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132 P. Perier
Fig. 2 Waste in the OR after the use of an external clamp
to start the heart lung machine after having opened the thorax and wean the patient off bypass when the thorax is ready to be closed. On the contrary, the use of a double lumen tube allows to shorten the hear lung machine time, but the operation altogether is longer, because of the placement of the tube, the necessity to change it at the end of the operation. Many centers use one lumen tube.
The patient is in supine position, with a small elevation of the right hemithorax with the right arm minimally hyper-extended so that the fore­arm is just below level of the table (Fig. 3). Special care is taken to protect the bony promi­nences of the right arm.
Drape ensuring exposure of the right neck, sternum, right chest superiorly to axilla and posteriorly to the posterior axillary line, both groins and both legs. It is necessary to be able to control the colour and the aspect of the leg after
cannulation to make sure that the cannula is not obstructing distal blood ow. Mark the groin creases and femoral pulses bilaterally. Mark the sub-mammary fold, including the 4 cm limits of the planned skin incision.
The Iron-Assistinstrument holder (Geister Medizintechnik GmbH, Tuttlingen, Germany) and camera holder are positioned at the left and right head of the table respectively.
5 Cannulation
and Cardiopulmonary Bypass (Video 1)
Routinely a single femoral venous cannula is used except when the patient is above 1, 9 m or weighs more than 100 kg. In those instances, an Edwards Fem-Flex II 16 FR cannula (Edwards Lifesciences, Irvine, CA) is placed by the
Endoscopic Mitral Valve Surgery Using the External Clamp 133
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Fig. 3 Position of the patient
anesthesiologist in the jugular vein under tran­soesophageal echocardiographic (TEE) guidance. In case of tricuspid repair, a dual stage venous canula is used, and the IVC and SVC are snared on the canula, controlling that the portion with­out side holes is in the right atrium.
A longitudinal 3 cm skin incision, 2-ngers lateral to the femoral pulse, has been observed to reduce seroma formation. Dissect ion proceeds medially to expose the anterior aspect of the femoral vessels only, without encircling. After palpation of these vessels conrms them to be suitable a full dose of heparin is given. 2 adven­titial arterial and 1 partial thickness venous 5-0
®
Prolene
(Ethicon, Somerville, United States)
purse strings are placed and the bypass lines are handed out.
Using the TOE bicaval view for Seldinger guided venous cannulation the wire is crossed to the SVC ensuring no kinks or confusion with other lines occur. The dilator is used and a 1– 2 mm cut anteriorly placed on the vein onto the dilator. A 22, 24 or 28French QuickDraw single stage venous cannula (Edwards, Irvine, Unites States) is inserted with TOE. The arterial cannula with Seldinger wire and a 1 mm anterior cut onto the dilator is placed. (16, 18 (up to 5 l/min), 20, 22French EOPA
®
arterial cannula,
collar at 5 cm (see Video 1).
134 P. Perier
Video 1 Safe peripheral cannulation (https://doi.org/10.1007/000-a7n)
It is also possible to cannulate the femoral
vessels percutaneously.
Bypass is commenced before entry into the pleural space to allow the ventilator to be dis­connected, and the patient is cooled to 32 °C. All peripheral venous lines must be closed before the vacuum-assist bypass is initiated. If adequate bypass ow is not achieved have a low threshold for bilateral femoral arterial cannulation.
Visually inspect the leg for adequate perfusion periodically during bypass. Poor leg perfusion will necessitate distal femoral artery cannulation, via the main femoral cannulas side arm, using an 8French cannula and purse string.
