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6 Arterial Revascularization
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widths above the ankle joint to prevent punc­ture of the muscle compartments.
• The tibial arteries in patients with CLI tend to be calcied along with low intravascular pres­sure from more proximal disease, which may pose as a technical challenge.
• In the setting of multilevel occlusive disease, the distal artery wall may be more pliable than normal due to low lling pressures and punc­turing the artery wall with the needle may require the operator to change the angle of entry. In addition, because of the lack of stiff­ness of the arterial wall the vessel may escape the needle trajectory.
• The operator may also face difculty with the amount of pressure required to successfully puncture given the low lling pressure and lack of artery wall stiffness. The vessel may collapse under such pressure, and eventually, the needle will puncture the posterior wall. This represents a true Seldinger technique. The operator will have to withdraw the needle very slowly while gently advancing the wire to aid in releasing posterior wall from the nee­dle and allowing the access wire to easily advance within the true lumen. Figure 6.16 shows a longitudinal view of needle access into the distal PT.
Imaging protocols for diagnostic ultrasound
assessment of tibial arteries vary by institution. In a CLI center, technologists perform an exten­sive evaluation, or mapping, of the three tibial arteries. In addition, particular attention is paid to
areas of disease, vessel integrity, and proximal and distal CTO location. Evaluating collateral ow and communication between tibial arteries is of particular importance for the operator in planning the revascularization approach.
• As tibiopedal access becomes an essential part of treating CLI patients, the use of arterial mapping can dene patients that have ade­quate targets for tibial access.
• A phenomenon described as the white stop sign refers to complete loss of vessel lumen preventing successful access. In these patients, the distal tibial artery is completely opacied with calcied plaque along the length of a seg­ment of the vessel.
• EVUS can distinguish this feature from short areas of occlusion, a situation in which the operator can choose another location within the same vessel to access, usually above or below the occlusion to obtain successful access.
Table 6.1 shows a list of common US land-
marks the operator can depend on to identify position within the vascular tree
EVUS is also able to identify prominent
branches of the tibial arteries. The proximal ante­rior tibial (AT) artery gives way to the anterior tibial and posterior tibial recurrent branches. Identifying this landmark is important because in many instances the AT occlusion occurs in the proximal segment. The posterior recurrent branch tends to compensate for the AT if occluded. This branch is commonly mistaken for the AT.
• This collateral tends to be tortuous and becomes very small toward the ankle. It is important to recognize this vessel, especially with retrograde tibial access, in order to pre­vent the wire from naturally sub-selecting this branch.
Another important landmark for tibial access
is the anterior and posterior communication branches of the peroneal artery. While each
Fig. 6.16 An access needle is visualized on EVUS while obtaining retrograde pedal access
patient is different, EVUS with color Doppler can identify the communicating vessels, usually
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Table 6.1 Tips for EVUS Guided Procedures
Detailed Anatomical Map for Procedure Planning
•Multiple modalities including duplex ultrasound, CTA, and MRA may be used.
•Selective angiography has a better correlation with arterial duplex imaging and in patients with PVD [30].
•Assessing adequate conduits for access approach. EVUS Characteristics of Arteries
•Layers of the arterial wall dene the intima, media, and adventitia to provide safest and most effective therapy.
•Plaque location and type to ensure safe access and appropriate therapy.
•Calcium content within the vessel may impact imaging.
Severe calcication will create acoustic shadowing rendering US imaging obsolete. Calcium can be as dense as bone tissue and does not allow the sound waves to penetrate beyond the anterior wall of a vessel. In these cases, EVUS may not be effective.
EVUS Anatomical Landmarks
•Identication of the head of the femur for groin access.
•Identication of collateral branches and bifurcations.
•Identication of the muscle compartments within the calf for tibial access.
Characteristics of Endovascular Devices
•Echogenic tip needle.
•Bright double lumen of a catheter or sheath.
•Bright single line of a wire.
•Moving/rotating of atherectomy device.
•Stent strut identication. Chronic Total Occlusion Mapping
•The proximal CTO cap morphology, architecture, shape.
•The distal CTO cap morphology, shape.
