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Carbon Based Nanomaterials for Drug Delivery
Smart Nanomaterials Technology
Series Editors
Azamal Husen Mohammad Jawaid, Chemical and Petroleum Engineering, United Arab Emirates
University, Al Ain, United Arab Emirates
, Wolaita Sodo University, Wolaita, Ethiopia
Nanotechnology isa rapidly growing scientific field and has attracted a great interest over the last few years because of its abundant applications in different fields like biology, physics and chemistry. This science deals with the production of minute particles called nanomaterials having dimensions between 1 and 100 nm which may serve as building blocks for various physical and biological systems. On the other hand, there is the class of smart materials where the material that can stimuli by external factors and results a new kind of functional properties. The combination of these two classes forms a new class of smart nanomaterials, which produces unique functional material properties and a great opportunity to larger span of applica­tion. Smart nanomaterials have been employed by researchers to use it effectively in agricultural production, soil improvement, disease management, energy and environ­ment, medical science, pharmaceuticals, engineering, food, animal husbandry and forestry sectors.
This book series in Smart Nanomaterials Technology aims to comprehensively cover topics in the fabrication, synthesis and application of these materials for applications in the following fields:
Energy Systems—Renewable energy, energy storage (supercapacitors and elec-
trochemical cells), hydrogen storage, photocatalytic water splitting for hydrogen
production
Biomedical—controlled release of drugs, treatment of various diseases, biosen-
sors,
Agricultural—agricultural production, soil improvement, disease management,
animal feed, egg, milk and meat production/processing,
Forestry—wood preservation, protection, disease management
Environment—wastewater treatment, separation of hazardous contaminants from
wastewater, indoor air filters.
Sarat Kumar Swain
Editor

Carbon Based Nanomaterials for Drug Delivery

Editor
Sarat Kumar Swain Department of Chemistry Veer Surendra Sai University of Technology Burla, Sambalpur, Odisha, India
ISSN 3004-8273 ISSN 3004-8281 (electronic) Smart Nanomaterials Technology ISBN 978-981-97-8085-3 ISBN 978-981-97-8086-0 (eBook)
https://doi.org/10.1007/978-981-97-8086-0
© The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd. 2025
This work is subject to copyright. All rights are solely and exclusively licensed by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptivenames,registerednames,trademarks,service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, expressed or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
This Springer imprint is published by the registered company Springer Nature Singapore Pte Ltd. The registered company address is: 152 Beach Road, #21-01/04 Gateway East, Singapore 189721, Singapore
If disposing of this product, please recycle the paper.
The editor dedicates this book to…
Lord Jagannath, Lord Balabhadra and Devi Subhadra

