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29 Laparoscopic Colectomy in the Obese Patient
331
Fig. 29.13 Notice the inferior umbilicus in this patient with a BMI 30 and WHR of 1.2
“overmobilization”—i.e., more mobilization than what one would normally perform for a normal body habitus patient— often will reduce the possibility of any issues related to ten­sion and subsequent need to further dissect and mobilize after the specimen has been removed.
Lastly, the most critical element of the operation—the anastomosis—must then be accomplished, and the specimen extraction wound usually again plays a role. In the case of right colectomy, the two ends of bowel are exteriorized and anastomosed by the technique of choice. Again, thoughtful consideration should take into account that the umbilicus tends to be lower due to the effects of the weight of the pan­nus (Fig. 29.13 ). Exteriorizing the transverse colon can therefore be diffi cult if the specimen extraction wound is too low. Surgeons will then be forced to extend the wound ceph­alad to effect exteriorization of the transverse colon for anastomosis. To avoid this, the author bases his extraction wound on bony prominences: the midpoint of the specimen extraction wound is the midpoint between the costal margin and the iliac spine in the anterior axillary line. This midline vertical wound will be positioned just caudal to the third portion of the duodenum facilitating exteriorization of the hepatic fl exure and transverse colon in the case of right col­ectomy and serves the same purpose well for exteriorization of the splenic fl exure and transverse colon in the case of left­sided resections. In the obese patient, the wound will tend to be cranial or cephalad to the umbilicus (Fig.
29.14 ).
Undoubtedly, the wound is more conspicuous; however, issues related to cosmesis clearly remain secondary to the
Fig. 29.14 Hand-port incision superior to the umbilicus
ultimate successful outcome of performing a complex operation with a small incision, which remains “dwarfed” by the size of the patient’s girth.

