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35 Principles ofPostoperative Care
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403
Complications After Cardiac Surgery
Postoperative Bleeding [6, 2628]
• Excessive postoperative bleeding is associated with increased blood transfu­sions, hospital length of stay, and cost. Postoperative hemorrhage occurs in approximately 2–6% of cardiac surgery patients. Management of postoperative bleeding starts before even leaving the OR.Utilization of a checklist to ensure common areas of bleeding are checked and treated prior to closing has been associated with reduced rates of re-exploration. Often, time will be spent in the OR after the chest is closed monitoring chest tube output to identify patients who require surgical interventions to obtain hemostasis.
• An important focus in the immediate postoperative period is maintaining chest tube patency. If the chest tubes become clogged with clotted blood, this can lead to cardiac tamponade or clinically signicant hemothorax, which can require invasive interventions.
• Close monitoring for coagulopathy and thrombocytopenia is critical in cardiac surgery patients as is treatment with transfusions to correct these abnormalities. Treating hypothermia can also help to reverse coagulopathy. Anti-brinolytic agents, like epsilon-aminocaproic acid (Amicar) and tranexamic acid (TXA), have been found to be associated with reduced transfusion requirements in car­diac surgery patients without signicant increase in morbidity. Red blood cell transfusions can replace blood loss while providing time for correction of coagulopathies.
• If the above interventions are not successful in reducing blood loss, re- exploration and washout in the OR are denitive treatments for postoperative blood loss.
Tamponade [2, 3, 6, 2931]
• Cardiac tamponade occurs when the chambers of the heart become compressed by external forces, often uid or blood. This leads to an equalization of pressures between the four chambers and reduced venous lling. This reduces end dia­stolic volume and subsequently cardiac output. Tamponade can occur in the car­diac surgery patient when there is bleeding without sufcient drainage. This is often signaled by tachycardia, narrowed pulse pressure, increased CVP, and reduced cardiac output. Pulsus paradoxus can also been seen. Pulsus paradoxus is a reduction in systolic blood pressure greater than 10mmHg during inspira­tion. Tamponade is also associated with increased vasopressor requirement and worsening markers of perfusion.
• In non-surgical patients, TTE is often utilized to be the gold standard of diagno­sis for cardiac tamponade. However, TEE has a greater ability to visualize peri­cardial uid/blood in patients after cardiac surgery. This is because TTE can be
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limited by chest tubes, patient position, incision, and ventilation. Further, TEE also allows for visualization of the posterior pericardium, where uid or clot may have accumulated.
• Echocardiographic evidence of cardiac tamponade includes collapse of the atria during systole or ventricles during diastole, respiratory variation of mitral and tricuspid ow, and enlargement of the inferior vena cava with reduced pulsatility. A chest X-ray can show an enlarged cardiac silhouette, and EKG can show low voltage. However, classic signs of tamponade after cardiac surgery may not be initially present so tamponade should be suspected in patients with hemody­namic instability and a pericardial collection.
• Maintaining chest tube patency is critical in the postoperative period to prevent the accumulation of blood around the heart. Additionally, avoiding signicant coagulopathy can reduce bleeding postoperatively. In the immediate postopera­tive period, a denitive measure to treat tamponade is re-exploration in the OR, including opening of the chest and washout with identication and treatment of any areas of bleeding. In decompensating patients, the chest can be opened at the bedside. In patients who are several days from surgery, pericardial drain place­ment can relieve tamponade.
L. Franko and K. Shelton
Atrial Fibrillation [2, 5, 6, 3234]
• Atrial brillation is common after cardiac surgery. Rates of atrial brillation are between 10 and 50% after cardiac surgery, depending on the patient population and surgery. High rates of atrial brillation are associated with increased age, mitral valve disease, COPD, and valve surgery. Of note, medications likely epi­nephrine and norepinephrine can increase the risk of atrial brillation because of sympathetic stimulation. Atrial brillation in the postoperative period is associ­ated with signicant morbidity and increased length of stay.
• Beta blockers have been utilized at some institutions prophylactically to prevent postoperative atrial brillation. Amiodarone has also been used prophylactically, but often second line at many institutions due to possible toxicities and adverse effects.