Preface

Carbon (roots from Latin word carbo; coal), most primitive element ever known to mankind, is also the most abundant element on earth and is known as the “ele­ment of life”. Its unique properties keep on fascinating us, which allows it to form numerous allotropic forms via sp, sp structural characterization of graphite by John D. Bernal in the Twentieth Century, carbon became the focus of an extensive line of research. The detailed study related to carbon and its properties, “carbon chemistry” formed the backbone of organic chemistry. With due course of time, the motivation of miniaturizing devices gave birth to an extremely robust class of nanomaterials known as “Carbon-Based Nano­materials”. The history of nanotechnology and carbon-based nanomaterials is highly intertwined. Following the invention of electron microscope and introduction of the term “nanotechnology”, the miraculous discovery of fullerenes or “Bucky ball” in 1985 laid the first stepping stone in the history of nanomaterials. It became the first structurally investigated nanomaterial to be reported and it is the biggest milestone in the journey of nanotechnology. Science then, several forms of nano-dimensional carbonaceous matters have been discovered and reported which have revolution­ized the field of material science. In the past decades, the remarkable mechanical, electrical, and optical properties of carbon-based nanomaterials havemade them the center of attraction for academicians and industrialists for their applicability in a plethora of applications ranging from aeronautics to biomedical science. These tiny miracles have proved to be a boon in the field of therapeutics. Sustained encapsula­tion and release of optimized dosages of therapeutics in their hollow cavities make them the most promising candidates for drug delivery applications. Various forms of carbonaceous nanomaterials like fullerenes, carbon nanotubes, carbon nanofibers, nanodiamonds, graphene, carbon quantum dots, nanohorns, and nano-onions have found the way toward success in the field of drug delivery. The book mainly focuses ontheeffectivenessofdifferentnanomaterials toward targeteddeliveryof therapeutic compounds to different parts of the body.
The key objective of this book entitled Carbon Based Nanocomposites for Drug Delivery is to bring forward the journey of carbon nanomaterials right from pre­historic times to Indian mothers preparing kohl using wick lamps to the advanced
2
, and sp3hybridization. Immediately after the
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viii Preface
research in material science, specifically in the field of biomedical application in particular to drug delivery. The book dives into the evolution of carbon-based nano­materials,shedding light into variouscarbonaceous nanoforms as well as theirbiolog­ical aspects and highlights the utilization of these nanomaterials in different facets of drug delivery applications. The book is divided into 18 chapters contributed by eminent authors from more than 10 countries; each addressing different aspects of carbon-based nanomaterials, their nanocomposites and potency of these functional materials in different forms of drug delivery. The detailed introduction regarding carbon-based nanomaterials, their roles in drug delivery, drug encapsulation, and release efficacies in isolated or hybrid states as well as illuminates the noteworthy achievements of academicians and researchers in the concerned field. The present book brings together the functionalities of carbon-based nanomaterials in different types of drug delivery under one roof for providing a better reading experience to the readers.
It would be a matter of great pleasure, if our united efforts will be an addition to the existing literature regarding nanotechnology in drug delivery.
Burla, Sambalpur, Odisha, India January 2024
Prof. Sarat Kumar Swain

Acknowledgements

With heartfelt appreciation, I extend my sincere gratitude to the Springer Nature, Singapore Pte. Ltd. for publishing this book entitled Carbon Based Nanomaterials for Drug Delivery. With due regards, I express my thanks and respect to the eminent Series Editor, Prof. Mohammad Jawaid and Dr. Ramesh Nath Premnath, Publishing Editor of Springer for their invaluable opportunity to present my ideas through this bookas part of thebook series Smart Nanomaterials Technology.Specialappreciation goes to Dr. Karthik Raj, Project Coordinator, for his unwavering support during the editing process.
I would like to express my deep sense of gratitude to the research groups of Prof. Martínez-Vargas, Prof. Lei Nie, Prof. Guin, Prof. Hoque, Prof. Li, Dr. Noor An’amt, Dr. Pourmadadi, Dr. Biswal, Prof. Sarkar, Prof. Wiwanitkit, Dr. Yasri, Prof. Mahmoud, Prof. Maruthupandy, Prof. Cho, Prof. Nam, Dr. Chat­terji, Prof. Palanisamy, Prof. Sharma, and Prof. Roushani for contributing their valu­able works to make this complete one. I am equally indebted to the tireless efforts of the dedicated members of my research group, namely, Dr. Anuradha Biswal, Ms. Swapnita Patra, Mr. Shuvendu Shuvankar Purohit, and Mr. Susobhan Swain for their timely help. However, effort of Ms. Krishna Manjari Sahu, my Ph.D. Scholar is highly appreciated for her active involvement during entire editing process. At the outset, I also acknowledge the support to the Vice-Chancellor of my University, “Veer Surendra Sai University of Technology” for his encouragement. The last but not least, I express my gratitude to my beloved parents for their inspirations and blessings.
It is my sincere hope that, in collaboration with the contributing authors and publishers, this work will meet the needs of academics, researchers, and students in industrial, biomedical, and pharmaceutical domains.
Prof. Sarat Kumar Swain
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