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8
1 Anal Fissure
sumed to be due to sepsis) in a case series of Chambers et al. (2010).

1.6 Suture Dehiscence

Suture dehiscence is most common in patients with diabetes or Crohn’s disease. In these cases, Yakovlev et al. (2011) suggest to perform a tempo­rary sacral nerve stimulation.
In perianal wounds, a suture breakdown is not particularly problematic; the wound is small (it should not be > 1-2 cm) and will heal by second­ary intention. The only shortcut possible is to use catgut (which is often not available) or Vicryl Rapid which gives way if sepsis develops under­neath so that the pus can drain off. Moreo ver, Nelson (2005) demonstrated that, among the surgi­cal wounds made in treating anal fissure, the later­al internal sphincterotomy wound heals best and the most quickly.
We now shift the discussion to sutures of the mucosal or, more frequently, cutaneous flap used in anoplasty. As mentioned earlier, a small dehis­cence of this suture occurred in 3 out of 21 of my patients. Fortunately, there was only a slight dehis­cence (involving 2-3 stitches) and there were no significant consequences, except for delayed wound healing (Fig. 1.6). The wounds did not become chronic and the fissures did not recur. The
same problem was seen in 2 of the 16 patients of Patti et al. (already cited) but neither patient had to undergo re-operation. However, one of the 3 patients of Chambers et al. (cited above) who developed suture dehiscence required re-operation.
Kundall et al. (2003) reported that hyperbaric oxygen therapy is effective for patients with surgical wounds that do not heal with any other treatment.
Can the method used to perform anoplasty influence the risk of dehiscence? Probably it can, even though I do not know of any randomized tri­als on this subject. Various authors have empha­sized the fact that they did not use electrocautery to prepare the skin flap, did not harvest the flap from the posterior commissure (the midline is less well vascularized), and did remove the underlying fibrotic tissue (in order to place the sutures in healthy tissue). These are elementary principles of plastic surgery and I adhere to them as well.
There was no anal stenosis after anoplasty in my patients but it has been described in the litera­ture. This is one of the dangers associated with a large dehiscence. Patients at risk should be advised to perform self-dilatation at home, for instance with Dilatan from Sapimed.
If the wound persists, wound healing agents, such as oil-based VEA, Colostrum, Vulnamin, Abound, Cicatrene, or Fitostimoline, should be prescribed. If there is also anal hypertonia, which may slow down or impede healing, it can be treat-
Fig. 1.6 Partial dehiscence of
cutaneous anoplasty (asterisk) after excision of a chronic fis­sure in a patient without anal hypertonia. The anorectal ring is pink. Cutaneous flap detach­ment from the epithelium of the high anal canal reveals the underlying sphincteric fibers

