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Ординатура / Хирургия / Библиотека им академика М.И. Перельмана / Книга_1054_Библиотеки_им_академика_М_И_Перельмана

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S. H. Ali and R. Parmeshwar
While it is still a standard practice to decide the implants on the basis of measurements taken, there are now 3D cameras with integrated soft­ware which can aid in deciding the implant style and volume and also give a visual impression of the likely appearance of the reconstructed or aug­mented breasts. They should be an adjunct to sur­geons’ own assessment rather than a substitute. The same applies to the practice of using weight of the mastectomy specimen andcertain mathematics formulae by some sur­geons to calculate implant volume.
28.7 Complications Related
toSilicone Implants
Implant based reconstructions, although techni­cally simpler to an autologous reconstruction to perform, a consistently good and lasting outcome can be hard to achieve. This is related to use of prosthetic material as opposed to autologous tis­sue even though the results are now much improved because of the use of biological meshes [20]. A total subcutaneous placement is associ­ated with very high risk of failure and is not rec­ommended [21].
28.7.1 Early Complications
Seroma Infection Skin necrosis Implant loss
In the rst few weeks, the seroma and infec­tion are the biggest challenges in implant based reconstruction [2224]. These two often go together and can be minimized by appropriate case selection and meticulous surgical technique (careful tissue handling, judicious use of dia­thermy, minimizing the use of retractors, thor­ough wash of pocket, use of drains and prophylactic antibiotics). Theatre environment (keeping patient warm, use of masksbyeveryone inside the theatre, minimizing movement in and out of theatre and number of people within the­atreand preferable use of laminar ow) and care-
ful implant and biological mesh selections are also very important. Most of the large series on implant based reconstruction will show an implant loss rates of at least5–10%, overall com­plication rates of 25% with a90day readmission rates of about 10% and reoperation rates of 10–15%. Skin necrosis has a direct relation­ship with smoking, diabetes and high implant volume [19, 2527].
28.7.2 Delayed Complication
Asymmetry Rotation Migration Leak/rupture Capsular contracture Breast associated anaplastic large cell lymphoma
(BIA ALCL)
The long-term issues with implant based reconstruction are related to changes happening in the reconstructed breast as well as in the host.
Implants can also rotate, migrate, leak or rup­ture. Rotation of an anatomical implant can lead to altered shapes of the reconstructed breasts. Even inthe absence of any compromise in posi­tion or integrity of the implant, asymmetry is quite common in unilateral implant based breast reconstruction and tends to get more obvious with time mainly owing to capsulation and also because of change in body weight and ageing of the contralateral normal breast.
Gel bleed is a phenomenon wherein the sili­cone gel (broken down short chain PDS) leaks through the silicone elastomer shell which behaves like a semi-permeable membrane. This differs from implant rupture as gel bleed is micro­scopic leakage through an intact implant shell. Both gel bleed and implant rupture can cause sili­cone migration to liver, lymph nodes, upper limbs, pleural uid and synovium. Gel bleed in most cases are just an incidental intra-operative nding and on its own does not require interven­tion. Implant rupture on the other hand usually occurs a decade after implantation (10–15years) with incidence increasing with implant age.
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Fig. 28.7 Ultrasound scan of axilla showing sand-storm echo pattern
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Fig. 28.8 MRI scan of breasts showing gel bleed (left) and intracapsular rupture (right)
Diagnosis of implant rupture on clinical exami­nation is challenging however most common pre­sentations are pain, loss of breast shape, asymmetry, inammation, swelling and mass for­mation. Physical examination alone fails to diag­nose implant rupture in more than 50% of cases. A leaked silicone implant can cast a typical “sandstorm” echo pattern on ultrasound (Fig.28.7) scan but in doubtful cases MR scan (Fig.28.8) can be helpful which provides a better denition of the shell and also whether the leak is intra-capsular or extra-capsular. The latter obvi­ously requires more urgent attention because of the risk of silicone granulomas formation in the
parenchyma or lymphatic uptake into the axillary lymph nodes.