Pelvic Operations

Essential Technical Adjustments
Pelvic dissections require additional exposure as the ura­chus, bladder, uterus, prostate, and lateral retroperitoneal fat all conspire to limit visualization. Clearly, additional ports enable insertion of graspers and fan retractors to facilitate traction and countertraction for clarifi cation of the mesorec­tal fascial plane. Sling retraction of the uterus and bladder using suspension sutures placed percutaneously using heavy suture on a straight needle facilitates anterior visualization (Video 29.4 ). In addition, a 45° angle laparoscope also pro­vides superior imaging of the deep pelvis anteriorly. These two simple maneuvers have proven critical to conducting deep dissection.
Strategy for Deep Dissection
Generally, posterior dissection approaching the sacral prom­ontory should be just dorsal to the superior hemorrhoidal artery, thereby avoiding traction and potential dissection of the superior hypogastric nerves. As one dissects onto the
332
A. Siripong and H.D. Vargas
mesorectum, this plane can be followed into loose areolar tissue posteriorly that is more familiar to pelvic surgeons. The maximal dissection of this plane should be performed undermining the lateral aspects of the spheroid-shaped mesorectum. The anterior dissection should then be under­taken opening the cul de sac of the pouch of Douglas and identifying the mesorectal fascia anteriorly and dissecting between the leaves of Denonvilliers’ fascia. The demonstra­tion of the plane in a female can be enhanced by having an assistant go to the perineum and place an intestinal-sizer instrument into the vaginal vault and displace the vagina ventrally. Once the plane is established, the author prefers placing the fan retractor onto the posterior aspect of the vagina and then retracting the anterior mesorectum posteri­orly (Video 29.5 ). The dissection can then be carried distally to the anorectal ring. In the male patient, the fan retractor is positioned onto Denonvilliers’ fascia on the seminal vesicles and then subsequently the prostate gland.
Most importantly, the lateral aspects of the dissection are then undertaken using the planes developed anterior and pos­terior to guide the dissection. The lateral mobilization of the mesorectum often remains underestimated and arguably rep­resents the most challenging plane to demonstrate due to the redundancy of the lateral tissues. The retroperitoneal adipose tissues displace the mesorectal plane and diminish efforts for appropriate traction and countertraction. The tendency is to dissect more laterally, which oncologically is not necessarily worse; however, such dissection brings into play the branches of the hypogastric artery and anterolaterally the nervi erigen­tes in a male and the uterine vessels in a female. For obvious reasons, this lateral dissection can prove consequential and potentially disastrous. As we know, the appropriate plane gen­erally is bloodless. Nuisance bleeding suggests imprecise dis­section and continued dissection will prove humbling. If this occurs, you should stop and redirect your dissection to another area to fi nd the right plane (e.g., if bleeding occurs while dis­secting anterior to posterior in the lateral aspect, change to posterior to anterior or vice versa). Dissection to the pelvic fl oor and into the hiatus should be confi rmed by performing intraoperative digital rectal exam and palpating circumferen­tially. Overall, the pelvic dissection in an obese patient and especially an obese male with a narrow pelvis represents one of the truly most diffi cult operations. This demands patience, persistence, meticulous method, and capable and experienced assistants. The reward remains a bloodless fi eld, an intact anal anastomosis and sphincter preservation.
Table 29.3 Postoperative considerations
• Early ambulation
• Perioperative DVT prophylaxis
• Atelectasis
• Wound infection
• Cardiovascular dysfunction
• Pulmonary toilet
a linear increase in wound infections seen with increasing body mass index and may still range as high as 20 % accord­ing to a recent NSQIP study [ 36 ]. Currently, means to reduce wound infections remain theoretic or anecdotal at best. The author utilizes wound protectors for the specimen extraction site and irrigates with pulse evac using a bacitracin-saline solution. The latter serves to debride necrotic fat and dilute bacterial contamination. Anecdotally, I have found a reduced infection rate and have noticed that when infections do occur, the magnitude appears much diminished. Wound abscess and dehiscences seem much more rare when this technique is employed. This is especially true of the obese patient with deep subcutaneous layer. While there is an increased cost of the bacitracin and the pulse evac device, wound infections remain costly and potential savings by avoiding infection easily will be avoided.
Postoperative Care and Enhanced Recovery Pathways (ERP)