• Pericardial effusions have been associated with increased rates of atrial brilla­tion, thought to be due to the effusion causing local inammation and oxidative damage. Posterior left pericardiotomy has been shown to reduce rates of atrial brillation without increasing complications. This procedure involves an inci­sion in the posterior pericardium that allows postoperative pericardial uid to drain into the left pleural space.
• The decision to anticoagulant postoperative patients with atrial brillation is somewhat controversial though most patients with persistent atrial brillation and higher CHA2DS2 VASc score are recommended to start on anticoagulation.
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Stroke [6, 35, 36]
• The overall risk of stroke with neurological decits after cardiac surgery is approximately 2–3%. The risk of stroke is associated with increased age, diabe­tes, known preoperative cerebrovascular disease, and emergent operations. The risk of stroke is highest in aortic and mitral valve surgery. Stroke is associated with increased morbidity and mortality after cardiac surgery.
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15. Bojar R.Manual of perioperative care in adult cardiac surgery. 5th ed. Wiley-Blackwell; 2011.
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16. Overgaard CB, Dzavík V.Inotropes and vasopressors: review of physiology and clinical use in cardiovascular disease. Circulation. 2008;118(10):1047–56.
17. Totaro RJ, Raper RF.Epinephrine-induced lactic acidosis following cardiopulmonary bypass. Crit Care Med. 1997;25(10):1693–9.
18. Devereaux PJ, Lamy A, Chan MTV, Allard RV, Lomivorotov VV, Landoni G, et al. High-sensitivity troponin I after cardiac surgery and 30-day mortality. N Engl J Med. 2022;386(9):827–36.
19. Tolsma M, Kröner A, van den Hombergh CL, Rosseel PM, Rijpstra TA, Dijkstra HA, etal. The clinical value of routine chest radiographs in the rst 24 h after cardiac surgery. Anesth Analg. 2011;112(1):139–42.
20. Mwaura L, Vuylsteke A.Fueling the debate on albumin after cardiac surgery. J Cardiothorac Vasc Anesth. 2019;33(11):2928–9.
21. Kim JH, Kim HJ, Kim JY, Ahn H, Ahn IM, Choe WJ, etal. Meta-analysis of sodium bicarbon­ate therapy for prevention of cardiac surgery-associated acute kidney injury. J Cardiothorac Vasc Anesth. 2015;29(5):1248–56.
22. Haase M, Haase-Fielitz A, Bellomo R, Devarajan P, Story D, Matalanis G, etal. Sodium bicar­bonate to prevent increases in serum creatinine after cardiac surgery: a pilot double-blind, randomized controlled trial. Crit Care Med. 2009;37(1):39–47.
23. Tie HT, Luo MZ, Luo MJ, Zhang M, Wu QC, Wan JY.Sodium bicarbonate in the prevention of cardiac surgery-associated acute kidney injury: a systematic review and meta-analysis. Crit Care. 2014;18(5):517.
24. Chan JL, Miller JG, Murphy M, Greenberg A, Iraola M, Horvath KA.A multidisciplinary protocol-driven approach to improve extubation times after cardiac surgery. Ann Thorac Surg. 2018;105(6):1684–90.
25. Fitch ZW, Debesa O, Ohkuma R, Duquaine D, Steppan J, Schneider EB, etal. A protocol­driven approach to early extubation after heart surgery. J Thorac Cardiovasc Surg. 2014;147(4):1344–50.
26. Elassal AA, Al-Ebrahim KE, Debis RS, Ragab ES, Faden MS, Fatani MA, etal. Re-exploration for bleeding after cardiac surgery: revaluation of urgency and factors promoting low rate. J Cardiothorac Surg. 2021;16(1):166.
27. Christensen MC, Dziewior F, Kempel A, von Heymann C.Increased chest tube drainage is independently associated with adverse outcome after cardiac surgery. J Cardiothorac Vasc Anesth. 2012;26(1):46–51.
28. Gerstein NS, Brierley JK, Windsor J, Panikkath PV, Ram H, Gelfenbeyn KM, et al. Antibrinolytic agents in cardiac and noncardiac surgery: a comprehensive overview and update. J Cardiothorac Vasc Anesth. 2017;31(6):2183–205.
29. Imren Y, Tasoglu I, Oktar GL, Benson A, Naseem T, Cheema FH, etal. The importance of transesophageal echocardiography in diagnosis of pericardial tamponade after cardiac surgery. J Card Surg. 2008;23(5):450–3.
