Добавил:
Sekretar
kiopkiopkiop18@yandex.ru
t.me/Prokururor I Вовсе не секретарь, но почту проверяю
Опубликованный материал нарушает ваши авторские права? Сообщите нам.
Вуз:
Предмет:
Файл:Ординатура / Хирургия / Библиотека им академика М.И. Перельмана / Книга_5604_Библиотеки_им_академика_М_И_Перельмана.pdf
X
- •Carbon Based Nanomaterials for Drug Delivery
- •Preface
- •Acknowledgements
- •Contents
- •Editor and Contributors
- •Abbreviations
- •1.2 Market Statistics
- •Carbon-Based Nanomaterials: An Overview
- •1. Introduction
- •1.1 Evolution of Carbon-Based Nanomaterials
- •2. Carbon-Based Nanostructures
- •2.1 Fullerene
- •2.2 Carbon Nanotubes (CNTs)
- •2.4 Graphene
- •2.5 Nanodiamonds (NDs)
- •2.6 Nano-Onions (CNOs)
- •2.7 Nanohorns (CNHs)
- •2.8 Carbon Dots (CDs)
- •2.9 Nanoporous Activated Carbon
- •3. Synthesis Techniques
- •4. Properties of Carbon-Based Nanomaterials
- •4.1 Physicochemical Properties
- •4.2 Thermal Properties
- •4.3 Mechanical Properties
- •4.4 Optoelectronic Properties
- •4.5 Antimicrobial Properties
- •4.6 Biological Properties
- •5. Applications of Carbon-Based Nanomaterials
- •5.1 Environmental Remediation
- •5.2 Agriculture
- •5.3 Biofuel
- •5.4 Energy Storage
- •5.5 Biomedical Applications
- •6. Challenges and Future Perspectives
- •7. Concluding Remarks
- •References
- •Carbon-Based Nanostructured Materials: Designing, Properties and Applications
- •1. Introduction
- •2.1 Zero-Dimensional Carbon-Based Nanostructures (0D)
- •2.2 One-Dimensional Carbon-Based Nanostructures
- •2.3 Two-Dimensional (2D) Carbon-Based Nanostructures
- •2.4 Three-Dimensional (3D) Carbon-Based Nanostructures
- •3.1 Chemical Vapor Deposition
- •3.2 Hydrothermal and Solvothermal Techniques
- •3.3 Microwave-Assisted Technique
- •3.4 Chemical Oxidation Synthesis
- •4. Properties of Carbon-Based Nanostructured Materials
- •4.1 Thermal Properties
- •4.2 Mechanical Properties
- •4.3 Optoelectronic Properties
- •4.4 Antimicrobial Properties
- •4.5 Biological Properties
- •5. Applications of Carbon-Based Nanostructured Materials
- •5.2 Antibacterial and Antiviral Applications
- •5.3 Theragnostic
- •5.4 Wound Healing
- •5.5 Tissue Engineering
- •5.6 Drug Delivery
- •5.7 Biosensing
- •6. Challenges and Future Perspectives
- •7. Concluding Remarks
- •References
- •Drug Delivery System and Technologies
- •1. Introduction
- •2. Drug Delivery System
- •2.1 Conventional Drug Delivery System
- •2.2 Advanced Drug Delivery System
- •2.3 Controlled and Sustainable Drug Delivery System
- •3. Drug Delivery Technologies
- •3.1 Active and Passive Drug Delivery
- •3.2 Smart Drug Delivery
- •3.3 Intravenous and Extravaneous Drug Delivery
- •3.4 Various Types of Delivery Technologies
- •4. Challenges and Future Perspectives
- •5. Conclusion
- •References
- •Carbon-Based Nanomaterials for Drug Delivery: Past, Present, Future Directions
- •1. Introduction
- •3. Current Status in Drug Delivery by CNMs
- •3.1 Graphene-Based Nanomaterials in Drug Delivery
- •3.4 Nanodiamond Based Drug Delivery Systems
- •3.5 Nano-Onions in Drug Delivery
- •3.6 Nanohorns in Drug Delivery
- •3.7 Fullerene in Drug Delivery
- •4. Challenges and Future Perspective
- •5. Conclusions
- •References
- •Carbon Nanomaterial-Incorporated Supramolecular Drug Delivery
- •1. Introduction
- •2. Different Carbon Nanomaterials in Drug Delivery
- •2.1 Carbon Nanotubes (CNTs)
- •2.3 Graphene
- •2.4 Carbon Quantum Dots
- •2.5 Fullerene
- •2.6 Carbon Nanohorns
- •2.7 Carbon Nano-Onions
- •2.8 Nano-Diamond
- •3. Supramolecular Chemistry in Drug Delivery
- •3.1 Principles of Supramolecular Chemistry
- •3.3 Applications of Supramolecular Biomaterials
- •4. Carbon Nanomaterial-Incorporated Supramolecular Drug Delivery
- •5.1 Cyclodextrins
- •5.2 Calixarenes
- •5.3 Cucurbituril
- •5.4 Pillarenes
- •5.5 Crown Ether
- •6. Toxicity Concerns of Carbon Nanomaterials