Generally, postoperative care of the obese patient undergoing laparoscopic colectomy follows standard algorithms (Table 29.3 ). Although there is no standardized universal pathway, most ERPs involve the following facets of postop­erative care: minimally invasive surgical technique, reduced perioperative fl uid resuscitation, strategies for reducing post­operative nausea and vomiting, multimodal pain management with reduction in narcotic use, early postoperative feeding and avoidance of nasogastric tubes, early ambulation, and deep venous thromboembolism prevention. Enhanced recovery pathways have been shown to improve postopera­tive outcomes of colectomy in regard to reduced ileus, post­operative complications, length of stay, and reduced cost [ 37 ]. Essentially, there are no contraindications for imple- mentation of ERPs for obese patients and exceptions should be made on a case-by-case basis.
Wound Management
Wound infections remain the bane of operations in the obese patient. While laparoscopic colectomy reduces wound infections when compared to open colectomy, there remains
Venous Thromboembolism (VTE) Prophylaxis
One controversial area of postoperative care that requires attention is duration of VTE prophylaxis. Obesity, malig­nancy, pelvic dissection, infl ammatory bowel disease, and
29 Laparoscopic Colectomy in the Obese Patient
Table 29.4 Modifi ed Caprini risk assessment model for VTE in general surgical patients
1 Point 2 Points 3 Points 4 Points
• 41–60 years old • 61–74 years old • Age >75 years old • Stroke (<month prior)
• Minor surgery • Major open surgery (45 min) • History of VTE • Elective arthroplasty
• BMI >25 kg/m
• Sepsis (<1 month) • Malignancy • Factor V Leiden • Acute spinal cord injury (<1 month)
• Severe lung disease, including
pneumonia (<1 month ago)
• Acute MI • Central venous access • Congenital
• Infl ammatory bowel disease
• Congestive heart failure
Surgical risk category Score Very low 0 <0.5 • Early ambulation Low 1–2 1.5 • IPC Moderate 3–4 3.0 • LMWH (30 mg BID or 40 mg daily)
High 5 or greater 6.0 • LMWH (extended duration) Adapted from: Gould MK, Garcia DA, Wren SM, et al. Prevention of VTE in nonorthopedic surgical patients: antithrombotic therapy and preven-
tion of thrombosis, 9th ed: American College of Chest Physicians evidence-based clinical practical guidelines. Chest 2012;141: e2275S VTE venous thromboembolic disease, BMI body mass index, MI myocardial infarction, HITT heparin-induced thrombotic thrombocytopenia, IPC intermittent pneumatic compression, LMWH low molecular weight heparin
a
Extended duration (3–4 weeks) after postoperatively
2
• Laparoscopic surgery (45 min) • Family history of VTE • Hip, pelvis, or leg fracture
• Immobile (>72 h) • HITT history
hypercoagulable condition
Estimated VTE risk in absence of pharmacologic or mechanical prophylaxis Recommended prophylaxis regimen
• Or UFH (5,000 units subq TID)
• Plus IPC
333
b
and IPC
colorectal resections are well-described additive risk factors for the development of VTE. Furthermore, colorectal proce­dures have been associated with a 4–10 % risk of deep vein thrombosis and fourfold higher rate of pulmonary embolism compared to other surgical patients. Therefore, optimizing VTE prophylaxis in the obese colorectal surgery patient is imperative.
Current recommendations regarding VTE prophylaxis in surgical patients have been published by the American College of Chest Physicians (ACCP) and are based on the modifi ed Caprini risk assessment model (Table 29.4 ). Based on this system, the majority of obese patients undergoing colorectal procedure are classifi ed into the moderate or high­risk group. While these guidelines recommend the use of mechanical (pneumatic compression devices) and chemo­prophylaxis (unfractionated heparin or low molecular weight heparin) pre- and postoperatively, there is little consensus regarding the optimal prophylactic regimen dosing and duration of prophylaxis in high-risk patients. ACCP guide­lines suggest that high-risk factors, including previous his­tory of VTE and abdominal or pelvic surgery for malignancy, are indications for extended VTE prophylaxis (4 weeks) [
3843 ]. However, the role of obesity as a high-risk feature
is unclear.
Separate from the ACCP guidelines, the bariatric literature and American Society of Bariatric and Metabolic Surgery’s (ASBMS) position statement highlight the lack of consensus and insuffi cient data available to provide recommendations
for the duration of VTE prophylaxis in the setting of morbid obesity [ 44 ]. Recently published studies, however, suggest decreased VTE complications without increased risk of bleeding when extended VTE prophylaxis is administered after laparoscopic bariatric procedures [ 4547 ]. Of note, defi - nitions of therapy duration are inconsistent in the literature, ranging from 10 to 30 days after discharge. The bariatric population clearly represents those with the most severe form of obesity. Although the bariatric data cannot be directly extrapolated to the colorectal obese population, these results nonetheless highlight the controversial nature and evolving recommendations regarding VTE prophylaxis in the setting of obesity.