30. Price S, Prout J, Jaggar SI, Gibson DG, Pepper JR. ‘Tamponade’ following cardiac sur­gery: terminology and echocardiography may both mislead. Eur J Cardiothorac Surg. 2004;26(6):1156–60.
31. Carmona P, Mateo E, Casanovas I, Peña JJ, Llagunes J, Aguar F, etal. Management of cardiac tamponade after cardiac surgery. J Cardiothorac Vasc Anesth. 2012;26(2):302–11.
32. Boons J, Van Biesen S, Fivez T, de Velde MV, Al Tmimi L.Mechanisms, prevention, and treat­ment of atrial brillation after cardiac surgery: a narrative review. J Cardiothorac Vasc Anesth. 2021;35(11):3394–403.
33. Gaudino M, Sanna T, Ballman KV, Robinson NB, Hameed I, Audisio K, etal. Posterior left pericardiotomy for the prevention of atrial brillation after cardiac surgery: an adaptive, single- centre, single-blind, randomised, controlled trial. Lancet. 2021;398(10316):2075–83.
34. Arsenault KA, Yusuf AM, Crystal E, Healey JS, Morillo CA, Nair GM, etal. Interventions for preventing post-operative atrial brillation in patients undergoing heart surgery. Cochrane Database Syst Rev. 2013;2013(1):Cd003611.
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35. Sultan I, Bianco V, Kilic A, Jovin T, Jadhav A, Jankowitz B, etal. Predictors and outcomes of ischemic stroke after cardiac surgery. Ann Thorac Surg. 2020;110(2):448–56.
36. Karunanantham J, Ali JM, Evans NR, Webb S, Large SR.Impact of stroke on outcomes fol­lowing cardiac surgery: propensity matched analysis. J Card Surg. 2020;35(11):3010–6.
407
Index
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A
Abdominal aortic trauma
initial evaluation, 264
mechanism of, 263 Abdominal vascular trauma, 266 Aberrant right subclavian artery, 23 Activated clotting time (ACT), 105, 111 Acute aortic syndrome (AAS), 78, 79
anatomy and classication, 248
cannulation strategy, 254
axillary, right subclavian, innominate,
and other arch branch arterial
cannulation, 255 direct aortic, 255 femoral, 254
denition, 247, 248 diagnosis, 251, 252 indications for surgery
ascending aorta, 252, 253 descending aorta, 254
outcome, 247, 248 pathophysiology and clinical presentation,
250, 251
Acute coronary syndromes, 124 Acute mitral regurgitation
diagnosis, 135 management, 136
pathogenesis, 135 Acute mitral regurgitation (AMR), 133 Acute myocardial infarction, 134 Acute normovolemic hemodilution
(ANH), 104 Acute pericarditis, 291–293, 295 Acute pulmonary embolism (PE), 275
indications for surgery, 278
operative techniques for pulmonary
embolectomy, 278, 279 presentation and diagnosis, 276 risk stratication, 277, 278 treatment, 277
Acute type A aortic dissection (ATAAD), 248 Adult coarctation of the aorta (CoA), 375–378 Adults with congenital heart disease
(ACHD), 365 adult coarctation of the aorta, 375–378 complex, 381–384 cor triatriatum dexter, 379–381 coronary artery anomalies, 369–370 Tetralogy of Fallot, 367–369 vascular ring, 371–374
Afterload, 394 Alcohol septal ablation, 311 Alpha-stat, 114 American Society of Anesthesiologists (ASA)
Monitoring, 93
Anemia, 105
preoperative treatment of
nonpharmacologic intervention, 100 pharmacologic intervention, 100
Anesthesia
cardiopulmonary bypass, 97, 98 hemodynamic and physiologic monitoring
advanced hemodynamic monitoring, 94 Standard American Society of
Anesthesiologists Monitoring, 93 lesion specic considerations, 95, 96 pharmacology of induction and
maintenance, 94, 95 pulmonary artery catheter, 97 vasoactive medications, 96
Springer Nature Switzerland AG 2024 J. P. Bloom, T. M. Sundt (eds.), Cardiac Surgery Clerkship, Contemporary Surgical Clerkships, https://doi.org/10.1007/978-3-031-41301-8
