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Carbon-Based Nanostructured Materials: Designing, Properties and Applications

Verónica Esparza-Cordero, Camila Castanedo-Carrillo, Alain R. Picos-Benítez, and Blanca L. Martínez-Vargas
Abstract Carbon (C) is considered the most abundant element on the planet, so
it is desirable to be applied to different studies. Carbon nanostructures are present in several shapes and forms, each with different properties that their nanometric size can modify. Carbon nanotubes (CNTs) and graphene show unique electronic, optical, mechanical, and chemical properties, which has led to the development of new nanomaterials with unique properties and new devices. The application of these novel nanomaterials will depend mainly on the synthesis method, where chemical vapor deposition is the most used, using graphite as the primary precursor. The applications of CNTs and graphene are in the electronic industry for storage energy in electronic devices; some other multifunctional materials are used as catalysts and sensors, and carbon-based nanomaterials are reported to be used in the medical area due to their antibacterial properties. Its small size and weight suggest potential uses in wearable equipment, sensors, devices, and medications that can contribute to diseases such as cancer. This chapter describes the different structures of carbon, its synthesis methods currently used, and the main properties that make it attractive in health sciences areas.
Keywords Carbon-based nanostructure Biosensing·Drug delivery
· Synthesis techniques · Wound healing ·
Abbreviations
˙OH Hydroxyl
μs Microseconds
V. Esparza-Cordero Unidad Profesional Interdisciplinaria de Ingeniería Campus Zacatecas, Instituto Politécnico Nacional, 98160, Zacatecas, México
C. Castanedo-Carrillo · A. R. Picos-Benítez · B. L. Martínez-Vargas ( Centro de Estudios Científicos y Tecnológicos No. 18, Instituto Politécnico Nacional, 98160, Zacatecas, México e-mail: bmartinezv@ipn.mx
B
)
39
40 V. Esparza-Cordero et al.
CD Carbon dots CNH Carbon nanohorns CNM Carbon nanomaterials CNO Carbon nano-onions CNT Carbon nanotubes CPT Camptothecin CS Chitosan DNA Deoxyribonucleic acid DOX Doxorubicin GO Graphene oxide GQDs Graphene quantum dots HA Hyaluronic acid HCoV-229E7 Human coronavirus HIV-1 Immunodeficiency virus MRSA Methicillin-resistant S. aureus MWCNT Multi-walled carbon nanotubes ND Nanodiamonds NIR Near-infrared ns Nanoseconds PDT Photodynamic therapy PL Photoluminescence PLLA Poly-L-lactic acid PTT Photothermal therapy rGO Reduced graphene oxide RNA Ribonucleic acid ROS Reactive oxygen species S42 Schwann cells SWCNH/SWNHs Single-walled carbon nanohorns

1 Introduction

Carbon-based materials have multiple applications derived from their different crys­talline structures. Furthermore, as it is the most abundant element on the planet, it can be used individually or in conjunction with other hybrid materials to be applied as a base for solar cells, as a photocatalyst, in the design and construction of biosensors, in the health area, as already mentioned. Technological advances have allowed the development of new sciences, such as nanoscience and nanotechnology, which have allowed the study and development of nanoscale materials that range from structures on metal based to carbon based. Regarding those that are carbon based, we find materials such as fullerene, graphene and its derivatives, nanotubes, nanodiamonds, carbon quantum dots, and all derivatives, materials due to their physical, chemical, and biological properties range from their size, its chemical bonds, the surface area,
Carbon-Based Nanostructured Materials: Designing … 41
the ability to combine with other chemical elements, its biocompatibility, its photo­luminescent capacity, high resistance, and electrical conductivity [1, 2]. They are undoubtedly materials with various applications in the medical area for the diag­nosis and treatment of diseases, through their use for the marking of tumor cells or for their use in the arrest of target molecules and creation of biosensors, as well as the destruction of the same by photodynamic or photothermal therapy, as well as to be used as drug vehicles to treat various pathologies of various kinds, including infec­tious diseases due to their antimicrobial and antiviral capacity, in addition to being used as a scaffolding structure for the development and proliferation of cells and tissues, its use covers the agricultural industry for the development of biofertilizers, as well as the environmental industry to determine contaminating biosensors and the remediation of contaminated soils or waters [2, 3]. This describes the character­istics and general properties of carbon-based nanomaterials and some applications, highlighting their use in health.
2 Types of Carbon-Based Nanostructured Materials:
Structure Analysis
Carbon could be defined as one of the elements that are found in the Earth’s crust in abundance. Nanostructured carbon materials, also known as “NCMs,” give a variety of allotropes, some of the ones that can be mentioned: diamond, graphene (GR), amorphous carbon, carbon nanotubes (CNTs), and carbon dot (CDs) with a consid­erable number of electrochemical applications. As mentioned earlier, carbon can be organized into several dimensions, from zero- to three-dimensional nanomaterials, which will give the material its properties.

