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38 PART II Imaging
(d)
(f)
(a)
(b)
Figure 5.4 (a) Long RCA-CTO. (b) Parallel-wiring technique using stiff wires could not provide successful wire crossing. (c) An IVUS catheter was advanced through the wire in the false channel. (d) The image clearly showed an expanded subintimal space and a collapsed true channel. (e and f) Then a tapered stiff wire (Confianza, Asahi Intecc, Japan)
(c)
(g)
(e)
(h)
was delivered under the IVUS guidance to penetrate the true channel from subintimal space and this procedure was finally successful. (g) The wire was carefully advanced to the distal true lumen. (h) Final angiographic result after multiple stenting.
Also an 8 Fr guiding catheter is indispensable to con­duct the simultaneous wiring under IVUS guidance. After successful wire crossing, multiple stenting is mandatory to fully cover the enlarged subintimal space. However, by using this technique, we can retrieve some of unsuccessful CTOs initially per­formed by angiographical guidance [3, 4]. Thus, this technique could be one of the last alternatives in the antegrade approach when standard wiring procedures fail in cases without a chance of retrograde approach. A representative case is shown in Figure 5.4.
New technologies of IVUS-guided recanalization of CTO
Recently, a low-profile IVUS catheter has been devel­oped in Japan, which enables us to perform IVUS­guided re-entry from intimal or sub-intimal space more precisely and intentionally [5]. These new tech­nologies warrant further evaluation to open another door of CTO-PCI.
References
1 Stone GW, Colombo A, Teirstein PS et al. Percutaneous
recanalization of chronically occluded coronary arteries: procedural techniques, device, and results. Cathet Cardiovasc Interv 2005; 66: 217–236.
2 Werner GS, Diedrich J, Schlz KH et al. Vessel reconstruc-
tion in total coronary occlusions with a long subintimal wire pathway: use of multiple stents under guidance of intravascular ultrasound. Cathet Cardiovasc Diagn 1997; 40: 46–51.
3 Ito S, Suzuki T, Ito T et al. Novel technique using intravas-
cular ultrasound-guided guidewire cross in coronary intervention for uncrossable chronic total occlusions. Circ J 2004; 68: 1088–1092.
4 Matsubara T, Murata A, Kanyama H et al. IVUS-guided
wiring technique: promising approach for the chronic total occlusion. Catheter Cardiovasc Interv 2004; 61: 381–386.
5 Suzuki S, Okamura A, Nagai H et al. Tip detection-ante-
grade dissection and reentry using intravascular ultra­sound in chronic total occlusion intervention: first human case report. Eur Heart J Case Rep 2022; 6: 1–5.
6
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CHAPTER 6
Optical Coherence Tomography to Guide the Treatment of Chronic Total Occlusions
Francesca Maria Di Muro*, Giulia Nardi, Niccolò Ciardetti, Selcuk Kucukseymen, Alessio Mattesini & Carlo Di Mario*
Structural Interventional Cardiology, Department of Clinical and Experimental Medicine, Careggi University Hospital, Clinica Medica, Florence, Italy
* Corresponding authors
Introduction
Percutaneous coronary intervention (PCI) of chronic total occlusions (CTO) has been rapidly evolving in recent years [1].The main limitation approaching a CTO by PCI remains the inability to visualize the lesion. X ray coronary angiography is the cornerstone imaging modality in the cardiac catheterization labora­tory, but it has well-known limitations. It does not allow the operator to determine the course of the occluded vessel, making the progression of a stiff guidewire quite a blind operation, especially in the absence of an angio­graphically visible stump. Furthermore, angiography is unable to give a precise estimation of the lesion charac­teristics, from vessel remodeling to calcium burden, and does not offer sufficient information to guide optimal stent sizing and placement.
The development of intracoronary imaging tech­niques, such as intravascular ultrasound (IVUS) and optical coherence tomography (OCT), has improved the success rate for CTO recanalization, providing additional information that is complementary to angiography [2],reducing complications, contrast medium injection, and procedural time. Intravascular imaging thus aids in the selection of treatment strat­egies and guidance of percutaneous coronary inter­vention (PCI) [3].Optical coherence tomography (OCT) has gained wide acceptance to select the correct
stent diameter and length, to optimize stent deployment
and identify complications. In this chapter we focus on the specificities of OCT guidance in the treatment of
chronic total occlusions.