1.7 Tricks of the Trade

9
ed with Antrolin, a calcium channel blocker and analgesic, or Rectogesic (active ingredient: nitro­glycerin); these are creams for topical use. Dermatrans and similar medications, i.e., patches that release nitrates that cause vasodilatation and relax the sphincter, can also be used but they should not be given to patients who are hypoten­sive, on vasodilating drugs, or who are pregnant. The main side effect is headache. In cases of hypertonia and subacute stenosis, anal dilators such as Dilatan can be prescribed.
One more thing to note, not about skin flaps but about the skin incision in sphincterotomy, is that it heals more slowly if made posteriorly (Saad and Omer, 1992) because, as mentioned above, the blood supply to this area is very limited.
1.7 Tricks of the Trade
This is the first Tricks of the Trade section. Some of these tricks will already be familiar to the reader, others will seem to be self-evident, but in any case they are worth mentioning. In addition, please be aware that in the journal Techniques in Coloproctology of which I am the Editor-in-Chief (www.springerlink.com) there is also a Tricks of the Trade section, to which one’s own tricks can be submitted. Consult the Instructions for Authors regarding online contributions.
As for tricks related to anal fissures:
1. The risk of intraoperative bleeding can be kept to a minimum during internal sphincterotomy. Instead of dividing the muscle with scissors or electrocautery, rest the tip of the (very narrow, blunt) forceps on the distal edge of the sphinc­ter and then ask the instruments nurse to touch the forceps with the electrocautery device. Dissection will occur gradually and with only minimal bleeding (Fig. 1.7).
2. Another tip for obtaining good hemostasis: If after internal sphincterotomy the dissection margins bleed, avoid becoming obsessed with coagulating because the end result might be ischemia, necrosis, and ulceration of the epithelium of the anal canal and thus an endoanal wound that is very slow to heal. Instead, first try this: use your finger to exert pressure on the area; then infiltrate the area with adrenaline, with or without a needle.
3. If the fissure is deep and has hard thick margins and you are concerned that simple curettage is not sufficient to remove it or that it might con­tain neoplastic cells, use scissors or electro­cautery to obtain removal and, if necessary, send the specimen for histological analysis. If the patient has anal hypertonia or if you have decided to proceed with an internal sphinctero­tomy anyway, try to avoid a lateral sphinctero­tomy, although it is commonly performed,
Fig. 1.7 Electrocauterization
“transferred” to the clamp used to perform a hemostatic lateral internal sphincterotomy. Direct electrocauterization by the electrocautery tip is more like­ly to cause intraoperative bleeding
10
1 Anal Fissure
because this will result in a second surgical wound, thus preventing the patient’s unprob­lematic recovery. In these cases, I perform a posterior sphincterotomy at the point where the fissure has been excised and the internal sphincter exposed. The wound is then covered with anoplasty using the Arnoux or the Martin technique, just barely lowering the mucosa of the distal rectum. Or better yet, to avoid the risk of ectropion of the mucosa, the epithelium of the proximal part of the anal canal can be used to cover the surgical defect. It is advisable to perform this repair because otherwise, as men­tioned earlier, there is a less resistant triangular area which might cause soiling. This trick is especially helpful in patients with Crohn’s dis­ease or diabetes, since their wounds heal less easily and two surgical wounds are obviously a bigger problem than one. However, this approach is not recommended for patients who already had soiling preoperatively since it will aggravate their problems with incontinence. But, as repeatedly stated in this chapter, in the patient with anal hypotone, it is better to avoid sphincterotomy in the first place.