409© The Editor(s) (if applicable) and The Author(s), under exclusive license to
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Index
Anesthesia team, 388, 393 Aneurysm, 67, 76, 229 Aneurysm repair, 218 Angiography, 234 Angiosarcomas, 303 Annular dilation, 167 Annuloplasty, 158, 159 Antegrade cannulation, 121 Antegrade cardioplegia, 120 Antegrade cerebral perfusion (ACP), 115 Anterior interventricular groove, 15 Anterolateral papillary muscle, 21 Anticoagulant management, 100, 101 Anticoagulation via heparin, 111 Antiplatelet management, 101 Aorta, 22, 23, 76
imaging ndings
acute aortic syndrome, 78, 79 aneurysm, 76 coarctation, 80 double rule-out, 81
pre-procedural CT, 80, 81 indications, 76 volume-rendered reconstruction, 81
Aortic aneurysm formation, 217 Aortic arch, 216, 223, 255
surgery, 221–223 variants, 23
Aortic cross-clamp, 359 Aortic diameter, 231 Aortic dissection (AD), 247, 248
classication, 248 diagnosis, 251, 252 pathophysiology and clinical presentation,
250, 251 Aortic insufciency (AI), 192, 342 Aortic lesions, 96 Aortic pseudoaneurysm, 79 Aortic regurgitation (AR), 52, 53, 144 Aortic root
anatomy, 215 etiology and dilation, 217
surgery, 218–220 Aortic root replacement, 8 Aortic stenosis (AS), 52, 143, 144 Aortic trauma
abdominal aortic trauma
initial evaluation, 264
mechanism of, 263 indications for intervention, 265–267 mechanism of, 262 operative approach, 267–272
thoracic aortic trauma
initial evaluation, 263, 264
mechanism of, 262 Aortic valve, 22 Aortic valve annulus, 215 Aortic valve bioprosthetic failure, 192 Aortic valve disease, 192 Aortic valve repair, 378
indications, 144, 145 of bicuspid aortic valve with R-L
fusion, 146
techniques, 145
Aortic valve replacement, 378
indications, 144, 145 mechanical valves, 147 Ozaki procedure, 147 paravalvular regurgitation, 148 prosthesis selection, 148 Ross procedure, 147 small aortic roots, 148 stented bioprosthetic valves, 146
stentless valves, 147 Aortomitral curtain, 19 Arrhythmias, 301 Arrhythmogenic right ventricular
cardiomyopathy, 347 Arrythmias, 156 Arteria lusoria, 23 Arterial cannulation, 255 Arterial line, 94 Arterial reconstruction, 241 Articial chordae, 172 Articial heart, 10 Articial shunt, 2 Ascending aorta, 215, 252, 253 Ascending aorta replacement, 378 Atrial brillation
(AF), 283, 285, 286, 404
classication, 284 LAA management, 287 surgical treatment options
Cox-Maze, 284–286
PVI, 286 Atrial septal defect (ASD), 3, 195 Atrial tumors, 301 Atrioventricular (AV) node, 24 Atrioventricular groove, 15 Atrioventricular node, 20 Atrioventricular septal defect (AVSD) repair,
173, 174 Autoimmune disorders, 229 Autologous pericardium, 157
Index
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411
B
Bachmann’s bundle, 25 Bacterial endocarditis, 218 Bare mental stents (BMS), 88 Barlow’s disease, 153 Basic metabolic panel (BMP), 33 Basiliximab, 352 Benzodiazepines, 94 Beta blockers, 404 Bicaval cannulation, 111, 340 Bicaval venous cannulation, 222 Bicuspid aortic valve (BAV) stenosis, 202 Bicuspid aortic valves, 143, 145 Bicuspidization, 172 Bioprosthetic mitral valve replacement
(MVR), 160, 161
Biventricular assist devices
(BiVADs), 342–343 Blalock-Taussig shunt, 2 Bleeding, 342, 403 Blood management
intraoperative
hemostasis testing, 102, 103 nonpharmacologic intervention for
blood conservation, 102
perfusion interventions to reduce blood
loss, 104
pharmacologic intervention for
bleeding prevention, 102
post-bypass and postoperative
lab studies, 105
transfusion triggers, 105 Blood pressure monitor, 93 Blue babies, 3 Blunt abdominal aortic injury (BAAI), 263,
266, 269