6 Surgical Access
Most often it is possible at palpation to feel the 4th intercostal space and therefore to guide where the incision should be located. Most of the time it is in the immediate vicinity of the nipple. In men,
a 2 to 3 incision is made at the border of the areolar depending on the location of the inter­costal space between 11 and 5 or 9 and 3 (Fig. 4 and Video 2). In women, if possible, a peri areolar incision is performed in the same way, but sometimes it would be too anterior, whi ch will lead to an approach of the mitral valve with a too marked angle, making the operation difcult. In this case a more lateral incision trough the breast is indicated. A posterior incision in the mammary groove is too posterior and will increase the dis­tance between the incision and the mitral valve, furthermore, there will be no angle with the mitral valve, making the visualization of some aspect of the mitral apparatus difcult. After opening the intercostal space, a soft tissue retractor is placed to spread the tissues and to avoid that debris are brought in the cardiac cavity with the motions of the instruments. No rib retractor should be used! The port for the endoscope is placed in the same intercostal space as the incision (Video 2).
Endoscopic Mitral Valve Surgery Using the External Clamp 135
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Fig. 4 Peri-areolar Incision 9-3
Video 2 Creating the Peri-areolar incision (https://doi.org/10.1007/000-a7m)
136 P. Perier
7 The Set Up (Figs. 3, 4, 5 and 6)
Everything should be made as simple as possible,
but not simpler.
Albert Einstein
The set up should always be the same and kept simple. A 10 mm 30° angle high-denition 3D endoscope is inserted through a port made in the 4th intercostal space, posterior to the internal part of the soft tissue retractor. Signicant pericardial fat at the sterno-diaphragmatic area is removed. An L-shaped incision is cut in the pericardium far away from the phrenic nerve using the dia­thermy, from the diaphragm to the aortic reec­tion superiorly, then adjacent to the diaphragm surface, posteriorly, to a level just anterior to the inferior vena cava (IVC) avoiding the phrenic nerve (Video 3).
Three 2-0 Vicryl sutures are placed with the Endo Close (Medtronic) using a nger to protect the lung, posterior to the camera port, 2 intercostal spaces below (posterior axillary), and 1 space above (axillary) where they are clipped in place or tied around rubber tubing. The inferior pericardial
®
(Ethicon) pericardial stay
stay suture should be placed close to the dia­phragm, pulling on the suture will take the dia­phragm out of the way, avoiding placing stay sutures directly on the diaphragm.
The pericardial reflection posterior to the IVC is opened with long Metzenbaum scissors then rough sucker. This facilitates the left atriotomy; the infe­rior vena cava is encircled twice with a 0 black silk to snare the IVC, if required, in case of concomitant tricuspid surgery. A small stab and blunt dissection are made-1-2 rib spaces inferior to camera port, midaxillary, for the sump sucker. This is tem­porarily positioned posterior to the IVC.
Ensure the heart is empty and properly decompressed when entering the pericardium. The operation should not be started if the venous return is not satisfactory. A simple measure is to make sure that the venous canula is at the top of the thorax, at the level of the innominate vein, at the limit of the camera view.
If a SVC snare is necessary, the pericardial incision is extended superiorly for full exposure. The pericardial reection over the SVC is cut and a right-angle clamp is used to blunt dissect.
The operative eld should be ooded with CO
to avoid air in the heart cavities and to
2
Video 3 Opening the pericardium (https://doi.org/10.1007/000-a7k)
Endoscopic Mitral Valve Surgery Using the External Clamp 137
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Fig. 5 The setup
Fig. 6 Peri-areolar incision
facilitate the deairing. At the beginning of our experience, we started CO
insufation as soon
2
as the thorax was open at a rate of 3 L/Mn. The perfusionists and the anesthetists complained because of blood acidosis and hypercapnia. We
progressively reduced the ow to 1 L/Mn, which was not enough. At the present time, we start CO
insufation when we place the sutures for
2
the ring, at the end of the repair, with the same efciency.
138 P. Perier
8 Placement of the External Clamp
(Video 4)
It is certainly possible to place the external clamp in the transverse sinus, but there are drawbacks: the left appendage is in the vicinity vulnerable to injury as well as the pulmonary artery. Moreover, there is not much space left on the ascending aorta below the clamp for the cardioplegia nee­dle. After having had all the complications mentioned, we looked for another method.
