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Medicinal Plants – Chemical, Biochemical, and Pharmacological Approaches
51
https://t.me/medicina_free
and taxane accumulation.
Microorganisms. 2023;11(7):1645
[88] Cragg GM, Pezzuto JM. Natural
products as a vital source for the
discovery of cancer chemotherapeutic
and chemopreventive agents. Medical
Principles and Practice. 2016;25(Suppl.
2):41-59
[89] Bo G, Haiyan L, Lingqi Z. Isolation
of an fungus producting vinbrastine.
Journal of Yunnan University (Natural
Sciences). 1998;20(3):214-215
[90] Lingqi Z, Bo G, Haiyan L,
Songrong Z, Hua S, Su G, et al.
Preliminary study on the isolation of
endophytic fungus of Catharanthus
roseus and its fermentation to produce
products of therapeutic value. Zhong
Cao Yao= Chinese Traditional and
Herbal Drugs. 2000;31(11):805-807
[91] Kumar A, Ahmad A.
Biotransformation of vinblastine to
vincristine by the endophytic fungus
Fusarium oxysporum isolated from
Catharanthus roseus. Biocatalysis and
Biotransformation. 2013;31(2):89-93
[92] Palem PP, Kuriakose GC,
Jayabaskaran C. An endophytic fungus,
Talaromyces radicus, isolated from
Catharanthus roseus, produces
vincristine and vinblastine, which
induce apoptotic cell death. PLoS One.
2015;10(12):e0144476
[93] Ayob FW, Simarani K, Zainal
Abidin N, Mohamad J. First report on a
novel Nigrospora sphaerica isolated from
Catharanthus roseus plant with
anticarcinogenic properties. Microbial
Biotechnology. 2017;10(4):926-932
[94] Anjum N, Chandra R. Endophytic
bacteria of Catharanthus roseus as an
alternative source of vindoline and
application of response surface
methodology to enhance its production.
Archives of Biological Sciences. 2019;
71(1):27-38
[95] Birat K, Siddiqi TO, Mir SR, Aslan J,
Bansal R, Khan W, et al. Enhancement of
vincristine under in vitro culture of
Catharanthus roseus supplemented with
Alternaria sesami endophytic fungal
extract as a biotic elicitor. International
Microbiology. 2022;25(2):275-284
[96] Xianzhi Y, Lingqi Z, Bo G,
Shiping G. Preliminary study of a
vincristine-proudcing endophytic
fungus isolated from leaves of
Catharanthus roseus. Zhong Cao Yao=
Chinese Traditional and Herbal Drugs.
2004;35(1):79-81
[97] Kumar A, Abnave P, Ahmad A.
Cultural, morphological and molecular
characterization of vinca alkaloids
producing endophytic fungus Fusarium
solani isolated from Catharanthus
roseus. International Journal of Botany
and Research. 2013;3(2):2277-4815
[98] Kumar A, Patil D, Rajamohanan PR,
Ahmad A. Isolation, purification and
characterization of vinblastine and
vincristine from endophytic fungus
Fusarium oxysporum isolated from
Catharanthus roseus. PLoS One. 2013;
8(9):e71805
[99] Kuriakose GC, Palem PP,
Jayabaskaran C. Fungal vincristine from
Eutypella spp-CrP14 isolated from
Catharanthus roseus induces apoptosis
in human squamous carcinoma cell lineA431. BMC Complementary and
Alternative Medicine. 2016;16(1):1-8
[100] Ashoka H, Hegde P, Manasa K,
Madihalli C, Pradeep S, Shettihalli A.
Isolation and detection of vinca alkaloids
from endophytes isolated from
Catharanthus roseus. European Journal
The
52
https://t.me/medicina_free
Endophytes: A New Resource for Vulnerable Plant Bioactive Compounds
ITexLi.112931
of Biomedical and Pharmaceutical
Sciences. 2017;10:675-683
[101] Zafari D, Leylaiee S, Tajick MA.