- •7. Improving the Effectiveness of Nanoparticle Systems
- •8. Future of Nanomedicine
- •9.1 Challenges
- •9.2 Future Perspectives and Opportunities
- •9.3 Conclusions
- •References
- •Carbon Nanomaterial-Based Polymeric Nanocomposites for Drug Delivery
- •1. Introduction
- •2.1 Carbon Quantum Dot-Based Polymer Nanocomposite
- •2.2 Carbon Nanotube-Based Polymer Nanocomposite
- •2.3 Graphene Quantum Dot-Based Polymer Nanocomposite
- •2.5 Fullerene-Based Polymer Nanocomposite
- •2.6 Nanodiamond-Based Polymer Nanocomposite
- •3. Drug Delivery Systems Using Carbon Nanomaterial
- •3.1 Anticancer Drug Delivery
- •3.3 Infectious Disease Drug Delivery
- •3.4 Topical Drug Delivery
- •3.5 Brain Drug Delivery
- •3.6 Oral Drug Delivery
- •4. Challenge and Future Perspectives
- •5. Conclusion
- •References
- •Carbon Nanomaterial-Incorporated Polysaccharide-Based Nanocomposite for Drug Delivery
- •1. Introduction
- •1.1 Drug Delivery
- •1.2 Carbon Nanomaterials
- •1.3 Polysaccharide-Based Nanocomposite
- •2.1 CN-Incorporated Alginate-Based Nanocomposite
- •2.2 CN-Incorporated Cellulose-Based Nanocomposite
- •2.3 CN-Incorporated Chitosan-Based Nanocomposite
- •2.4 CN-Incorporated Dextran-Based Nanocomposite
- •2.5 CN-Incorporated Hyaluronic Acid-Based Nanocomposite
- •2.6 CN-Incorporated Starch-Based Nanocomposite
- •2.7 CN-Incorporated Pectin-Based Nanocomposite
- •2.8 CN-Incorporated Guar Gum-Based Nanocomposite
- •2.9 CN-Incorporated Agarose-Based Nanocomposite
- •2.10 CN-Incorporated Carrageenan-Based Nanocomposite
- •2.11 CN-Incorporated Glucomannan-Based Nanocomposite
- •3. Challenges and Future Prospective
- •4. Concluding Remarks
- •References
- •Graphene-Based Nanomaterials for Drug Delivery
- •1. Introduction
- •1.1 Challenges in Conventional Drug Delivery Systems
- •1.2 Overview of Nanomaterials for Drug Delivery
- •1.3 Role of Graphene-Based Nanomaterials in Drug Delivery
- •2. Synthesis of Graphene
- •2.1 Chemical Reduction Method
- •2.2 Thermal Reduction
- •2.3 Electrochemical Reduction
- •2.4 Chemical Vapor Deposition Method
- •2.5 Mechanical Exfoliation
- •2.6 Epitaxial Growth Method
- •2.7 Growth in Solvothermal and Hydrothermal Systems
- •2.8 Electrochemical Deposition
- •3. Types of Graphene-Based Materials
- •3.1 Graphene Quantum Dots, (GQDs)
- •3.2 Graphene Oxide (GO)
- •3.3 Graphene Nanoribbons (GNRs)
- •3.4 Oxidized Graphene Nanoribbons
- •4. Graphene Functionalized Materials for Drug Delivery
- •4.1 In Bone Tissue Regeneration
- •4.2 In Neural Regeneration
- •4.3 In Photodynamic and Photothermal Therapy
- •4.4 In Enhancing Cellular and Humoral Immunity
- •4.6 Miscellaneous
- •5. Challenges and Future Perspective
- •6. Conclusion
- •References
- •Carbon Quantum Dots Based Materials for Drug Delivery
- •1. Introduction
- •2. Synthesis Process of Carbon Quantum Dots
- •2.1 Top-Down Approaches
- •2.2 Bottom-Up Approaches
- •2.3 Microwave-Assisted Method
- •2.4 Electrochemical Method
- •2.5 Laser Ablation Method
- •2.6 Pyrolysis Method
- •2.7 Template-Assisted Method
- •4. Challenges and Future Perspective
- •5. Concluding Remarks
- •References
- •Carbon-based Nanocarriers for Sustained Drug Release in Dentistry
- •1. Introduction
- •2.1 Oral Mucosa Structure
- •2.2 Sites for Drug Delivery
- •2.3 Permeability
- •3. Local Drug Delivery for Dental Diseases
- •3.1 Odontogenic Infection
- •3.2 Non-odontogenic Infection
- •4. Bio-adhesive Nanoparticles: Novel Treatment Modality
- •4.1 Bio-adhesive Nanoparticles
- •4.2 Mechanism of Bioadhesion
- •5.1 Carbon Nanotubes
- •5.2 Graphene
- •5.3 Nanodiamonds
- •5.4 Fullerenes
- •5.5 Porous Carbon
- •5.6 Carbon Dots
- •6. Drug Delivery Systems Based on CBNs
- •6.2 Immediate Drug Delivery System (IDDS)
- •6.3 Sustained-release Drug Delivery Systems
- •6.4 Controlled Drug Delivery System (CDDs)
- •8. Conclusion
