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- •Preface to the Third Edition
- •Dedications and Acknowledgments
- •Contents
- •Contributors
- •Perineal Body
- •Anococcygeal Ligament
- •Pelvic Floor Muscles
- •Puborectalis Muscle
- •Iliococcygeus Muscle
- •Pubococcygeus Muscle
- •Introduction
- •Anal Canal Epithelium
- •Internal Anal Sphincter
- •Conjoined Longitudinal Muscle
- •External Anal Sphincter
- •Mesorectum
- •Presacral Fascia
- •Retrosacral Fascia
- •Waldeyer’s Fascia
- •Denonvilliers’ Fascia
- •Anorectal Spaces
- •Perianal Space
- •Intersphincteric Space
- •Submucous Space
- •Ischioanal/Ischiorectal Space
- •Supralevator Space
- •Retrorectal Space
- •Lateral Ligaments
- •Rectal Blood Supply
- •Superior Rectal Artery
- •Middle Rectal Artery
- •Inferior Rectal Artery
- •Physiology
- •Colonic Absorption
- •Colonic Motility
- •Rectal Function
- •The Pelvic Floor
- •The Anal Sphincter Complex
- •Internal Anal Sphincter (IAS)
- •Conjoined Longitudinal Muscle
- •References
- •2: Patient Evaluation
- •Introduction
- •Anatomy
- •History
- •Chief Complaint
- •Bowel Habits
- •Personal History
- •Common Complaints
- •Bleeding
- •Pain
- •Itching
- •Incontinence
- •Constipation
- •Physical Examination
- •Abdominal Examination
- •Anorectal Examination
- •Visual Inspection
- •External Palpation
- •Digital Rectal Examination
- •Diagnostic Studies
- •Anoscopy
- •Proctoscopy
- •Flexible Sigmoidoscopy
- •Endoluminal Ultrasound
- •Computed Tomography
- •Magnetic Resonance Imaging
- •Physiologic Testing
- •Summary
- •References
- •3: Anorectal Physiology Testing
- •Introduction
- •Techniques
- •Anorectal Manometry
- •Balloon Expulsion
- •Electromyography
- •Needle Electrode EMG
- •Surface Electrode EMG
- •Rectal Pressure Testing (Manometry)
- •Cinedefecography
- •Magnetic Resonance Defecography
- •Pudendal Nerve Terminal Motor Latency Testing (PNTML)
- •Clinical Considerations
- •Hirschsprung’s Disease
- •Low Anterior Resection Syndrome (LARS)
- •Anismus
- •Perineal Descent
- •Fecal Incontinence
- •Summary
- •References
- •Introduction
- •Anorectal Malformations
- •Embryology
- •Associated Anomalies
- •Presentation
- •Management
- •Divided Colostomy
- •Posterior Sagittal Anorectoplasty
- •Bowel Management
- •Hirschsprung’s Disease
- •Pathophysiology
- •Presentation
- •Neonatal Obstruction
- •Childhood Constipation
- •Hirschsprung’s-Associated Enterocolitis (HAEC)
- •Diagnosis
- •Contrast Enema
- •Anorectal Manometry
- •Rectal Biopsy
- •Suction vs. Full-Thickness
- •Management
- •Surgical Approaches
- •Swenson
- •Duhamel
- •Soave
- •Modern Approach
- •Long-Segment Disease
- •Complications
- •Incontinence
- •Constipation
- •HAEC
- •Reoperation
- •Laparoscopic-Associated Anorectoplasty (LAARP)
- •Fistula-in-ano/Perianal Abscess
- •Anal Fissure
- •Rectal Prolapse
- •Solitary Rectal Ulcer Syndrome (SRUS)
- •Sexual Abuse
- •References
- •5: Perioperative Management
- •Introduction
- •Preoperative Care
- •Patient Education
- •Aspirin Use
- •Bowel Preparation
- •Perioperative Care
- •Antibiotic Prophylaxis
- •Deep Vein Thrombosis (DVT) Prophylaxis
- •Perioperative Intravenous Fluids
- •Postoperative Care
- •Enhanced Recovery
- •Patient Education
- •Antibiotics
- •Sitz Baths
- •Wound Care
- •Diet
- •Bowel Regimen
- •Pain Management
- •Topical Analgesia
- •Outpatient Follow-Up
- •Ambulatory Surgery Outcomes
- •Complications After Anorectal Surgery
- •Acute Complications
- •Infection
- •Urinary Retention
