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324
Y. Lu and S. Wu
Fig. 32.4 Illustration of SIJ injection
sacroiliac joint disease. Yet, even the sacroiliac joint injection has been shown to be not very reliable. The effects of two consecutive injec­tions are identical only 60 % of the time. One possible explanation for the inaccuracy of the sacroiliac joint injection is the diffusion of the anesthetic agents out of the sacroiliac joint dur­ing injection. The diffusion causes the anesthetic agents to come in contact with adjacent nerve trunks or roots, which leads to temporary pain relief even if the sacroiliac joint may not be the sources of pain. Injection of the anesthetic agents into the sacroiliac joint might relieve pain from numerous surrounding ligaments as well.
Given the uncertainty of diagnosing sacroiliac joint disease, it is without surprise that it is not easy to identify an effective treatment for the dis­ease. The fi rst-line treatments for sacroiliac joint pain are conservative treatments including anal­gesic and anti-infl ammatory medications, physi­cal therapy, and several types of injection treatments. When conservative therapies fail to relieve the symptoms and the physicians believe the pain is originating from the sacroiliac joint, more invasive treatment modalities are consid­ered. Two such treatment options are surgical fusion of the sacroiliac joints or ablative therapy to denervate the joints. A systemic review of the published results from six fusion studies and fi ve
denervation ablative studies reported that the majority of patients were satisfi ed after receiving either treatment [ 2 ]. Both procedures reported effi cacy in improving pain and functional out­come. However, the evidence was low to very low since all the studies were case series and the number of patients in those studies was generally low. In addition, the effects were relatively moderate. The mean rate of patient satisfaction was 57.6 % for fusion studies with great varia­tions (range from 18 % to 100 %). The mean pain improvement in the studies that reported visual analog or numeric rating showed the improve­ment in the pain scale of 3.5 and 4.9 points, respectively. One study that documented Oswestry Disability Index (ODI) showed an improvement of 14.0 points. These two treat­ments (fusion and denervation ablation surgery) have comparable improvements in pain relief and functional outcome. The denervation ablation studies generally have a short follow-up of 6–12 months; therefore, it is unclear whether the denervation procedures provide durable pain relief. It is worth noting that many lumbar facet joint denervation ablation studies showed loss of effi cacy after about 2 years.
When conservative treatment fails to relieve pain from suspected sacroiliac joint disease, fusion surgery becomes a treatment option. Various open fusion surgery techniques have been developed including the posterior or Smith­Petersen approach, the anterior approach, and the posterior midline fascia splitting approach [ 4 , 14 ]. The results from the open sacroiliac joint fusion surgeries were mixed. Some reported great effi cacy, yet some results were disappoint­ing. In one study by Schutz et al., the nonunion rate with instability was 41.2 %, and more than 80 % of the patients still had signifi cant pain after the surgery [ 21 ]. The open surgery itself is usu- ally painful due to the extensive dissection needed for the surgery. The relatively high com­plications and nonunion rates of open surgeries encourage surgeons to search for alternatives with possible lower morbidities and higher effi cacy.
In recent years, several minimally invasive sacroiliac joint arthrodesis techniques have been
32 Minimally Invasive Sacroiliac Joint Fusion
325
developed [ 1 , 17 , 20 , 26 ]. Not all the techniques have clinical data to back up their effectiveness yet. However, the limited publications up to date indicated generally good clinical outcomes using minimally invasive sacroiliac joint fusion tech­niques in treating sacroiliac joint pain that had failed conservative treatments.