Principles of intra-coronary optical coherence tomography
Optical coherence tomography (OCT) performs high-resolution cross-sectional tomographic imaging of the microstructure of the vessel wall [4]. OCT uses a catheter to deliver and collect near infrared light (e.g., 1,300 nm) to create cross-sectional and three dimensional volumetric images of the lumen micro­structures and wall by measuring the amplitude and time delay of the backscattered light.
The shorter wavelength of the infrared light in OCT
m) compared with ultrasound in IVUS (~40 m
(1.3 at 40 MHz) confers greater axial resolution (10–20 m versus 50–150 m) but lower penetration depth (1–2 mm versus 5–6 mm), which limits OCT imaging, particularly in the presence of highly attenuating struc­tures such as red thrombus or lipid/necrotic core.
A. Ziad et al. [3] described the necessary steps for OCT imaging acquisition as four “P”s: position, purge, puff, and pullback. The OCT catheter is advanced on the coronary guidewire and located distal to the target lesion, then it is again purged, a small volume of flush is “puffed” through the guide catheter to evaluate clearance (if clarity is marginal, the engagement of the
Chronic Total Occlusions: A Guide to Recanalization, Third Edition. Edited by Ron Waksman and Shigeru Saito. © 2024 John Wiley & Sons Ltd. Published 2024 by John Wiley & Sons Ltd.
39
40 PART II Imaging
Table 6.1 Advantages and disadvantages of intravascular ultrasound and optical coherence tomography for PCI guidance and optimization.
IVUS OCT
• Extensive clinical experience (IVUS has been used clinically for all most three decades).
• Contrast free technique. • Additional contrast.
• IVUS can guide the operator to identify the ideal entry point to the CTO, particularly in occlusions at the bifurcation, stumpless occlusions, and ostial occlusions.
• Crucial role in optimizing stent implantation and for the detection of procedure-related vessel damage in both antegrade and retrograde techniques.
• Tissue characterization is limited. • Better tissue characterization. Calcium burden
• Assessment of strut malapposition, stent expansion is limited. • Useful to detect edge dissection, tissue
• Less clinical experience but 10x higher resolution compared with IVUS.
• Risk of damage if OCT is used to monitor the progression of a second wire in the true lumen with the first one (and OCT) positioned in the subintimal space.
• Useful in PCI guidance, choosing lesion preparation technique and stent measure­ments according to EEL-EEL algorithm.
estimation according to 5s algorithm.
coverage of stent struts, and malapposition.
guide catheter with regard to the target vessel is checked and adjusted), and pullback is activated.
In severely stenotic lesions where the OCT catheter may not cross the target lesion or the vessel clearance is expected to be poor, predilation should be performed.
It is possible to perform cine angiography during pullback and utilize contrast injection for angiog­raphy and OCT co-registration if available.
There are multiple intracoronary imaging OCT sys­tems, the two most employed are the OPTISTM system (Abbott Vascular, Santa Clara, CA, USA), which also provides combined angiographic and the Lunawave system (Terumo Corporation, Tokyo, Japan).
®
Image interpretation has been facilitated by the application of Artificial Intelligence (AI). In the most recent Ultreon OCT system (Abbott Vascular, Santa Clara, CA, USA) a Deep Learning (DL) data-driven AI algorithm [5] has been implemented, based on the observation of data by training a designed model, to make predictions in unexplored data sets. In the next future this new technology might guarantee an objective imaging analysis with a full quantification of plaque composition to optimize percutaneous coro­nary intervention (PCI) outcomes. At present the main advantage of AI-OCT is the automatic detection of calcific plaques, with accurate off line analysis of calcium distribution and thickness [6].
Use of imaging and OCT for CTO lesion crossing
CTO recanalization with a guidewire is the most important and difficult step in CTO intervention [7], sometimes complicated by subintimal crossing and the creation of a false lumen or by a complete wire exit. Intracoronary imaging can be useful to clarify
anatomical structures that cannot be identified by angiography alone, especially with an ambiguous position of the proximal occlusion cap. In particular, the use of IVUS in the recanalization of CTO enables precise location of the guidewires within an artery (i.e. true lumen versus subintima) [8].
It can also determine the optimal entry point and evaluate guidewire penetration of the proximal cap of a CTO.
Even when the guidewire enters into the subintimal space and attempts to re-enter the true lumen under fluoroscopic guidance are unsuccessful, IVUS may facilitate the location of the true lumen. An IVUS cath­eter can be placed into the subintimal space after pre­dilation with a balloon catheter, and then be advanced into the subintimal tract. A second guidewire can then be advanced alongside the IVUS catheter [9].