1.8 An Unforgettable Complication

Now for the first in a series of striking postopera­tive complications that I have observed in my career, after performing anorectal and pelvic floor surgery. Each one is presented as an interactive exercise. Halfway through, the reader is asked: What happened next? Why did the complication occur? What would you have done?
Note: After nearly all of these complications, there is a drawing that sums up the dynamics of the situation and the treatment. I would suggest that, if you choose to participate in the exercise, do not look at the drawing until you have finished reading the case report; otherwise you will obviously dis­cover ahead of time how the problem was solved.
The patient in our first unforgettable complica­tion was a psychologically stable 47-year-old woman suffering from chronic constipation, proc­talgia, and moderate rectal bleeding.
Her general practitioner found that she had an anal fissure, which was treated with an analgesic cream containing cortisone. As this was unsuc-
cessful, the patient decided to consult with a spe­cialist, who after digital rectal examination diag­nosed an internal mucosal prolapse of the rectum. The woman was operated on a few days later, undergoing a stapled transanal rectal resection (STARR). Neither proctoscopy, nor manometry, nor transanal ultrasound was performed preopera­tively.
A week later, the patient developed a high fever and abdominal pain, and was found to have suture dehiscence and anal stenosis. A few months later, she sought a new surgeon and came to me. She had obstructed defecation, tenesmus, and rectal bleed­ing. The results of the various diagnostic tests revealed, among other things, retained staples, some of which were floating in the lumen of the rectum. I therefore decided to operate and found a fistula and a rectal diverticulum, both results of the earlier dehiscence, as well as a rectal stenosis.
So, what would you do at this point?
I laid open the fistula and diverticulum, removed the staples, and performed an anoplasty (Figs. 1.8 and 1.9).
The patient improved for a few months but then had a recurrence of intense proctalgia, with the pain occurring upon defecation, which had a very negative effect on her quality of life. Boccasanta et al. (2004) reported that 20% of patients who undergo STARR develop painful defecation. Since my patient refused a temporary colostomy, I sug­gested a period of total parenteral nutrition at home so that her intestine could recover and she would have as few bowel movements as possible. With this approach, the pain was indeed greatly reduced. Follow-up visits included the extraction of a staple from her rectum. However, after 3 months, when she had resumed a normal diet, the severe pain returned. Over a year has passed and the patient is still suffering from proctalgia—all of this the result of an improperly treated anal fissure.
Nonetheless, STARR is not useless for treating anal fissures. In Correspondence recently published in the British Journal of Surgery, German authors reported the healing of a concomitant anal fissure in some patients who underwent STARR for obstructed defecation linked to other causes. The patients probably had anal hypertonia that was cor­rected by dilatation with the 36-mm circular anal
1.8 An Unforgettable Complication
Fig. 1.8 STARR was performed in this patient with anal fissure,
to treat a rectal internal mucosal prolapse. This resulted in rec­tal suture dehiscence (top) followed by a stricture stenosis, a rectal diverticulum, and fistula (black, bottom left). After a course of home parenteral nutrition, the wounds healed but the patient still suffers from severe chronic proctalgia despite removal of the staples
11
Fig. 1.9 a This patient, in the Sims position, was treated for a
recurrence of a rectal internal mucosal prolapse
Fig. 1.9 b Sagittal magnetic resonance imaging. The patient
had severe proctalgia and had undergone a STARR procedure one year earlier. In the high portion of the rectovaginal septum, a round area of activity indicates abscess or inflammation (large arrow). Small arrow: sacrococcyx
Fig. 1.9 c Transanal ultrasonography with a rotating probe in a
patient in the Sims position. Anteriorly (arrow), just above the puborectalis muscle, the hyperechogeneic area indicates the retained staples and postoperative fibrosis. During rectal explo­ration, the patient had pain in this area
12
1 Anal Fissure
dilator (CAD), as if a mini anal stretch had been performed. In any case, however, treating an anal fissure with STARR is like using a Kalashnikov to kill a mosquito that is buzzing around your house: the insect will be eliminated, but a big hole will be left in the wall. That is what happened to the patient above. The rectal wall gave way, due to the trauma caused by the surgery, and the result was a dehis­cence followed by a fistula and diverticulum. The cure was worse than the disease.
Just as the patient’s ill health has continued so does her law suit against the first surgeon, whom she is suing for a rather large amount in damages. Since offense is the best form of defense, this sur­geon has blamed me for the patient’s problems. The case has yet to be decided.

Summary

Local sepsis and hemorrhage are rare after surgery for anal fissure. The most common complication is incontinence, usually gas and mucus incontinence, but it is seldom either severe or permanent, except after anal divulsion. It is advisable to avoid internal sphincterotomy unless the patient has anal hyperto­nia, and to perform only a limited sphincterotomy if the patient has hypertonia and deficient sphincters. Elderly or multiparous women as well as individuals suffering from diarrhea are high-risk patients.
Fissurectomy with injections of Botox and sim­ple laying-open of the fissure are the two proce­dures associated with the least risk of inconti­nence.
Delayed wound healing and anal sepsis can occur, especially in patients with diabetes or Crohn’s disease, and in those who undergo fissure excision and anoplasty. Suture dehiscence can be a complication of the latter procedure.

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Hemorrhoids

2.1 Introduction

Although only a limited number of surgical proce­dures to treat anal fissure have been described in the literature, many surgical procedures are avail­able to treat hemorrhoids. We know that there are also many possible complications of hemorrhoid surgery. Early complications include hemorrhage; somewhat later there may be abscess formation, and over the long-term incontinence (Hall and Goldberg, 2003).
I think it is best to first cover the most commonly performed operations. According to the Annual Report of the Italian Society of Colo-Rectal Surgery (Società Italiana di Chirurgia Colo-Rettale, SICCR), published in Techniques in Coloproctology by Occelli and Bruni, there are two well-established methods (the Milligan-Morgan and the Ferguson pro­cedures), one that is gaining in importance (transanal hemorrhoidal dearterialization/Doppler-guided hem­orrhoidal artery ligation, THD/DGHAL), and anoth­er that is becoming slightly less popular (the proce­dure for prolapse and hemorrhoids, PPH). The com­plications associated with the two well-established procedures and with THD are on the whole well­known, whereas PPH/stapled hemorrhoidopexy can cause unusual problems that are sometimes severe and are therefore discussed here separately.
In comparing the problem of fissure with that of hemorrhoids, surgeons (especially in Italy) tend to forget one thing that the two conditions have in common: only rarely is surgical treatment neces­sary, perhaps in only one out of ten cases if not even less often. And clearly, the more we operate, the greater the risk of complications.
In this chapter, instead of making a list of com­plications and commenting on them, as in the pre-
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vious chapter, we discuss their prevention and/or their causes during surgery. For practical purposes, we shall start with the latter.