- •Hemorrhage
- •Chronic Complications
- •Fecal Incontinence
- •Anal Stenosis
- •Chronic Pain
- •Summary
- •References
- •Introduction
- •Positioning
- •Anesthetic Techniques
- •General Anesthesia
- •Regional Anesthesia
- •Monitored Anesthetic Care (MAC)
- •Local Anesthesia
- •Lighting
- •Instrumentation
- •Anoscopes
- •Speculums
- •Retractors
- •Supporting Material
- •References
- •7: Functional Anorectal Disorders
- •Introduction
- •Anismus
- •Perineal Descent Syndrome
- •Solitary Rectal Ulcer Syndrome
- •Sigmoidocele
- •References
- •Introduction
- •Abdominal Approaches
- •Open Rectopexy
- •Laparoscopic Rectopexy
- •Mesh Techniques
- •Laparoscopic Mesh Rectopexy
- •Results of Mesh Rectopexy
- •Ventral Mesh Rectopexy
- •Resection Rectopexy
- •Perineal Approaches
- •Perineal Rectosigmoidectomy
- •Delorme
- •Anal Encirclement
- •Recurrent Rectal Prolapse
- •Rectal Intussusception
- •References
- •9: Fecal Incontinence
- •Introduction
- •Normal Continence
- •Evaluation
- •Treatment
- •Conservative Management
- •Non-surgical Devices
- •Surgical Management
- •Sphincter Augmentation
- •Malone Antegrade Continence Enema
- •Colostomy
- •References
- •10: Anorectal Abscess and Fistula in Ano
- •Introduction
- •Anatomy
- •Abscess
- •Etiology and Pathophysiology
- •Evaluation
- •Symptoms
- •Physical Examination
- •Diagnostic Imaging
- •Treatment
- •General Principles
- •Operative Management
- •Catheter Drainage
- •Primary Fistulotomy
- •Antibiotics
- •Postoperative Care
- •Complications
- •Recurrent Abscess
- •Incontinence
- •Special Considerations
- •Necrotizing Anorectal Infection
- •Treatment
- •Management
- •Fistula-in-Ano
- •Pathophysiology
- •Etiology
- •Evaluation
- •Symptoms
- •Physical Examination
- •Imaging
- •Treatment
- •General Principles
- •Operative Management
- •Fistulotomy
- •Staged Fistulotomy
- •Endoanal Advancement Flap
- •Anal Fistula Plug
- •Fibrin Glue
- •Stem Cells
- •Summary
- •References
- •11: Rectovaginal Fistula
- •Introduction
- •Etiology
- •History
- •Medical Management
- •Crohn’s-Related RVF
- •Surgical Management
- •Simple Fistula Repair
- •Endorectal Advancement Flap
- •Biologic Repairs
- •Overlapping Sphincteroplasty (OS)
- •Perineoproctotomy (PP)
- •Complex Fistula Repair
- •Bulbocavernosus Muscle Flap
- •Gracilis Muscle Transposition Flap (GMTF)
- •Transperineal Omental Flap (TPOF)
- •Resection Repair
- •Bricker Patch Repair
- •Stent Repair
- •Crohn’s-Related RVF Repair
- •Ileoanal Pouch–Vaginal Fistula (IPVF) Repair
- •Diversion
- •References
- •Introduction
- •Rectocele
- •Diagnosis
- •Physical Examination
- •Imaging/Anorectal Physiologic Tests
- •Treatment
- •Nonoperative
- •Operative
- •Transvaginal (Posterior Colporrhaphy)
- •Transperineal
- •Transanal
- •Laparoscopic Rectocele Repair Technique
- •Diagnosis
- •Treatment
- •Medical
- •Surgical
- •Apical Prolapse
- •Enteroceles
- •Perineal Hernia
- •Primary Perineal Hernia
- •Secondary Perineal Hernia
- •Transabdominal Repair
- •Laparoscopic Repair
- •Perineal Repair
- •Summary
- •References
- •13: Pruritus Ani
- •Introduction
- •Etiology
- •Idiopathic Pruritus Ani
- •Dietary Factors
- •Secondary Pruritus Ani
- •Infectious Agents
- •Viruses
- •Parasites
- •Organic Colorectal Conditions
- •Dermatologic
- •Neoplastic Disease
- •Systemic Diseases
- •Psychological
- •Drugs
- •Patient Evaluation
- •History
- •Physical Examination
- •Treatment
- •Recent Advances
- •Summary
- •References
- •Anal Fissure
- •Introduction
- •Pathogenesis