•Collaterals at the proximal CTO cap.
around or just above the ankle. Ideally, if the operator can visualize the takeoff of these ves­sels, access can then be achieved above their ter­mination allowing blood ow beyond the access point to the foot.
Ultrasonic Features of Endovascular Therapeutic Devices
made up of multiple different types of material to ensure lubricity and mobility of the wire to pre­vent sticking to anatomical structures or devices. The metal of the wire is easily identied with ultrasound and is visualized as a bright white line. Because of the movement of the wire and the density of the material, reverberation artifact is often seen. Identifying the true position of the wire will eliminate any complications from this artifact.
• CTO crossing with EVUS is an advanced technique that allows the operator to directly visualize the wire cross into the CTO, avoid­ing the subintimal space, and ensures that the wire maintains a true luminal position for the length of the CTO to provide the best treat­ment possible.
Catheters andSheaths
Identifying sheath location during intervention is pertinent, especially for treatment in close prox­imity to the tip of the sheath. The sheath is visual­ized as two bright white parallel lines due to the density of the sheath wall under EVUS.Catheters look very similar under EVUS, however tend to be much smaller in size. Visualization of cathe­ters depends on material utilized to build the device. Typically, larger catheters (0.035 and
0.018) are easier to visualize due to their size.
Some catheters are double braided increasing the echogenicity of the catheter.
• Catheters with a bend tip offer a particular advantage as the operator rotates the device, and this is well observed with EVUS.This in turn will allow the operator to engage areas within the vessel such as the CTO cap or guide the wire away from side branches to avoid complications during treatment.
Needles andWires
Needles are made of stainless steel and may have indentation along the distal length of the needle for better ultrasound visualization, referred to as an “echogenic tip” needle. It is essential to visu­alize the needle as the skin is punctured, and the needle is advanced toward the artery. Wires are
Balloons
Angioplasty balloon catheters are made up of multiple layers. Depending on the balloon type (rapid exchanged or over the wire), the shaft of the balloon appears as a lumen with a wire through it. As the balloon is advanced, the thick­ening of the catheter indicates that the bladder
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portion of the balloon has come into view. Once balloon position is conrmed under EVUS and uoroscopy, EVUS-guided ination of the bal­loon allows for direct visualization of the arterial wall interrogation.
• Balloons that are underinated or undersized will demonstrate a dark echogenic gap between the balloon wall and the arterial wall.
• Properly sized inated balloons will demon­strate no gap with complete balloon opposition to the arterial wall, and in some cases, a step down is visualized at the proximal and distal end of the balloon to account for vessel recoil.
• Sometimes, the lesion will not immediately comply with balloon ination. Slow ination with EVUS guidance allows live monitoring of vessel wall compliance to ensure adequate and safe balloon ination while avoiding uoroscopy.
Atherectomy andCTO Crossing Devices
The appearance of atherectomy devices varies depending on the mechanical component. For Diamondback orbital atherectomy (CSI), the metal crown is covered with a synthetic diamond coating to modify the surface of the plaque, allowing for more effective adjunctive therapy. EVUS allows for visualization of the crown inter­rogation of plaque. Laser atherectomy creates an ablation bubble ahead at the tip of the catheter and creates micro-cavitation within the artery to disintegrate plaque. The micro-cavitation bubble created when the catheter is activated can be visualized with EVUS.
Stents
Stents deployed in the infrainguinal region are most often self-expanding, while stents deployed in the tibial arteries tend to be balloon expand­able. Regardless of the type of stent, all stents are well visualized under EVUS due to the thin metal struts that are highly echogenic. Identifying the location of the stent struts allows the operator to successfully interrogate an occluded stent while avoiding crossing behind the stent. Operators can visualize wires, catheters, and balloons travers­ing the stent, preventing equipment from getting stuck behind a stent strut, or creating a false lumen between the stent and the arterial wall. EVUS-guided sizing and deployment of a stent can also be performed with precision. For exam­ple, EVUS-guided stent deployment performed from a retrograde tibial approach in the ostium of the SFA allows the operator to avoid stenting across and jailing the profunda femoral artery (Fig.6.17).