- •References
- •Fullerene Based Materials for Drug Delivery
- •1. Introduction
- •2. Types of Fullerene Derivatives
- •2.1 Exohedral Fullerene Derivatives
- •2.2 Endohedral Fullerene Derivatives
- •2.3 Surface Derivatized Fullerenes
- •3. Interaction of Fullerene Derivatives for Drug Delivery
- •4. Fullerene Based Materials for Drug Delivery
- •4.1 Nucleic Acid Delivery
- •4.2 Peptide Delivery
- •4.3 Topical Drug Delivery
- •4.4 Infectious Diseases Drug Delivery
- •4.5 Anticancer Drug Delivery
- •4.7 Brain Drug Delivery
- •4.8 Ocular Drug Delivery
- •5. Challenges and Future Perspectives
- •6. Concluding Remarks
- •6.1 Abbreviations
- •References
- •Graphene Quantum Dots-based Nanomaterials for Drug Delivery
- •1. Introduction
- •2. Synthesis of GQDs
- •3. GQD’s Properties for Drug Delivery
- •3.1 Optical Properties
- •3.2 Physicochemical Properties
- •3.3 Mechanical Properties
- •3.4 Biocompatibility and Cytotoxicity
- •4. Characterization of GQDs-Based Nanomaterials
- •4.1 Characterization of Multifunctional GQDs-Based Nanomaterials
- •5.1 Strategies for Developing Medication Delivery Systems Based on GQD
- •5.2 PH-responsive Drug Delivery Systems (GQD-DDSs)
- •5.3 Targeted Drug Delivery Using Ligand-Based GQDs as a Mediator
- •5.4 Improvement of Medicines’ Pharmacological Properties Using GQDs
- •5.5 Enhancing Cytotoxicity with GQD-DDS
- •7. Applications of Chiral GQDs
- •10. Challenges and Future Perspectives
- •11. Conclusions
- •References
- •Carbon Nano-onions for Drug Delivery
- •1. Introduction
- •2. Carbon Nano-Onion: A Multi-Layered Nanocarrier
- •3. Synthesis of Carbon Nano-Onions
- •3.1 Annealing Method
- •3.2 Carbon Ion Implantation Method
- •3.3 Arc Discharge Method
- •3.4 Carbon Vapour Deposition Method
- •3.5 Pyrolysis Method
- •6. Carbon Nano-Onions in Drug Delivery
- •6.1 Delivery of Therapeutic Agents
- •6.2 Delivery of Targeting Agents
- •6.3 Delivery of Imaging Agents
- •7. Challenges and Future Perspectives
- •8. Concluding Remarks
- •References
- •Chitosan/Carbon Nanocomposites in Drug Delivery and Cardiovascular Diseases
- •1. Introduction
- •1.1 Drug Delivery
- •1.2 Cardiovascular Diseases
- •1.3 Chitosan and Its Properties
- •1.4 Chitosan/Carbon Nanocomposites
- •2. Chitosan/Carbon Nanocomposites in Drug Delivery
- •3. Chitosan/Carbon Nanocomposites in CVDs
- •3.1 Chitosan-Based Scaffolds
- •3.2 Chitosan in Cardiac Tissue Engineering
- •3.3 Chitosan-Based Cell Therapy
- •3.4 Chitosan-Based Gene Delivery
- •3.5 Chitosan-Protein Interaction
- •4. Challenges and Future Perspective
- •5. Concluding Remarks
- •References
- •Graphene Reinforced Chitosan Nanocomposites for Drug Delivery
- •1. Introduction
- •2. Chitosan: Structure and Properties
- •3. Graphene: Structure, Types and Properties
- •4.1 Electrospinning Method
- •4.2 Sol–gel Method
- •4.3 Solution Mixing Method
- •4.4 In-situ Polymerization Method
- •5.2 Chitosan/Graphene Aerogels
- •5.3 Chitosan/Graphene Hydrogels
- •5.4 Chitosan/Graphene Thin Films
- •6.1 Oral Drug Delivery
- •6.2 Mucosal Drug Delivery
- •6.3 Transdermal Drug Delivery
- •6.4 Parenteral Drug Delivery
- •7. Challenges and Future Perspectives
- •8. Concluding Remarks
- •References
- •1. Introduction
- •2. Functionalization of CNFs
- •2.1 The Need for Functionalization

Drug Delivery System and Technologies 95
molecularly imprinted polymers, intelligent biomaterials, quantum sensing, CRISPR
CAS9 based systems, 3D printing, and so on. The innovations in related technologies
will promote the new design of drug delivery system, which will ultimately provide
patients with personalized medication and improve therapeutic efficacy.
Acknowledgements Lei Nie acknowledges the support from the Nanhu Scholars Program for
Young Scholars of XYNU.
Conflicts of Competing Interest The authors declare no competing financial interest.
