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10 Hemorrhoids: Anatomy, Physiology, Concerns, and Treatments
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10.1.4 Discussion
Early hemorrhoid disease will frequently present as painless bleeding noted as streaking on toilet paper. It is important to differentiate hemorrhoids from other pathological conditions including fi ssure, polyps, IBD, or cancer. It is uncommon for bleeding hemorrhoids to present with anemia and all other conditions should be ruled out prior to treating the hemorrhoids. As stated earlier, hemorrhoidal grading is determined by protrusion. Enlarged hemorrhoids that do not protrude below the dentate line are considered grade 1. Factors leading to development of hemorrhoids include hard stools from a low-fi ber diet, limited fl uid intake, straining to pass bowel movements, and prolonged sitting during bowel movements. With distention of the hemorrhoid vessels within the anal canal, irritation from passage of stool and wip­ing can lead to excoriation and bleeding. As the anoderm above the dentate line is largely insensate, patients will not present with pain as an initial symptom.
10.1.5 Treatment
Initial treatment of grade 1 hemorrhoids consists of lifestyle modifi cation focused upon the causative factors identifi ed above. Patients are encouraged to increase dietary fi ber and fl uid intake either through meal selection or supplements. This will improve stool bulk to provide softer bowel movements and limit straining. Behavior modifi cation focuses upon time spent sitting in the bathroom. If unable to pass a bowel movement after 2 min on the toilet, patients should be encouraged to leave the bathroom and reattempt at a later time. Additionally, the use of hydrocortisone either topically or in suppository form may result in decreased swelling, while behavior modifi cation is implemented. These conservative measures are successful in the majority of patients and prevent progression of hemorrhoid disease. For patients who continue to have bleeding despite these changes when all other causes have been eliminated, interventions such as rubber band ligation, sclerotherapy, and infrared photocoagulation can be used .

