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68 PART III Wires Technology
12 Saito S, Miyake S, Hosokawa G et al. Transradial coro-
nary intervention in Japanese patients. Catheter Cardiovasc Interv 1999; 46: 37–41.
13 Saito S, Tanaka S, Hiroe Y et al. Comparative study on
transradial approach vs. transfemoral approach in pri­mary stent implantation for patients with acute myocar­dial infarction: results of the test for myocardial infarction
by prospective unicenter randomization for access sites (TEMPURA) trial. Catheter Cardiovasc Interv 2003; 59: 26–33.
14 Takahashi S, Saito S, Tanaka S et al. New method to
increase a backup support of a 6 French guiding coro­nary catheter. Catheter Cardiovasc Interv 2004; 63: 452–456.
9
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CHAPTER 9
Microcatheters: Characteristics and Use
John D. Hung1,* & James C. Spratt
1
Liverpool Heart and Chest Hospital, Liverpool University Foundation Trust, UK
2
St George’s University Hospitals NHS Foundation Trust, London, UK
* Corresponding author
Introduction
Microcatheter (MC) engineering has developed sig­nificantly in recent years, as indications for their use have continued to expand. In the era of complex coro­nary intervention, microcatheters are an essential tool for all interventional cardiologists and a working (or even advanced) knowledge of their characteristics is essential to use them effectively and safely.
Whilst originally used for simple wire exchange, microcatheters have evolved into essential tools in several diverse scenarios. In chronic total occlusion (CTO) PCI, multiple MCs are now available to facili­tate antegrade wiring and retrograde approaches, each with unique properties. Dual lumen MCs are useful in side branch wiring and maintaining main vessel posi­tion, as well as in targeted drug delivery to the distal vessel or coronary microvasculature. Angulated microcatheters have been developed to facilitate wir­ing around tortuous vessels, and management of small vessel perforation or vein graft occlusion can be per­formed comfortably by delivery of helical coils.
Microcatheters should be thought of as tubular extensions of the guide catheter, another step beyond a guide extension catheter. This allows the base of operations to move closer and with increased control. In so doing they provide increased wiring support, stability, and the ability to confidently maintain posi­tion within the vessel, facilitating rapid wire exchange and without losing any ground.
Critically, MCs should be chosen empirically, based on the task at hand. Familiarity with equipment is undoubtedly an important factor and should influ­ence selection, but other variables such as proximity to the catheter lab, favored manufacturers or color should not be important considerations. Like all
2
equipment in intervention, MCs are developed by engineers with deliberate properties and specifica­tions to perform particular tasks. These differences inevitably make them very good at some applications but much less good at others. For example, a coiled and threaded high penetration MC like the Turnpike Spiral is best suited to penetrating the tough proximal cap of a CTO, due to its size, strength, and external nylon coils. These properties make it pushable and supportive, to give increased back-up and penetrative force in traversing resistant plaque. However, these same properties would work against it in navigating tortuous retrograde collaterals, when the features of trackability and lubricity are required. The reverse would be true of the Caravel, which is smaller and more flexible. None of these properties would be needed for a simple wire exchange.
Microcatheters can therefore be classified in several ways according to their design and properties. No sys­tem can neatly divide them into definite exclusive cat­egories, but broad groupings into big or small, pushable or trackable, coiled or non-coiled, tapered or non-tapered, can help to narrow down to the few which are appropriate, or even better – ideally suited to the application in question.
To choose the right MC for the task therefore requires in-depth knowledge of each. It is critical to understand how they’re constructed, what properties they therefore have, and what their intended uses are.
This chapter will describe each of the key charac­teristics of selected microcatheters, describe specific examples for use, and how to use them safely and effectively. This section should increase understand­ing of modern-day MCs and provide an aide-mem­oire to the modern-day CTO operator.
Chronic Total Occlusions: A Guide to Recanalization, Third Edition. Edited by Ron Waksman and Shigeru Saito. © 2024 John Wiley & Sons Ltd. Published 2024 by John Wiley & Sons Ltd.
69
70 PART III Wires Technology
Characteristics
Several key characteristics allow classification of microcatheters, although there is overlap, and multi­ple potential classifications exist (Figure 9.1).