We lift the aorta away from the pulmonary artery with long-shafted forceps, divide the adventitia with long-shafted scissors. Proceed between the aorta and the pulmonary artery towards the left shoulder with blunt dissection, using the rough sucker and long-shafted forceps until the contralateral pericardial space is entered, and the pericardium seen. Using a small stab with blunt dissection 1 or 2 intercostal space superior to camera and working port, mid-axillary at the level of the video port, insert the aortic clamp curved caudally, and once in the thorax turn it cranially. Place the clamp across the aorta at its
upper visible limit, taking care to avoid the pul­monary artery and left atrial appendage, and leave open.
Clear any signicant fat on the ascending aorta to make a suitable landing zone for the cardioplegia canula. A double purse string with 4-0 nonabsorbable polypropylene is placed. This is proximal to the aortic clamp and lateral to the uppermost aortic aspect, using forceps to stabi­lize and ease the placement of the sutures. A long, single lumen cardioplegia cannula (2 notches for stays) is placed, snared and spigoted. Tuck the snare away in the left pericardial cavity. A mid-clavicular stab in the 2nd intercostal space is used to externalize and connect the clamped cardioplegia line.
A 5 cm jaw transthor acic aortic clamp is usually used although a 7.5 cm transthoracic aortic clamp is preferable with larger aortae or obstructive shoulders or patient with a large thorax.
The end of the cardioplegia cannula is cut off to remove fat debris before connecting it to the cardioplegia line via a 3-way tap.
Video 4 Placement of the external clamp (https://doi.org/10.1007/000-a7p)
Endoscopic Mitral Valve Surgery Using the External Clamp 139
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Cardioplegia is then given. We use Bretschneider solution. Typically, the heart arrest occurs after 200–300 ml. If cardioplegic arrest is delayed it may be due to an aortic insufficiency, a displacement of the cardioplegia canula or a lack of efficiency of the aortic clamp. It is necessary to nd the cause of this delay. We routinely infuse 1500 ml for patients above 80 kg; for those with a lower weight to decrease the evolution we infuse only 1000 ml. After 90 mn of aortic cross clamping, if obviously the operation will last longer than 2 h, we inject another 500 ml cardioplegia.
9 Atriotomy
A 2-0 Vicryl®stay suture is placed in the fat anterior to the interatrial groove, exerting traction will improve the exposure of the left atrium, for the opening, the closure and later to control the lack of bleeding. A long needle is used as a guide by placing through the chest wall lateral after having palpated the intercostal space (4th) the needle has to be delicately handled; its role is to avoid hitting the internal mammary vessel. Internally this is located just medial to the
®
Alexis A 5 mm stab is done at the level of the exploring needle and pass the interatrial stay suture and the shaft for the left atrial retractor.
right inferior and towards the right superior pulmonary vein. A hand held sump sucker in left atrium retracting inferiorly provides a good view. A 2-0 Ethibond in the fat anterior to the interatrial groove. A long needle is used as a guide by placing through the chest wall lateral to the internal mammary artery, level with working ports, and left atrium. Inter­nally this is located just medial to the Alexis inner ring using ngertip proprioception. A 5 mm stab lateral to the needle is made and a Pean artery clip is used to develop the tract. Use the above stab hole to pass through the atriotomy stay suture and site the shaft of atrial retractor.
inner ring using ngertip proprioception.
Incise the left atrium midway between the
®
atriotomy stay suture is placed
Incise the left atrium midway between the right inferior and towards the right superior pulmonary vein. A handheld sump sucker in left atrium retracting inferiorly provides a good view. The left atrial incision is carried out with long shafted scissors towards the roof of the left atrium and under the IVC. The atrial wall is retracted anteriorly by inserting the blade of the atrial retractor and xing the shaft with the Iron­Assistantand clamp at the base of the atrial retractor shaft. Most of the time the inferior wall of the left atrium is blocking the view of the mitral valve.