10.2 Case 2: Grade 2/3 Internal Hemorrhoids

10.2.1 Presentation
A 52-year-old male presents with a history of bright red blood per rectum. The patient reports blood dripping in the toilet as well as on the toilet paper with bowel movements. He can feel swelling at his backside that subsides about 30 min after defecation; he occasionally will need to push on the swelling to achieve resolution. He has a history of congestive heart failure treated with diuretics and seasonal aller­gies treated with intermittent antihistamines. He reports regular bowel movements and does not strain on the toilet. His wife reports that he will sometimes spend 15–20 min in the bathroom.
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10.2.2 Diagnosis
Grade 2/3 internal hemorrhoids
10.2.3 Discussion
Progression of hemorrhoid disease to grade 2 or 3 is defi ned by protrusion of inter­nal hemorrhoids below the dentate line with spontaneous reduction in grade 2 or manual reduction in grade 3 (Fig. 10.3 ). Again, painless bleeding will frequently be
Fig. 10.3 Grade 3 internal mixed hemorrhoid
10 Hemorrhoids: Anatomy, Physiology, Concerns, and Treatments
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a patient’s presenting complaint, but with advance hemorrhoids the feeling of a mass or swelling is common. For some patients, pruritus ani will develop when protrusion of hemorrhoid tissue allows seepage of rectal contents through the anal sphincters leading to irritation and infl ammation of the sensate squamous epithe­lium below the dentate line.
10.2.4 Treatment
Initial treatment of grade 2 internal hemorrhoids follows the dietary and behavioral modifi cation outline for grade 1 disease. Additionally, patients with grade 2 or 3 hemorrhoids are encouraged to soak in a warm tub or even apply ice packs to their perianal area. There is no strong evidence to support this practice, but many patients report signifi cant relief of their symptoms with this treatment option. For patients refractory to dietary and behavioral modifi cation, rubber band ligation of the inter­nal hemorrhoids in the clinic setting provides a simple and elegant solution.
First described in 1963 by Barron, banding is performed during anoscopy [ 5 ]. Conventional banding uses an atraumatic clamp and a bander to deploy a rubber band gathering redundant mucosa above the hemorrhoidal column. A purpose-built suction bander serves a similar function and can be operated with one hand. The bander is placed within the anal canal above the prominent hemorrhoid column. The anorectal mucosa is drawn into the device. A trigger deploys the rubber band to permanently gather this tissue. Banding proximally tethers the hemorrhoid columns within the anal canal preventing protrusion. Over the following 3–5 days, the banded tissue will strangulate, necrose, and pass with a bowel movement occasionally her­alded by a brief episode of self-limited bleeding. Most patients can achieve cure with this intervention at success rates of 75% [ 6 ] (Figs. 10.4 and 10.5 ). Some patients may require repeat banding depending on the severity of their hemorrhoids. Recurrence is prevented by continued adherence to dietary and behavioral modifi ca­tions. Complications of rubber band ligation include pain, thrombosis, bleeding, and potential life-threatening pelvic sepsis. In our experience, most patients will experience a dull ache for 24–48 h. Symptomatic relief is provided by Tylenol or ibuprofen and sitting in a warm tub. Any patient who develops urinary retention with severe pelvic pain and fever should be promptly evaluated for pelvic sepsis. Early intervention with possible removal of the band, IV antibiotics, and careful observation are important steps to prevent further complications.
Another option for treatment of grade 2 or 3 hemorrhoids is sclerotherapy . Historically, this was performed prior to the advent of rubber band ligation. This process involves injection of a caustic agent to decrease the blood fl ow and induce fi brosis. Many different solutions have been used for sclerotherapy, but most clini­cians now use a commercially available 5–10 % phenol solution with oil. Using a 25-gauge needle, the submucosa 1 cm above the dentate line is infi ltrated with 1–2 mL of solution. Long-term results are very similar to banding in grade 1 and 2 hemorrhoid patients [ 7 ].
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Fig. 10.4 Grade 3 internal hemorrhoid prior to banding
O. Coughlin and M. Page
Infrared photocoagulation (IRC) is another less frequently used option for the treatment of hemorrhoids. IRC uses infrared light to generate heat which coagulates tissue proteins and evaporates water from cells. This leads to infl ammation and scar­ring providing fi xation of the hemorrhoid and treating the prolapse. IRC has been shown to work best with grade 1 and 2 hemorrhoids [ 7 ].
For 5–10 % of patients, failure of medical and noninvasive treatment will require a formal excisional hemorrhoidectomy. Indications for hemorrhoidectomy include grade 3 or 4 hemorrhoids with severe symptoms, concomitant anorectal disease requiring surgery, or patient preference. The two most described surgical proce­dures are the open Milligan-Morgan hemorrhoidectomy and the closed Ferguson hemorrhoidectomy. A multitude of descriptions and modalities for these procedures
10 Hemorrhoids: Anatomy, Physiology, Concerns, and Treatments
Fig. 10.5 Internal hemorrhoid post banding
233
exist—each with similar outcomes. Briefl y, tenants of the procedures will include ligation of the vascular pedicle above the hemorrhoid column, excision of the hem­orrhoid tissue, and either closure of the anal mucosa defect or healing by secondary intention [ 8 ]. Classically, this procedure has been performed with either scalpel or electrocautery, but some clinicians prefer to use either the harmonic scalpel (Ethicon Endo-Surgery, Cincinnati, OH) or the LigaSure (Covidien, Boulder, CO). Most studies have shown no difference in healing rates or pain ratings with these newer devices. As a benefi t, they can reduce operating room time and have less bleeding associated with their use [ 9 ]. Complications of surgical hemorrhoidectomy include pain, bleeding (0.3–6 %), anal stenosis (0–6 %), urinary retention (2–36 %), and incontinence (2–12 %).
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Because pain is the largest barrier to hemorrhoid surgery, many new devices have come to market which purport to give the same long-term improvement in symp­toms with less post-procedural pain. These include Doppler-guided transanal hem­orrhoid devascularization (THD™, AMI™), stapled hemorrhoidectomy or procedure for prolapsed hemorrhoids (PPH), and the hemorrhoid energy therapy (HET™) bipolar system.
The transanal hemorrhoid devascularization technique fi rst described by Morinaga et al. in 1995 involves ligation of each of the six feeding vessels of the hemorrhoidal columns. The vessels are identifi ed with a Doppler probe and ligated with an absorbable suture like Vicryl. A prolapsed hemorrhoid is then reposited to its formal location by pulling it up with a similar suture which starts at or above the ligation site and ends just above the dentate line. Results with the procedure are favorable with recurrence rates at 1 year around 10–15 % [ 10 ].
The stapled hemorrhoidectomy was introduced for hemorrhoids in 1998. First, an anal dilator is used to secure a circumferential purse-string stitch 2–4 cm above the dentate line. A modifi ed EEA stapler is then inserted into the anal canal and the purse-string stitch draws redundant mucosa into the head of the stapler. The stapler is then fi red excising a ring of redundant tissue and creating a circumferential staple line above the dentate line. Most long-term studies show no difference in pain when compared to conventional hemorrhoidectomy, but recurrence rates appear to be higher. Additionally, there are several unique complications associated with stapled hemorrhoidectomy including fi stula, staple-line bleeding, and chronic pain [ 11 ].
The HET bipolar system represents the newest procedure to be employed for hemorrhoidal disease. Introduced in 2014, hemorrhoid energy therapy involves a patented anoscope with a window through which the hemorrhoidal tissue is iso­lated. Closing and activating the device around the hemorrhoid heats the submuco­sal vessels to induce coagulation and decreased blood fl ow. Early reports are encouraging with minimal pain and good short-term results, but to date no long­term studies have been performed.
There are a variety of nonoperative and operative treatment options for hemor­rhoidal disease. It is important to exclude other entities that may mimic hemor­rhoids. Each treatment options has its own set of advantages and disadvantages so it is important to be familiar with all the available treatment options so that patients may have the best long-term outcomes.