Ultrasonic Features ofChronic Total Occlusion (CTO)
CTOs are some of the most complex arterial pathologies to treat and are composed of a proxi­mal cap and distal CTO cap, often with mixed plaque types along the length of the occluded segment. Depending on the length and age of the occlusion, the CTO segment may have a hiber­nating lumen in between the proximal and distal caps. In extreme cases, the whole vessel between the proximal and distal cap is occluded.
EVUS can be used to assess the type and loca-
tion of the CTO cap. Mapping the morphology of
a bc
Fig. 6.17 (a) A support catheter is seen traversing an occluded tibial artery, (b) an orbital atherectomy crown visualized while treating a tibial artery, and (c) a stent is
deployed utilizing EVUS guidance to avoid jailing the profunda femoral artery
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the CTO caps will allow better assessment of access approach and treatment options. While the composition and calcium content may differ from one CTO cap to another, one common quality observed among most CTO caps is the shape.
• The chronic total occlusion crossing approach based on the plaque cap morphology (CTOP) analysis evaluated patients with CTOs involv­ing the SFA/popliteal and tibial regions [29].
• Shape of the CTO cap was categorized into two shapes: concave and convex. The shape is determined based on the shape of the cap from an antegrade direction. For example, Fig.6.18 shows a concave-shaped CTO cap. This CTO cap is imaged via EVUS and angiography.
• The cap description also allows the operator to predict which CTO cap will allow for true lumen wire crossing of the vessel and which will direct the wire into the subintimal space.
• A convex CTO cap will include at-shaped caps, oblique caps, or oblique caps leading to a collateral. All of these are features sugges­tive of a cap that is difcult to penetrate. Based on a simple dichotomous distinction between the caps and the fact there are usually proxi­mal and distal caps, there would be four pos­sible combinations in patients with CTOs.
• Utilizing EVUS to assess for CTOP cap mor­phology will allow the operator to choose whether or not to implement retrograde pedal access to mediate CTO crossing.
Conclusion
EVUS utilization for endovascular intervention in CLI is a viable option for patients with com­plex disease including multilevel and multi­vessel CTOs. Patients with CLI can benet from the utilization of EVUS as it may signicantly lower the use of contrast and radiation exposure, especially during access and CTO crossing. EVUS is an effective tool in obtaining pedal access and can guide the treatment of complex tibial disease. The utilization of EVUS in CLI interventions should be an essential tool for oper­ators tackling advanced PVD and CLI.
Fig. 6.18 A concave CTO cap is assessed with EVUS and angiography
6.2.2 Femoro-Popliteal Access
andClosure
S.JayMathews
6.2.2.1 Introduction
While radial and pedal access may be preferable and relatively safe alternative accesses, some­times they are not feasible nor effective for cer­tain pathologies. Popliteal, antegrade supercial femoral artery (SFA), and retrograde supercial femoral artery (SFA) access offer additional interventional options for challenging anatomies. However, careful considerations must be made to optimize the ergonomics of the procedure while ensuring patient safety during and after the case.
6.2.2.2 Popliteal Access
Popliteal access allows for retrograde crossing of difcult supercial femoral artery (SFA) occlu-
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sions, especially when the cap morphology is not amenable to antegrade crossing. In the modern era, direct pedal access is usually preferable to popliteal access, offering similar retrograde crossing capabilities with easy vessel closure via extra-vascular compression [31].
• In terms of alternative access, popliteal access is considered one of the least desirable points of entry due to difculty in compression.
• As a result, postoperative pseudoaneurysms, hematomas, and bleeding are more common [32].
• In the setting of poor tibial vessel caliber or tibial occlusion, and where modied Schmidt access (direct access into an occluded vessel segment) is not successful, direct popliteal access may be preferable as long as the vessel is not diseased.
Access is most commonly performed with the
patient in the prone position after which the patient is ipped supine [32].
• If this is a planned procedure, the preparation process can be simplied as the patient can have a limited draping performed for sheath access after which a complete draping done in the supine position.
• Ideal use a longer sheath (25–45cm) to facili­tate easy access once supine. Performance of the entire procedure can also be done in the prone position, but obese patients or those with airway management issues may not toler­ate long-duration interventions without anes­thesia support.
• Alternative methods of access include placing the patient in the lateral decubitus position, but this is ergonomically less ideal for access. The “frog-leg” position has been described for popliteal access with external rotation and gentle knee exion, either from posterior puncture or anteromedial access [32, 33].