Blunt thoracic aortic injuries (BTAI), 262,
264, 265 Blunt thoracic aortic trauma, 262 Bovine arch, 23, 216 Bretschneider solution, 122 Bridge to transplant (BTT)., 337 Buckberg solution, 121 Bundle of His, 24
C
Calcium score scan, 60, 62 Cannulation strategy, 110, 254
axillary, right subclavian, innominate, and
other arch branch arterial
cannulation, 255
direct aortic, 255
femoral, 254 Carbon dioxide (CO2) monitor, 93 Cardiac catheterization, 280, 294
with coronary angiography, 37 Cardiac chamber assessment, 60 Cardiac computer tomography (CCT), 301 Cardiac Index, 396 Cardiac magnetic resonance
(CMR), 301, 308 Cardiac mass, contrast-enhanced scan, 70 Cardiac metabolic demand, in different states,
117, 118 Cardiac MRI, 168
imaging nding, 72–75 indications
ow and function evaluation, 71
tissue characterization, 71 patient selection, 71 protocol, 72
Cardiac operating room teams
culture of safety, promoting, 390 preoperative brieng, impact of, 390 roles/responsibilities
anesthesia team, 388
cardiac surgery, 387, 388
nursing team, 389
perfusion, 388, 389
scrub person, 389 variations in cognitive load during cardiac
surgery, 389, 390 Cardiac output (CO), 396 Cardiac surgery, history of, 2
early, 1–3 minimally invasive cardiac surgery, 10, 11 myocardial protection, 5–7 open heart surgery, 3, 4 transplantation, 9, 10
valve repair and replacement, 7–9 Cardiac tamponade, 403, 404 Cardiogenic shock, 328, 346 Cardioplegia, 6, 7
for congenital heart surgery, 7
ow and pressure, 120, 121
mode of delivery, 120
optimization of, 6 Cardioplegic solutions, 118, 121, 122
avoidance of myocardial edema, 119
avoidance of substrate depletion, 119
buffering of, 119
hypothermia, 120
rapid cardiac arrest, 119
412
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Index
Cardiopulmonary bypass (CPB), 97, 98, 278,
281, 296, 340, 349 CABG using, 128, 129 cannulation strategies, 110 circulatory arrest and special
considerations, 114, 115 cooling and warming, 112 criteria for discontinuing, 114 heparin dosage and reversal, 111 initiation, 112, 113 optimal ow rate and MAP, 111, 112 separation, 113
Carotid artery studies, 39, 40 Carpentier classication system, 154 Catheter ablation techniques, 287 Cell salvage, 104 Cell saver, 104 Central brous body, 19 Central venous oxygen saturation (ScvO2), 400 Central venous pressure (CVP), 97, 397 CentriMag®, 320, 322 Cerebral oximeter, 94 Cerebral perfusion pressure (CPP), 234 Chest CT, 35 Chest tube patency, 404 Chest x-ray (CXR), 35 Chest x-rays evaluation, 400 Child-Turcotte-Pugh score, 34 Chronic obstructive pulmonary disease
(COPD), 355
Chronic pulmonary embolism (PE)
indication for surgery, 280 pathogenesis, 279 presentation and diagnosis, 280 pulmonary thromboendarterectomy,
operative techniques for, 281, 282
Chronic thromboembolic pulmonary
hypertension (CTEPH),
276, 279–281
Chronic total occlusion (CTO), 60 Circulatory arrest, 114 Clamshell incision, 360 Coagulopathy, 106 Coarctation, 80 Cognitive workload, 390 Complete metabolic prole (CMP), 33 Complex multi-valve endocarditis, 210 Composite valve conduit root
replacement, 221
Computed tomographic angiography
(CTA), 36, 229
Computed tomography (CT), 59
aorta, pre-procedural, 80, 81
contrast-enhanced scan (see Contrast-
enhanced scan) indications, 60, 61 non-contrast/calcium score scan, 62 patient selection, 61 protocol, 61, 62 scan, 251
Computed tomography pulmonary angiogram
(CT-PA), 277, 280
Conduction system, 24, 25 Cone repair, 173 Congenital heart disease, 72, 170 Congenital tricuspid valve dysplasia, 166, 170 Constrictive pericarditis, 291, 292 Contractility, 394 Contrast echocardiography, 58 Contrast-enhanced scan