Outcomes of Laparoscopic Colectomy in the Obese Patient

The perception persists that perioperative outcomes are worse among obese patients compared to non-obese patients. Unfortunately, this infl uences many surgeons’ clinical decision- making. Such bias unfortunately often is reinforced by anecdotal experiences. In the case of laparoscopic colec­tomy, the obese patient in fact benefi ts from a minimally inva­sive approach over open colectomy. As is the case in non-obese patients, short-term perioperative outcomes such as return of bowel function, tolerance of a diet, pain, and complications are improved when laparoscopic colectomy is employed.
334
A. Siripong and H.D. Vargas
Yet, when comparing to non-obese population, as expected, outcomes are worse. In a recent systematic review, Makino et al. examined results of prospective comparative trials of laparoscopic colectomy in obese and non-obese patients [ 48 ]. The analysis of this collective experience indicates that lapa­roscopic colectomy in the obese patient represents a greater technical challenge requiring more ports, longer operative time and more often result in conversion to open laparotomy compared to non-obese patients.
In spite of such technical diffi culty, the other periopera­tive outcomes pertaining to morbidity including blood loss, wound infection, anastomotic leak, and mortality were not conclusively shown to be higher in the obese patient popula­tion undergoing laparoscopic colectomy [
48 ]. In part, this is
a result of differences in the defi nition of obesity, heteroge­neous cohorts, and a few randomized prospective trials. What consistently has been shown is that there is no increased mortality. Future studies hopefully will be designed with improved methodology and provide more conclusive evi­dence regarding the utility of laparoscopic colectomy in the obese patient and benefi ts validating the increased effort put forth by surgeons to perform this challenging operation in the obese patient.
Pearls and Pitfalls
• Expect longer, more technically diffi cult operations with
attendant-increased conversion.
• Special attention must account for changes in the ergo-
nomics of laparoscopic colectomy in the obese patient.
• Bowel preparation reduces intestinal size and weight and
should improve visualization and retraction.
• Reduced abdominal domain, along with larger and heavier
organs, diminishes operative exposure requiring increased ports and skilled assistants to perform laparoscopic colectomy.
• In the obese patient, hand-assisted laparoscopic colec-
tomy potentially offers the benefi t of improved retraction, exposure, and dissection technique.
• Wounds remain at a high risk for infection mandating
meticulous technique and decreased threshold to investi­gate their presence.
• Prolonged prophylaxis to prevent deep venous thrombosis
should be considered.