• Given the proximity of the tibial, peroneal, and more proximal sciatic nerves, access should not be performed without extra­vascular ultrasound (EVUS). Moreover, the popliteal vein also may lay on top of the artery,
which can lead to inadvertent arteriovenous stula formation with through-and-through access.
Ideally, access should be kept as small as pos­sible potentially utilizing 2.9 to 4/5 Fr thin-walled sheaths or sheathless approaches (i.e., Bareback). Avoidance of the popliteal artery as the solo access will allow for balloon compression of the entry site at the end of the procedure from an alternate femoral access above. Data are limited with larger sheaths as these may be prone to more vascular complications. Vascular closure devices (VCDs) have been used with some success [34].
• Given the mobility of the vessel, extra-
vascular closure devices may be less reliable
leading to hematoma or pseudoaneurysm for-
mation [35].
• Active VCDs (intravascular hemostatic plugs,
active xation/clips, and suture-mediated clo-
sure) may be potentially effective but at the
risk of acute vessel closure, dissection, or
other vascular complications [36].
6.2.2.3 Antegrade SFA Access
Antegrade femoral approaches are utilized over contralateral femoral access when contralateral access is unfavorable. This can be due to bifurca­tion issues (e.g., acute iliac angulation, extreme iliac tortuosity, bifurcated endografts, or iliac stents), inadequate shaft length for below-the­knee (BTK) interventions, or inadequate support for difcult crossing [37]. Antegrade SFA access may be preferable to antegrade common femoral access [38, 39].
• In patients with even mild amounts of trun-
cal obesity, the angle at the inguinal crease
will be unfavorable resulting in more per-
pendicular access into the common femoral
artery [40].
• Angulation of entry may also drive the access
wire into the profunda rather than down the
SFA.The proximal supercial femoral artery
is fairly supercial under the skin and may
allow a more favorable shallow entry angle
avoiding kinking of the sheath.
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• Ultrasound-guided access of the proximal supercial femoral artery is reliable [41].
• Closure of the SFA can be challenging as manual hemostasis below the femoral head is impaired by lack of adequate compression.
• VCD closure of the access site can be per­formed similar to a retrograde common femo­ral approach, except in an opposite fashion. More distal antegrade access increases risk of closure-related complications, but active vas­cular closure devices may help secure the access more reliably.
• In this pictured example, after antegrade ultrasound- guided SFA access (Fig. 6.19a) and completion of the procedure, the Celt ACD vascular closure device is utilized given its low-prole and easy uoroscopic visual­ization (Fig.6.19b).
Ergonomics are more challenging with an antegrade approach. If positioning the patient on the table in standard fashion, after micropuncture access of the SFA, the access can be switched to a 45 cm braided sheath, which can be curved either ipsi- or contra-laterally and secured with adhesive dressing.
• The contralateral thigh may be preferable as
the angulation will be less extreme, which will
be less likely to adversely impact stent deploy-
ment systems or delivery of other equipment
(Fig.6.20a).
• Alternatively, the patient can be positioned
with the feet at the head of the table
(Fig.6.20b). This will allow for more natural
access angle, but should be utilized with an
anesthesia halo to avoid covering the patient’s
face with the drape. The uoroscopic image
Fig. 6.19 (a) Antegrade SFA access. (b) SFA Celt ACD occlusion
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Fig. 6.20 (a) Antegrade SFA access with a 45cm long sheath with operator standing on contra the contralateral side. (b) Antegrade SFA access, with a short (13–30cm) sheath, patient inverted and operator on ipsilateral side
can be also ipped digitally to the correct orientation.
6.2.2.4 Retrograde SFA Access
Proximal retrograde SFA access has been well described as an alternative to common femoral access in patients with high profunda bifurca­tions or unfavorable common femoral anatomy. Large vessel access for structural heart procedures and endovascular aortic repair has successfully utilized this technique [42].
• Distal retrograde SFA access is more chal­lenging but sometimes necessary when ante­grade crossing of an SFA occlusion is not possible or successful, especially with extreme calcium or stent fractures leading to unfavor­able subintimal crossing.