Isolation and identification of vinblastine
from the fungus of Chaetomium
globosum Cr95 isolated from
Catharanthus roseus plant. Biological
Journal of Microorganism. 2019;8(32) :1-14
[102] Parthasarathy R,
Shanmuganathan R, Pugazhendhi A.
Vinblastine production by the
endophytic fungus Curvularia
verruculosa from the leaves of
Catharanthus roseus and its in vitro
cytotoxicity against HeLa cell line.
Analytical Biochemistry. 2020;593:
113530
[103] Bandara CJ, Siriwardhana A,
Karunaratne DN, Ratnayake
Bandara BM, Wickramasinghe A,
Krishnarajah SA, et al. Production of
vincristine and vinblastine by the
endophytic fungus Botryosphaeria
laricina strain (CRS1) is dependent on
stimulating factors present in
Catharanthus roseus. The Natural
Products Journal. 2021;11(2):221-230
[104] Andriambeloson OH, Noah RMA,
Rigobert A, Jean-Marc C, Luciano R,
Rado R. Isolation of Novel Vincristine
and Vinblastine Producing Streptomyces
Species from Catharanthus Roseus
Rhizospheric Soil. Research Square.
2021. DOI: 10.21203/rs.3.rs-1082130/v1
Report on vincristine-producing
endophytic fungus Nigrospora
zimmermanii from leaves of
Catharanthus roseus. Metabolites. 2022;
12(11):1119
[107] Min C, Wang X. Isolation and
identification of the
10-hydroxycamptothecin-producing
endophytic fungi from Camptotheca
acuminata decne. Acta Botanica BorealiOccidentalia Sinica. 2009;29(3):614-617
[108] Kusari S, Zühlke S, Spiteller M. An
endophytic fungus from Camptotheca
acuminata that produces camptothecin
and analogues. Journal of Natural
Products. 2009;72(1):2-7
[109] Puri SC, Verma V, Amna T,
Qazi GN, Spiteller M. An endophytic
fungus from Nothapodytes f oetida that
produces Camptothecin. Journal of
Natural Products. 2005;68(12):1717-1719
[110] Ran X, Zhang G, Li S, Wang J.
Characterization and antitumor activity
of camptothecin from endophytic
fungus Fusarium solani isolated from
Camptotheca acuminate. African Health
Sciences. 2017;17(2):566-574
[111] Rehman S, Shawl A, Kour A,
Andrabi R, Sudan P, Sultan P, et al. An
endophytic Neurospora sp. from
Nothapodytes foetida producing
camptothecin. Applied Biochemistry and
Microbiology. 2008;44:203-209
[105] Ashraf J, Sharma MK, Biswas D.
Separation, purification and
characterization of vincristine and
vinblastine from fusarium oxysporum,
an endophytic fungus present in
catharanthus roseus leaves. Journal of
Advanced Scientific Research. 2021;12
(01 Suppl 2):128-136
[106] Birat K, Binsuwaidan R, Siddiqi TO,
Mir SR, Alshammari N, Adnan M, et al.
[112] Rehman S, Shawl A, Kour A,
Sultan P, Ahmad K, Khajuria R, et al.
Comparative studies and identification
of camptothecin produced by an
endophyte at shake flask and bioreactor.
Natural Product Research. 2009;23(11):
1050-1057
[113] Gurudatt P, Priti V, Shweta S,
Ramesha B, Ravikanth G, Vasudeva R,
et al. Attenuation of camptothecin
Medicinal Plants – Chemical, Biochemical, and Pharmacological Approaches
53
https://t.me/medicina_free
production and negative relation
between hyphal biomass and
camptothecin content in endophytic
fungal strains isolated from
Nothapodytes nimmoniana Grahm
(Icacinaceae). Current Science. 2010;
98(8):1006-1010
[114] Shweta S, Zuehlke S, Ramesha B,
Priti V, Kumar PM, Ravikanth G, et al.