In 2008, Wise and Dall described a minimally invasive sacroiliac joint fusion procedure and published their series of 13 consecutive patients [ 26 ]. All the patients had no relief after more than 6 months of conservative therapy and completed exhaustive workups to rule out lumbar spine as the source of pain. A fl uoroscopically guided intra-articular injection with a mixture of local anesthetic and corticosteroid was used to confi rm the diagnosis of sacroiliac joint dysfunction. Their surgical technique involved inserting cages along the anterior-posterior (AP) axis of the sac­roiliac joint percutaneously. The key for safe placement of the cages in the AP axis was the understanding of the safe cephalad and caudad margins of the sacroiliac joints and the depth of placement based on preoperative images. It is important to avoid placing the cage too deep through the anterior portion of the joint and into the pelvis. Preoperative CT scans of the bilateral sacroiliac joints with the patients in the prone position (same position as in the surgery) were used to determine the area with the most bony surface available on both sacral and iliac sides of the joint as the “safe zone” for cage placement. During surgery, with the patient in prone posi­tion, the starting point of the incision was made on the most prominent part of the posterior supe­rior iliac spine (PSIS) and extended 1 cm caudad and 4 cm cephalad. The dissection was carried down to the PSIS, and a calibrated Steinman pin was tapped into the bone carefully. The place­ment of the Steinman pin was approximately 6–7 mm cephalad to the caudal margin of the safe zone. The depth of the Steinman pin advance­ment was carefully monitored using fl uoroscopy so that it was within the preoperative measure­ments (usually between 4.5 and 6.5 cm). When the pin was at the predetermined position, a 9-mm cannulated drill was used to drill over the pin. The surgeon watched the lateral fl uoroscopic
images carefully to make sure the tip of the pin was not advancing with the drill to avoid its advancement into the pelvis. After palpation of the drilled hole, a threaded titanium cage, mea­suring 11 × 25 mm (Medtronic Sofamor Danek, Memphis, TN), was then packed with BMP and inserted in the hole with the open slots of the cage’s sidewalls pointing to the sacrum and the ileum. After the fi rst cage was placed, the second cage was inserted in a similar fashion, approxi­mately 6–7 mm cephalad to the fi rst cage. In their series of 13 consecutive patients, an 89 % fusion rate was achieved based on the 6-month CT scan. The low back pain improved by an average of 4.9 points on a ten-point visual analog scale. Leg pain improved by an average of 2.4 points, and dyspareunia improved by an average of 2.6 points. Seventy-seven percent of the patients reported satisfaction with the results of the surgery.
Al-khayer et al. from the UK published their method of percutaneous sacroiliac joint fusion and analyzed their outcomes from nine patients in the same year [ 1 ]. In their procedure, the authors used one single hollow modular anchor­age (HMA) screw (Aesculap, Sheffi eld, UK), which is a hollow cylindrical implant made from one piece of titanium alloy and placed the screw perpendicular to and across the sacroiliac joint from the lateral side. The screw passed through the sacral alar to the body of S1 vertebra at the midpoint between the S1 neural foramina and the L5/S1 disc. Patients were placed supine on a radiolucent table. Four views (lateral, anteropos­terior, inlet, and outlet) of the pelvis were obtained. A guidewire was placed percutane­ously and advanced across the sacroiliac joint to the body of the S1 vertebra under fl uoroscopic guidance. A cannulated 10-mm drill was then used to drill over the guidewire with the protec­tion of a guide tube, also under fl uoroscopic guidance. The guidewire was then removed, and a 10-mm tap was used to prepare for screw inser­tion. The HMA screw was then packed with the bone graft from the bone reaming obtained dur­ing drilling with demineralized bone matrix and screwed into the prepared tunnel. The usual length of the screw was about 40–50 mm.
326
Y. Lu and S. Wu
The position of the screw was confi rmed using the fl uoroscope. In their series of nine patients with an average follow-up of 40 months, the mean VAS dropped from 8.1 preoperatively to
4.6 postoperatively. The mean ODI dropped from 59 to 45. The mean patient satisfaction was 6.8, and all the patients stated that they would undergo the same procedure again under the same circum­stances. Placing the anchoring screws across the sacroiliac joint may have the benefi ts of immedi­ate stabilization, before the fusion happens. Although the posteriorly placed grafts into the AP axis of the SI joints like the ones used by Wise and Dall may have the same effect function­ing as a door wedge stabilizing a pivoting door.
Khurana et al. also reported their experience with 15 patients using the same hollow modular anchorage screws fi lled with demineralized bone matrix to treat the refractive sacroiliac joint dis­ease [ 17 ]. In a mean follow-up of 17 months, the average Short Form-36 scores improved from 37 to 80 for physical function and from 53 to 86 for general health. Thirteen patients (87 %) had good to excellent outcomes.
There are several commercial minimally inva­sive sacroiliac joint fusion systems available on the market currently. Most of the systems were developed within the past several years; there­fore, only limited data is available regarding the clinical effi cacy of these systems.
1. iFuse ® : The iFuse Implant System ® from
SI-BONE ® places several (usually three)
porous plasma-coated titanium implants
across the sacroiliac joints laterally through an
incision of approximately 3 cm (Fig. 32.5 ).
The surgical technique includes initial place-
ment of guidewire pins across the sacroiliac
joint under fl uoroscopic guidance. A drill and
a triangular broach are then used to prepare
the bone over the pins with the help of a soft
tissue protector. The triangular implant is then
inserted into the prepared tunnel with a mal-
let. Usually three implants are placed, in the
sacral alar, above or adjacent to the S1 fora-
men, and between the S1 and S2 foramen,
respectively (Figs. 32.6 and 32.7 ). There are
several unique features of the iFuse system.