• Retrograde access below the adductor canal has been well described and can be safely per­formed [43]. EVUS should be utilized when possible but may be challenging as visualiza­tion through the musculature may be poor, especially in obese patients. Fluoroscopic guided access may be necessary utilizing road mapping from a proximal injection site.
Occasionally, a modied Schmidt technique
can be used within an occluded stent [44].
ba
• This can be performed with a micropuncture needle through the strut interstices, with advancement of an 0.018 stiff wire (ideally nitinol based to avoid kinking) torqued into a drill-like appearance through several rotations.
• This wire is continuously spun clockwise and counterclockwise with steady force. A micro­puncture sheath or sheathless technique can be used with a 0.018 crossing catheter after which the wire can be directed or snared into the proximal access.
• Sheathless approaches for balloon crossing and even stenting is also possible from the ret­rograde SFA access [45].
• Of note, closure of the SFA puncture is usu­ally easily performed with balloon tamponade from a proximal access, but occasionally with extreme calcium, a persistent channel may form requiring adjunctive use of a covered self-expanding stent.
6.2.2.5 Case Example
An 81-year-old man with diabetes, dyslipidemia, and chronic tobacco abuse presented with a Rutherford 5 left hallux wound. Antegrade cross­ing of a severely calcied SFA was not possible (Fig.6.21). The tibial vessels could not easily be identied on EVUS due to occlusion and poor caliber. Direct SFA access below the adductor
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Fig. 6.21 Diagnostic angiogram showing heavily calcied arteries, with distal SFA CTO and mid-popliteal artery reconstitution (a) and inability of antegrade wire crossing (b)
canal was performed with ultrasound guidance (Fig.6.22). A micropuncture sheath was left in place with wire crossing retrograde. After ante­grade atherectomy, drug-coated balloon angio­plasty, and prolonged percutaneous transluminal angioplasty (PTA) were performed. A persistent leak was seen once the micropuncture sheath was removed (Fig.6.23a). Ultimately, a focal Viabahn (W.L.Gore & Associates, Inc.) covered stent was necessary to seal the leak (Fig.6.23b).
ease (PAD) treatment toolbox. A radial approach is typically selected in cases where it is difcult or unsafe to access the common femoral artery, in patients with previous abdominal endografts or bifurcation stenting, or if anticoagulation is unable to be stopped [46]. With the currently available tools, plain balloon angioplasty, bare metal stenting, and atherectomy are the only treatment options for treating infrainguinal PAD via radial access, and covered stent graft are yet to be available. New longer devices that are small enough to t through a 6 Fr sheath have expanded
6.2.3 Arm Access forPeripheral Arterial Disease
the scope of PAD interventions that can be per­formed via TRA.In the past, axillary and bra-
chial accesses were used for interventions RickiA.Korff, RaghuramPosham, and RobertA.Lookstein
requiring larger sheath sizes where femoral
access was contraindicated. Now that technologi-
cal advancements have facilitated radial artery Transradial access (TRA) is an essential compo­nent of the endovascular peripheral arterial dis-
access up to 6 Fr in most patients and even 7 Fr in
some patients, axillary and brachial accesses are
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Fig. 6.22 Distal retrograde SFA access after failed ante­grade access and no suitable tibial access
rarely used. While with good ultrasound-guided access and other techniques, the common femo­ral use is still standard for many operators with­out signicant complications; however, alternative access and tools are of interest to many and growing.
105
• The system is then exchanged for a stiff sup­port wire such as a 260 cm angled GLIDEWIRE (0.035, Terumo) and an angled catheter such as an angled GLIDECATH (4 Fr, 120/150cm, Terumo).
Common and external iliac artery lesions:
• Crossed with a support catheter (i.e., 3.2 Fr × 150-cm Quick-Cross Select catheter, Philips) over a support wire. If stenting is indi­cated, the stiff support wire is then exchanged for a super stiff 0.035 260cm Amplatz wire in preparation for stent deployment.
• The largest diameter stent that can be deployed via TRA is a 12mm diameter×60mm length self-expanding stent, which is available on a 6 Fr×120cm platform (Boston Scientic Epic Stent). This allows for stenting of the majority of external iliac arteries and common iliac arteries in select patients.