References
1. Adepu S, Ramakrishna S (2021) Controlled drug delivery systems: current status and future
directions. Mol 26(19):5905
2. Ezike TC, Okpala US, Onoja UL, Nwike CP, Ezeako EC, Okpara OJ, Okoroafor CC, Eze SC,
Kalu OL, Odoh EC, Nwadike UG, Ogbodo JO, Umeh BU, Ossai EC, Nwanguma BC (2023)
Advances in drug delivery systems, challenges and future directions. Heliyon 9(6):e17488
3. Vargason AM, Anselmo AC, Mitragotri S (2021) The evolution of commercial drug delivery
technologies. Nat Biomed Eng 5(9):951–967
4. Sun CC (2017) Microstructure of tablet-pharmaceutical significance, assessment, and engineering. Pharm Res 34(5):918–928
5. Sun CC (2009) Materials science tetrahedron–a useful tool for pharmaceutical research and
development. J Pharm Sci 98(5):1671–1687
6. Liu J, Zeng X, Chen Q, Cai Y,Chen F, Wang Y, Zhou H, Lin M, Shi J, Wang Z, Zhang Y (2006)
An evaluation on the efficacy and safety of amlexanox oral adhesive tablets in the treatment of
recurrent minor aphthous ulceration in a Chinese cohort: a randomized, double-blind, vehiclecontrolled, unparallel multicenter clinical trial. Oral Surg Oral Med Oral Pathol Oral Radiol
Endod 102(4): 475–481
7. De Koker S, Hoogenboom R, De Geest BG (2012) Polymeric multilayer capsules for drug
delivery. Chem Soc Rev 41(7):2867–2884
8. Bao Q, Burgess DJ (2018) Perspectives on physicochemical and in vitro profiling of ophthalmic
ointments. Pharma Res 35(12):234
9. Lozada-Nur F, Huang MZ, Zhou GA (1991) Open preliminary clinical trial of clobetasol
propionate ointment in adhesive paste for treatment of chronic oral vesiculoerosive diseases.
Oral Surg Oral Med Oral Pathol 71(3):283–287
10. Eccles R (2006) Mechanisms of the placebo effect of sweet cough syrups. Respir Physiol
Neurobiol 152(3):340–348
11. Gao MS, Liu S, Wang AW (2016) Preparation and clinical observation of Koukuining granules
in 50 patients with recurrent aphthous ulcer.Shanghai kou qiang yi xue = Shanghai J Stomatol
25(5):579–582
12. Purohit TJ, Hanning SM, Wu Z (2018) Advances in rectal drug delivery systems. Pharm
Develop Technol 23(10):942–952
13. Tiwari G, Tiwari R, Sriwastawa B, Bhati L, Pandey S, Pandey P, Bannerjee SK (2012) Drug
delivery systems: an updated review. Int J Pharm Investig 2(1):2–11
14. Ashique S, Sandhu NK, Chawla V, Chawla PA (2021) Targeted drug delivery: trends and
perspectives. Curr Drug Deliv 18(10):1435–1455
15. Li J, Mooney DJ (2016) Designing hydrogels for controlled drug delivery.Nat Rev Mater 1(12)
16. Hamidi M, Okoro OV, Milan PB, Khalili MR, Samadian H, Nie L, Shavandi A (2022)
Fungal exopolysaccharides: properties, sources, modifications, and biomedical applications.
Carbohydr Polym 284:119152

96 W. G uo e t al .
17. Chun C, Lee SM, Kim CW, Hong KY, Kim SY, Yang HK, Song SC (2009) Doxorubicinpolyphosphazene conjugate hydrogels for locally controlled delivery of cancer therapeutics.
Biomater 30:4752–4762
18. Nie L, Li J, Lu G, Wei X, Deng Y, Liu S, Zhong S, Shi Q, Hou R, Sun Y (2022) Temperature responsive hydrogel for cells encapsulation based on graphene oxide reinforced poly
(N-isopropylacrylamide)/hydroxyethyl-chitosan. Mater. Today Commun. 31:103697
19. Du XJ, Wang ZY, Wang YC (2018) Redox-sensitive dendrimersomes assembled from
amphiphilic Janus dendrimers for siRNA delivery. Biomater Sci 6(8):2122–2129
20. Yellepeddi VK, Mohammadpour R, Kambhampati SP, Sayre C, Mishra MK, Kannan RM,
Ghandehari H (2018) Pediatric oral formulation of dendrimer-N-acetyl-l-cysteine conjugates
for the treatment of neuroinflammation. Int J Pharm 545(1–2):113–116
21. Osmani RA, Hani U, Bhosale RR, Kulkarni PK, Shanmuganathan S (2017) Nanosponge
carriers- an archetype swing in cancer therapy: a comprehensive review. Curr Drug Targets
18(1):108–118
22. Mendes C, Meirelles GC, Barp CG, Assreuy J, Silva MAS, Ponchel G (2018) Cyclodextrin based nanosponge of norfloxacin: intestinal permeation enhancement and improved