A 4-0 Prolene is passed through the atrial wall at around 5 oclock, 2 cm behind the inferior wall and will nicely expose the mitral valve. The endoscope is then placed to have the mitral valve in full view, in the mid dle of the screen. Instead of bringing the endoscope close to the mitral valve, it is preferable to use the zoom properties of the equipment. The endoscope should remain as close to the thorax wall as possible to avoid conicts with the instruments.
10 Mitral Valve Repair
Mitral valve repair is performed according to the standard techniques. After careful analysis, the proper technique can be selected and implanted according to the lesions. Surgery must be driven by the strategy, which is to restore a good surface of coaptation, smooth and regular, as long as possible and located in the inow of the left ventricle.
A ring annuloplasty is routinely used, special care has to be taken to avoid an injury of the aortic valve or the circumex arter y.
®
11 Mitral Valve Replacement
Any type of mitral valve replacement can be carried out, mechanical or biological. The only particularity is that the incision of the working port is planned long enough to accommodate to
140 P. Perier
the bulky prosthesis. Using the Cor-knot®device (LSI Solutions) may help to have a standard tension on the knots.
12 Concomitant Tricuspid Repair
In case of indication of a tricuspid repair, it is necessary to carefully take this into account in the planning of the operation. In contrast to an operation performed through sternotomy, a min­imally invasive tricuspid repair is time consum­ing, around 45 mn. The exposure is not always easy, and the closure of the right atrium has to be perfect with no bleeding, and this takes time.
In our daily practice we start with the tricuspid repair before the mitral valve. It avoids having the stay suture in the way.
13 End of the Operation
and Deairing
It is crucial that, after the closure of the left atrium and before deairing, when the heart is still totally decompressed, a pacemaker wire is placed on the diaphragmatic face of the right ventricle.
A left vent is placed in the left ventricle, suction is applied on the cardioplegic needle, the heart is lled. Deairing should be controlled with echocardiography. CO of the time, there are just isolated bubbles, at the most.
After unclamping the aorta, and some reper­fusion, ventilation may be resumed, and the HLM ow may be reduced to ½ liter, while controlling the oxygen saturation. A preview echocardiographic control is performed. It saves a lot of time if at that stage the result is not satisfactory, and if it is necessary to improve the result of the repair. Everything is still in place.
In case of a good result, the HLM can proceed again full ow, the ventilation has to be stopped. The cardioplegia line is removed and the hole is secured with a 4-0 Prolene.
Closure, hemostasis, discontinuation of CPB, decannulation and echoc ardiographic control are performed in a normal way.
is very potent and most
2
This minimally invasive mitral surgery is increasingly being shown to yield comparable or better resul ts to open mitral surgery with all the added benets associated with endoscopic pro­cedures, and foremost is associated with an extremely high patient satisfaction. One motto is never losing sight of patient safety and quality of the results. This non compromise attitude is best achieved with a dedicated team approach. A team is made of surgeons, anesthetists, perfusionists, and nurses. As Simon Sinek as taught us, a team is not only a group of people working together, but a team is also a group of people trusting each other. Another point is the necessity of building a routine, which will allow the team to develop the required skills and to build an experience on which everyone can rely. It means that a minimal number of cases per year is necessary to start a program of minimally invasive mitral surgery. It is even more important in the beginning to be able to select patients according to ones level of expertise.
Endoscopic minimally invasive mitral surgery is a fantastic training tool. The trainees can per­fectly see what the senior surgeon is doing, contrary to what happens in the conventional surgery. When assisting a younger surgeon, it is possible to totally control each manoeuvre of the operation.
Tips
1. Maintaining a regular theatre team allows for a smooth procedure.
2. Having good TOE images are crucial for safe peripheral cannulation.
3. The external clamp is best placed by making the incision on the upper border of the rib to avoid the neuromuscular bundle running at the lower aspect of each rib.