Endophytic fungal strains of Fusarium
solani, from Apodytes dimidiata E. Mey.
ex Arn (Icacinaceae) produce
camptothecin, 10-hydroxycamptothecin
and 9-methoxycamptothecin.
Phytochemistry. 2010;71(1):117-122
[115] Pu X, Qu X, Chen F, Bao J, Zhang G,
Luo Y. Camptothecin-producing
endophytic fungus Trichoderma
atroviride LY357: Isolation,
identification, and fermentation
conditions optimization for
camptothecin production. Applied
Microbiology and Biotechnology. 2013;
97:9365-9375
[116] Shweta S, Bindu JH, Raghu J,
Suma H, Manjunatha B, Kumara PM,
et al. Isolation of endophytic bacteria
producing the anti-cancer alkaloid
camptothecine from Miquelia dentata
Bedd. (Icacinaceae). Phytomedicine.
2013;20(10):913-917
[117] Shweta S, Gurumurthy BR,
Ravikanth G, Ramanan US,
Shivanna MB. Endophytic fungi from
Miquelia dentata Bedd., produce the
anti-cancer alkaloid, camptothecine.
Phytomedicine. 2013;20(3–4):337-342
[118] Su H, Kang J-c, Cao J, Mo L,
Hyde KD. Medicinal plant endophytes
produce analogous bioactive
compounds. Chiang Mai Journal of
Science. 2014;41(1):1-13
kinetic modeling of cell-associated
camptothecin production from an
endophytic Fusarium
oxysporum NFX06. Preparative
Biochemistry and Biotechnology. 2015;
45(2):158-172
[120] Venugopalan A, Srivastava S.
Enhanced camptothecin production by
ethanol addition in the suspension
culture of the endophyte, Fusarium
solani. Bioresource Technology. 2015;
188:251-257
[121] Pu X, Chen F, Yang Y, Qu X,
Zhang G, Luo Y. Isolation and
characterization of Paenibacillus
polymyxa LY214, a camptothecinproducing endophytic bacterium from
Camptotheca acuminata. Journal of
Industrial Microbiology and
Biotechnology. 2015;42(8):1197-1202
[122] Bhalkar BN, Patil SM,
Govindwar SP. Camptothecine
production by mixed fermentation of
two endophytic fungi from
Nothapodytes nimmoniana. Fungal
Biology. 2016;120(6–7):873-883
[123] Soujanya KN, Siva R, Mohana
Kumara P, Srimany A, Ravikanth G,
Mulani FA, et al. Camptothecinproducing endophytic bacteria from
Pyrenacantha volubilis Hook.
(Icacinaceae): A possible role of a
plasmid in the production of
camptothecin. Phytomedicine. 2017;36:
160-167
[124] Aswini A, Soundhari C. Production
of camptothecin from endophytic fungi
and characterization by high-performance
liquid chromatography and anticancer
activity against colon cancer cell line.
Asian Journal of Pharmaceutical and
Clinical Research. 2018;11(3):166-170
[119] Musavi SF, Dhavale A,
Balakrishnan RM. Optimization and
[125] Clarance P, Lalitha J, Sales J,
Khusro A, Agastian P. Anticancer
The
54
https://t.me/medicina_free
Endophytes: A New Resource for Vulnerable Plant Bioactive Compounds
ITexLi.112931
activity of camptothecin producing
endophytes isolated from Chonemorpha
fragrans (moon) Alston. (Apocynaceae).
Research Journal of Biotechnology. 2019;
14(5):74-82
[126] Ghiasvand M, Makhdoumi A,
Matin MM, Vaezi J. Exploring the
bioactive compounds from endophytic
bacteria of a medicinal plant: Ephedra
foliata (Ephedrales: Ephedraceae).
