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19 Anterior Lumbar Interbody Fusion of the Lumbosacral Spine: L3 Through the Sacrum
Fig. 19.2 Standing lateral radiograph shows 3 mm of ret­rolisthesis at L5–S1 (arrow)
Fig. 19.4 Flexion radiograph shows retrolisthesis at L5– S1 and normal motion patterns at discs above that level
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Fig. 19.3 Extension radiograph demonstrates the disc space narrowing, anterior osteophyte formation (arrow)
Postoperative anteroposterior (Fig. 19.5) and lateral (Fig. 19.6) radiographs show central positioning of the interbody cage, expansion of disc space height, enlargement of the neural foramina, and segmental fixation of the inter­body fusion device.
Fig. 19.5 Postoperative anteroposterior radiograph shows interbody cage device

Technical Pearls

• Axial cuts of the MRI or computerized axial tomography scan are helpful in documenting the dimensions of the intervertebral disc space and the size of implants to be used. The shape of the vertebral body is important in planning the depth of insertion of the spinal implants.
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Fig. 19.6 Postoperative lateral radiograph
The implants should be recessed within the confines of the intervertebral disc space. The implants should contact the vertebral apophy­sis but remain well seated within the interver­tebral disc space.
• Position the patient with a roll under the affected lumbar motion segment to increase lumbar lordosis and facilitate disc space distraction.
• Critically assess the vascular structures on preoperative MRI. Knowledge of anomalies and the location of bifurcation are important to avoid iatrogenic injury.
• Perform a complete discectomy under direct visualization. This will prevent retropulsion of any disc fragments, ensure an adequate fusion bed for the intervertebral body grafts, and allow for appropriated mobilization of the disc for restoration of an anatomic configuration of the disc.
• Adequately distract the disc space to the height of the adjacent vertebral motion segment. Avoid overdistraction and underdistraction.

Complications and Strategies for Avoidance

Intraoperative problems usually involve mobili­zation of the great vessels. The left iliac vein is generally the anatomic structure the surgeon has
J.K. Burkus
the most trouble adequately mobilizing [24]. Inadvertent tears in the vein should be promptly repaired using fine sutures. ALIF is a safe pro­cedure when performed by a combined surgical team of vascular surgeon and spine surgeon with acceptably low complication rates [23]. The team approach results in short operative times and length of stay, with rapid control of intraoperative vessel injury and low overall blood loss.
Patients with previous abdominal surgery or calcified vascular disease involving the aorta and iliac vessel are not candidates for stand-alone anterior interbody fusion. These patients are bet­ter treated by posterior posterolateral approaches to the lumbosacral spine.
Retrograde ejaculation can occur in men after this procedure [25]. This problem can be avoided by careful blunt dissection, bifurcation of the great vessels, and ligation along the lateral border of the iliac. Avoiding electrocautery during the initial dissection of disc spaces will also limit the occurrence of this problem.
Multilevel lumbar fusions (more than two disc space levels) are associated with high rates of pseudarthrosis. Long lumbar fusions are also associated with restricted lumbar motion and stress transfer to the sacroiliac joints.

Conclusion

Anterior lumbar interbody fusions have clinical advantages over posterior lumbar approaches. Interbody fusion procedures place bone grafts within the disc space at the center of rotation of the vertebral motion segment. The intervertebral area is highly vascular, and the grafts have a wide contact area and are inserted in the weight­bearing axis of the spinal motion segment. An anterior interbody fusion allows the surgeon to directly manipulate the spinal motion segment through the collapsed disc space. Intersegmental distraction enables the surgeon to restore the nor­mal sagittal plane contours of the spine, achieve immediate stabilization of the spinal motion seg­ment, and facilitate the fusion process without damaging the posterolateral soft tissues or mobi­lizing and retracting neural tissues.
19 Anterior Lumbar Interbody Fusion of the Lumbosacral Spine: L3 Through the Sacrum
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References