Conclusion

The obese patient represents a true technical challenge for the general and colorectal surgeon. Unfortunately, diseases often requiring colorectal surgery are impacted by the obese condition, and given the epidemic nature of obesity, you
must anticipate increased frequency managing these patients. Laparoscopic colorectal surgery offers potential benefi ts for such patients. Increased technical diffi culty, however, hum­bles even experienced laparoscopic surgeons. Specifi c prepa­ration, additional skilled assistants, and operative strategies should be employed to enhance operative outcomes. Hand­assisted laparoscopic colectomy in particular offers practical technical advantages and should be considered part of the armamentarium of the surgeon attempting to apply a mini­mally invasive approach in those with increased BMI. Finally, it is important to keep in mind that despite the poten­tial struggles, when the colectomy is completed using mini­mally invasive technique, the obese patient will benefi t from improved outcomes.

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Minimally Invasive Surgery in Crohn’s Disease Patients

Chang Sik Yu
30

K e y P o i n t s

• Running the entire small bowel is necessary to prevent omitting skip lesions. Manual examination after exterior­ization of the bowel is preferable.
• Do not hesitate to convert to hand-assisted or open proce­dure in complex fi stulous condition.
• Advanced procedures such as laparoscopic total procto­colectomy are associated with increased conversion rates and should be attempted only with increased experience and expertise.

Introduction

Since the early 1990s, a laparoscopic approach to colorectal surgery incorporating various surgical procedures has been applied to many colorectal diseases. Crohn’s disease (CD) is a good indication for laparoscopic surgery because it is a benign disease, meaning the challenges associated with oncological conditions, such as a proximal ligation of the vascular pedicle, lymphadenectomy, and direction of mesen­teric dissection, do not apply. Furthermore, CD patients are usually young, socially active, and body-image conscious. Therefore, cosmesis and a rapid recovery and return to daily activities are crucial issues for this cohort.
CD is currently incurable, and more than half of surgically
treated patients are destined to undergo further surgery. Minimally invasive (MI) surgery is an important consideration
Electronic supplementary material: Supplementary material is available in the online version of this chapter at
1581-1_30 com/videos/978-1-4939-1580-4
C. S. Yu , M.D., Ph.D. (*) Department of Colon & Rectal Surgery, Asan Medical Center , University of Ulsan College of Medicine , 388-1 Poongnap-dong , Songpa-gu, Seoul 138-736 , Korea e-mail:
. Videos can also be accessed at http://www.springerimages.
.
csyu@amc.seoul.kr; csyu007@amc.seoul.kr
10.1007/978-1-4939-
for the surgeon as well as the patient, as an MI approach can lead to less adhesion formation and faster recovery.
Although surgical procedures for CD patients are usually limited to refl ect the extent and location of the infl ammation, the most common laparoscopic procedures are ileocolic resection and stoma creation. A thickened mesentery, infl am­matory mass or phlegmon, and enteric fi stula can make lapa­roscopic surgery technically challenging (Fig. complex cases often regarded as relative contraindications. However, even these complex cases may be satisfactorily undertaken with surgical experience and expertise.
The short-term benefi ts of MI surgery have been shown in randomized controlled trials and meta-analyses, although most trials had a limited sample size and were mainly con­cerned with the surgical outcomes of ileocolic resections.
30.1 ), with