Advances in Traditional Medicine. 2020;
20:61-70
[127] Aswani R, Jasim B, Arun Vishnu R,
Antony L, Remakanthan A,
Aravindakumar CT, et al. Nanoelicitor
based enhancement of camptothecin
production in fungi isolated from
Ophiorrhiza mungos. Biotechnology
Progress. 2020;36(6):e3039
[128] Mohinudeen IAHK, Kanumuri R,
Soujanya KN, Shaanker RU, Rayala SK,
Srivastava S. Sustainable production of
camptothecin from an Alternaria sp.
isolated from Nothapodytes
nimmoniana. Scientific Reports. 2021;
11(1):1478
[129] Dhakshinamoorthy M,
Ponnusamy SK, Nyayiru Kannaian UP,
Srinivasan B, Shankar SN, Kilavan PK.
Plant-microbe interactions implicated in
the production of camptothecin – An
anticancer biometabolite from
Phyllosticta elongata MH458897 a novel
endophytic strain isolated from
medicinal plant of Western Ghats of
India. Environmental Research. 2021;
201:111564
[131] El-Sayed ASA, Hassan WHB,
Sweilam SH, Alqarni MH, El Sayed ZI,
Abdel-Aal MM, et al. Production,
bioprocessing and anti-proliferative
activity of Camptothecin from
Penicillium chrysogenum, an endozoic
of marine sponge, Cliona sp., as a
metabolically stable Camptothecin
producing isolate. Molecules. 2022;27:9
[132] El-Sayed ASA, George NM, Abou-
Elnour A, El-Mekkawy RM, ElDemerdash MM. Production and
bioprocessing of camptothecin from
Aspergillus terreus, an endophyte of
Cestrum parqui, restoring their
biosynthetic potency by Citrus limonum
peel extracts. Microbial Cell Factories.
2023;22(1):4
[133] Degambada KD, Kumara PAASP,
Salim N, Abeysekera AM,
Chandrika UG, Diaporthe sp. F18; a new
source of camptothecin-producing
endophytic fungus from Nothapodytes
nimmoniana growing in Sri Lanka.
Natural Product Research. 2023;37(1):
113-118
[134] Xianzhi Y, Shiping G, Lingqi Z,
Hua S. Select of producing
podophyllotoxin endophytic fungi from
podophyllin plant. Natural Product
Research and Development. 2003;15(5):
419-422
[135] Zeng S, Shao H, Zhang L. An
endophytic fungus producing a
substance analogous to podophyllotoxin
isolated from Diphylleia sinensis. Journal
of Microbiology. 2004;24:1-2
[130] El-Sayed ASA, Khalaf SA, Azez HA,
Hussein HA, El-Moslamy SH, Sitohy B,
et al. Production, bioprocess
optimization and anticancer activity of
Camptothecin from aspergillus terreus
and aspergillus flavus, endophytes of
Ficus elastica. Process Biochemistry.
2021;107:59-73
[136] Guo S, Jiang B, Su Y, Liu S,
Zhang L. Podophyllotoxin and its
analogues from the endophytic fungi
derived from Dysosma veitchii.
Biotechnology. 2004;14:55-57
[137] Lu L, He J, Yu X, Li G, Zhang X.
Studies on isolation and identification of
Medicinal Plants – Chemical, Biochemical, and Pharmacological Approaches
55
https://t.me/medicina_free
endophytic fungi strain SC13 from
harmaceutical plant Sabina vulgaris ant.
and metabolites. Acta Agriculturae
Boreali-occidentalis Sinica. 2006;15:
85-89
[138] Eyberger AL, Dondapati R,
Porter JR. Endophyte fungal isolates
from Podophyllum peltatum produce
podophyllotoxin. Journal of Natural
Products. 2006;69(8):1121-1124
[139] Puri SC, Nazir A, Chawla R,
Arora R, Riyaz-ul-Hasan S, Amna T,
et al. The endophytic fungus Trametes
hirsuta as a novel alternative source of
podophyllotoxin and related aryl tetralin
lignans. Journal of Biotechnology. 2006;
122(4):494-510
[140] Li C. Fermentation conditions of
Sinopodophyllum hexandrum
endophytic fungus on production of
podophyllotoxin. Food and
Fermentation Industries. 2007;33(9):28
[141] Kour A, Shawl AS, Rehman S,
Sultan P, Qazi PH, Suden P, et al.