antibacterial activity. Carbohydr Polym 195:586–592
23. Singh R, Vyas SP (1996) Topical liposomal system for localized and controlled drug delivery.
J Dermatol Sci 13(2):107–111
24. Ibrahim HK, El-Leithy IS, Makky AA (2010) Mucoadhesive nanoparticles as carrier systems
for prolonged ocular delivery of gatifloxacin/prednisolone biotherapy. Mol Pharmaceutics
7(2):576–585
25. Tayeb HH, Sainsbury F (2018) Nanoemulsions in drug delivery: formulation to medical
application. Nanomedicine (Lond) 13(19):2507–2525
26. Levy-Nissenbaum E, Radovic-Moreno AF, Wang AZ, Langer R, Farokhzad OC (2008)
Nanotechnology and aptamers: applications in drug delivery. Trends Biotechnol 26(8):442–449
27. Park K (2014) Controlled drug delivery systems: past forward and future back. J Control
Release 190:3–8
28. Luo M, Feng Y, Wang T, Guan J (2018) Micro-/nanorobots at work in active drug delivery.
Adv Funct Mater 28(25):1706100
29. de Ávila BE, Angsantikul P, Li J, Angel Lopez-Ramirez M, Ramírez-Herrera DE, Thamphiwatana S, Chen C, Delezuk J, Samakapiruk R, Ramez V (2017) Micromotor-enabled active
drug delivery for in vivo treatment of stomach infection. Nat Commun 8(1), 272 (2017)
30. Nie L, Sun S, Sun M, Zhou Q, Zhang Z, Zheng L, Wang L (2020) Synthesis of aptamer-PEIg-PEG modified gold nanoparticles loaded with doxorubicin for targeted drug delivery. JoVE
(Journal of Visualized Experiments). e61139
31. Basha SA, Salkho N, Dalibalta S, Husseini GA (2019) Liposomes in active, passive and
acoustically-triggered drug delivery. Mini Rev Med Chem 19(12):961–969
32. Shao J, Xuan M, He Q, Dai L (2018) Bioinspired platform conjugated active drug delivery.
Curr Drug Targets 19(4):328–338
. Park B-W, Zhuang J, Yasa O, Sitti M (2017) Multifunctional bacteria-driven microswimmers
for targeted active drug delivery. ACS Nano 11(9):8910–8923
34. Caliceti P, Salmaso S, Semenzato A, Carofiglio T, Fornasier R, Fermeglia M, Ferrone M, Pricl
S (2003) Synthesis and physicochemical characterization of folate cyclodextrin bioconjugate
for active drug delivery. Bioconjugate Chem 14(5):899–908
35. Suryaprakash S, Lao Y-H,Cho H-Y, Li M, Ji HY,Shao D, Hu H, Quek CH, Huang D, Mintz RL
(2019) Engineered mesenchymal stem cell/nanomedicine spheroid as an active drug delivery
platform for combinational glioblastoma therapy. Nano Lett 19(3):1701–1705
36. Rahim MA, Jan N, Khan S, Shah H, Madni A, Khan A, Jabar A, Khan S, Elhissi A, Hussain
Z (2021) Recent advancements in stimuli responsive drug delivery platforms for active and
passive cancer targeting. Cancers 13(4):670
37. Liu D, Yang F, Xiong F, Gu N (2016) The smart drug delivery system and its clinical potential.
Theranostics 6(9):1306