2.2 Surgical Complications After Manual Hemorrhoidectomy (Ferguson and Milligan-Morgan Procedures): Live from the Operating Room

Let’s imagine we are at the operating table, faced with a case that is not simple: a 60-year-old multi­parous woman with fourth-degree hemorrhoids, (i.e., irreducible ones) that have an external fibrot­ic component (Fig. 2.1). We have decided to per­form a hemorrhoidectomy, which, as shown by various meta-analyses, is the most radical opera­tion in a proctologist’s repertoire.
Fig. 2.1 Hemorrhoids with fibrotic external tissue
M. Pescatori, Prevention and Treatment of Complications in Proctological Surgery, © Springer-Verlag Italia 2012
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Before proceeding, it is necessary to insert one comment about preoperative antibiotic prophylaxis. While some excellent surgeons do not use it, it is definitely necessary in cardiopathic and immuno ­depressed patients. Cases of Fournier’s gangrene after hemorrhoidectomy have been reported. Although very rare, this complication can lead to abdominoperineal resection of the rectum.
Assume that we are performing a Ferguson pro­cedure not only because that is what I do most often, but also because Jóhansson and Påhlman (2006) reported that continence is better after a Ferguson than after a Milligan-Morgan procedure, and our patient already has deficient anal sphinc­ters.
Does the patient’s position have an effect on the complication rate? The only difference is that if the patient is in the jack-knife position the hemor­rhoids are usually “deflated” such that no blood runs into the operative field, which simplifies the work of the surgeon and the surgical team.
Before the operation begins, we must consider the preparation by the anesthetist. The patient is awake, which means that she has been given spinal anesthesia, placing her at greater risk of urinary retention after surgery. We therefore caution the anesthetist not to give the patient large volumes of intravenous fluids. (If the patient was an elderly man with prostate problems it would be essential that he receive minimal fluids). The first surgical move that we make is one that can easily cause damage, i.e., insertion of the anal retractor (as this is a Ferguson procedure and assessing the rectum is never a bad idea), since we know that the patient has weak sphincters due to her age and multiple deliveries. To avoid stretching the muscle fibers and thereby damage the continence mechanism, it is best to use an instrument that does not overly dilate and is not too wide (< 32 mm), such as a Fansler, Ferguson, or Sapimed Beak dilator (Fig. 2.2). Some surgeons prefer the 36-mm circular anal dilator (CAD) used on PPH. It should be noted that even if the patient were a young male with a narrow anus, we could damage (lacerate) the sphincter by the excessively energetic insertion of a large retractor. It is therefore essential that we choose the right instrument and perform the maneuver delicately. If a Milligan-Morgan procedure is being performed, an anal retractor is not needed.
2 Hemorrhoids
Fig. 2.2 Ferguson’s hemorrhoidectomy with the patient in the
lithotomy position. The anal retractor used to prevent sphincter trauma should not be too large. A Beak dilator (Sapimed) was used in this case
We now make the surgical incision. If the patient is in the lithotomy position, we do not start at the anterior hemorrhoid as this will cause blood to fill the operative field. The incision, especially in the Ferguson procedure, should be sufficiently long and in a narrow V-shape, extending to the perianal skin; otherwise, after suturing, there will be unaesthetic “dog’s ears,” which will result in painful swelling. A cold scalpel is used to avoid skin burns, which could facilitate suture dehis­cence and cause pain.
Next we identify the internal sphincter (obvi­ously this is also done in the Milligan-Morgan pro­cedure), so that we can avoid injury to it during excision of the hemorrhoidal nodules. Note: Some surgeons, when performing the Ferguson proce­dure, place a Kelly under the hemorrhoid and cut the tissue from above. While this is a quick method that prevents bleeding, I do not use it because it does not provide a good view of the internal sphincter proper. In fact, with the Kelly one might even inadvertently pinch the sphincter.