Indications and Contraindications

Although the vast majority of laparoscopic procedures in CD patients are for ileocolic resection, a variety of procedures, including total proctocolectomy, have been successfully attempted. However, these MI procedures may be associated with a high rate of conversion to open procedures, with the presence of a complicated fi stula or abscess and recurrent disease identifi ed as risk factors for conversion.
Schmidt et al. [ 1 ] analyzed 45 cases of conversion (40 % conversion rate) and found that palpable mass, complicated fi stula, preoperative malnutrition, extracecal colonic disease, and steroid administration were risk factors. Moorthy et al. [ 2 ], using multivariate analysis, found that surgery for recur- rence and the presence of a clinical mass were risk factors for conversion to open procedures (Table 30.1 ).
Interestingly, the majority of studies on conversion showed comparable postoperative morbidity to surgeries that did not require conversion. This implies, for the experienced surgeon, that laparoscopic surgery can be applied for almost all procedures and comorbidities in patients with CD.
H.M. Ross et al. (eds.), Minimally Invasive Approaches to Colon and Rectal Disease: Technique and Best Practices, DOI 10.1007/978-1-4939-1581-1_30, © Springer Science+Business Media New York 2015
337
338
C.S. Yu
Fig. 30.1 Crohn’s disease of the terminal ileum
Table 30.1 Risk factors for conversion
No. of
Author Year Schmidt [
Moorthy [
Alves [
Okabayashi [
1 ] 2001 110 40 Internal fi stula,
3 ] 2004 48 (26
31 ] 2005 69 30 Recurrent medical
21 ] 2007 91 13.2 Vienna classifi cation
patients
recurrent vs. 22 primary)
Conversion rate (%) Risk factors
smoking, steroid administration extracecal colonic disease, malnutrition
42.3 vs. 13 Age, recurrent case, presence of a clinical mass
episodes, intra-abdominal abscess or fi stula
B3L3/4
Obesity is a widely recognized challenge for both open and laparoscopic surgery. Canedo et al. [ 3 ] evaluated 213 laparoscopic surgery cases in patients with CD or ulcerative colitis and found a conversion rate of 18 % when the body mass index (BMI) was between 18.5 and 24.9 kg/m 2 and 22 % when the BMI was greater than or equal to 25 kg/m 2 . This difference was not statistically signifi cant. The authors also demonstrated comparable intergroup postoperative complication rates and hospital stays. This implies that being overweight or obese is not a contraindication for laparo­scopic surgery for CD or ulcerative colitis.