cardiac mass, 70 coronary arteries
anomalies, 63 CAD, 63, 65 coronary artery aneurysm, 67 coronary artery dissections, 66
valvular disease
infective endocarditis, 68, 69 pre-transcatheter procedure
assessment, 67, 68
valvular masses, 69 Contrast media, 83 Cor triatriatum, 379 Cor triatriatum dexter (CTD), 379–381 Cor triatriatum sinister (CTS), 379 Corevalve Evolut (self-expanding), 197 Coronary angiography, 18, 83, 84, 137
access, 84 imaging modalities, 86, 87 percutaneous coronary intervention, 87
stent choice and DAPT duration, 88
vs. PTCA, 88
vs. surgical revascularization, 87, 88
physiologic assessment, 86 RHC, 90
access, 90
data, 90
indications, 89
standard projections and catheterization
laboratory setup, 84, 85
Coronary angiography, cardiac catheterization
with, 37
Coronary arteries
computed tomography angiography of, 36 contrast-enhanced scan
anomalies, 63
Index
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413
CAD, 63, 65 coronary artery aneurysm, 67 coronary artery dissections, 66
Coronary artery anomalies, 369
imaging, 370 origin, 369–370 risk of sudden cardiac death, 370 surgical repair, 370
Coronary artery bypass grafting (CABG), 28,
128–130, 136
Coronary artery disease (CAD), 63, 65
CABG using CPB, 128, 129 conduit options, 128 epidemiology and pathophysiology, 123 indications for revascularization,
124, 125
on pump versus off pump coronary artery
bypass, 129, 130
staples of medical management, 124 Coronary artery dissections, 66 Coronary CT angiogram (CTA), 60 Coronary CT fractional ow reserve (CT
FFR), 63 Coronary lesions, 95 Coronary plaque, 87 Coronary revascularization, 124 Coronary sinus, 19 Coronary veins, 19 Cox-Maze, 284–286 Crawford/Sa classication, 227 Cross-circulation, 4, 5
postoperative care and complications,
243, 244
testing, 229, 230 Destination therapy (DT), 337 Diastolic arrest, 121 Diastolic dysfunction, 57 Diastolic function, 57 Diastolic hyperemia-free radio (DFR), 86 Dimensionless index (DI), 52 Direct acting oral anticoagulants
(DOACs), 277 Direct procurement and perfusion (DPP), 349 Dobutamine, 96 Donation after brain death (DBD), 349, 350 Donation after circulatory death (DCD), 349,
350, 352 Donor cardiectomy, 350 Donor pneumonectomy, 358–360 Doppler echocardiography, 49 Double-lung transplants, 10 DPP protocol, 351 Dual antiplatelet therapy (DAPT), 88, 101 Dual stage cannulation, 110 Durable mechanical circulatory support
devices, 339 left ventricular support, 337, 338 post-operative complications, 341, 342 REMATCH clinical trial, 339 right ventricular support, 342, 343 surgical implantation techniques, 340, 341
Dyspnea, 307
D
Dacron tube graft, 242 David reimplantation technique, 220 D-dimer, 276 Deep hypothermic circulatory arrest
(DHCA), 221 Deep venous thrombosis (DVT)., 275 Degenerative aneurysms, 223 del Nido solution, 121 Descending aorta, 254 Descending thoracic aortic aneurysms
(DTAAs), 227
endovascular repair of, 232–234 history and physical examination, 229 management and treatment, 231, 232 open repair of, 235, 236
arterial reconstruction, 241 closure, 242, 243 extracorporeal circulation, 238–240 incision and exposure, 236, 237
E
Ebstein anomaly, 166, 170 Ebstein repair, 174 Echocardiogram, 276, 280, 397 Echocardiography, 36, 68, 293, 294
common cardiac pathologies
aortic regurgitation, 52 diastolic function, 57 left ventricular function, 56 mitral regurgitation, 54 mitral stenosis, 53 tamponade and constriction, 56, 57 tricuspid regurgitation, 55, 56
valvular aortic stenosis, 52 contrast, 58 stress, 58 TEE, 50, 51 tricuspid valve, 168 TTE, 49, 50
Ectasia, 217