• There are currently no drug-coated balloons indicated for treatment of the iliac arteries.
• Numerous percutaneous transluminal angio­plasty (PTA, POBA) balloons are available on 6 Fr platforms reaching up to 12mm in diam­eter, with working lengths capable of treating iliac artery lesions, compatible with both
0.035 and 0.018 wire systems (Fig.6.24).
• For treatment of external iliac artery lesions, the 10 mm diameter self-expanding WALLSTENT is available on a 6 Fr×135cm platform (Boston Scientic).
6.2.3.1 Device Selection forRadial Access
For treatment of common femoral and super-
cial femoral artery (SFA) lesions: Prior to performing a peripheral arterial interven­tion via transradial access, preprocedural plan­ning and knowledge of available devices are essential.
• The short introducer sheath and diagnostic catheter are exchanged for a long stiff intro­ducer sheath and support guiding catheter. Examples of long stiff sheaths include R2P
• In a typical transradial PAD case, radial access is obtained, a 6 Fr radial sheath is placed, and a radial cocktail is administered.
• A guidewire and catheter such as the 110cm OPTITORQUE Sarah Radial Catheter (5 Fr, Terumo) are used to navigate the infrarenal abdominal aorta.
Destination Slender Sheath (6 Fr, 119/149cm, Terumo), Pinnacle Destination Guiding Sheath (6 Fr, 45cm, Terumo) with a 100cm GLIDECATH (5 Fr, Terumo), R2P SLENGUIDE Catheter (7 Fr OD, 6 Fr ID, 120/150 cm, Terumo), Sheathless Eaucath (6.5–7.5 Fr OD, 4–5 Fr ID, 100cm, Asahi),
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Fig. 6.23 Persistent SFA access site bleeding after prolonged angioplasty (a). Followed by resolution of SFA access site bleeding after covered stenting (b)
PAD Devices Compatible
with Radial Access
Common and external iliac artery
Angioplasty
interventions
Bare Metal
Stent
- Epic Stent
(6Fr, 120cm, 12mm max OD, Boston Scientific)
- Wallstent
(6Fr, 135cm, 10mm max OD, Boston Scientific)
(up to 125-135 cm from left wrist, 8-12mm)
Plain Balloon
- Conquest
(6Fr, 120cm, 12mm max OD, BD Interventional)
- Dorado (5-6Fr, 120/135cm, 10mm max OD, BD
interventional)
- Charger (6Fr, 135cm, 10mm max OD, Boston Scientific Corporation)
- Mustang
(6Fr, 135cm, 10mm max OD, Boston Scientific Corporation)
Common femoral and SFA
Angioplasty
interventions
Bare Metal
Stent
- Everflex Entrust (5Fr, 150cm, 7mm max OD, Medtronic)
- R2P Misago Rx
(6Fr, 200cm, 8mm max OD, Terumo)
(up to 155-170 cm from left wrist, 5-10mm)
Plain Balloon
- Pacific Plus
(4Fr, 180 cm, 7mm max OD, Medtronic)
- Ultraverse Rx
(4-5Fr, 200cm, 5mm max OD, Bard)
- Jade PTA
(4-7Fr, 200cm, 7mm max OD, Cardiovascular Systems Inc.)
Plain Balloon
Angioplasty
- Advance 14LP
(4Fr, 170cm, 2-4mm OD, Cook)
- Pacific Plus
(4Fr, 180 cm, 2-7mm OD, Medtronic)
- Ultraverse Rx
(4-5Fr, 200cm,
1.25-7mm max OD, Bard)
- Jade PTA
(4-7Fr, 200cm, 2-7mm OD, Cardiovascular Systems Inc.)
- Sublime
(5Fr, 250cm, 2-4mm OD, Surmodics)
Popliteal and below-the-knee
interventions
(up to >170 cm from left wrist, 2-7mm)
Atherectomy
- Diamondback Orbital Atherectomy System
(4-5Fr, 200cm, CSI)
Fig. 6.24 Peripheral arterial disease devices compatible with radial access. PAD peripheral arterial disease, S FA super- cial femoral artery, OD outer diameter
Bare Metal
Stent
- R2P Misago Rx
(6Fr, 200cm, 6-8mm, Terumo)