-Making/Differential Diagnosis
- •Non-scarring Alopecias
- •Androgenetic Alopecia
- •Focal Hair Loss
- •Diffuse Hair Loss
- •Scarring Alopecia
- •Lymphocytic
- •Acne Keloidalis
- •Neutrophilic
- •References
- •Introduction
- •Key H&P
- •History
- •Medications
- •Social History
- •Physical Examination
- •Differential Diagnosis
- •Decision-Making
- •Treatment
- •References
- •Introduction
- •Key H&P
- •History
- •Physical Examination
- •Differential Diagnosis
- •Intrinsic Shoulder Pain
- •Decision-Making
- •Treatment
- •Rotator Cuff Injury
- •Adhesive Capsulitis
- •References
- •Introduction
- •Key H&P
- •History
- •Medications
- •Social History
- •Physical Examination
- •Differential Diagnosis
- •Decision-Making
- •Treatment
- •Pharmacotherapy
- •Non-pharmacotherapy
- •References
- •Introduction
- •Decision-Making/Differential Diagnosis
- •Vertigo
- •Central vs. Peripheral Vertigo
- •BPPV
- •Meniere’s Disease
- •Labyrinthitis/Vestibular Neuritis
- •Migrainous Vertigo
- •Presyncope
- •Disequilibrium
- •Lightheadedness
- •Dix-Hallpike Maneuver
- •Nystagmus
- •Hearing Evaluation
- •Romberg Testing
- •Other Diagnostic Testing
- •Treatment
- •BPPV
- •Vestibular Neuritis/Labyrinthitis
- •Meniere’s Disease
- •Disequilibrium
- •Presyncope
- •Lightheadedness
- •References
- •Introduction
- •History

Chapter 25. Dizziness
503
Meniere’s Disease
The abnormal fluid balance of this condition can be managed
based on the severity of disease. All patients should be
referred for an ENT evaluation. Noninvasive treatments
include salt restriction, diuretics, antihistamines, vestibular
suppressants, and antiemetics. Patients should also be referred
for vestibular rehabilitation. Patients with refractory or
severe disease despite medical therapy may be candidates for
invasive therapies such as intratympanic gentamicin or glucocorticoids and, in some cases, surgical therapy [1].
Disequilibrium
The evaluation of a patient with disequilibrium involves
looking for other disorders that are contributing to the symptoms as treatment is focused on addressing the issues that
underlie this condition. This may involve withdrawal of precipitating medications, referral for ophthalmologic evaluation
and corrective lenses for visual impairment, providing an
ambulatory assistive device (cane or rolling walker), physical
therapy evaluation, and the treatment of any metabolic, neurologic, or movement disorders that were unveiled during the
evaluation.
Presyncope
The evaluation of patients with presyncope is the same as for
patients who experienced true syncope. As with all other
causes of dizziness, the history guides the clinician to the
appropriate exam and relevant testing needed to secure the
diagnosis. Any potentially offending medications that can
safely be tapered or discontinued should be a priority.
Patients with orthostatic hypotension can benefit from volume replacement if they are volume depleted. Refractory
orthostasis should prompt the clinician to consider autonomic dysregulation. In addition to management of underly-

504
R. Kennedy Jr
ing metabolic and endocrine disorders, medications such as
midodrine or fludrocortisone can be initiated. Patient education with behavior modification should be provided to
patients with a neurocardiogenic process. Patients with atherosclerotic cardiovascular disease history or risk factors,
those with sudden or exertional syncope, and those who
experience syncope in a supine position should undergo thorough evaluation and treatment for potentially malignant
causes [13].
Lightheadedness
Hyperventilation syndrome often coupled with psychiatric
disorders (anxiety and depression) is the main contributor to
the vague and imprecise symptoms of lightheadedness. As
previously noted, if the hyperventilation provocation test successfully recreates the patient’s symptoms, this can also be
therapeutic and reassuring to the patient [1]. Conscious
breathing exercises can control future events. If a mood disorder is revealed during symptom evaluation, this should be
treated with the appropriate agents, and the patient can also
be referred to the relevant behavioral health specialist.
Clinical Pearls
• The patient’s initial, raw, unguided description of symp-
toms is the most important step in determining the cause
of dizziness.
• Movement worsens all types of vertigo, and even though
patients with peripheral vertigo may not want to move,
they are usually able to walk. In comparison, patients with
central vertigo experience greater impairment in gait and
posture and are often very ataxic and unable to walk.
• All patients with Meniere’s disease should be referred to
ENT early in the disease process as even though vertigo
attacks may be controlled in most patients, hearing loss
can be progressive.

