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Файл:Ординатура / Хирургия / Библиотека им академика М.И. Перельмана / Книга_5386_Библиотеки_им_академика_М_И_Перельмана.pdf
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Nano Physical Pharmaceutics of Liposome-Based System
3.2.4 Detergent Depletion Method
3.3 Theory of Liposome Formation
Theory of Liposome Formation
95
(a)
(b)
(c)
Figure 3.2 The general process and principle of the assembly of liposomes.
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Nano Physical Pharmaceutics of Liposome-Based System
P
P = VAL
where V
A L
P
Theory of Liposome Formation
97
Figure 3.3 Phase diagram of liposome/DNA polyplex formaon and the
complex stability. Reproduced with permission from [15].
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Nano Physical Pharmaceutics of Liposome-Based System
NPP of Liposomes in Drug Delivery
99
3.4 NPP of Liposomes in Drug Delivery
3.4.1 Physiochemical Properties of Liposome
3.4.1.1 Size of liposome
3.4.1.2 Phase transition temperature of liposome
Tc
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Nano Physical Pharmaceutics of Liposome-Based System
Tc
3.4.1.3 Membrane permeability of liposome
in vivo Tc
3.4.1.4 Membrane charge of liposome
NPP of Liposomes in Drug Delivery
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3.4.2 Drug-Loading Behavior of Liposome
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Nano Physical Pharmaceutics of Liposome-Based System
in vivo in vitro
NPP of Liposomes in Drug Delivery
103
3.4.3 Stability of Drug-Loaded Liposome
3.4.3.1 Physical stability of drug-loaded liposome