Drug Delivery System and Technologies 97
38. Mura S, Nicolas J, Couvreur P (2013) Stimuli-responsive nanocarriers for drug delivery. Nat
Mater 12(11):991–1003
39. Sharma M (2019) Transdermal and intravenous nano drug delivery systems: present and future,
applications of targeted nano drugs and delivery systems. Elsevier, pp 499–550
40. Peterfreund RA, Philip JH (2013) Critical parameters in drug delivery by intravenous infusion.
Exp Opin Drug Deliv 10(8):1095–1108
41. Laffleur F, Bauer B (2021) Progress in nasal drug delivery systems. Int J Pharm 607:120994
42. Boche M, Pokharkar V (2017) Quetiapine nanoemulsion for intranasal drug delivery: evaluation
of brain-targeting efficiency. AAPS Pharm Sci Tech 18:686–696
43. Hong S-S, Oh KT, Choi H-G, Lim S-J (2019) Liposomal formulations for nose-to-brain
delivery: recent advances and future perspectives. Pharm 11(10):540
44. Allyn MM, Luo RH, Hellwarth EB, Swindle-Reilly KE (2022) Considerations for polymers
used in ocular drug delivery. Front Med 8:787644
45. Kim HM, Woo SJ (2021) Ocular drug delivery to the retina: current innovations and future
perspectives. Pharma 13(1):108
46. Alqahtani MS, Kazi M, Alsenaidy MA, Ahmad MZ (2021) Advances in oral drug delivery.
Front Pharmacol 12:618411
47. Rubbens J, Mols R, Brouwers J, Augustijns P (2018) Exploring gastric drug absorption in
fasted and fed state rats. Int J Pharm 548(1):636–641
48. Boyd BJ, Bergström CA, Vinarov Z, Kuentz M, Brouwers J, Augustijns P, Brandl M, BernkopSchnürch A, Shrestha N, Préat V (2019) Successful oral deliveryof poorly water-soluble drugs
both depends on the intraluminal behavior of drugs and of appropriate advanced drug delivery
systems. Eur J Pharm Sci 137:104967
49. Hua S (2019) Advances in nanoparticulate drug delivery approaches for sublingual and buccal
administration. Front Pharmacol 10:1328
50. Teubl BJ, Meindl C, Eitzlmayr A, Zimmer A, Fröhlich E, Roblegg E (2013) In-vitro
permeability of neutral polystyrene particles via buccal mucosa. Small 9(3):457–466
51. Ramadon D, McCrudden MT, Courtenay AJ, Donnelly RF (2021) Enhancement strategies for
transdermal drug delivery systems: current trends and applications. Drug Deliv Transl Res
1–34
52. Jeong WY, Kwon M, Choi HE, Kim KS (2021) Recent advances in transdermal drug delivery
systems: a review. Biomater Res 25:1–15
53. Jing Y, Ruan L, Jiang G, Nie L, Shavandi A, Sun Y, Xu J, Shao X, Zhu J (2023) Regenerated
silk fibroin and alginate composite hydrogel dressings loaded with curcumin nanoparticles for
bacterial-infected wound closure. Biomater Adv 149:213405
54. Osmałek T, Froelich A, Jadach B, Tatarek A, Gadziński P, Falana A, Gralińska K, Ekert M, Puri
V, Wr o t y ńska-Barczyńska J (2021) Recent advances in polymer-based vaginal drug delivery
systems. Pharm 13(6):884
55. Jalalvandi E, Jafari H, Amorim CA, Petri DFS, Nie L, ShavandiA (2021) Vaginal administration
of contraceptives. Sci Pharm 89(1):3
56. Zou P, Suo J, Nie L, Feng S (2012) Temperature-responsive biodegradable star-shaped block
copolymers for vaginal gels. J Mater Chem 22(13):6316–6326
57. Nie L, Zou P, Dong J, Sun M, Ding P, Han Y, Ji C, Zhou Q, Yuan H, Suo J (2019) Injectable
vaginal hydrogels as a multi-drug carrier for contraception. Appl Sci 9(8):1638
58. Bartucci R, Paramanandana A, Boersma YL, Olinga P, Salvati A (2020) Comparative study of
nanoparticle uptake and impact in murine lung, liver and kidney tissue slices. Nanotoxicology
14(6):847–865
59. Hassan S, Zhang YS (2019) Microfluidic technologies for local drug delivery. Microfluidics
for Pharmaceutical Appl 281–305
60. Wei T, Cheng Q, Min Y-L, Olson EN, Siegwart DJ (2020) Systemic nanoparticle delivery of
CRISPR-Cas9 ribonucleoproteins for effective tissue specific genome editing. Nat Commun
11(1):3232


Carbon-Based Nanomaterials for Drug Delivery: Past, Present, Future Directions
N. B. Singh, Tanaya Kundu, and Mridula Guin
Abstract The carbon-based nanomaterials are promising candidates in the field of
drug delivery. Their unique physicochemical properties and remarkable biocompatibility are garnering major interest for their application in drug delivery. This chapter
delivers a comprehensive overview of the past, present, and future directions of
utilizing carbon-based nanomaterials for drug delivery and other biomedical applications. The chapter discusses in detail about drug delivery by nanomaterials based
on graphene, graphene quantum dots (GQDs), carbon nanotubes (CNTs), carbon
nanodiamonds (NDs), carbon nano-onions (CNOs), carbon nanohorns (CNHs),
and fullerene. Through this comprehensive examination of the past, present, and
future of carbon-based nanomaterials for drug delivery, the chapter aims to provide
valuable insights to researchers, scientists, and clinicians involved in developing
next-generation drug delivery systems with enhanced efficacy and reduced adverse
effects.
Keywords Drug delivery
Carbon nano-onions
· Graphene · Carbon nanotubes · Nanodiamond ·
1 Introduction
In recent times diagnosis and treatment of chronic diseases are done through traditional approaches such as chemotherapy, radiation therapy, immunotherapy, and
hormonal therapy.In most of these cases, the diagnosis is delayed and target-oriented
action of drugs is a major issue. This also requires several shot drug doses [1, 2].
In this respect, nanotechnology has made a great impact to overcome the shortcomings in this field. Now, nanotechnology-based drug delivery systems are developed
N. B. Singh · M. Guin (B)
Department of Chemistry and Biochemistry, Sharda University, Greater Noida, India
e-mail: mridula.guin@sharda.ac.in
T. Kundu
Undergraduate Programmes, Indian Institute of Science, Bangalore 560012, India
99

100 N. B. Singh et al.
for diagnostic and treatment of diseases [3–5]. Drug delivery systems are defined
as formulations and approaches to protect, release, and transport therapeutic agents
into a targeted site [6–12]. Drug delivery is a process to administrate pharmaceutical
compounds in humans or animals [13]. Researchers are being conducted to buildnew
and novel materials for effective delivery of drugs at targeted sites [14]. Such systems
have the power to treat multiple diseases very effectively. The traditional methods
of drug administration have several issues. However, using of nano drug carriers has
the potency of several benefits, such as selective and stronger binding to a particular
site, lesser dosing frequency, better absorption, and enhanced stability and efficacy of
the drug, with reductions in toxic metabolites. In recent times, different technologies
using different nanomaterials havebeen developed and used [6]. Innovations in materials chemistry have initially fuelled the progress of drug delivery systems, creating
carriers that are biocompatible, biodegradable, targeting, and stimulus-responsive.