Chapter 25. Dizziness
505
• Orthostasis can be caused by intravascular volume deple-
tion, many medications, and autonomic dysfunction.
• Visual impairment, deafness, peripheral neuropathy, mus-
cle weakness, and deconditioning can all contribute to
disequilibrium.
• The hyperventilation test for suspected lightheadedness
can be both therapeutic and diagnostic.
Do Not Miss This!
• These are findings on the physical exam that suggest
stroke in dizzy patients: normal bilateral vestibulo-ocular
reflexes (noted on head impulse test), skew deviation,
abnormal visual tracking (saccadic pursuit), and direction-
changing nystagmus.
• Syncope that occurs while supine, with exertion, or sud-
denly (without prodrome) should raise clinical suspicion
for malignant cardiac arrhythmias (VT, high-grade heart
block, prolonged sinus pauses) or structural cardiac abnor-
malities (severe aortic stenosis or HOCM).
References
1. Post RE, Dickerson LM.Dizziness: a diagnostic approach. Am
Fam Physician. 2010;82(4):361–8.
2. Neuhauser HK, etal. Burden of dizziness and vertigo in the community. Arch Intern Med. 2008;168:2118.
3. Kroenke K, et al. Causes of persistent dizziness. A prospective study of 100 patients in ambulatory care. Ann Intern Med.
1992;117:898.
4. Stanton VA, etal. Overreliance on symptom quality in diagnosing dizziness: results of a multicenter survey of emergency physicians. Mayo Clin Proc. 2007;82:1319.
5. Baloh RW. Differentiating between peripheral and central
causes of vertigo. Otolaryngol Head Neck Surg. 1998;119:55.
6. Hotson JR, Baloh RW. Acute vestibular syndrome. N Engl J
Med. 1998;339:680.
7. Kerber KA, Baloh RW.The evaluation of a patient with dizziness. Neurol Clin Pract. 2011;1:24.

506
R. Kennedy Jr
8. Wood KA, etal. Frequency of disabling symptoms in supraventricular tachycardia. Am J Cardiol. 1997;79:145.
9. Maarsingh OR, et al. Causes of persistent dizziness in elderly
patients in primary care. Ann Fam Med. 2010;8:196.
10. Reilly BM.Dizziness. Clinical methods: the history, physical, and
laboratory examinations. 3rd ed. Boston: Butterworths; 1990.
p.220.
11. Furman JM, etal. Benign paroxysmal positional vertigo. N Engl
J Med. 1999;341:1590.
12. Cohen HS, etal. Standing balance tests for screening people with
vestibular impairments. Laryngoscope. 2014;124:545.
13. Sloane PD, etal. Management of dizziness in primary care. J Am
Board Fam Pract. 1994;7:1.

Chapter 26
Headache
SchantalPolanco
Abbreviations
AVM Arteriovenous malformation
CDH Chronic daily headache
CVT Chronic venous thrombosis
GCA Giant cell arteritis or temporal arteritis
HC Hemicrania continua
LP Lumbar puncture
MO Medication overuse
PH Paroxysmal hemicranias
SAH Subarachnoid hemorrhage
SDH Subdural hematoma
SUNCT Short-lasting unilateral neuralgiform headache
TAC Trigeminal autonomic cephalalgia
TMJ Temporal mandibular joint
TTH Tension-type headache;
S. Polanco (*)
Albert Einstein College of Medicine, Jacobi Medical Center,
Bronx, NY, USA
e-mail: schantal.polanco@nychhc.org
© The Author(s), under exclusive license to Springer Nature
Switzerland AG 2022
E. Sydney et al. (eds.), Handbook of Outpatient Medicine,
https://doi.org/10.1007/978-3-031-15353-2_26
507

508
S. Polanco
Introduction
Headache is a common neurological complaint in the outpatient setting [1]. The importance of proper diagnosis is crucial
to our management. Most headaches are of benign etiology
and fall under the category of primary headache disorders.
Tension-type headache is more common than migraine headache [2]. However, migraine headaches tend to be disabling
and cause functional impairment leading patients to seek
medical assistance more frequently for this ailment [2].
Cluster headaches fall under the category of trigeminal autonomic cephalalgia and this disorder has a prevalence of less
than 1% [3]. It is important to recognize the characteristics
and diagnostic criteria of primary headaches to assist with
management. As an initial first step in our assessment, it is
important to focus on key aspects of the history and physical
examination to exclude secondary causes of headache which
may stem from other systemic, neurological, psychiatric, or
traumatic etiologies. Once these “red flags” in the history and
physical examination are excluded, one can focus on the
more common primary etiologies of headache (Fig.26.1).

pneumonic?
Old with no “Red Flags”
Does it meet 4/5 *POUND
Chapter 26. Headache
disorder-refer to Table 2
Other Primary headache
No
TAC
*POUND pneumonic
Pulsatile
One day duration
Unilateral
TTH
Nausea association
Disabling intensity
509
Headache
New or “Red Flags”
No evidence of
secondary cause
Headache
Rule out Secondary
Yes=Migraine
Likely primary
headache with
atypical features
secondary headaches
Key history and suspected
1 month
Treat using recommendation
from Table 3 and reassess in
Signs of
infection
Any focal
or symptom
neurological sign
use
state or OCP
Pro-thrombotic
Thunderclap
>50
Age
consultation
Refer for neurological
diagnostic uncertainty
Persistent, MO or headache with
Encephalitis
Meningitis or
SAH CVT CVA
GCA
F . Headache algorithm