10.3 Case 3: Grade 4 Internal Hemorrhoids

10.3.1 Presentation
A 50-year-old woman presents to the emergency department with painful anal mass. She describes a history of progressively worsening hemorrhoids requiring manual reduction after bowel movements for the past 4 months. Today, she was unable to reduce her hemorrhoid tissue. She has subsequently developed increasing pain and tenderness prompting presentation.
10 Hemorrhoids: Anatomy, Physiology, Concerns, and Treatments
Fig. 10.6 Grade 4 prolapsed hemorrhoids
10.3.2 Examination
235
Swollen, engorged, prolapsed internal hemorrhoid tissue with bluish, black appear­ance (Fig. 10.6 ). Manipulation of the hemorrhoid tissue is painful. Surrounding perianal skin exhibits erythema and warmth.
10.3.3 Diagnosis
Grade 4 internal hemorrhoids
10.3.4 Discussion
The fi ndings of grade 4 hemorrhoids are characterized by incarceration of the pro­lapsed hemorrhoids. This alarming fi nding should cause concern in the astute provider as the natural history of this disease is progressive swelling, strangulation, and necrosis of the hemorrhoid tissue. Urgent surgical consultation should be requested as delay in treatment can lead to progressive necrosis and potentially systemic infection.
10.3.5 Treatment
Treatment of incarcerated internal hemorrhoids typically requires emergent hemor­rhoidectomy. In the instance of multiple herniated columns, the greatest and most threated hemorrhoids are selected for excision with planned elective return to
236
address the lesser hemorrhoids. This staged approach limits the incidence of stenosis following circumferential excision. In select patients, an alternative to surgery is a local block and direct injection of the hemorrhoids with a mixture of 0.25 % bupi­vacaine, 1:100,000 epinephrine, and hyaluronidase. This solution greatly reduces tissue edema and swelling allowing for reduction and ligation of the prolapsing hemorrhoid. The external thrombosis can then be excised. The results of this method have shown it to be safe and effective when compared to surgical hemorrhoidec­tomy with the added benefi t of an earlier recovery and less pain [ 12 ].
O. Coughlin and M. Page

10.4 Case 4: Thrombosed External Hemorrhoids

10.4.1 Presentation
A 45-year-old man presents to the emergency department with new onset of perianal pain and pressure. He describes 12 h of constant throbbing at the anal opening worsened by sitting, palpation, or bowel movements and improved when lying on his side.
10.4.2 Examination
Rectal examination reveals swollen, exquisitely tender, purple mass with attenuated skin below the anal verge protruding into the anal canal (Fig. 10.7 ). No evidence of surrounding erythema. No evidence or expression of purulent drainage.
10.4.3 Diagnosis
Thrombosed external hemorrhoids
10.4.4 Treatment
Treatment of thrombosed external hemorrhoids is dictated by the time between onset of symptoms and the patient’s presentation to the outpatient clinic or emer­gency department. If diagnosed and treated within 48–72 h of onset, then an ellipti­cal excision of overlying skin with evacuation of the thrombosed clot can provide signifi cant symptomatic relief from pain and pressure. Topical or injectable 1 % lidocaine with 1:100,000 epinephrine can provide procedural analgesia and assist with hemostasis. Care must be taken to fully unroof the overlying skin to prevent re-closure and potential abscess formation. Post-procedural sitz baths three times daily and with soiling will allow for healing by secondary intention and a low inci­dence of postoperative abscess formation. If diagnosed beyond 72 h, treatment is conservative with warm packs and appropriate hygiene as pain and tenderness resolve over the following 5–7 days. Topical and systemic analgesics are appropri­ate for symptomatic relief during this period [ 13 ].
10 Hemorrhoids: Anatomy, Physiology, Concerns, and Treatments
Fig. 10.7 Thrombosed external hemorrhoid
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10.5 Case 5: Bleeding Hemorrhoids

10.5.1 Presentation
A 65-year-old man with atrial fi brillation on therapeutic anticoagulation presents to the emergency department with complaint of lower gastrointestinal bleeding. He relates a history of hemorrhoids with a mass occasionally palpable at his anal open­ing. His current bleeding started 2 h prior to presentation. He describes passing a number of bowel movements with a large amount of blood each time. He denies hematemesis.
10.5.2 Examination
The patient has a normal external anal exam. A digital rectal exam reveals a combi­nation of clotted and bright red blood. He has large internal hemorrhoids that pro­lapse with removal of examining fi nger and then spontaneously reduce. While prolapsed, his hemorrhoid tissue demonstrates visible bright red bleeding (Fig. 10.8 ).
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Fig. 10.8 Prolapsed internal hemorrhoid
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10.5.3 Diagnosis
Bleeding internal hemorrhoids
10.5.4 Discussion
Presentation of bloody bowel movements warrants a full workup and assessment for upper and lower GI bleeding that is beyond the scope of this case. Bleeding hemor­rhoids may represent up to 10 % of lower GI bleeds. Although hepatic cirrhosis is commonly associated with bleeding hemorrhoids, portal hypertension does not lead to development of hemorrhoids, and hemorrhoidal disease in cirrhotic patients is no different than that of the general population. Portal venous hypertension predis­poses to anorectal varices, but these cause massive bleeding less than 1 % of the