The most common and well-known delayed complication after breast implantation is capsular contracture occurring in up to 30 per cent of patients [28] and hence the need for revision sur­gery is not uncommon. The trigger for capsular contracture remains uncertain. Bacteria invading the surface of implants (biolms) may lead to inammation of the adjoining tissue, causing brosis and capsular contracture. The other risk factors are axillary dissection and for obvious reasons, radiotherapy to the reconstructed breast is a major risk factor in the development of cap-
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Table 28.2 Baker’s grading of capsular contracture
Grade Breast Firmness Implant Implant visibility I Soft Not palpable Non-visible II Minimal Palpable Non-visible III Moderate Easily palpable Distortion visible IV Severe and painful Hard, tender, cold Distortion marked
From Baker JL Jr.: Augmentation mammoplasty. In Owsley JQ Jr., Peterson RA, editors: Symposium on aesthetic Surgery of the Breast, 1978, St Louis, 1978, CV Mosby
S. H. Ali and R. Parmeshwar
sular contracture and that too of grade 3/4. Positioning of implants (sub-glandular or sub­muscular) or even chemical interference were thought to be possible factors [29]. The Baker classication is a common method to assess clin­ically increasing levels of capsular contracture (Table28.2).
Breast ALCL occurs in the implant capsule itself. A typical presentation is the development of seroma usually a decade after silicone implant placement (range 1–32years) [30]. Other notable symptoms are presence of a palpable lump or Bakers capsular contracture Grade III or IV. Systemic symptoms are rare. Triple assess­ment with clinical examination, imaging and cytology play a vital role in diagnosis. The diag­nosis, however, can be difcult in the absence of a mass. It is quite possible that the actual inci­dence of BIA ALCL could be higher than reported. It is important to have a high index of suspicion in appropriate cases. In suspected cases of ALCL, clinicians and radiologists must spec­ifythe suspicion and request for cytological eval­uation of seroma uid for cluster of differentiation (CD30) and anaplastic lymphoma kinase (ALK) markers. Any capsulectomy performed for revi­sion of reconstruction must be subjected to histo­logical examination. In cases of diagnosed ALCL majority of the women responds to surgery (removal of implant and capsulectomy), chemo­therapy and radiotherapy and the prognosis is generally good.
28.8 Summary
Silicone implant based breast reconstructions are the mostcommon technique in the western world and its use seems to be on the rise because of the
developments around biological meshes which in turn have lead to improved aesthetic outcomes. These implant based reconstructions are easier to perform and are far less invasive compared to the autologous reconstructions such as a LD ap or a free DIEP ap. They also offer quicker recovery and avoid donor site related morbidities. However, they are not free from immediate and long-term problems and are certainly associated with high incidence of readmission, reoperation andneed for revisions.
They continue to bethe focus of passionate debates because of their association with ALCL and some of the less clear systemic manifesta­tions. A careful patient selection, good surgical technique with sound knowledge of appropriate implants and the issues associated with them are crucial to achieving a consistent good outcome. It is absolutely essential to provide full informa­tion to the patient and make a truly shared decision.
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12. https://doi.org/10.1007/s00266- 019- 01521- 3.
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18. Atlan M, Bigerelle M, Larreta-garde V, et al. Characterization of breast implant surfaces, shapes, and biomechanics: a comparison of high cohe­sive anatomically shaped textured silicone, breast implants from three different manufacturers. Aesthet Plast Surg. 2016;40:89–97. https://doi.org/10.1007/
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gov/715039/
22. Chatterjee A, Nahabedian MY, Gabriel A, Macarios D, Parekh M, Wang F. Grifn l, Sigalove S. early assessment of post-surgical outcomes with pre­pectoral breast reconstruction: a literature review and meta-analysis. J Surg Oncol. 2018;117(6):1119–30.