- •Presentation
- •Medical Therapy
- •Operative Therapy
- •PLIS Operative Techniques
- •Alternative Treatment Concepts
- •Subcutaneous Fissurotomy
- •Dilation
- •Flaps
- •Simple Cutaneous Advancement Flap
- •V-Y Advancement Flap
- •Unique Situations
- •Post-PLIS Fissure
- •Hypotonic Fissure
- •Extreme Pain
- •HIV-Related Fissure
- •Non-healing Wounds
- •Anal Stenosis
- •Introduction
- •Pathogenesis
- •Presentation
- •Medical Treatment
- •Dilation
- •Operative Therapy
- •Stricturoplasty
- •Flaps
- •Mucosal Advancement Flap
- •Y-V Advancement Flap
- •V-Y Advancement Flap
- •House Flap
- •Diamond-Shaped Flap
- •Rotational “S” Flaps
- •References
- •15: Pilonidal Disease
- •Background
- •Etiology
- •Clinical Presentation/Diagnosis
- •Treatment
- •Non-operative Management
- •Operative/Excisional Management
- •Basic Procedures
- •Complex Procedures
- •Karydakis Flap
- •Cleft Lift Procedure
- •Rhomboid/Limberg Flap
- •Disease Recurrence
- •References
- •16: Perianal Hidradenitis Suppurativa
- •Introduction
- •Pathogenesis
- •Bacteria
- •Imaging
- •Medical Treatment
- •Antibiotics
- •Steroids
- •Anti-TNF Agents
- •Surgical Treatment
- •Squamous Cell Carcinoma
- •References
- •17: Hemorrhoidal Disease
- •Introduction
- •Anatomy
- •Pathophysiology
- •Etiology
- •Evaluation
- •Symptoms
- •Examination
- •Treatment
- •General Principles
- •Internal Hemorrhoids
- •Flavonoids
- •Rubber Band Ligation
- •Infrared Photocoagulation
- •Sclerotherapy
- •Cryotherapy
- •Electrocautery
- •Dilatation
- •Internal Anal Sphincterotomy
- •Transanal Hemorrhoidal Dearterialization (THD)
- •External Hemorrhoids
- •Acute Thrombosis
- •Operative Hemorrhoidectomy
- •Alternate Energy Sources
- •Special Considerations
- •Summary
- •References
- •Introduction
- •History
- •Physical Examination
- •Anoscopy/Rigid Proctoscopy
- •Imaging/Testing
- •Acute Pelvic Pain
- •Thrombosed External Hemorrhoid
- •Anal Fissure
- •Anorectal Abscess
- •Pruritus Ani
- •Hidradenitis Suppuritiva
- •Infectious
- •Gonorrhea
- •Chlamydia
- •Herpes Simplex/Zoster
- •Syphilis (Treponema Pallidum)
- •Chancroid (Haemophilus Ducreyi)
- •Granuloma Inguinale (Calymmatobacterium Granulomatis)
- •Perianal Crohn’s Disease
- •Proctitis/Pouchitis
- •Radiation
- •Anal Stricture
- •Anal/Rectal Cancer
- •Rectal Prolapse
- •Retrorectal Tumors
- •Prostatitis
- •Gynecological Causes
- •Neurogenic Pain
- •Chronic Pelvic Pain
- •Urogynecological Causes
- •Pelvic Floor Pain Syndrome
- •Levator Ani Syndrome
- •Proctalgia Fugax
- •Coccygodynia
- •Pudendal Neuralgia
- •Summary
- •References
- •19: Anal Neoplasms
- •Introduction
- •Anatomy
- •Anal Squamous Cell Cancer
- •Etiology
- •Diagnosis
- •Staging
- •Treatment
- •Salvage Treatment
- •Functional Results After Radiotherapy
- •Anal Adenocarcinoma
- •Anal Melanoma
- •Sarcoma/Gastrointestinal Stromal Tumor (GIST)
- •Paget’s Disease
- •High-Grade Squamous Intraepithelial Lesion
- •Anal Margin Squamous Cell Cancer
- •Anal Margin Basal Cell Cancer
- •References
- •20: Anal Intraepitheial Neoplasia
- •Introduction
- •Prevention
- •Screening
- •Diagnosis
- •Treatment
- •Expectant Management
- •Ongoing Surveillance
- •Summary
- •References
- •21: Rectal Carcinoma: Imaging for Staging
- •Introduction
- •Imaging Modalities
- •Endorectal Ultrasound
- •Lymph Node Involvement
- •Magnetic Resonance Imaging
- •MRI Technique
- •Lymph Node Involvement
- •Pelvic Side Wall Lymph Nodes
- •Extramural Vascular Invasion
- •Evaluating Tumour Response