Size: The tip of a microcatheter may be tapered, and
the severity of the taper can vary. Tapered micro­catheters are more suited to penetration, with better lesion engagement and crossability. Microcatheters which are larger at the tip and in the shaft are natu­rally stiffer, but increased size and stiffness results in less trackability when dealing with tortuosity. The Corsair Pro has a marked taper going from
0.42 mm (1.2Fr) at the tip to 0.87 mm (2.6Fr) in the distal shaft, making it a good choice for most antegrade CTO approaches.
Push Force: Pushability is dependent on catheter
rigidity and the ability to apply co-axial force. The Turnpike Gold is designed for maximal stiffness to deal with resistant lesions, with a large, tapered tip
0.71 mm (2.1Fr). It is therefore a very strong and supportive choice for antegrade CTO approaches but would not be useful for retrograde crossing or simple wire exchanges.
Torque : Ability to torque a microcatheter both improves
trackability and allows catheters with external threads to “drill” into a lesion increasing support. Coiled microcatheters are designed for torquing, but braided microcatheters should not be rotated and carry a risk of fracture if over rotated. The Finecross and Caravel should be cautiously rotated when advanced, as rota­tion reduces friction, but the coiled microcatheters should be actively spun and critically only in the “right” direction (clock or anti-clock). Torquing MC to advance through a lesion should be performed by
right hand index finger and thumb spin the hub, grip­ping the guide wire between the little finger and hypothenar eminence.
Lubricity: The majority of microcatheters have some
lubricious coating to reduce friction and improve trackability.
Trackability: Flexible microcatheters with a lubri-
cious coating will be more trackable, but there is a trade off with push force. The Caravel MC is small
and lubricious, which makes it a good choice for tortuous retrograde collaterals, but less well suited to penetrating a hostile lesion in antegrade approaches.
Threads: Modern CTO microcatheters with external
nylon threads are designed to “screw” into CTO lesions. This fixes the MC in situ and gives improved support for wiring and improves pusha­bility for crossing. Importantly they are directional and the direction of torque is different between manufacturers.
Table 9.1 summarises key microcatheter features, including out diameters and torque direction.
Types
Braided
Braided microcatheters have a soft and flexible tip, with low-crossing profile, enabling multi-purpose use for wire exchanges and retrograde collateral crossing. Due to their non-coiled construction, braided micro­catheters should be pushed to advance, not torqued, to avoid damage to the microcatheter. Small size, lubricity and flexibility allow good trackability in tor­tuosity, but the trade-off is less pushability and co­axial force which is needed for crossing more resistant lesions. Most microcatheters are available in shorter 130cm or 135 cm length for antegrade approaches, and longer 150cm for retrograde.
Caravel
The Caravel (Figure 9.2) is a braided microcatheter with a small tip and high flexibility. This enables improved trackability for small, tortuous collateral channels and crossability for tight stenoses. It should not be “over-torqued” as it is not structurally designed for this, and when impacted into a lesion would risk damage to structural integrity.
Finecross
The Finecross (Figure 9.3) is a braided, non-tapered tip microcatheter with a small entry profile. It is useful for simple wire exchanges, and well-suited to crossing tight lesions. As with any braided catheter, it should
Figure 9.1 Microcatheter characteristics.
Hydrophilic Threaded Tapered OD tip OD distal OD shaft ID tip ID prox Torque
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Construction
0.62mm (1.9Fr) 0.85mm (2.6Fr) 0.016 0.022 No
0.6mm (1.8Fr) 0.87mm (2.6Fr) 0.018 0.021 No
(1.4Fr)
(1.8Fr)
0.87mm (2.6Fr) 0.93mm (2.8Fr) 0.015 0.018 Anti-clock
0.87mm (2.6Fr) 0.93mm (2.8Fr) 0.015 0.018 Anti-clock
(1.2Fr)
0.71m (2.1Fr) 0.95mm (2.9Fr) 0.015 0.019 Anti-clock
(1.2Fr)
0.87mm (2.6Fr) 1.02mm (3.1Fr) 0.015 0.018 Clockwise
(1.3Fr)
1.02mm (3.1Fr) 1.02mm (3.1Fr) 0.015 0.018 Clockwise
(1.6Fr)
0.74mm (2.2Fr) 0.97mm (2.9Fr) 0.015 0.018 Clockwise
(1.6Fr)
0.46mm (1.4Fr) 0.81mm (2.4Fr) Clockwise
(1.6Fr)
0.46mm (1.4Fr) 0.71mm (2.1Fr) Clockwise
(1.4Fr)
(1.4Fr)
0.71mm (2.1Fr) 0.71mm (2.1Fr) 0.016 0.025 Anti-clock
0.88mm (2.6Fr) 1.0mm (3Fr) 0.016 0.018 Anti-clock
(1.8Fr)
(2.1Fr)
1.07mm (3.2Fr) 1.02mm (3.1Fr) 0.015 0.018 Anti-clock
(2.1Fr)
Name Length1 Length2 Brand Type Shaft
Caravel 135cm 150cm Asahi Braided Braided 70cm, 85cm No Yes 0.48mm
Table 9.1 Microcatheter specifications.