S. Polanco
510
Key History andPhysical Exam
A complete history and physical examination are essential in
the assessment of any headache. When done properly, the
potentially dangerous causes of headache which may warrant
emergent intervention can be identified. The following features in the history have been underlined to highlight information which may support a secondary cause of headache
(refer to Table26.1).
History
Age: New headache in a patient above 50years should raise
concerns for temporal arteritis, acute angle- closure glaucoma, and malignancy in the right context [1, 4–6], particularly if associated with visual disturbance, jaw claudication,
polymyalgia, cough, or weight loss.
Onset and Characteristic: An abrupt onset of maximum inten-
sity is suggestive of an ominous or secondary cause for the
headache. These symptoms fall under the umbrella term of
“thunderclap headache” typically described by patients as
“the worst headache of my life” and warrants immediate
attention with imaging and lumbar puncture when imaging
is nonrevealing and our clinical suspicion is high. Etiologies
T . Differential diagnosis as outlined by the International
Headache Society
Primary headache Secondary headache based on “red flags”
1. Tension-type
headache
(TTH)
2. Migraine
3. Trigeminal
autonomic
cephalalgias
(TACs)
Look for clues in your history, physical exam,
laboratory studies, and imaging to guide
your differential diagnosis when a secondary
headache is suspected.

Chapter 26. Headache
T . (continued)
Primary headache Secondary headache based on “red flags”
4. Other primary
headache
disorders
• Primary
cough
headache
• Primary
exercise
headache
• Primary
headache
associated
with sexual
activity
• Primary
thunderclap
headache
• Cold stimulus
headache
• External
pressure
headache
• Primary
stabbing
headaches
• Nummular
headache—
Coin shaped
• Hypnic
headache—
1. Headache attributed to infection.
2. Headache attributed to trauma.
3. Headache attributed to a vascular
disorder (CVA, SAH, SDH, arteritis,
unruptured vascular malformation, carotid
or vertebral artery disorder, genetic
vasculopathy, pituitary apoplexy, and
other acute intracranial disorders such
as those resulting from an endovascular
procedure or conditions less clearly
understood such as reversible cerebral
vasoconstriction syndrome.
4. Headache attributed to other nonvascular
intracranial disorder (cerebrospinal fluid
pressure—High or low), noninfectious
intracranial inflammatory diseases,
intracranial neoplasm, seizure, Chiari
malformation)
5. Headache attributed to substance
exposure, use, or withdrawal (including
those prescribed, illicit, and contained in
food).
6. Headache attributed to a disorder of
homeostasis (hypoxia, hypercapnia,
dialysis, hypertension, hypothyroidism,
fasting, etc.)
7. Headache attributed to disorder of facial
or cervical structures.
8. Headache attributed to psychiatric
disorder.
Only during
sleep
• New daily
persistent
headache
511

512
S. Polanco
which may present this way include subarachnoid hemorrhage, cavernous venous thrombosis, pituitary apoplexy,
hypertensive emergency, arterial dissections, and acute
angle-closure glaucoma, which require emergent intervention [1, 4, 5].
Duration and Relevant Past Medical History: Persistent or
progressive headache in a patient with a past medical
history of cancer, HIV, Lyme disease, systemic vascular
disorder, or hypercoagulable state warrants further
workup of secondary causes. Additionally, patients with
a past medical history of a primary headache such as
migraine may be at increased risk of developing brain
lesions including posterior circulation stroke-like lesions
[7]. A new headache or prior changes in the characteristics of a known headache disorder warrant further
investigation.
Medications: Use of anticoagulants, NSAIDs, steroids, or
drugs of abuse such as cocaine place patients at an
increased risk of intracranial bleed and can be an indication for neuroimaging [1]. The use of birth control pills is
associated with increase in migraine severity but also an
increased risk of CVT [8, 9].
Context: Headache in the setting of trauma, uncontrolled
hypertension, motor, sensory, cerebellar, personality, or
cognitive change warrants imaging to further investigate the neurological symptom. The presence of systemic symptoms should precipitate additional
considerations. In patients who were hospitalized with
COVID-19, headache was considered a presenting
symptom and this diagnosis should be considered in the
appropriate clinical context [10].
Aggravating factors that raise intracranial pressure such as
exertion, cough, and lying down may reflect an intracranial
etiology and require additional investigation [4].
Location: Careful history and palpation over maxillary and
frontal sinuses, orbits, temporal artery, TMJ, ears, occipital nerve, and upper posterior neck can reveal pain from
various secondary headaches and neuralgias [5].
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