Nanoparticles (NPs) can be employed for delivering a variety of pharmaceuticals,
which is safer, and more effective [15]. Size and shape of NPs can help in navigating
biological carriers. Inorganic and organic nanocarriers can be used for delivery of
drugs at appropriate sites. Some important organic nanocarriers include dendrimers,
polymeric nanoparticles, polymeric micelles, solid liquid nanoparticles, liposomes,
and virus-based nanoparticles. Examples of inorganic nanoparticles are mesoporous
silica NPs and carbon nanotubes (CNTs). Variousnanocarriers having applications in
drug delivery are shown in Fig. 1 [16]. Among the nanomaterials, CNMs are found to
be of much interest in the biomedical field. CNMs show different chemical reactivity
and structural, morphological, and physical characteristics. Different allotropes of
carbon with different applications are s hown in Fig. 2 [17].
Allotropic forms of carbon like graphite, diamonds, amorphous carbon, carbon
nanotubes, carbon quantum dots, graphene, graphene oxide (GO), reduced graphene
oxide (rGO), Carbon nanohorn, carbon nano-onion, and fullerene have some unique
properties, which make them exciting material for diagnosis and treatment of critical
diseases. They are effectively used for drug delivery system for oxidative stressrelated diseases, for example, cancer, neurodegenerative diseases, and inflammation
[18]. In comparison to other conventional materials, CNMs have a large specific
surface area and unique features that are more suitable for use in drug delivery and
medicinal applications. In this chapter, different types of CNMs have been discussed
for drug delivery. Past, present, and future directions on the subject are also discussed.
2 Historical Background of Carbon-Based Nanomaterials
for Drug Delivery Applications
The historical background of carbon nanomaterials (CNMs) for application in drug
delivery is a journey marked by significant discoveries, challenges, and advancements. CNMs for drug delivery are rooted in the development of nanotechnology and
the exploration of various nanomaterials for medical applications. CNMs including

Carbon-Based Nanomaterials for Drug Delivery: Past, Present, Future … 101
Fig. 1 Different nanocarriers for drug delivery applications. Reproduced with permission from
Elsevier [16]
carbon nanotubes (CNTs), graphene, and fullerenes, have garnered a great deal of
attention due to their unique properties and potential of application in drug delivery
systems. The history of carbon nanomaterials begins in 1985 with the discovery of
fullerenes by famous scientists Richard Smalley, Robert Curl, and Harold Kroto.
Fullerenes are spherical molecules composed entirely of carbon atoms organized in

102 N. B. Singh et al.
Fig. 2 Different allotropes of carbon nanomaterial and their applications. Adapted and modified
with permission from Elsevier [17]
a special way to a structure resembling a soccer ball. This discovery led to the Nobel
Prize in Chemistry in 1996 [19, 20]. In the early 1990s, Sumio Iijima discovered
carbon nanotubes (CNTs), which opened a new avenue for nanomaterial research,
including their potential for drug delivery due to their hollow structures and controllable dimensions [21]. During the 2000s, researchers began exploring the potential of
carbon nanomaterials, particularly CNTs and fullerenes, in drug delivery applications
[22].
In 2004, researchers isolated and characterized graphene that consist of a monolayer of carbon atoms organized in a 2D honeycomb lattice. Its 2D structure and
functionalizability offered advantages for loading and delivering drugs. As research
advanced, carbon nanomaterials began showing promise in preclinical studies for
various drug delivery applications. They were investigated for the targeted delivery
of various therapeutic agents such as proteins, nucleic acids, and tiny molecules to
target specific illness. The ability to functionalize their surfaces allowed for improved
targeting, controlled release, and enhanced drug stability. In recent years, due to dose
reduction, prolonged action, quantum behavior,target ability,etc., nano drug delivery
systems particularly CNTs as drug delivery and drug carrier have increased considerably [23]. It is one of the most impressive element that transform material science
immensely.Carbon nanotubes (CNTs) are now being used in drug delivery and diagnostics [24]. CNTs have drawn a lot of interest in the field of biomedical science
because of their extraordinary properties such as high stability, drug loading capacity,
high surface area, needle-like structure, flexible interaction with cargo, biocompatibility, excellent electrical and mechanical characteristics, considerable strength, and
the capacity to supply drugs to the exact location of tissues. Apart from a number of
advantages, it has some demerits such as toxicity and low biodegradability [25].
Cancer is a serious concern and it increases the mortality rate. Thus people are
in search of drug delivery systems that are safe, target specific, and highly effective for curing cancer. In 2021, 1,898,160 new cases of cancer and 608,570 deaths
were reported in USA alone. To overcome some problems of cancer, nanomedicines
were tested in diagnosis. CNMs were found to be effective drug delivery agents.
They have the property of controlled drug release, prolonged delivery, and target

Carbon-Based Nanomaterials for Drug Delivery: Past, Present, Future … 103
specific delivery of the drug, which improvesthe pharmacological activityof the drug.