The triangular implant profi le minimizes
i Fuse Implants: 30–70mm length, 4 and 7mm diameter
Fig. 32.5 iFuse ® implant system
Fig. 32.6 iFuse ® implants across the SI joints
rotations of the implant. The porous surface is designed to minimize micromotion of the implants and promotes bony overgrowth leading to eventual fusion. Usually three implants are placed in one sacroiliac joint; therefore, rotation movements of the sacroiliac joints with the single-threaded cage system
32 Minimally Invasive Sacroiliac Joint Fusion
327
Fig. 32.7 X-ray image of iFuse ® implants across SI joint
should be minimized, and strong immediate
stabilization of sacroiliac joint is achieved.
According to the company website, biome-
chanical studies demonstrated that the 7-mm
triangular implant is three times stronger in
shear and bending strength than an 8-mm can-
Fig. 32.8 SI-Lok ® sacroiliac fi xation system
nulated screw. In the iFuse system, no autolo-
gous graft, allograft, or other fusion extenders
were placed in the sacroiliac joints, nor does
the sacroiliac joint be decorticated in prepara-
tion for fusion. The eventual bony fusion was
therefore dependent upon the porous surface
of the implants. Rudolf reported the use of
iFuse for minimally invasive sacroiliac joint
fusion on the fi rst consecutive 50 patients
treated [ 20 ]. Pain scale decreased from 7.6 to
3.3 at the 12-month follow-up and to 2.0 at the
24-month follow-up. Eighty-two percent of
the patients reported satisfaction of the sur-
gery. No radiographic outcomes about
Fig. 32.9 SI-Lok ® screws across the SI joints
whether the implants led to fusion were dis-
cussed. Eleven patients (22 %) experienced
complications including three cases of super-
fi cial cellulitis, one deep infection, two large
buttock hematomas, one nondisplaced ilium
fracture, and one delayed loosening of the
implants causing recurrence of symptoms.
Three patients were taken back to the OR for
implant penetration into the sacral neural fora-
men or L5 neural foramen.
2. SI-LOK ® : Globus Medical Inc. also devel-
oped a minimally invasive sacroiliac joint fi x-
ation system SI-LOK ® (Fig. 32.8 ). SI-LOK ®
system places three hydroxyapatite-coated
screws laterally through the sacroiliac joints (Figs. 32.9 and 32.10 ). The optional bone graft slots in the SI-LOK ® screws allow sur­geon to place bone grafts in the screws to pro­mote fusion. Furthermore, the optional lag screw thread is designed to apply compression force across the SI joint during insertion, further improving chances of fusion. Clinical and biomechanical studies of the SI-LOK ® system are currently underway.
3. SImmetry ® : SImmetry ® system from Zyga Technology Inc. places two cannulated titanium screws (one 12.5-mm and one 6.5-
328
Y. Lu and S. Wu
Fig. 32.10 Fluroscopic images of SI-Lok ® screws placed across the SI joint
for SI joint decortication using a series percutaneously placed stainless steel cutters and bone graft placement into the SI joints. These steps are designed to promote arthrod­esis across the sacroiliac joints (Fig. 32.12 ).
Using the lateral fl uoro view, a 6-mm dila­tor with obturator is advanced to the ilium at the planned trajectory and entry point. Obturator is then exchanged with the 3.2-mm guide pin, and the pin is driven into the outer ilium cortex slightly. Inlet- and outlet-oblique views are then used to confi rm the correct tra­jectory of the guide pin. Under the outlet­oblique view, the guide pin is advanced to the joint. The lateral ilium cortex is then serially dilated with slap hammer and the 6-mm, 8-mm, and 9-mm dilators. After the guide pin
Fig. 32.11 SImmetry ® sacroiliac joint fusion system
is removed, a working cannula is tapped into the sacroiliac joint until the working cannula shoulder contacts the lateral ilium cortex.
mm anti-rotation screw) across the sacroiliac joint laterally (Fig. 32.11 ). The screws are available from 30 to 70 mm in length. Unique features of SImmetry ® include special steps
A 17-mm sleeve is then advanced over the working cannula. Scraper and serial special sacroiliac joint curettes are used to remove the cartilage and decorticate a portion of the
32 Minimally Invasive Sacroiliac Joint Fusion
Fig. 32.12 SImmetry ® system uses specials tools to decorticate the SI joints and place bone grafts into the SI joints
329
sacroiliac joint to create a bleeding bed for fusion (Fig. 32.12 ). A graft inserter loaded with 2-cc bone graft is then inserted into the working cannula just proximal to the joint.