Isolation and identification of an
endophytic strain of Fusarium
oxysporum producing podophyllotoxin
from Juniperus recurva. World Journal
of Microbiology and Biotechnology.
2008;24:1115-1121
[142] Nadeem M, Ram M, Alam P,
Ahmad MM, Mohammad A, Al-Qurainy
F, et al. Fusarium solani, P1, a new
endophytic podophyllotoxin-producing
fungus from roots of Podophyllum
hexandrum. African Journal of
Microbiology Research. 2012;6(10):
2493-2499
[143] Huang J-X, Zhang J, Zhang X-R,
Zhang K, Zhang X, He X-R. Mucor
fragilis as a novel source of the key
pharmaceutical agents podophyllotoxin
and kaempferol. Pharmaceutical Biology.
2014;52(10):1237-1243
[144] Liang Z, Zhang J, Zhang X, Li J,
Zhang X, Zhao C. Endophytic fungus
from Sinopodophyllum emodi (wall.)
ying that produces Podophyllotoxin.
Journal of Chromatographic Science.
2016;54(2):175-178
[145] Aharwal RP, Kumar S, Sandhu SS.
Endophytic mycoflora as a source of
biotherapeutic compounds for disease
treatment. Journal of Applied
Pharmaceutical Science. 2016;6(10):
242-254
[146] Wang T, Ma Y, Ye Y, Zheng H,
Zhang B, Zhang E. Screening and
identification of endophytic fungi
producing podophyllotoxin compounds
in Sinopodophyllum hexandrum stems.
Chinese Journal of Experimental
Traditional Medical Formulae. 2017;39:
402-408
[147] Tan X-m, Zhou Y-q, Zhou X-l,
Xia X-h, Wei Y, He L-l, et al. Diversity
and bioactive potential of culturable
fungal endophytes of Dysosma
versipellis; a rare medicinal plant
endemic to China. Scientific Reports.
2018;8(1):5929
[148] Gohar UF, Attia Majeed BM,
Mukhtar H. Optimum conditions for
enhanced production of Podophyllotoxin
from Penicillium sp. isolated from
Khanspur, Pakistan. Pakistan Journal of
Zoology. 2022;54(6):2775
[149] Thi Tran H, Thu Nguyen G, Thi
Nguyen HH, Thi Tran H, Hong Tran Q,
Ho Tran Q, et al. Isolation and cytotoxic
potency of endophytic fungi associated
with Dysosma difformis, a study for the
novel resources of Podophyllotoxin.
Mycobiology. 2022;50(5):389-398
[150] Nguyen GT, Nguyen HTH,
Tran HT, Tran HT, Ho AN, Tran QH,
et al. Enhanced podophyllotoxin
production of endophyte Fusarium
The
56
https://t.me/medicina_free
Endophytes: A New Resource for Vulnerable Plant Bioactive Compounds
ITexLi.112931
proliferatum TQN5T by host extract and
phenylalanine. Applied Microbiology
and Biotechnology. 2023;107(17):
5367-5378
[151] Kusari S, Lamshöft M, Spiteller M.