2.1 Zero-Dimensional Carbon-Based Nanostructures (0D)

Among these dimensional nanostructures, we can find some carbonaceous graphitic nanoparticles (NPs), such as carbon-based (CQD) and graphene-based (GQD) quantum dots (Fig. 1), which have potential applications in the development of new electronic devices. This carbon nanostructure has gained attention, and because of that, it is considered an alternative material for developing new semiconductors due to its enhanced properties. Due to this, researchers have been inspired to employ them in many things, such as bioimaging, optoelectronic, catalytic, and energy storage applications [4].
42 V. Esparza-Cordero et al.
Fig. 1 Carbon-based nanostructures (fullerene C
) zero dimensional (0D)
60

2.2 One-Dimensional Carbon-Based Nanostructures

One of the principal characteristics of one-dimensional (1D) carbon nanostructures is that they can be used in different fields, which has led researchers to work in various applications. The primary study nanomaterials are carbon nanotubes (CNT), used as the central precursor materials for graphite sheets; the main structure formed by this precursor is cylindrical. However, some carbon allotropes can present a high length­to-diameter ratio. Usually, CNTs are tubular; the main property of this nanostructure is that their carbon atoms can present a hexagonal arrangement in a sheet. CNTs present some attractive characteristics, such as enhanced mechanical properties that allow these nanomaterials to develop new construction constituents. Also, CNTs have recently gained particular attention in developing new electronic device fields because of their unique electronic properties. CNTs have a high Young’s modulus, and it has been proved that the rigid molecules that compound these materials are more resistant than steel; also, CNTs are good conductors of heat and electricity. Finally, CNTs have been used to construct new sensors with real potential in nano­electromechanical systems (NEMS). The structures of these materials provide new functionality or enhance the performance of the newly developed devices [5]. The synthesis of 1D carbon nanostructures includes nanotubes, nanofibers, and nanowires (Fig. 2).

2.3 Two-Dimensional (2D) Carbon-Based Nanostructures

Recently, graphene has been increasingly used to synthesize new nanomaterials, and it is highly abundant, has the characteristic of building block of natural graphite, and is also a good electricity conductor. This new material has excellent conductive, optical properties like carbon nanotubes. It also has some other specific characteristics; the main structure is a 2D atomic sheet-like structure, which allows graphene to
Carbon-Based Nanostructured Materials: Designing … 43
Fig. 2 One-dimensional (1D) carbon-based nanostructures (carbon nanotubes)
Fig. 3 Two-dimensional (2D) carbon-based nanostructures (graphene)
empower various electronic devices via the quantum Hall effect and massless Dirac fermions. Graphene nanomaterials present some other exceptional characteristics like a high surface area, which is the result of an ultra-thin or small formed material, brilliant electrical conductivity, and enhanced mechanical flexibility, among others; graphene can also be used in the synthesis of new nanocomposites with that can be used in many electrochemical applications. Due to the atomically thin structure and consequent quantum confinement effect, 2D nanomaterials have remarkable physical and chemical properties [1, 5]. The structure of graphene is represented in Fig. 3.

2.4 Three-Dimensional (3D) Carbon-Based Nanostructures

Because of their structural interconnectedness, three-dimensional carbon-based nanostructures produce hierarchical porous channels with higher electrical conduc­tivity. Additionally, its structural-mechanical stability is superior. Recently, there has also been increased interest in various sectors regarding three-dimensional struc­tured nanodiamonds (ND) (Fig. 4), which are formed via high-energy conduction
44 V. Esparza-Cordero et al.
Fig. 4 Three-dimensional (3D) carbon-based nanostructures (nanodiamond)
of graphite, typically by explosion. They are primarily made of sp3carbon, and in practical application, various functional groups have been used to surface-functioned diamonds. Compared to 2D substrates, 3D structures are much better because they can offer more “hot spots,” which significantly promote the adsorption of probe molecules and a more significant specific surface area. Among the synthesized newly graphene-based 3D spatial SERS nanoparticles, we can find nanoporous structures and various layers connecting spatial sandwich structures between graphene and noble metal NPs, and others are examples of structures [1, 6].
3 Synthesis of Carbon-Based Nanostructured Materials
and Applications

3.1 Chemical Vapor Deposition

This method is one of the most common. It consists of the evaporation of the reactive compounds that can be in a solid or liquid phase and, after being evaporated, can be deposited in a substrate that can be another material or a layer composed of organic or inorganic material [710]. Chemical vapor deposition (CVP) has a great potential to produce graphene-based materials with a large area and high quality. The quality and size of the synthesized materials will depend on the pressure and temperature used during the process. Also, compared to other methods, CVP uses catalysts and some precursors instead of solvents. Carbon is almost not soluble in copper, which allows the deposition of several graphene layers; thus, it is the most used catalyst. Carbon precursor methane is preferably used because it has been widely studied [911].
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