IVUS is also useful to guide complex retrograde approaches that involve facing the lesion from both directions, advancing a balloon over the antegrade wire and inflating it within the intimal or subintimal space, allowing the IVUS catheter to be advanced and posi­tioned opposite to the retrograde wire. The retrograde wire can then be manipulated from the distal vessel position, which can be intimal or subintimal, into the true lumen and beyond the occluded segment.
In theory an OCT catheter positioned in a side­branch originating at the site of the occlusion is able to identify the stump with equal or greater accuracy than IVUS [10]. This requires the injection of crystalloids (generally contrast) at high pressure to clear the blood and complicates the advancement under imaging of the second guidewire (Figure 6.1). The inconvenience generated by the need of repeated high pressure injec­tion becomes a real risk of damage if OCT is used to monitor the progression of a second wire in the true
CHAPTER 6 Optical Coherence Tomography to Guide the Treatment of Chronic Total Occlusions 41
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Figure 6.1 (a) CTO of the posterolateral branch originating from the mid segment of the dominant LCx. (b) Preinterventional OCT showed precisely the localization and morphology of the CTO entry point. (c) Venture catheter with a deflectable tip and OCT imaging probe in the LCx. (d) There is a visible shadow from the Venture catheter and leading guidewire for the OCT probe. OCT confirmed good position of the guidewire
lumen with the first one (and OCT) positioned in the subintimal space. A power injection of contrast with the OCT catheter in the subintimal space can obvi­ously cause progression of the dissection downstream and should therefore be avoided.
Assessment of CTO length and prediction of stent measurements
In CTO PCI, the potential for stent undersizing at the index procedure is high, because of persistent vaso­constriction of the distal occluded segment, not immediately reversible with vasodilators. On the other hand, overaggressive post-dilatation can result in vessel perforation in the presence of wire passage in the subintimal space and in a vessel segment with severe calcification and negative remodeling [11].
Lesion length, location, composition, and com­plexity are predictors of stent failure. Increasing CTO length predicts escalation through the hybrid algorithm and subsequent procedural success. In a retrospective analysis by Tian et al., 5-year outcomes demonstrated CTO length >15 mm to be a predictor of TLR, whereas Ahn et al. found CTO length >30 mm was associated with higher repeat PCI driven by TVR at 2 years [12,13].
For this reason, an imaging guided PCI is crucial to assess lesion morphology, to guide lesion preparation
puncturing the entry point of CTO. (e) Angiographic result after implantation of stent into the posterolateral branch with corresponding OCT cross-sections (I–III). OCT cross-section images before final kissing balloon: (I) Well apposed struts in the posterolateral branch distal to the bifurcation. (II) Floating struts at the level of the bifurcation. (III) Malapposed struts just proximal to the bifurcation in the LCx.
and characterize the stent landing zones, thus allow­ing precise selection of balloons and stents.
OCT is able to identify a sufficiently “healthy” vessel reference segment proximal and distal to accu­rately predict the stent length. By scrolling through the OCT cross-sections at these sites, the most “normal” segments (such as segments within 5
mm from the lesion edges where there is minimal athero­sclerotic plaque and hence greatest visibility of the arterial media are selected as proximal and distal ref­erence frames) [14, 15]. The length of the lesion is then automatically calculated by the OCT software.
The modern Ultreon
to automatically define these two vessel references
1.0 Software system uses AI
and predict stent length.
Then, according to the most recently proposed algorithm, an EEL-guided sizing strategy should be preferred instead of a lumen guided strategy that leads to the selection of a smaller stent/balloon size increasing mismatch and post procedural complica­tion. This strategy can be used only if greater than 180° of EEL can be visualized. EEL-based measure­ments should be rounded down to determine the device size. If EEL is not visible the mean lumen diam­eter, recorded from the automated lumen profile fea­ture, is utilized for device sizing rounded up to
0.25 mm above. The distal measurements determine the stent size and post-dilation balloon size at the
42 PART II Imaging
Figure 6.2 OCT demonstrating the presence of a false lumen during the treatment of a heavily diseased left circumflex artery. Cypher 2.75×33 mm at 20 atm postdil prox 3.0 26 atm and kissing LCX-OM with 3.0 and 2.0 balloon at 12 atm (a) Initial angiogram. (b) Following initial
distal end of the stent, and the proximal measure­ments determine the balloon size for post-dilation at the proximal end of the stent.