We are now ready to excise the nodules. This may be done with scissors, a cold scalpel or elec­trocautery, Ultracision (the ultrasonic scalpel), a laser (infrequently used now), or radiowaves.
If we are performing a Milligan-Morgan and not a Ferguson procedure, LigaSure could certainly be
2.2 Surgical Complications After Manual Hemorrhoidectomy (Ferguson and Milligan-Morgan Procedures)
used. In fact, a Milligan-Morgan with LigaSure appears to be associated with fewer postoperative problems. In a review published in Colorectal Disease in 2010, Milito et al. evaluated randomized prospective trials (including SICCR: LigaSure vs. traditional Milligan-Morgan, Ferguson, and PPH). The results regarding postoperative complications after using LigaSure were: less pain than after tradi­tional hemorrhoidectomy and the same level of patient satisfaction as after PPH. In particular, a trial of PPH vs. LigaSure demonstrated that postoperative pain is the same after these two procedures (Kraemer et al., 2005). However, it should be noted that with LigaSure the hemorrhoids are removed, so that the procedure is more radical than stapled hemor­rhoidopexy. LigaSure is not associated with a lower risk of bleeding – there is no statistically significant difference between the procedures – nor is it associ­ated with a faster, uneventful recovery.
The comparison made by Fareed et al. (2009) between LigaSure and Ferguson hemorrhoidectomy showed that LigaSure is associated with fewer postop­erative pain and less problematic recovery. The compli ­cations that occur after Ligasure are listed in Table 2.1.
Fig. 2.3 Ferguson’s hemorrhoidectomy with the patient in the
lithotomy position. Hemorrhoid excision can be extended a few centimeters upward if there is a concomitant rectal internal mucosal prolapse. A report by Gaj and Trecca (2005), based on a study carried out at the Italian coloproctology units, showed that a concomitant rectal internal muocosal prolapse is present in about one-third of hemorrhoid patients. To reduce the risk of postoperative anal incontinence, the internal sphincter should be identified to avoid its damage, as shown in the figure
Continuing our operation: During dissection of the hemorrhoids there will be bleeding, especially if scissors are used or a cold scalpel. Since the less blood the better, we could proceed slowly and coagulate the hemorrhoidal plexus as we go. I use a maneuver (described in “Tricks of the Trade”, below) to reduce intraoperative bleeding which seems to work well and was also mentioned in the chapter on anal fissure. With the tip of a pair of forceps, I touch the tissue, as is done using an elec­trocautery device, to excise the pile. At the same time, the instruments nurse touches the other end of the forceps with the electric scalpel.
Obviously, in a Ferguson procedure it is less essential at this phase to obtain hemostasis because one can count on the suture – in part, a hemostatic
suture – that will later close the surgical wound. However, it is still important to avoid cutting the underlying fibers of the internal sphincter or else postoperatively there may be soiling (Fig. 2.3).
Now we reach the apex of the hemorrhoid. If there is no prolapse of the internal mucosa of the rectum we can stop here; otherwise it is necessary to extend the dissection upwards for 1-3 cm (Fig.
2.4). Should the hemorrhoidal peduncle be ligat­ed? Consider that a peduncle is not always present. If one performs a Milligan-Morgan procedure with diathermy using the technique of Lentini or Phillips (2009), coagulation is sufficient. If a tradi­tional Milligan-Morgan or Ferguson procedure is
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Table 2.1 Percentage of complications in various case series after hemorrhoidectomy with LigaSure
Luo, 2010 Wang, 2006 Kraemer, 2005 Chung, 2003 Colorect Dis World J Surg Dis Colon Rectum Dis Colon Rectum n = 207 n = 42 n = 25 n = 30
Urinary retention 0 2 1 1
Severe rectal bleeding 6 1 1 1
Anal stenosis 0 2 - -
Severe constipation 0 3 - -