Aspergillus fumigatus Fresenius, an
endophytic fungus from Juniperus
communis L. Horstmann as a novel
source of the anticancer pro-drug
deoxypodophyllotoxin. Journal of
Applied Microbiology. 2009;107(3):
1019-1030
[152] Li W, Zhou J, Lin Z, Hu Z. Study on
fermentation condition for production of
huperzine a from endophytic fungus
2F09P03B of Huperzia serrata. Chinese
Medicinal Biotechnology. 2007;2(4):
254-259
[153] Zan J, Wang J, Pan S. Isolation and
preliminary identification of the
endophytic fungi which produce
Hupzine a from four species in
Hupziaceae and determination of
Huperzine a by HPLC. Fudan University
Journal of Medical Sciences. 2009;36(4):
445-449
[157] Wang Y, Yan R, Zeng Q, Zhang Z,
Wang D, Zhu D. Producing huperzine a
by an endophytic fungus from Huperzia
serrata. Mycosystema. 2011;30(2):
255-262
[158] Wang Y, Zeng QG, Zhang ZB,
Yan RM, Wang LY, Zhu D. Isolation and
characterization of endophytic
huperzine A-producing fungi from
Huperzia serrata. Journal of Industrial
Microbiology and Biotechnology. 2011;
38(9):1267-1278
[159] Shu S, Zhao X, Wang W, Zhang G,
Cosoveanu A, Ahn Y, et al. Identification
of a novel endophytic fungus from
Huperzia serrata which produces
huperzine a. World Journal of
Microbiology and Biotechnology. 2014;
30:3101-3109
[160] Dong L-H, Fan S-W, Ling Q-Z,
Huang B-B, Wei Z-J. Indentification of
huperzine A-producing endophytic
fungi isolated from Huperzia serrata.
World Journal of Microbiology and
Biotechnology. 2014;30:1011-1017
[154] Zhou S, Yang F, Lan S, Xu N,
Hong Y. Huperzine a producing
conditions from endophytic fungus in
SHB Huperzia serrata. Journal of
Microbiology. 2009;3:32-36
[155] Zhu D, Wang J, Zeng Q, Zhang Z,
Yan R. A novel endophytic Huperzine
A–producing fungus, Shiraia sp. Slf14,
isolated from Huperzia serrata. Journal
of Applied Microbiology. 2010;109(4):
1469-1478
[156] Zhang ZB, Zeng QG, Yan RM,
Wang Y, Zou ZR, Zhu D. Endophytic
fungus Cladosporium cladosporioides
LF70 from Huperzia serrata produces
Huperzine A. World Journal of
Microbiology and Biotechnology. 2011;
27:479-486
[161] Su J, Yang M. Huperzine a
production by Paecilomyces tenuis YS13, an endophytic fungus isolated from
Huperzia serrata. Natural Product
Research. 2015;29(11):1035-1041
[162] Han W, Song T, Yang S, Li X,
Zhang H, Wu Y, et al. Identification of
alkaloids and huperzine A-producing
endophytic fungi isolated from wild
Huperzia serrata. Journal of
International Pharmaceutical Research.
2015;6:507-512
[163] Zhang F, Wang M, Zheng Y, Liu H,
Zhang X, Wu S. Isolation and
characterzation of endophytic
Huperzine A-producing fungi from
Phlegmariurus phlegmaria.
Microbiology. 2015;84:701-709
Medicinal Plants – Chemical, Biochemical, and Pharmacological Approaches
57
https://t.me/medicina_free
[164] Wang Y, Lai Z, Li X-X, Yan R-M,
Zhang Z-B, Yang H-L, et al. Isolation,
diversity and acetylcholinesterase
inhibitory activity of the culturable
endophytic fungi harboured in Huperzia
serrata from Jinggang Mountain, China.
World Journal of Microbiology and
Biotechnology. 2016;32:1-23
[165] Thi Minh Le T, Thi Hong Hoang A,
Thi Bich Le T, Thi Bich Vo T, Van
Quyen D, Hoang CH. Isolation of
endophytic fungi and screening of
Huperzine A–producing fungus from
Huperzia serrata in Vietnam. Scientific
Reports. 2019;9(1):16152
[166] Zaki AG, El-Shatoury EH,
Ahmed AS, Al-Hagar OE. Production
and enhancement of the
acetylcholinesterase inhibitor, huperzine
a, from an endophytic Alternaria
brassicae AGF041. Applied Microbiology
and Biotechnology. 2019;103:5867-5878
[167] Kang X, Liu C, Shen P, Hu L, Lin R,
Ling J, et al. Genomic characterization
provides new insights into the
biosynthesis of the secondary metabolite
huperzine a in the endophyte
Colletotrichum gloeosporioides
Cg01. Frontiers in Microbiology. 2019;
9:3237
[168] Wen-Xia H, Zhong-Wen H, Min J,
Han Z, Wei-Ze L, Li-Bin Y, et al. Five
novel and highly efficient endophytic
fungi isolated from Huperzia serrata
expressing huperzine a for the treatment
of Alzheimer’s disease. Applied
Microbiology and Biotechnology. 2020;
104:9159-9177
[170] Le TTM, Hoang ATH, Nguyen NP,
Le TTB, Trinh HTT, Vo TTB, et al. A
novel huperzine A-producing
endophytic fungus Fusarium sp. Rsp5.2
isolated from Huperzia serrate.