Assessment of vessel wall constituents
Even if OCT has a limited role before lesion crossing (i.e., crossing the stump lesion), it could be best applied following crossing and dilatation of the dis­eased segment. When the distal vessel is successfully accessed and the operator is confident that an antero­grade true-to-true lumen crossing was achieved, an OCT pull-back can then be performed during high pressure injection to accurately characterize some important vascular parameters not identified with angiography (and occasionally also with IVUS).
OCT offers a detailed assessment of normal and diseased morphology feasible by understanding the optical attenuation characteristics of vascular tissue layers. An algorithm recently developed could be useful in describing the most frequent pathological
treatment. (c) OCT of proximal vessel. (d) Stent interruption; no stent struts can be seen. (e) Bifurcation LCX/OM. (f and g) “Biluminal” segment of the vessel, the second guidewire is clearly visible (asterisks). (h) End of the biluminal segment. (i) Angiographic final result. (l) OCT final result.
findings in the vessel wall. It includes low-attenuating, signal-rich lesions (fibrous plaques), high- attenuating, signal-poor regions covered with fibrous cap (lipid­rich plaques), low-attenuating, sharply delineated, signal-poor regions (calcific plaques), and those inside the lumen, including the low-attenuating white thrombus and the high-attenuating red thrombus that casts a shadow on the vessel wall.
CTOs, compared with other lesions, are charac­terized by greater plaque burden, longer segments of disease, and the presence of higher amounts of calcium. Calcification in CTOs presents additional challenges during revascularisation of these com­plex coronary lesions. The presence of calcium pre­dicts lower procedural success rates and a higher risk of complications. Pre-procedural CTCA and intravascular imaging are useful tools to under­stand the distribution, morphology, and severity of calcium [16, 17].
In calcified lesions, IVUS is able to determine the calcification arc but not its thickness because of reflec­tion of ultrasound waves off calcium. In contrast,
CHAPTER 6 Optical Coherence Tomography to Guide the Treatment of Chronic Total Occlusions 43
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OCT allows determination of both calcification arc and thickness in most cases.
In particular, the modern Ultreon software is able to self-detect and measure calcium angle and max­imal thickness, giving an objective estimation of calcium burden. Each OCT frame shows an orange arc which represents calcium augmentation. It is cal­culated from the lumen center and is displayed only when calcium angle is at or above 60 degrees of cir­cumferential calcium. On the other side, calcium thickness is indicated by a small triangle and calcium length automatically displayed below the longitudinal pullback.
These measurements can be entered into the Fujino score, [18]developed from a multivariate linear regression model to correlate calcium burden and predict stent under expansion [19]. The parame­ters which correlate with poor outcomes may be easily recalled as the “rule of 5s”: 1 point for maximum thickness >0.5 mm, 1 point for contiguous length of
calcium >5
mm, and 2 point for maximum arc >50 % of the circumference of the vessel (i.e., >180° of the circumference)
Target lesions with a total score of ≥3 requires lesion preparation with cutting or scoring balloon, atherectomy, or intravascular
lithotripsy [20] while lesions with scores of ≤2 had generally an acceptable expansion.
It is well established that PCI in CTO is associated with higher rates of re-occlusion and repeat revascu­larization compared to conventional PCI. This is hardly surprising given higher number of stents and a greater mean stent length required by complex CTO lesions (Figure 6.3).
It remains controversial whether clinical outcomes are influenced by the technique used for revasculari­zation. Zhao et al. [21] reviewed the clinical results of 5265 patients at 12–24 months, in terms of restenosis and other adverse clinical events. They analyzed 12 non-randomized cohort studies and found higher risk
Figure 6.3 Chronic total occlusion of the left anterior descending in a patient with three vessel disease (a) Proximal disease of the right coronary artery with retrograde filling of the left anterior descending. (b) Severe disease of the proximal left system. (c) Reverse CART technique was used as follows: Retrograde (Corsair catheter + Miracle 4.5 wire); Anterograde Over-the-Wire
Balloon 1.5 mm x 12 mm + Confianza Wire. (d) Final angiogram. (e) OCT LM LA 16:42 mm LAD wire LCX wire. (g) OCT proximal LAD LA 4.57 mm Small dissection < 5 mm post-stent. (i) 3D reconstruction of OCT runs of the proximal LAD. A wire can be seen passing into the circumflex; note that the side struts of the stent have been well dilated to leave the ostium open.