Therefore, CNMs specifically carbon nanotubes, carbon quantum dots, graphene,
and graphene oxide, can easily replace and overcome the defect and side effects of
conventional cancer treatment methods [26]. Different data bases from 1965 to 2021
were analyzed, in order to have publications on the use of CNMs for drug delivery.
A lot of data on this topic were obtained from SCOPUS, within the time span of
1985 to February 7, 2022 [27]. After careful inspection of SCOPUS database, it was
found that a total of 1846 publications were based on drug delivery applications of
CNMs.
3 Current Status in Drug Delivery by CNMs
Carbon nanomaterials (CNMs) such as graphene quantum dots, carbon nanotubes,
nanohorns, nanodiamonds, nano-onions, and graphene quantum dots have significant
applications in the biomedical field. Recent development of various forms of carbon
nanomaterials for drug delivery applications are discussed in this section.
3.1 Graphene-Based Nanomaterials in Drug Delivery
Graphene has received enormous research interest due to its exceptional characteristics and widespread applications in various science and technological fields, since
2
its discovery. It is a carbon allotrope comprised of monolayer sp
hybridized carbon
with π-electron clouds. It has a two-dimensional honeycomb planar lattice structure.
Graphene’s unique geometrical and structural features lead to its remarkable physiochemical properties. Young’s modulus (~1000 GPa) and fracture strength (~130
GPa) are of greater value for graphene [28]. It has a very large theoretically calcu-
2
lated specific surface area of ~ 2630 m
/g. It is a zero-band gap semiconductor whose
valence and conductance bands meet at Dirac points [29]. Graphene has low resis-
4
tivity, exceptionally high electrical (~10
mK), and rapid charge carrier mobility with a reported value of 2 × 10
S/cm) and thermal conductivity (~5000 W/
5cm2
/Vs
[28, 29]. It has high mechanical strength and optical transmittance [30]. Along with
these exceptional properties, graphene and its derivatives are capable of crossing
biological barriers making them an attractive platform for biomedical applications,
particularly in delivering drugs and biomolecules [31].
Graphene generally refers to monolayer sheets with single atom thickness.
However, graphene nanomaterials include few layer graphene, bilayer graphene,
graphene oxide (GO), and reduced graphene oxide (rGO). They differ in thickness, in-plane dimensions, purity, surface chemistry, and compositions[28]. Bilayer
graphene consists of two single layers of graphene and the thickness of few layer
graphene is up to 10 layers [32]. Graphene nanomaterials are mainly prepared from
graphite using either mechanical or chemical method. Graphene has low solubility

104 N. B. Singh et al.
in aqueous media because of its high hydrophobic character. Its derivatives, for
example, GO, which is a chemically functionalized and highly oxidized form of
graphene, are often employed in biomedical applications. GO has better aqueous
solubility, as it is decorated with polar functional groups having oxygen atoms, like
hydroxyl (-OH), carboxylic acid (-COOH), and epoxide (–O–). The basal plane of
GO has the unmodified hydrophobic graphene domains which can easily load drug
molecules efficiently using π–π interactions. GO has been reduced to prepare rGO,
where the oxygen containing functional groups are mostly reduced (Fig. 3)[33].
Oral administration of the drug may induce its degradation by stomach acids
and enzymes, uneven distribution, rapid clearance, and low bioavailability. Drug
molecules may not cross the cellular membrane or distribute poorly when these are
administered intravenously [32]. Therefore, a drug carrier is desirable for immobilizing drug molecules to overcome these disadvantages. Graphene surface can
easily be functionalized and modified to improve its characteristics, biocompatibility, stability, and target specificity of drugs. In 2008, Dai research group reported
the utilization of graphene as an effective drug carrier for the first time [34, 35].
Doxorubicin (DOX) is an anticancer drug use to treat various types of cancers by
destroying the cell DNA [36]. GO has shown significant result to entrap DOX and
release it to the target cell. Quinine part of DOX is involved in hydrophobic and π-π
interaction with basal plane of GO, where as hydroxyl and amino groups of DOX are
involved in hydrogen bonding interactions with the carboxyl and hydroxyl groups
present on GO surface. These bonding interactions are strong in neutral media and
become weak in acidic pH (tumor environment), which leads to the release of DOX
[30, 32]. Many other anticancer drugs, such as 5-fluorouracil, camptothecin (CPT),
cisplatin, paclitaxel, protocatechuic acid, mitoxantrone, zolendronic acid, have been
delivered by graphene-based nanomaterials [36, 37].
Various covalentand non-covalentfunctionalization is utilized to modify graphene
surfaces. Dai research group has incorporated a hydrophilic biocompatible polymer,
polyethylene glycol (PEG) functionalization on GO for drug delivery applications
[34–36]. Other polymers, such as polyvinyl alcohol (PVA), polyethyleneimine (PEI),
poly(N-isopropyl acrylamide) (PNIPAM), polysebacic anhydride (PSA), poly-Llysine (PLL) have been coupled covalently with GO to enhance the biocompatibility
[36, 38]. Electrostatic interactions, van der Waals interactions, hydrogen bonding
Fig. 3 Conversion of graphene into GO and rGO. Reproduced with permission from Springer
Nature [33]
Соседние файлы в папке Библиотека им академика М.И. Перельмана