Evidence in the Literature

Since the introduction of laparoscopic colorectal surgery, many authors have reported on the short-term outcomes of laparoscopic surgery in patients with CD. However, most
studies were conducted at a single center and were case controlled rather than randomized. Furthermore, the vast majority of these studies used ileocolic resection as the operation type in which laparoscopic and open approaches were compared. In this chapter, a review of high-quality studies and more recent evidence is presented.
Laparoscopic vs. Open Surgery for Ileocolitis
There are only two randomized controlled trials (RCT) in the literature: Milsom’s study [ 4 ] from the Cleveland Clinic and Maartense’s study [ 5 ] from three centers in the Netherlands. In both studies, 60 patients were recruited: 31 laparoscopic vs. 29 open, and 30 laparoscopic vs. 30 open, respectively. Patients undergoing elective surgery with disease confi ned to the terminal ileum and cecum were included. Exclusion cri­teria were emergency or urgent surgery, multiple disease sites, a history of prior surgery, and obesity (BMI > 32 kg/ m 2 ). Both studies showed fewer complications and shorter hospital stays in the laparoscopic group. Also, Milsom et al. [ 4 ] found faster recovery of pulmonary function, and Maartense et al. [ 5 ] showed an earlier return to diet and lower cost in the laparoscopic group. However, there was no sig­nifi cant difference in the use of morphine or the Quality of Life Scale score.
The long-term outcomes of these two RCTs were reported by Stocchi et al. [ 6 ] and Eshuis et al. [ 7 ] with a median fol- low- up of 10.5 and 6.7 years, respectively. They concluded that open surgery was more likely to lead to incision hernia and small bowel obstruction. The recurrence rate was com­parable between the groups. Eshuis et al. noted better body­image ratings and cosmesis in the laparoscopic group.
Recently, Dasari et al. [ 8 ] in their Cochrane review ana- lyzed these RCTs exclusively and found no difference in the perioperative outcomes and reoperation rate for recur­rence. They argued that no reliable conclusions could be drawn regarding the benefi ts of laparoscopic surgery prob­ably because of the limited data available from these two small RCTs.
Other meta-analyses, however, reported faster recovery of bowel function and oral intake, shorter hospital stay, and lower complication rates, with one meta-analysis noting a lower surgical recurrence in laparoscopic patients (Table 30.2 ). Excluding Dasari’s Cochrane review, which had limited inclusion criteria, the other meta-analyses showed a general consensus that there were short-term benefi ts associated with laparoscopic ileocecal resection for CD [ 812 ].
Lesperance et al. [ 13 ] analyzed Nationwide Inpatient Sample (NIS) data between 2000 and 2004. Among 49,609 resections in patients with CD, only 6 % were performed laparoscopically. They found that an age of less than 35 years old (OR 2.4), female gender (OR 1.4), ileocecal location
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Table 30.2 Meta-analysis of laparoscopic vs. open ileocolic resection for Crohn’s disease
Author Years
8 ] 2011 2 120 C C C C
Dasari [
9 ] 2007 14 881
Tan [
10 ] 2006 14 729 C
Polle [
11 ] 2006 15 783
Tilney [ Rosman [
C, comparable; ↑, longer; ↓, shorter or lesser; –, nothing stated
12 ] 2005 16 840
(OR 1.5), and undergoing the procedure in a teaching hospital (OR 1.2) were predictors of undergoing laparoscopic surgery for CD. Open surgery was an independent predictor of inpatient complications (OR 3.4).
Lee et al. [ 14 ] analyzed the National Surgical Quality Improvement Program (NSQIP) database (2005–2009). They identifi ed 1,917 cases of ileocolic resections for CD, of which 644 (33.6 %) were performed laparoscopically. They found that laparoscopy was associated with a signifi cantly lower rate of 30-day major and minor complications and a shorter hospital stay.
No. of study
No. of patients
Recovery
Op.
of bowel
time
function
Hosp. stay Morbidity Recurrence
C – C
C
The role of HALS in other diseases remains controversial. Orenstein et al. [ 18 ] reported favorable outcomes in a HALS group, while Cochrane review by Moloo et al. [ 19 ] showed only a decreased conversion rate in HALS groups.
There is no defi nitive evidence supporting the superiority of laparoscopic surgery or HALS in patients with Crohn’s colitis. This may be due to the diversity of disease extent, complexity of surgical technique, and lack of surgical cases in a particular center to enable an RCT to be performed.
Complex Crohn’s Disease
Laparoscopic Colon Resections
Evidence in support of laparoscopic surgery for Crohn’s colitis is lacking, and there are no RCTs for this condition. Instead, there are only a few limited retrospective case­control studies.
The largest series was conducted by Umanskiy and col­leagues [ 15 ]. They analyzed the data of 125 prospectively collected cases, including 55 (44 %) laparoscopic proce­dures. The most common procedures were total colectomy and total proctocolectomy with ileostomy. Surprisingly, they reported a shorter mean operative time (212 vs. 286 min, P = 0.032) in the laparoscopy group, which is a unique result. The authors suggested that this may be due to the high level of experience of the laparoscopic surgeons. Other short-term benefi ts of laparoscopy included less blood loss, early return of bowel function, and shorter hospital stay.
A case-matched study from the Cleveland Clinic [ 16 ] with 27 laparoscopic and 27 open colectomies showed that laparoscopy was associated with a longer operative time (240 vs. 150 min, P = 0.01), but no other short-term benefi ts were demonstrated.
Nakajima et al. [ 17 ] evaluated 38 patients with Crohn’s colitis who underwent subtotal or total colectomies divided into three groups (14 open, 18 hand assisted, and 6 laparoscopic). The operation time for the hand-assisted laparoscopic surgery (HALS) group was shorter than that for the laparo­scopic group, but there was no difference in complication rates or blood loss.
Infl ammatory conditions, such as abscess, phlegmon, or enteric fi stulas, are frequently associated with CD and make laparoscopic surgery more challenging. Some surgeons have regarded these conditions as relative contraindications for laparoscopic surgery, due to the high conversion rate and postoperative morbidity.
Goyer et al. [
20 ] reviewed 54 cases of laparoscopic
Ileocolic resections for complex CD in which 43 % had fi s­tula, 30 % abscess, and 27 % recurrent disease. They reported that the presence of complex CD was signifi cantly associated with increased operation time (214 vs. 191 min, P < 0.05), increased conversion rate (37 % vs. 14 %, P < 0.01), and increased use of temporary stoma (39 % vs. 9 %, P < 0.001). Postoperative morbidity and hospital stay were comparable.
Okabayashi et al. [ 21 ] investigated the association of Vienna classifi cation with outcomes following 107 cases of laparoscopic surgery for CD. They found a signifi cant asso­ciation between conversions and more complicated types of CD (B3, L3/4). However, there was no difference in the rate of complications.
Recently, a case-match study was published by Beyer­Berjot et al. [ 22 ]. They compared 11 laparoscopic ileocecal resections for fi stulizing CD with 22 matched controls. They found no signifi cant difference in operation time (120 vs. 120 min), conversion rate (9 % vs. 0 %), postoperative mor­bidity (18 % vs. 32 %), and hospital stay (8 vs. 9 days).
Recurrent CD is found in approximately 50 % of surgically treated CD patients who have had the disease for over 10–15 years. Adhesion and the complex infl ammatory condition of
340
C.S. Yu
Table 30.3 Laparoscopic surgery for recurrent Crohn’s disease (case-control study)
No. of
Author Year Control group Holubar [ Pinto [ Chaudhary [ Aytac [
26 ] 2010 Converted 30 vs. 10 25 159 vs. 165 10 vs. 30
24 ] 2011 Primary laparoscopic 50 vs. 80 32 vs. 18.7 201 vs. 182 40 vs. 36.2
25 ] 2011 Primary laparoscopic 30 vs. 29 6.7 vs. 10.3 125 vs. 85 16.7 vs. 24.1
23 ] 2012 Open 26 vs. 26 12 169 vs. 158 38.5 vs. 69.2
patients Conversion (%)
Op. time (min) Complication (%)
Fig. 30.2 Trocar placement for a laparoscopic ileocolonic resection
the bowel make these reoperations more diffi cult, although many surgeons have tried to perform various laparoscopic surgeries for recurrent CD.
Aytac et al. [ 23 ] performed a case-matched study to com- pare the effectiveness of laparoscopic vs. open resection for recurrent CD. Twenty-six patients who underwent various laparoscopic procedures were compared with a matched control group. The conversion rate was 12 %, with adhesions cited as the primary cause. Comparable short-term results were reported except for a decreased wound infection rate in the laparoscopic group.
Pinto et al. [ 24 ] and Chaudhary et al. [ 25 ] compared pri- mary and reoperative laparoscopy for CD and found similar perioperative and postoperative outcomes. They also found no intergroup differences in the effectiveness and feasibility of the resections. Holubar et al. [ 26 ] [ 27 ] reported a 20 % conversion rate in laparoscopic re-resection and no increased morbidity in converted cases (Table
30.3 ).