2
. (f) OCT Bifurcation
2
. (h)
44 PART II Imaging
of myocardial infarction (MI), target-vessel revascu­larization (TVR), in-stent restenosis (ISR), and in­stent re-occlusion in dissection and reentry technique when compared with classical anterograde wiring. There are two registries, ISAR-CTO and CONSISTENT-CTO, which performed follow-up angiography with optical coherence tomography in large groups of CTO patients to clarify the possible mechanism of this phenomenon, not confirmed in other large registries of DR techniques. CONSISTENT­CTO [22] performed 175 optical coherence tomog­raphy late after CTO recanalization, with patients divided nearly equally into DR techniques and no DR group. More than 90% of stent struts were covered in both groups without features at risk for stent throm­bosis. ISAR-CTO [23] showed a numerically higher percentage of uncovered struts and significantly more malapposed struts in the DR technique group.
Another important aspect is to avoid stent strut malposition which is related to a higher risk of stent thrombosis. Here again angiography is deficient, being unable to assess stent strut malapposition, defined from the lack of full contact between stent struts and the vessel wall following PCI [24].
It may be present immediately after stent implan­tation or may develop later and it is very common in CTO lesions which are usually extensive and have diffuse calcification and fibrous tissue – these char­acteristics complicate stent strut apposition and coverage [25]. The OCT analysis can be used to identify this complication and decide the correct balloon diameter for post-dilatation, following which a further run can be obtained in order to assess if the desired improvement in strut malappo­sition has indeed been achieved.
OCT is also useful to define stent under-expansion that is another powerful predictor of early stent thrombosis and restenosis after DES implantation. The percentage of stent or lumen expansion is defined as MSA or minimal lumen CSA divided by the mean of the largest proximal and distal reference lumen CSAs. Maehara et al. [26] showed that OCT may achieve a comparable degree of stent expansion as that with IVUS guidance, with a similarly low frequency of major stent malapposition, tissue prolapse, and edge dissections.
Stent implantation can also result in vessel wall injury between the edge of the stent and the adjacent vessel wall. Deep and large dissections cause a high rate of stent thrombosis, MACE and new revasculari­zations. OCT, better than angiography alone, is able to detect stent edge dissections (SED) that are also not so clear with IVUS.
Several previous studies investigated the factors associated with SED after stent implantation including
excessive vessel stretching, calcified or lipidic plaques, residual plaque eccentricity, stent length, and ST-elevation MI presentation. In particular, progres­sive atherosclerotic plaques (lipidic and fibrocalcific plaques) by OCT and lumen eccentricity are associ­ated with SED. Therefore, operators should avoid locations with these features as stent landing zones. Another potential reasons for SED is stent-oversizing when the stent landing zones were different from those initially planned. Therefore, the possibility of stent landing at unplanned zones should be consid­ered when stent length is selected. Finally once the stent is chosen the appropriate size of post-dilatation balloon should be decided to correct stent malapposi­tion if present [27].
Conclusion and future perspectives
There is reasonable evidence that IVUS improves mid­to long-term outcome in the specific setting of CTO recanalization, a field where IVUS already offers unique information to correctly engage stumpless occlusions and to guide reentry from a subintimal path. The role of OCT before CTO crossing is limited by the need to dis­place blood to generate images, with the possible creation of large dissections. If the lesion is entered anterogradely true-to-true before stenting and in all cases after stenting, OCT becomes a valid alternative to IVUS thanks to its superior image resolution which facilitates the detection of edge damage and applies automatic algorithms for an objective definition of calcium burden and to optimize stent expansion.
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8
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Nakatani S, Proniewska K, Pociask E et al. How clini-
cally effective is intravascular ultrasound in interven­tional cardiology? present and future perspectives. Expert Rev Med Devices 2013; 10(6): 735–749. doi:
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10
Ali ZA, Maehara A, Généreux P et al. Optical coherence
tomography compared with intravascular ultrasound and with angiography to guide coronary stent implanta­tion (ILUMIEN III: OPTIMIZE PCI): a randomised con­trolled trial. Lancet 2016; 388(10060): 2618–2628. doi:
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12
in patients with chronic total coronary occlusion treated with drug-eluting vs bare-metal stents: a case-control study. Can J Cardiol 2013; 29(8): 945–950. doi: 10.1016/j. cjca.2012.10.002.
13
Ahn J, Rha SW, Choi B et al. Impact of chronic total
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14
Räber L, Mintz GS, Koskinas KC et al. Clinical use of
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24
Izumi D, Miyahara M, Fujimoto N et al. Optical coher-
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25
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III
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PART III
Wires Technology