Tricks
1. Incising the tissue over the pulmonary artery and creating the bloodless eld below the aorta gives extra space to apply the clamp and avoids injury to the left atrial appendage.
Endoscopic Mitral Valve Surgery Using the External Clamp 141
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2. A circular suture in the adventitia of the aorta placed above the sino-tubular junc­tion acts as a safe way to anchor the car­dioplegia cannula.
3. If an extra suture is required at the car­dioplegia site a pledged braided suture can be tied with a CorKnot to control the bleeding. This is best done with a reduced pump ow.
Traps
1. In large patients with a lot of adipose tissue over the pericardium an energy source is useful to dissect the fat off the pericardium prior to opening it.
2. In patients with short aortas avoid the temptation to place the cardioplegia can­nula in the non coronary sinus area as this can be difcult to control in some patients.
3. In case of bleeding from the stab incisions a period of pressure applied by a peanut swab until heparin is reversed helps to localise the cause and often this can then be dealt with diathermy to the site.
References
1. Carpentier A, Loulmet D, Carpentier A, Le Bret E, Haugades B, Dassier P, et al. Open heart operation under videosurgery and minithoracotomy. First case (mitral valvuloplasty) operated with success. C R Acad Sci III. 1996;319(3):219–23.
2. Mohr FW, Falk V, Diegeler A, Walther T, van Son JA, Autschbach R. Minimally invasive port­access mitral valve surgery. J Thorac Cardiovasc Surg. 1998;115(3):567–74;discussion 74–6.
3. Vanermen H, Wellens F, De Geest R, Degrieck I, Van Praet F. Video-assisted Port-Access mitral valve surgery: from debut to routine surgery. Will Trocar­Port-Access cardiac surgery ultimately lead to robotic cardiac surgery? Semin Thorac Cardiovasc Surg. 1999;11(3):223–34.
4. Cheng DCH, Martin J, Lal A, Diegeler A, Fol­liguet TA, Nifong LW, et al. Minimally invasive versus conventional open mitral valve surgery: a meta-analysis and systematic review. Innov Technol Tech Cardiothorac Vasc Surg. 2011;6(2):84–103
https://doi.org/10.1097/IMI.0b013e3182167feb.
5. Perier P, Hohenberger W, Lakew F, Batz G, Diegeler A. Rate of repair in minimally invasive mitral valve surgery. Ann Cardiothorac Surg. 2013;2 (6):751–7.
6. Casselman FP, Van Slycke S, Wellens F, De Geest R, Degrieck I, Van Praet F, et al. Mitral valve surgery can now routinely be performed endoscop­ically. Circulation. 2003;108 Suppl 1:II48–54.
7. Suri RM, Antiel RM, Burkhart HM, Huebner M, Li Z, Eton DT, et al. Quality of life after early mitral valve repair using conventional and robotic approaches. Ann Thorac Surg. 2012;93(3):761–9.
8. Murzi M, Cerillo AG, Bevilacqua S, Gasbarri T, Kallushi E, Farneti P, et al. Enhancing departmental quality control in minimally invasive mitral valve surgery: a single-institution experience. Eur J Car­diothorac Surg. 2012;42(3):500–6.
9. Holzhey DM, Seeburger J, Misfeld M, Borger MA, Mohr FW. Learning minimally invasive mitral valve surgery: a cumulative sum sequential probability analysis of 3895 operations from a single high­volume center. Circulation. 2013;128(5):483–91.
10. Vo AT, Nguyen DH, Van Hoang S, Le KM, Nguyen TT, Nguyen VL, et al. Learning curve in minimally invasive mitral valve surgery: a single­center experience. J Cardiothorac Surg. 2019;14 (1):213.
11. Rival PM, Moore THM, McAleenan A, Hamilton H, Du Toit Z, Akowuah E, et al. Transthoracic clamp versus endoaortic balloon occlusion in minimally invasive mitral valve surgery: a systematic review and meta-analysis. Eur J Cardiothorac Surg. 2019;56 (4):643–53.