- •Hepatic Metastases
- •Pulmonary Metastases
- •Peritoneal Metastases
- •Summary
- •References
- •22: Rectal Carcinoma: Operative Treatment, Transanal
- •Local Approaches to Rectal Cancer
- •Transanal Excision (TAE)
- •Transanal Endoscopic Surgery
- •Intraoperative Complications
- •Peritoneal Entry
- •Conversion
- •Positive Margins
- •Postoperative Complications
- •Functional Outcomes
- •Future Directions: Transanal TME (TATME)
- •Summary
- •References
- •23: Rectal Cancer: Operative Treatment Transabdominal
- •Overview
- •Preoperative Evaluation
- •Preoperative Imaging Studies
- •Staging
- •T2N0 Rectal Cancer
- •Locally Advanced Rectal Cancer
- •Distant Metastatic (M1) Disease
- •Surgical Considerations
- •Radical Resection
- •Total Mesorectal Excision
- •Circumferential Resection Margin
- •Distal Resection Margin
- •Reconstruction Options Following Low Anterior Resection
- •Temporary Diversion Following Low Anterior Resection
- •Abdominoperineal Resection
- •Abdominal Dissection: Minimally Invasive Versus Open Technique
- •Perineal Dissection: Prone Versus Lithotomy Positioning
- •Perineal Reconstruction Options
- •Surgical Technique
- •Blood Supply
- •Autonomic Pelvic Nervous System
- •Open Abdominal Dissection
- •Robotic Total Mesorectal Excision
- •Transanal Extraction Techniques
- •Postoperative Care
- •References
- •Introduction
- •Locally Advanced Rectal Cancer
- •Total Mesorectal Excision
- •Neoadjuvant Therapy
- •Chemoradiation
- •Intraoperative Radiation Therapy
- •Endoluminal Brachytherapy
- •Surgery Related Outcomes Post Chemoradiation
- •Adjuvant Therapy
- •Adjuvant Chemotherapy
- •Induction vs. Adjuvant Chemotherapy
- •Adjuvant Chemotherapy Following PCR
- •Adjuvant Radiotherapy
- •Chemoradiation
- •Metastatic (Stage IV) Rectal Cancer
- •Recurrent Rectal Cancer
- •Summary
- •References
- •Introduction
- •Benign
- •Adenomatous Polyps
- •Treatment
- •Natural History
- •Malignant Polyps
- •Large Rectal Villous Tumors
- •Hyperplastic Polyps
- •Juvenile Polyps
- •Cronkhite-Canada Syndrome
- •Hamartomatous Polyps
- •Lipomas
- •Hemangiomas
- •Solitary Rectal Ulcer Syndrome/Colitis Cystica Profunda
- •Leiomyomas
- •Malignant
- •Leiomyosacrcoma
- •Gastrointestinal Stromal Tumors (GIST)
- •Carcinoid Tumors
- •Carcinoid Carcinomas
- •Lymphoma
- •Retrorectal/Presacral Tumors
- •Melanoma
- •References
- •26: Retrorectal (Presacral) Tumors
- •Introduction
- •Anatomy
- •Congenital Lesions
- •Cystic Lesions
- •Developmental Cysts
- •Duplication Cysts (Enterogenous)
- •Tail Gut Cysts (Cystic Harmatomas)
- •Anterior Sacral Meningocele
- •Solid Lesions
- •Sacrococcygeal Chordomas
- •Neurogenic Tumors
- •Osseous Tumors
- •Miscellaneous Tumors
- •Imaging
- •Preoperative Biopsy
- •Management
- •Surgical Approach
- •Posterior Approach
- •Outcomes
- •Malignant Lesions
- •Benign Lesions
- •References
- •Introduction
- •Sexually Transmitted Anorectal Disorders
- •Bacterial Infections
- •Gonorrhea
- •Chlamydia Trachomatis: Lymphogranuloma Venereum (LGV)
- •Chancroid
- •Granuloma Inguinale
- •Syphilis
- •Viral Infections
- •Herpes Simplex

10 Anorectal Abscess and Fistula in Ano
Fig. 10.18 Fibrin glue
183
abscess was observed in 4 (10%) of 40 glue
events [150]. Baseline anal sphincter function
is preserved after brin glue therapy [91, 150–
152]. A representative sample of published stud-
ies indicate healing in the range of 14–63% of
patients [149, 150, 152–158]. A series of patients