Finecross 130cm 150cm Terumo Braided Braided 70cm,90cm No No 0.6mm
Corsair 135cm 150cm Asahi Coil based Coils 60cm No Yes 0.42mm
Corsair Pro 135cm 150cm Asahi Coil based Coils 60cm No Ye s 0.42mm
135cm 150cm Asahi Coil based Coils 70cm, 85cm No Yes 0.4mm
Corsair Pro
XS
135cm 150cm Teleflex Coil based Braid and 2 coils 60cm Yes Yes 0.53mm
Turnpike 135cm 150cm Teleflex Coil based Coils 60cm No Yes 0.53mm
Turnpike
135cm 150cm Teleflex Coil based Braid and 2 coils 60cm No Yes 0.53mm
Spiral
Turnpike
LP
Mamba 135cm 150cm Boston Coil based Coils 60cm No No 0.46mm
135cm 150cm Boston Coil based Coils 60cm No No 0.46mm
Mamba
Flex
135cm Asahi Penetration Metallic No No Yes 0.61mm
135cm Asahi Penetration Metallic No No Yes 0.70mm
Tornus
2.6Fr
Tornus
2.1Fr
135cm Teleflex Penetration Braid and 2 coils 60cm Ye s Yes 0.71mm
(baby)
Turnpike
Gold
Hydrophilic Threaded Tapered OD tip OD distal OD shaft ID tip ID prox Torque
0.018 – No
1.05mm (3.2Fr) 0.016 0.017 No
0.87mm (2.6Fr) 0.018 – No
0.87mm (2.6Fr)
0.84mm (2.5Fr) /
1.08mm (3.3fr)
0.77mm (2.3Fr) /
1.08mm (3.3Fr)
0.77mm (2.3Fr) /
(1.5Fr)
(1.5Fr)
38cm No Yes 0.5mm
/ 1.08mm
(3.3Fr)
1.08mm(3.3Fr)
(1.5Fr)
80cm No No No
Name Length1 Length2 Brand Type Shaft
Table 9.1 (Continued)
Construction
and OTW
Sasuke 145cm Asahi Dual lumen Rapid exchange
135cm IMDS Dual lumen 2 x OTW 18cm No Yes 0.5mm
NHancer
RX
ReCross 140cm IMDS Dual lumen 2 x OTW Distal 0.5mm
tungsten
Directional Platinum/
Directional Platinum tip 24cm No No 0.75mm (2.2Fr) No
Vascular
Solutions
Vascular
Angled
Supercross
Venture
Solutions
RX
Figure 9.2 Caravel.
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CHAPTER 9 Microcatheters: Characteristics and Use 73
Figure 9.3 Finecross.
not be “over-torqued” particularly when impacted or entrapped due to the risk of shearing. It is also worthy of note that the Finecross length is slightly shorter at 130cm, which is helpful when the base of operations
external threads can increase stability within the lesion but increase the risk of entrapment. Coil based micro­catheters are designed to be torqued either clockwise or anti-clockwise, and this varies by manufacturer.
is distal in the artery to facilitate simpler exchange with a trapping balloon technique. A new iteration of the Finecross will be more tapered and with a longer lubricious segment.
Corsair and Corsair Pro
The Corsair and Corsair Pro microcatheters (Asahi Intecc) (Figure 9.4) are coiled, tapered, and flexible microcatheters. Initially designed for dilatation of
Coil-based
Microcatheters with a coiled construction are designed for higher pushability, torquability, and application of co-axial force in tortuous anatomy. Their more robust construction means a larger profile than braided microcatheters in general, and more penetrative microcatheters may be less trackable. The addition of
small collateral channels, they are also well suited to lesion crossing, benefitting from a combination of good crossability and trackability. The Corsair Pro was engineered for better torque transmission, with a smoother transition between shaft and tip and a “kink-resistant” hub. As with all Asahi microcathe­ters, they are directional due to their coil construction
74 PART III Wires Technology
Figure 9.4 Corsair and Corsair Pro.
and should only be torqued anti-clockwise to advance. The Corsair should be rotated in a 4:1 ratio, meaning 4 turns anti-clockwise, then 1 turn clockwise to release tension. It should not be rotated more than 10 times in any one direction, to avoid deformation of the catheter.