Pressing the back of the graft inserter extrudes bone graft into the denuded cavity in the sacroiliac joint (Fig. 32.12 ). A graft spreader is then used to spread the bone graft radially
330
Y. Lu and S. Wu
Fig. 32.13 12 month post-op CT scans showing fusion using SImmetry ®
into the cavity. The uneven surface of the SI joints may cause some diffi culty in the joint decortication and graft spreading. After the bone graft placement, 9-mm drill with the guide pin is replaced. Guide pin is advanced with a pin driver under fl uoroscopic guidance. A 9-mm drill is then advanced into the sacrum cortex to the same depth and removed. A 12.5­mm fusion rod with the selected depth is advanced into the pre-drilled path with the
12.5-mm driver until fully seated. At this time, the fl uoroscope is turned into lateral position, and a separate incision is made for the cepha­lad 6-mm anti-rotation screw. Similar tech­niques are used to place the 6-mm anti-rotation screw although there is no need to decorticate the sacroiliac joint here.
Currently Zyga Technology Inc. is con-
ducting ongoing 12-month postoperative CT
image studies with a third-party radiographic analysis group for all the patients who have received SImmetry ® implants. The fi rst few CTs showed solid fusion evidenced by extra­articular bone bridge, bone bridge immedi­ately adjacent to the rod, and no radiolucency in the ilium or sacrum (Fig. 32.13 ).
4. SIFix ® : SIFix ® from Nutech Medical Inc. is the fi rst commercial posterior minimally invasive sacroiliac joint system. It uses two carefully machinized threaded cancellous bone dowels measuring 22 mm × 11 mm (length × diameter) that are placed along the AP axis of SI joints to provide stabilization and fusion (Fig. 32.14 ). Because the SIFix ® uses a midline posterior incision, surgeons can perform bilateral SI joint fusion through a single midline incision. Without repositioning the patient, the inci­sion can also be easily extended to perform
32 Minimally Invasive Sacroiliac Joint Fusion
331
Fig. 32.14 SIFix ® system
Fig. 32.16 Drill bit in the SI joint to decorticate the joint
and create a void for the bone dowel
Fig. 32.15 Fluoroscopic assisted oblique view to visual­ize the SI joint
posterior spine procedures at the same time, if indicated. In SIFix ® , the use of allograft bone dowel as the implant is designed to enhance bony ingrowth and fusion.
In SIFix ® procedure, patient is placed in the prone position. An oblique view is obtained to visualize the SI joint (Fig. 32.15 ), and inferior and superior margin of the SI joint are identi­fi ed. A single 4-cm midline incision is made to accommodate two planned bone dowels, and place guidewires into the SI joints under fl uo­roscopic guidance (Fig. 32.15 ). Serial dilators are used to create the path, and the SI drill guide is then placed through the fi nal dilator to access the SI joint. Guidewire in the drill guide is then removed, and drill bit is used to create a void in the SI joint for implant place­ment (Fig. 32.16 ). Using the implant inserter, the implant is then inserted into the space. A second implant is placed in a similar fashion
Fig. 32.17 Fluoroscopic image showing the placement of two SIFix joint
®
bone dowels along the AP axis of the SI
(Fig. 32.17 ). After the bone dowels have been countersunk into the SI joint, bone graft of choice can be packed into the socket to aid in fusion (Fig. 32.18 ).
In summary, minimally invasive sacroiliac joint fusion has seen signifi cant advancement in the recent years. The advantages of minimally invasive sacroiliac joint fusion over the open fusion procedures are multifold. In addition to the minimal blood loss, shorter operation, and faster recovery time, minimizing damages to the surrounding ligaments preserved the intrinsic sta­bility of the sacroiliac joint prior to fusion. In other words, using the minimally invasive tech­niques, there is no need to destabilize the sacro­iliac joint fi rst to promote eventual fusion. This might lead to better patient outcome; certainly there is less need to restraint patient’s activity after the surgery. In comparison, in open SI fusion surgery, patients frequently need to be in no weight bearing status for 12 weeks.
332
Y. Lu and S. Wu
Fig. 32.18 CT scan showing evidence of SI joint fusion using SIFix
Traditionally, the benefi t and risk/morbidity ratio does not favor much in the treatment of SI joint degenerative pain with open surgery. However, the advancement of the minimally invasive alter­natives might change the balance and provide valid surgical options for patients with refractory degenerative SI joint disease. More clinical and radiographic data, however, is much needed to support the use of those new techniques and to prove their effi cacy (Fig . 32.18 ).

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