followed by Zmora and colleagues noted healing at 6months in 32 (53%) of patients of whom
approximately one-fourth had recurrent stula
with long-term follow-up [159]. A 2015 systematic review indicated the absence of a consistent
association between stula etiology, complexity,
tract length, or the use of a mechanical bowel
prep and successful brin glue therapy [160].
Despite the variability in healing of stula-inano with brin glue therapy, the real possibility
of success coupled with its being a sphincter-pre-
serving technique allows this therapy to remain
an option that may be considered for the treatment of stula-in-ano.
Stem Cells
Mesenchymal stem cells are an emerging therapy
for Crohn’s disease-related and cryptoglandular
anal stula. The stem cells are harvested from
patient or donor adipose tissue or bone marrow,
expanded with cell culture techniques, and then
prepared for injection into the stula tract. The
stem cells are believed to effect healing through
immunomodulatory and anti-inammatory pathways. A randomized placebo controlled trial, in
patients with Crohn’s disease and complex peri-

184
J. D. Vogel and C.-A. Vasilevsky
anal stula, demonstrated “combined remission”,
dened as clinical and radiological stula healing, at 24 weeks, in 51% and 36% of patients
who were treated with mesenchymal stem cells
or placebo, respectively (p = 0.021) [161]. At
52 weeks follow-up, combined remission was
observed in 56% and 39% of patients, respectively (p=0.013) [162]. In another trial, patients
with cryptoglandular or Crohn’s-related complex
anal stula were randomized to treatment with
brin glue or brin glue plus adipose-derived
mesenchymal stem cells. Fistula healing at
8weeks occurred in 71% of patients treated with
brin glue plus stem cells and 16% of patients
who received brin glue alone (p<0.001) [163].
An earlier randomized trial [164] and a recent
review [165] provide additional evidence to support the use mesenchymal stem cells for the treatment of complex stula-in-ano in patients with
Crohn’s disease.
Summary
Understanding anorectal anatomy is essential to
successfully managing anorectal abscesses and
stulas.
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Rectovaginal Fistula
ElizabethR.Raskin
11
Introduction
Rectovaginal stula (RVF) is an abnormal communication between the rectum and vagina that
results in the passage of gas and/or feces through
an epithelialized tract.
A distressing condition associated with physical and psychosocial sequelae for the female
patient, RVF represents a difcult challenge from
the surgeon’s perspective. Etiology and classication of RVF are important for developing medical and surgical treatment strategies. While many
surgical options have been described, success
rates are variable. Crohn’s disease-related RVF
can add complexity to the condition, as wound
healing and tissue integrity may be suboptimal.
Etiology
Worldwide, an estimated two million women
suffer from rectovaginal stula (RVF), with an
increased incidence in the developing countries
of sub-Saharan Africa and South Asia [1, 2]. The
leading cause of RVF is obstetric trauma. Acute
perineal laceration, assisted vaginal delivery, and
E. R. Raskin (*)
Division of Surgical Oncology, Department
of Surgery, Loma Linda University Health,
Loma Linda, CA, USA
e-mail: eraskin@llu.edu
prolonged ischemia with necrosis of the RV septum following obstructed labor are the primary
insults that precipitate the formation of RVF [3].