Biotechnology Letters. 2020;42(6):
987-995
[171] Putri NWPS, Ariantari NP.
Production of huperzine a by fungal
endophytes associated with huperziaceae
plants. Journal Pharmaceutical Science
and Application. 2023;5(1):45-52
[172] Ying Y-M, Shan W-G, Zhan Z-J.
Biotransformation of Huperzine a by a
fungal endophyte of Huperzia serrata
furnished sesquiterpenoid–alkaloid
hybrids. Journal of Natural Products.
2014;77(9):2054-2059
[173] Thirumalanadhuni V,
Yerraguravagari LL, Palempalli UMD.
Endophytic microflora: The
fountainhead of anticancer metabolites
—A systematic review. Recent
Developments in Applied Microbiology
and Biochemistry. 2021;2:13-20
[174] Madhusudhan CM, Bharathi RT,
Prakash SH. Isolation and purification of
bioactive metabolites from fungal
endophytes–a review. Current
Biochemical Engineering. 2015;2(2):
111-117
[175] Song X, Wu H, Yin Z, Lian M,
Yin C. Endophytic bacteria isolated from
Panax ginseng improves ginsenoside
accumulation in adventitious ginseng
root culture. Molecules. 2017;22(6):837
[169] Cruz-Miranda OL, Folch-Mallol J,
Martínez-Morales F, Gesto-Borroto R,
Villarreal ML, Taketa AC. Identification
of a Huperzine A-producing endophytic
fungus from Phlegmariurus taxifolius.
Molecular Biology Reports. 2020;47(1):
489-495
[176] Fu Y, Yin ZH, Yin CY.
Biotransformation of ginsenoside Rb1 to
ginsenoside Rg3 by endophytic
bacterium Burkholderia sp. GE 17-7
isolated from Panax ginseng. Journal of
Applied Microbiology. 2017;122(6):
1579-1585
The
58
https://t.me/medicina_free
Endophytes: A New Resource for Vulnerable Plant Bioactive Compounds
ITexLi.112931
Fu Y. Biotransformation of
[177]
ginsenoside
ginsenoside
bacterium
isolated
Applied
Rb1 to gyp-XVII and minor
Rg3 by endophytic
Flavobacterium sp. GE 32
from Panax ginseng. Letters in
Microbiology. 2019;68(2):
134-141
Yang H-R, Yuan J, Liu L-H,
[178]
Zhang
W,
Chen F, Dai C-C. Endophytic
Pseudomonas
sesquiterpenoid
by
gibberellic acid and jasmonic acid in
Atractylodes
plantlets.
Culture
Yin DD, Wang YL, Yang M,
[179]
DK, Wang GK, Xu F. Analysis of
Yin
chuanxiong
production
Bacillus
performance
quadrupole time-of-flight mass
with
spectrometry.
fluorescens induced
accumulation mediated
macrocephala Koidz
Plant Cell, Tissue and Organ
(PCTOC). 2019;138:445-457
Rhizoma substrate on
of
ligustrazine in endophytic
subtilis by ultra high
liquid chromatography
Journal of Separation
Science. 2019;42(19):3067-3076
[180]
Hemmati N, Azizi M, Spina R,
F,
Dupire
Accumulation
vinblastine
Arouei H, Saeedi M, et al.
of
ajmalicine and
in
cell cultures is enhanced
by endophytic fungi of Catharanthus
cv. icy pink. Industrial Crops and
roseus
Products.