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23. Berna G, Cawthorn SJ, Papaccio G, Balestrieri N.Evaluation of a novel breast reconstruction tech­nique using the Braxon acellular dermal matrix: a new muscle-sparing breast reconstruction. ANZ J Surg. 2017;87(6):493–8. https://pubmed.ncbi.nlm.
nih.gov/25266930/
24. Vidya R, Berna G, Sbitany H, Nahabedian M, Becker H, Reitsamer R, Rancati A, Macmillan D, Cawthorn S. Prepectoral implant-based breast reconstruc­tion: a joint consensus guide from UK, European and USA breast and plastic reconstructive surgeons. Ecancermedicalscience. 2019;13:927. https://asso-
ciationofbreastsurgery.org.uk/media/65096/ppbr­guidelines.pdf
25. Li L, Yonghui S, Bingqiu X, Xiaoyan H, Weiru C, Jianjing H, Yingying Z, Jinhui T, Jia W, Jiong W. Comparison of prepectoral and sub pectoral breast reconstruction after mastectomies: a system­atic review and meta analysis. Eur J Surg Oncol. 2019;45(9):542–1550. https://www.sciencedirect.
com/science/article/pii/s0748798319304536#!
26. Li Y, Xu G, Yu N, Huang J, Long X. Prepectoral versus sub pectoral implant-based breast reconstruc­tion: a meta-analysis. Ann Plast Surg. 2020;10:1097.
https://journals.lww.com/annalsplasticsurgery/ abstract/9000/prepectoral_versus_subpectoral_ implant_based.96778.aspx
27. Vidya R, Masià J, Cawthorn S, Berna G, Bozza F, Gardetto A, Kołacińska A, Dell’antonia F, Tiengo C, Bassetto F, Caputo GG, Governa M.Evaluation of the effectiveness of the prepectoral breast reconstruction with Braxon dermal matrix: rst multicenter European report on 100 cases. Breast J. 2017;23(6):670–6.
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28. Ersek RA. Rate and incidence of capsular con­tracture: a comparison of smooth and textured silicone double-lumen breast prostheses. Plast Reconstr Surg. 1991;87(5):879–84. https://doi.
org/10.1097/00006534- 199105000- 00012.
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29. Embrey M, Adams EE, Cunningham B, Peters W, Young VL, Carlo GL.A review of the literature on the etiology of capsular contracture and a pilot study to determine the outcome of capsular contracture inter­ventions. Aesthet Plast Surg. 1999;23(3):197–206.
https://doi.org/10.1007/s002669900268.
30. Ye X, Shokrollahi K, Rozen WM, Conyers R, Wright P, Kenner L, Turner SD, Whitaker IS. Anaplastic large cell lymphoma (ALCL) and breast implants: breaking down the evidence. Mutat Res Rev Mutat Res. 2014;762:123–32. https://doi.org/10.1016/j.
mrrev.2014.08.002.
Pre-pectoral Implant Based Breast
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Reconstruction
SreekumarSundaraRajan andRishikeshParmeshwar
29
29.1 Introduction
Implant based breast reconstruction is the most common technique used for immediate breast reconstruction (IBR) in Europe and America. Even though IBR with subcutaneous placement of implant after radical mastectomy was attempted almost 50years ago [13], it never gained popularity due to the very high risk of complications and at best a poor aesthetic out­come. In comparison the subsequently developed totalsub-muscular technique remained the main­stay for implant based reconstruction for nearly two decades and wasoften done in a delayed set­ting. In the sub-muscular breast reconstruction, the implant is placed under the pectoralis major muscle superiorly, serratus anterior muscle later­ally and supported inferiorly by the upper most aponeurosis of rectus abdominis. However, the cosmetic outcomes from these IBRs were often suboptimal due to the mismatch between the outer lamella (the skin envelope) and the inner lamella (the muscle cover overlying the implant), resulting in projection of the reconstructed breast like a mound on the chest which lacked natural ptosis. These reconstructed breasts also lacked
S. S. Rajan Queen Elizabeth Hospital, Birmingham, UK
R. Parmeshwar (*) University Hospitals of Morecambe Bay, Lancaster, UK
movement and maintain a xed position on the chest in contrast to a normal breast which is meant to have a natural movement [46].