Technical Considerations

Basic Surgical Techniques for Ileocolic Resection
Number of Ports
The standard ports are one camera port at the umbilicus and two 5 mm ports at the left iliac fossa and the left fl ank. Another 5 mm port can be added at the right side for an assistant depending on the particular site of pathology (Fig. 30.2 ). Recently, single-port or single-incision laparoscopic surgery has been used successfully. The surgical outcomes of this sin­gle-incision technique will be discussed in a later section.
Running the Bowel (Video 30.1 )
Despite the availability of contemporary preoperative imag­ing modalities, such as CT or MR enterography, thorough
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Fig. 30.3 Laparoscopic view of Crohn’s disease bowel with thickened mesentery
intraoperative examination of the entire small bowel, from the Treitz ligament to the ileocecal value, is mandatory for all cases.
The careful application of an atraumatic bowel grasper to the mesentery is strongly recommended in intracorpo­real evaluation. However, I recommend extracorporeal manual examination along the mesenteric border after mobilization of the right colon, as this is the best way to prevent omission of a skipped lesion. In particular, careful examination of terminal ileum is needed to rule out an internal fi stula.
Mobilization of the Bowel
A lateral to medial dissection is preferable because of the thickened mesentery, abscess or phlegmon, and enteric fi stula (Fig. 30.3 ). The extent of colonic mobilization should refl ect that of the proposed colonic resection. Except for ileocecal resection, mobilization of the hepatic fl exure is helpful for the anastomosis.
If the mesenteric thickening is not too severe, a traditional medial to lateral approach can be used without diffi culty. Identifi cation of the right ureter is important, especially in a complicated case with abscess or phlegmon.
vascular division should be made near the bowel wall to prevent compromise of blood supply to the residual bowel.
Anastomosis
The most popular methods of performing Ileocolic anasto­mosis are side to side and functional end to end using two linear staplers. They can be performed intracorporeally [ 27 , 28 ] or extracorporeally. A seromuscular suture can be added where linear staple lines intersect. The mesenteric defect is left open.
Complex Fistulous Cases (Video 30.2 )
Several types of internal fi stula such as entero-enteric and entero-colic are manageable laparoscopically without great diffi culty. However, various kinds of internal or external fi stu­las or severe phlegmons are hard to handle with laparoscopic devices only. At this moment, the surgeon has to decide conver­sion to open or hand-assisted procedure. It is a wise way to make a decision at the beginning of laparoscopic exploration. Should you encounter a phlegmon with an abscess, it is benefi ­cial to have the suction device readily available to have a large amount of spillage throughout the abdomen. Also, you should have the ability to intracorporeally suture should the need arise. With fi stula and abscesses in Crohn’s, you may inadvertently get into bowel (or require an enterotomy) to take down the fi s­tula. Closing this (or marking it for extracorporeal closing/ resection) is imperative to avoid future complications.
Simple enterovisceral fi stulas can be treated by the removal of the diseased small bowel and simple suture clo­sure of the victim organ, such as sigmoid colon or other seg­ment of small bowel. The small opening of the bladder can be left open without suture. However, a Foley catheter remained in place for at least 7 days.
Hand-Assisted Laparoscopic Surgery (HALS)
Its applicability and potential superiority in Crohn’s colitis was described previously. Of note, it may reduce the conver­sion rate, especially in complex CD.
Mesenteric Division
It can be performed intracorporeally or extracorporeally, and a variety of energy devices can be used. Extracorporeal mes­enteric division is exactly same with open method. Therefore, it is much easier to be performed when infl ammatory condi­tion of the mesentery is severe. We decide the appropriate device for vascular division according to size of the vessel and completeness of isolation.
Resection margin has to be minimized for bowel-saving surgery. Supple bowel wall and soft mesenteric border is the point of division. So, I would like to recommend extracorpo­real anastomosis after meticulous palpation. Mesenteric or
Single-Incision Laparoscopic Colectomy (SILC)
Recently, MI surgery has evolved into a single-port laparo­scopic surgery. Theoretically, such a minimal incision can pro­vide improved cosmesis, less postoperative pain, and faster recovery. However, there is only limited evidence to support these benefi ts at this stage. Rijcken et al. [ 29 ] analyzed 34 SILC studies on surgical procedures for infl ammatory bowel disease, including Ileocolic resections, sigmoid resections, total colectomies, and restorative proctocolectomies. They reported a similar overall complication profi le.