Despite repair of third-degree and fourthdegree perineal lacerations in close to 5% of all
vaginal births, RVF develops in approximately
1–2% of these patients due to wound dehiscence
[4]. While an increase in cesarean section rate in
the US has lessened the rates of episiotomy and
operative vaginal delivery, it is estimated that
RVF still develops after 0.1–0.5% of all births
[5, 6].
Nonobstetric operative trauma contributes to
RVF formation, especially following low anterior resection (LAR) (3–10%), hemorrhoidectomy, hysterectomy and synthetic mesh repair
for pelvic organ prolapse [5, 7–9]. Risk factors
for RVF development following LAR include
preoperative chemoradiation, serum albumin
<4.0g/dL, tumor size >5cm, anastomosis <5cm
from the anal verge, intraoperative bleeding
>200mL, and lateral lymph node dissection [9,
10]. Inammatory bowel disease is another major
etiology of RVF, with development in 2–10% of
all women with Crohn’s disease [5, 11].
Ileoanal pouch-vaginal stula after total proctocolectomy in patients with both ulcerative colitis and Crohn’s disease has been signicantly
associated with pouch failure and the need for
pouch excision [12–14].
Locally advanced gastrointestinal and gynecologic malignancy can result in RVF and may
© Springer International Publishing AG, part of Springer Nature 2019
D. E. Beck et al. (eds.), Fundamentals of Anorectal Surgery,
https://doi.org/10.1007/978-3-319-65966-4_11
191

192
E. R. Raskin
Table 11.1 Etiology of rectovaginal stulas
Congenital disorders
Acquired disorders
Trauma
Operative
Obstetric
Traumatic
Infection/Sepsis
Inammatory bowel disease
Radiation
Carcinoma
complicate appropriate oncologic treatment. In
addition, radiation therapy for pelvic malignancy
has been associated with acute development of
RVF, as well as, delayed presentation years later
[15, 16]. Fecal diversion may be needed to allow
for completion of radiation therapy when symptoms are intolerable. Diverticulitis, anorectal
cryptoglandular disease, Bartholin gland abscess
and other infectious entities, such as tuberculosis,
lymphogranuloma venereum, and HIV have been
reported to cause RVF [17].
Although sporadic, cases of RVF from
forceful coitus, fecal impaction, and neglected
vaginal pessaries are noted in the literature
[18–20]. A summary of etiologies is listed in
Table11.1.
Classication
Rectovaginal stulae are classied as either
simple or complex based on location, tract width,
and etiology. Typically, a simple RVF is one
that is located in the low or mid-vaginal septum
with a diameter ≤2.5 cm. Most simple RVFs
are due to either traumatic or infectious causes.
Alternatively, a complex stula is usually found
high in the rectovaginal septum or presents as a
cloacal defect. With a diameter of >2.5cm, the
complex stula tends to originate from neoplasia, radiation therapy, congenital malformations,
or inammatory bowel disease. Multiple organ
involvement, as well as, complicated tract orientation can be seen in this variety. A stula is
also considered complex if it results after a prior
repair (Table11.2).
Table 11.2 Classication of rectovaginal stulas
Simple
Through the low or mid vaginal septum
<2.5cm in diameter
Trauma or infection
Complex
Through the high vaginal septum
>2.5cm in diameter
Inammatory bowel disease, radiation, or neoplasia
Multiple failed repairs
History
Patients tend to present with complaints of passage of atus or stool through the vagina. Chronic
vaginal infection, foul smelling vaginal discharge,
and dyspareunia may also be reported. These
symptoms tend to be magnied with loose stool or
diarrhea. Fecal incontinence may be experienced,
as anal sphincter injuries are uniquely associated with obstetric trauma and other causes of
RVF formation. While recognized obstetric anal
sphincter injuries have been reported in 4–6% of
all vaginal deliveries, it is estimated that occult
sphincter injury occurs in up to 28% of patients
following a normal vaginal delivery [21, 22]. In a
series by Yee and colleagues, anal sphincter injury
was noted in 92% of patients undergoing surgical
repair for RVF.A thorough history should be elicited, focusing on symptoms, bowel habits, quality
of life, and possible etiologies for RVF formation.
A detailed obstetric history is important, making
note of complicated deliveries such as forceps or
vacuum assisted delivery or the presence of shoulder dystocia. Prior anorectal surgery, as well as, a
history of malignancy, radiation therapy, and IBD
should be investigated.