It was only after the introduction of various acellular dermal matrices (ADM) and synthetic meshes in the late 90s and the early 20s that led to a renewed interest in implant based IBR amongst plastic surgeons and oncoplastic breast surgeons. Since the publication of rst series of IBR with ADM in 2006 by Salzberg et al. [7], the use of biological and synthetic meshes have revolutionised the approach to IBR. The National Mastectomy and Breast Reconstruction Audit conducted in the UK between 2008 and 2011 showed only 30–35% of IBR were being carried out with implants whereas the current data suggest that implant based IBR now consti­tute about 70% of IBR in the UK and the USA [8, 9]. The use of ADM provides the surgeon with an internal hammock to support the implant below the Pectoralis major muscle facilitating in the natural ptosis of the reconstructed breast. The use of ADM or a synthetic mesh thus helps to compensate for the disparity arising between the outer and theinner lamella. It also provides a better denition of the infra and lateral mam­mary fold compared to a total sub-pectoral technique.
In the early years of the introduction of ADMsthe standard practice was to perform IBR in dual planes by dividing and elevating the Pectoralis major muscle along the lateral and
© The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd. 2023 S. V. S. Deo (ed.), Breast Oncoplasty and Reconstruction,
https://doi.org/10.1007/978-981-99-5536-7_29
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inferior borders and insert the implant in the sub- pectoral position and interpose an ADM or a synthetic mesh between the Pectoralis major inferolateral margin and infra-mammary fold to support the lower pole of the implant. Even though this technique was superior to total sub­muscular placement of the implant, it still had several signicant problems such as reduced mobility of the reconstructed breast, pain from the divided muscle, and animation of the restruc­tured breast from involuntary strong contractions of the Pectoralis major muscle [9, 10]. The renewed interest in pre-pectoral subcutaneous placement of implant in IBR has been a result of the efforts by the professionals to overcome these shortcomings of dual plane IBR. A substantial development in the quality of ADMs and syn­thetic meshes over the last 2 decades have been major factors in the process [11, 12].
Pre-pectoral implant based reconstruction (PPBR) is thus a relatively novel technique. The implant is placed in the pocket created after a skin sparing or nipple sparing mastectomy in front of the Pectoralis major muscle covered by an ADM or a synthetic mesh [13, 14]. The cover could be partial (anterior part opposed to the skin surface) or a complete wrap. The early reported outcomes from the PPBR technique are encouraging, both in terms of aesthetics as well as oncological outcomes with the added benet of avoiding the issues arising from division of the muscle. The evidences from the early publi­cationsdo indeed conrm that, at least in short term, there is no difference in the occurrence of seroma, infection, ap necrosis, and explanta­tion between pre-pectoral and sub-pectoral (dual plane) IBR techniques [15, 16]. The European and UK multicentric audits support these ndings [1719]. The potential benets of PPBR over a sub-pectoral technique are summa­rized in Table 29.1, and have led to a rapid uptake of this technique of immediate breast reconstruction both in Europe as well as in the USA and is fast becoming the preferred tech­nique in implant based IBR [20].
Table 29.1 Potential benets of Pre-pectoral Implant based reconstruction over sub-pectoral
Anatomical in concept (replacing the breast volume by implant with no other alterations)
Easier and quicker to perform No compromise of muscle function Less pain Early discharge (can be done as day case) Quicker recovery No animation Better movement Possible better tolerance to post mastectomy
radiotherapycompared to subpectoral ADM and implant IBR
29.2 Selection Criteria
Appropriate patient selection is paramount in any form of breast reconstruction and this assumes even greater signicance in implant based recon­structions as the safety margins are narrow. An inappropriate selection can lead to implant loss and suboptimal result. There are various patient related factors that should be considered while considering pre-pectoral implant-based reconstruction. Most of these selection criteria for PPBR apply to any implant based reconstruction. It is quite important to understand that despite improved outcomes from implant based reconstruction they are still not equivalent to a total autologous IBR.Patients need to be informed that the reconstructed breast with PPBR will not have the same feel of a natural breast,it will not have much sensation,can often feel cold to touch and it will not change its volume with patient’sweight loss or weight gain while the normal contralateral breast would and hence can lead to asymmetry. They will often change with time for the worse aesthetically, requiring revision surgery the incidence of which could be as high as 20–40% [21, 22].