Corsair Pro XS
Developing from the Corsair Pro, the XS device (Figure 9.5) has improved flexibility of the tip ena­bling enhanced crossability. It also has a longer hydro­philic coating, and is engineered specifically for trackability making it well-suited to crossing tortuous and small caliber retrograde channels.
Turnpike and Turnpike Spiral
The Turnpike and Turnpike Spiral MC (Teleflex) (Figure 9.6) is constructed with 2 coil layers laid down in opposite directions, to improve kink resistance and
torque transmission even in tortuosity. The coils are contained within a braid and is covered by polymer for lubricity. The tip is flexible and tapered, and well seen on fluoroscopy. Its utility is in penetration of cal­cific and tortuous CTOs, with enough flexibility to navigate tortuosity, but maintaining enough push force to allow forward progress.
The Turnpike Spiral has a 2cm section of external nylon coils laid in a clockwise direction. When advanced forward it should be torqued clockwise, with occasional anticlockwise turns to release tension. It should be removed by backwards traction with anti­clockwise turns.
Turnpike LP
The Turnpike LP (low profile) (Figure 9.7) is specifi­cally designed for navigating retrograde collaterals, with a narrow distal shaft (0.74 mm, 2.2 Fr compared with 1.02 mm, 3.1 Fr of Turnpike Spiral). It has a
Figure 9.5 Corsair Pro XS.
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CHAPTER 9 Microcatheters: Characteristics and Use 75
Figure 9.6 Turnpike and Turnpike Spiral.
76 PART III Wires Technology
Figure 9.7 Turnpike LP.
unidirectional coil distally, and should be advanced clockwise, removed anti-clock.
Mamba and Mamba Flex
The Mamba and Mamba Flex (Boston) (Figure 9.8) are flexible and constructed with a uni-directional coil and low crossing profile. The catheters are subtly different with a slightly smaller proximal shaft in the flex version, enabling better trackability when retro­grade. The Mamba flex is useful for both antegrade and retrograde applications, particularly lubricious and therefore useful for crossing calcific and tortu­ous lesions. The coils are directional and it should be advanced with clockwise torque.
Penetration
Penetration microcatheters are designed for maximum support and crossability in resistant lesions using ante­grade approaches. They are larger, and less trackable as a result, and only available in 135 cm lengths. As with coil based microcatheters each is designed to advance with rotation in a particular direction.
Tornus and Baby Tornus
The Tornus penetration catheters (Figure 9.9) are stiff and metallic, designed to enable wiring and crossing of resistant, calcific lesions. They are constructed with 8 exposed, wrapped metal coils and a long 15cm taper for maximal support. The larger version of the Tornus
Figure 9.8 Mamba and Mamba Flex.
Figure 9.9 Tornus.
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CHAPTER 9 Microcatheters: Characteristics and Use 77
offers most support with a 2.1 Fr tip, 2.6 Fr distal and
3.0 Fr proximal shaft, but the smaller (baby) Tornus is also stiff and pushable, just slightly smaller in profile. No more than 20 turns should be applied in an anti-clock direction, and due to absence of an inner coating tip injections are not possible.
Turnpike gold
The Turnpike Gold (Teleflex) (Figure 9.10) is designed for penetration, with a threaded metallic tip and 2cm section of nylon coils proximal to it similar to the Turnpike Spiral. It shares the same internal coil con­struction, and benefits from stiffness and pushability for resistant lesions, as always these advantages trade
off with flexibility to deliver co-axial force in tortuos­ity. It should be reserved for antegrade approaches in resistant lesions, and as with all Teleflex microcathe­ters should be advanced with clockwise rotation.
Dual lumen microcatheters
Dual lumen microcatheters (DLMC) are constructed with a rapid-exchange monorail and an over the wire (OTW) side port located proximal to the tip. They are useful for multiple applications in CTO and general PCI: (1) Access to sharply angulated proximal cap. The DLMC should be advanced over a workhorse guidewire positioned in an adjacent side branch, and an appropriate CTO wire delivered via the
Figure 9.10 Turnpike gold.