Physical exam should include a digital rectal
exam with anoscopy and a vaginal evaluation
with speculum exam. A palpable defect or dimple in the wall of the rectum and/or vagina may
be appreciated in a low to mid-RVF.A careful
assessment of the anal sphincter complex should
be performed to identify concomitant sphincter
defects. Anoscopy and vaginal speculum exam
may reveal stool in the vagina, evidence of vaginitis or inammation of the mucosa of the RV
septum. If tolerated by the patient, a stula probe

11 Rectovaginal Fistula
193
can be inserted through the tract for conrmation.
Conversely, the stula tract may not be identied
due to small size and patient discomfort, necessitating an exam under anesthesia for diagnosis.
Biopsies of indurated or inamed tissue
can be considered to exclude malignancy or
IBD.Despite these efforts, not all stulae will be
visible on examination and a high index of suspicion should be had with the patient with concerning symptoms and history.
Orally administered activated charcoal or
methylene blue enema tampon tests have been
used to detect occult RVFs or stulas located
high in the RV septum.
Endorectal ultrasound (ERUS), computed
tomography (CT), and magnetic resonance imaging (MRI) can be considered if the ndings are
unclear or if there is concern for accompanying
pathology, such as neoplasm, diverticular disease, or IBD [23]. Multiple studies have demonstrated the usefulness of ERUS and MRI for
collectively identifying RVF and mapping occult
sphincter defects [22, 24, 25].
Stoker and colleagues found positive predictive values (PPV) of 100% and 92% for ERUS and
MRI in detecting RVF, with similar PPV for associated anal sphincter defects [25]. Hydrogen peroxide-enhanced ERUS has been shown to improve
visualization of difcult to image tracts [26].
Lastly, colonoscopy with biopsy should be
performed to further elucidate the presence of
colorectal malignancy or IBD, if history or symptoms warrant.
Medical Management
While spontaneous healing of RVFs has been
noted in 7–10%, the vast majority of patients
will require medical and/or surgical intervention [4, 27]. Conservative management is warranted immediately following the presentation of
RVF due to traumatic etiologies. Prior to surgical repair, a minimum of 3–6months following
delivery should be considered in the setting of
RVF after obstetric injury. Bulking therapy and
antidiarrheal medications can be useful to minimize symptoms and to allow time for an appropri-
ate evaluation. Drainage of sepsis and antibiotic
therapy may be initially needed in the presence of
cryptoglandular or Crohn’s disease.
Crohn’s-Related RVF
Medical management of Crohn’s-related RVF
had limited success. Aimed at treating underlying inammatory disease, corticosteroids,
antibiotics, salicylates, and immunomodulators
have historically been the mainstay of medical
therapy despite lackluster healing of RVFs in
only 25–64% [28, 29]. High doses of intravenous
cyclosporine have been reported to induce RVF
closure in up to 80% of patients, however over
a third of these relapsed after converting to oral
therapy [30].
The advent of anti-tumor necrosis factor-α
(TNF-α) therapy in the late 1990s revolutionized treatment for stulizing Crohn’s disease,
with especially encouraging results for perianal
disease. To investigate the effects of iniximab
in patients with Crohn’s-related enterocutaneous
and perianal stulae, Present and colleagues performed a randomized, multicenter, double-blind
placebo-controlled trial [31]. In this study, rectovaginal stulae were not specically identied, as
the stulae were characterized as either “abdominal” or “perianal.” Patients were randomized to
either receive placebo, iniximab 5mg/kg, or inf-
liximab 10mg/kg at 0, 2, and 6weeks.
Results demonstrated a signicant reduction
in the number of draining stulae in the groups
treated with iniximab compared to placebo. The
effect was not dose-related as the group receiving
5mg/kg fared slightly better than the 10mg/kg
group, although not in a statistically signicant
manner. In patients who reached the primary end
point (greater than 50% reduction or more from
baseline in the number of draining stulae), the
benets of iniximab were seen rapidly (about
2 weeks) and lasted for a median of 3 months.
After 18 weeks, complete stula closure was
noted in 46% of patients treated with iniximab
but only 13% in the placebo arm.
In a study by Parsi and colleagues, an association with the type of stula and the effectiveness
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