2020;158:112776
Chapter 4
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A Review in Medical,
Pharmacological and Industrial
Importance of Roselle Hibiscus
sabdariffa L.
A
li S.Hassoon, Ahmed A.Kadhim and Madeha H.Hussein
Abstract
Medicinal plants and plants occupy a major place in the world’s agricultural and
industrial production as the main source of pharmaceutical drugs or as a source of
active substances that are used in the preparation of medicine. The Roselle plant
Hibiscus sabdariffa L.(Malvaceae Family) is known in Arabic as “karkade” and
“Roselle”. The continental regions of Africa and Asia are the original home of the
Roselle. The months of March and April and proceeds to reap the fruits during the
months of October to the end of December. Recent researches and studies have
pointed to the use of Roselle plant in the medical, food and industrial fields. It is used
in the manufacture of jellies and jams. The syrup is added to some medical preparations. It is refreshing, moisturizing, and helps digestion. It is also a useful drink in
the cases of bile. It causes urination and acts as an antifungal agent. and is used in the
treatment of high blood pressure, It is also used in cancer treatment.
Keywords: rosella, medicinally plants, pharmcological uses, industrial uses of rosella,
rosella as food
. Introduction
The current interest is in the exploitation of the active substances of some pharmaceutical plants and their manufacture as important medical drugs for the treatment of
many diseases and for the prevention, treatment and pain relief, and therefore these
plants have taken a great deal of attention and studies as the main source of these
drugs and the manufacture of safe medicines [1]. It has been used in many countries
of the world to treat various viral and microbial diseases because they are more useful
in different treatment stages and are safer and less expensive compared to laboratorybased chemical treatments [2].
Hibiscus sabdariffa L., which belongs to the Malvaceae family, is a medically
important plant [3]. Its medicinal significance is concentrated in its leaves, which are
a source of Hibiscus, which has a medical effect. Its leaves are rich in vitamin C, citric,
Medicinal Plants – Chemical, Biochemical, and Pharmacological Approaches
60
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Tartaric, It also contains Protocatechuic Acid (PCA), an important antioxidant as well
as its role in the treatment of certain cancers [4].
It is used as a refreshing beverage for the purpose of tempering the high temperatures and uses the red dye produced artificially as food nutritious natural food, and
also enters the manufacture of jams, ice, candy, and food preservation, and the seeds
contain a high proportion of oil up to the limit of 20–25% 30–35% protein [5].
. Plant classification and naming
Hibiscus sabdariffa L. belongs to the Malvaceae family of Malvales, a Sabdariffa
species of Hibiscus, a plant covered with Angiosperms dicotyledons seeds [6].
The origin of the name of the Rosella comes back to the area of Gujarat in India,
and it is known by many names that differ from one region to another. The common
name in Iraq is al-Gujarat tea. It is also called kaajah, red acid, kardipip, and gypsy.
In Arab countries, it is called Karkade. In Brazil, it is called “Rosela” and is called
commercially in America (Hibiscus). In England, it is called rozelle, sorrel, sour.
In France, it is called “Bissap” and “Jamaica”. In North and East Africa it is called
“karkade or carcade” Senegal (bissap) and Nigeria (serrol) and in Iran is known as
(Chaye -Torosh) [7, 8].
. Plant description
Agglutaceous leafy plant with roots, spines, and legs, cylindrical with a smooth
texture and greenish-red color, up to more than two meters depending on the variety.
The leaves are simple, reciprocal, hand-shaped, finely edged, greenish-red, longnecked and long-necked. The leaves are white, yellow or red, consisting of five large,
thick, succulent, thick leaves. The fruits are capsules containing a large number of
kidney seeds. The texture is dark brown (Figure ) [9, 10].
Figure 1.
Cultivation of rosella in my field of research.
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