29.2.1 Good Candidates
• Small to moderate size breast with the maxi­mum implant volume requirement of 450cc to
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500cc.Need for bilateral IBR is a good indi­cation for PPBR.
• Mild to moderate (Grade 1–2) ptosis only. See Table 29.3 for Regnault’s classication of breast ptosis.
• Good quality skin.
• Subcutaneous fat thickness of 1cm or more. Mediolateral oblique Mammograms can often give a good objective idea about subcutaneous fat thickness.
• Non-smokers.
• Young age (<50years).
• Realistic expectations with good understand­ing of likely outcome.
29.2.2 Relatively Unsuitable Candidates
• Obesity (BMI > 35)
• Smokers
• Diabetics
• Previous radiotherapy to the chest wall
• Likely need for post mastectomy radiotherapy
• Immuno-suppressed patients
29.3 Surgical Technique
29.3.1 Preoperative Marking
Pre-operative markings are crucial to any cos­metic or reconstructive procedure as they allow the surgeon to work on a planned template. In a reconstructive surgery the following markings are accepted as standard.
The markings are always done in sitting
upright or standing position with back straight and shoulders relaxed in neutral position. A tilted posture changes the surface markings signi­cantly and should be avoided.
The breast margins including upper pole,
infra-mammary fold (IMF), and the lateral mam­mary fold (LMF) are marked with an indelible marker pen as they help in mastectomy and also give an idea of the required implant volume. It is quite important to mark the contra-lateral IMF
and upper pole too as they help implant place­ment after mastectomy by means of offering a comparable template. In addition, they also give an idea if any signicant differences exist between the two sides preoperatively. Any such differences would be expected to have been noted in outpatients and implications explained to the patients. Similarly supra-sternal notch to nipple distance, midline to nipple distance and nipple to infra-mammary fold distances are important landmarks and must be clearly recorded. It is a good practice to keep a preoperative clinical pho­tograph along with one showing the markings followed by a series of post operative photo­graphs at dened intervals. Figure29.1 shows a typical preoperative marking in an implant based IBR and applies to PPBR too.
29.3.2 Patient Positioning, Skin Preparation andAntibiotic Prophylaxis
This is no different than any implant based IBR and focused on a supine neutral position, with arms out on arm boards with a torso position which allows sitting the patient up for subjective assessment.
• As with any procedure involving prosthesis
placement, antibiotic prophylaxis is impera­tive in form of a single dose of penicillin based antibiotic aimed at skin bacteria. It is best to follow the local antibiotic prophylaxis policy of the hospital. In authors practice this is 1gm of Flucloxacillin or 600mg of Clindamycin in case of penicillin allergy given at induction of anaesthetic.
• Both arms are kept abducted at 90° on arm
boards and patient as straight as possible.
• Patient’s arms secured on the arm board and a
pillow below the knees to prevent patient slid­ing while sat up during the surgery.
• Position of the patient on the table should
enable safe propping up to 60°–70° to check for symmetry. If not positioned properly, it
226
a
b
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Height
Width
Note left IMF lower than right
Fig. 29.1 (a) Pre-operative marking. (b) Position of the implant in relation to skin, ADM/mesh and chest wall
can cause awkward exion of the spine with potential injury and the chest area does
Pectoralis major
Mesh
Biological or Synthetic
Implant
injection on admission and continued till patient is fully mobile.
notallow proper assessment of the breasts.
• Skin preparation from umbilicus to neck and wellbeyond the shoulder joint and mid arm so
29.3.3 Incision
that once drapes are placed both the clavicle and shoulder joints are visible within the draped area.
• Uniform single application of 4% Chlorhexidine (in 70% ethyl alcohol) is used and sufcient time is allowed for it to evaporate and dry to maximize the antiseptic function. It also allows drapes to stick to skinproperly and prevents accidents from the use of electro-cautery.
• It is essential to put thrombo-prophylactic measures in place. This wouldusually be in the form of a combination of thromboembolic deterrent (TED) stockings, intra-operative pneumatic intermittent calve compression device, and low molecular weight heparin
The commonest technique of mastectomy used for PPBR is of skin sparing (SSM) type where the NA complex is sacriced. However, in appropriate cases nipple sparing mastectomy (NSM) is a valid option. It must be borne in mind that NSM carries higher risk of complication due to the added dimension of potential vascular compromise to the nipple areola complex and increased risk of infection due to natural coloni­zation of nipple with bacteria. NSM is hence best avoided in heavy smokers, poorly controlled dia­betics and those with poor quality skin. From oncological viewpoint extensive DCIS, cancer within 20mm of the base of the nipple are gener­allytaken as contraindications for NSM.
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• A range of incisions are possible including but not limited to elliptical central incision which can be horizontal, oblique or vertical (in SSM) and an infra-mammary fold incision, lateral mammary fold or a radialouter quadrant inci­sion (in NSM) depending on breast dimen­sions and patient’s preference. Surgeon’s own expertise and skills with these incisions also inuences the decision.
• If possible, peri-areolar incision is avoided due to increased risk of wound breakdown and infection.
• Use of nipple guard in cases of nipple sparing mastectomy helps minimizing the risk of infection.
29.3.4 Mastectomy
A good quality mastectomy is the key to a good outcome in any breast reconstruction but is par­ticularly important in implant based reconstruc­tion. The fact that the implant is placed in a subcutaneous position in PPBR, even though with a mesh wrap, a well perfused mastectomy ap acquires even greater signicance compared to some other forms of implant based recon­struction such as a sub-pectoral or a dual plane technique, where at least part of the implant is separated from skin by muscle which is a much better vascularised tissue. The attention to the following details helps achieving an onco­logically safe and yet a well perfused mastec­tomy envelope.
• Careful tissue handling using skin hooks in preference to strong retraction on skin by rela­tively more traumatic instruments.
• Sharp dissecting is preferable to diathermy but if the latter is chosen, its setting is kept to low and excessive use avoided by use of careful traction and counter traction.
• Chest wall perforators to the skin are identi­ed and carefully preserved to ensure ade­quate perfusion of skin aps. In this regard
perforators from the second and third inter­costals space coming from theinternal mam­mary artery, cutaneous branches from lateral thoracic artery and from intercostal artery perforators along the IMF and LMF are worth noting. The sub-dermal network of blood vessels must not be exposed or dam­aged by keeping the ap thickness uniform and sticking to the mastectomy plane. Exposure of dermis should be avoided at all costs as this risks ap necrosis and even if there is no ap necrosis, this results in adher­ence of skin to the capsule with poor aes­thetic outcome.
• Meticulous haemostasis is quite crucial as bleeding and haematoma can lead to risk of infection and poor integration of the ADM.A thorough wash of the pocket with saline/warm water is done with normalization of the blood pressure (normal for the patient) with the help of the anaesthetist is quite useful to achieve satisfactory haemostasis.
• It is important to recognise that unlike simple mastectomy where superior and inferior skin aps can be raised separately, when perform­ing SSM using elliptical central incision, skin aps should be raised all around simultane­ously to allow enough exposure and for the ease of dissection and hence reduce any inad­vertent injury to the skin ap.
• In cases of nipple sparing mastectomy with infra-mammary fold (IMF) incision, it is quite important to have proper assistance to get to the upper pole and perform a safe mas­tectomy. The use of a lighted retractor and lighted head gear is very useful in performing a safe NSM. It is quite important to choose carefully a candidate for NSM and small B/C cup breast with minimal ptosis are the best candidate.
• Care should be given to identify and pre­serve the infra-mammary fold (IMF) and the lateral mammary fold to achieve a stable pocket and avoid implant migration or rota­tion. If the IMF is compromised it must be