1. Wilder DG, Pope MH, Frymoyer JW. The biomechan­ics of lumbar disc herniation and the effect of overload and instability. J Spinal Disord. 1988;1(1):16–32.
2. Lane JD, Moore ES. Transperitoneal approach to the intervertebral disc in the lumbar area. Ann Surg. 1948;127:537–51.
3. Crock HV. Anterior lumbar interbody fusion. Clin Orthop. 1982;165:157–63.
4. Chow SP, Leong JCY, Ma A, Yau ACMC. Anterior spinal fusion for deranged lumbar intervertebral disc. Spine. 1980;5:452–8.
5. Goldner JL, Urbaniak JR, McCollom DE. Anterior excision and interbody spinal fusion for chronic low back pain. Orthop Clin North Am. 1971;2:543–68.
6. Harmon DH. Anterior excision and vertebral body fusion operation for intervertebral disc syndromes of the lower spine: three to five year results in 244 cases. Clin Orthop. 1963;26:107–27.
7. Sacks S. Anterior interbody fusion of the lumbar spine. J Bone Joint Surg Br. 1965;47:211–23.
8. Loguidice VA, Johnson RG, Guyer RD, Stith WJ, Ohnmeiss DD, Hochschuler SH, Rashbaum RF. Anterior lumbar interbody fusion. Spine. 1988;13:366–9.
9. Blumenthal SL, Baker J, Dossett A, Selby DK. The role of anterior lumbar fusion for internal disc disrup­tion. Spine. 1988;13:566–9.
10. Newman MH, Grinstead GL. Anterior lumbar inter­body fusion for internal disc disruption. Spine. 1992;17:831–3.
11. Kumar A, Kozak JA, Doherty BJ, Dickson JH. Interspace distraction and graft subsidence after anterior lumbar fusion with femoral strut allograft. Spine. 1993;18:2393–400.
12. Leong JCY, Chun SY, Grange WJ, Fang D. Long- term results of lumbar intervertebral disc prolapse. Spine. 1983;8:793–9.
13. Schroeder GD, Kepler CK, Millhouse PW, Fleischman AN, Maltenfort MG, Bateman DK, Vaccaro AR. L5/ S1 fusion rates in degenerative spine surgery: a sys­tematic review comparing ALIF, TLIF, and axial inter­body arthrodesis. Clin Spine Surg. 2016;29(4):150–5.
14. Verbruggen D, Tampere T, Uyttendaele D, Sys G, Poffyn B. Long-term follow-up of the anterior lum­bar interbody fusion procedure. Acta Orthop Belg. 2015;81(3):546–52.
15. Burkus JK, Gornet MF, Dickman C, Zdeblick TA. Anterior lumbar interbody fusion using rhBMP-2
with tapered interbody cages. J Spinal Disord. 2002;15:337–49.
16. Kuslich SD, Ulstrom CL, Griffith SL, Ahern JW, Dowdle JD. The Bagby and Kuslich method of lum­bar interbody fusion: history, techniques, and 2-year follow-up results of a United States prospective, mul­ticenter trial. Spine. 1998;21:1267–79.
17. Li J, Dumonski ML, Liu Q, Lipman A, Hong J, Yang N, Jin Z, Ren Y, Limthongkul W, Bessey JT, Thalgott J, Gebauer G, Albert TJ, Vaccaro AR. A multicenter study to evaluate the safety and effi­cacy of a stand- alone anterior carbon I/F cage for anterior lumbar interbody fusion: two-year results from a Food and Drug Administration investi­gational device exemption clinical trial. Spine. 2010;35(26):E1564–70.
18. Dennis S, Watkins R, Landaker S, Dillin W, Springer D. Comparison of disc space heights after anterior lumbar interbody fusion. Spine. 1989;14:876–8.
19. Schuler TC, Burkus JK, Gornet MF, Subach BR, Zdeblick TA. The correlation between preoperative disc space height and clinical outcomes after anterior lumbar interbody fusion. J Spinal Disord Tech. 2005 Oct;18(5):396–401.
20. Burkus JK, Gornet MF, Schuler TC, Kleeman TJ, Zdeblick TA. Six-year outcomes of anterior lumbar interbody arthrodesis with use of interbody fusion cages and recombinant human bone morphogenetic protein-2. J Bone Joint Surg Am. 2009;91:1181–9.
21. Modic MT, Steinberg PM, Ross JS, Masaryk TJ, Carter JR. Degenerative disc disease: assessment of changes in vertebral body marrow with MR imaging. Radiology. 1988;166:193–9.
22. Escobar E, Transfeldt E, Garvey T, Ogilvie J, Graber J, Schultz L. Video-assisted versus open anterior lumbar spine fusion surgery: a comparison of four techniques and complications in 135 patients. Spine. 2003;28(7):729–32.
23. Mobbs RJ, Phan K, Daly D, Rao PJ, Lennox A. Approach-related complications of anterior lumbar interbody fusion: results of a combined spine and vascular surgical team. Global Spine J. 2016;6(2):147–54.
24. Sasso RC, Best NM, Mummaneni PV, Reilly TM, Hussain SM. Analysis of operative complications in a series of 471 anterior lumbar interbody fusion proce­dures. Spine. 2005;30:670–4.
25. Sasso RC, Burkus JK, LeHuec JC. Retrograde ejacu­lation after anterior lumbar interbody fusion: trans­peritoneal versus retroperitoneal exposure. Spine. 2003;28:1023–6.

Transforaminal Lumbar Interbody Fusion

Robert F. Heary and John C. Quinn

Introduction

Lumbar spinal fusion has evolved as a treatment option for symptomatic spinal instability, spinal stenosis, spondylolisthesis, and degenerative sco­liosis [1, 2]. Lumbar spinal fusion is often per­formed after a posterior decompressive procedure when there is evidence of preoperative lumbar spinal deformity or instability that could worsen after laminectomy alone [3]. When performing a lumbar spine fusion, attaining a solid interbody arthrodesis through the intravertebral disc space has distinct biomechanical advantages when
fusions [4]. The advantages of interbody fusions include increased surface area for fusion to occur, the ability to restore and/or maintain foraminal height, and the ability to restore segmental lordo­sis across the fused segment [4]. Restoration of disc space height through placement of structural interbody grafts increases foraminal size which allows for indirect neural decompression [5, 6]. The posterior lumbar interbody fusion (PLIF) and transforaminal lumbar interbody fusion (TLIF)
R.F. Heary, MD (*) • J.C. Quinn, MD Department of Neurological Surgery, New Jersey Medical School, Rutgers, The State University of New Jersey, 90 Bergen Street – Suite 8100, Newark, NJ 07103, USA e-mail: heary@njms.rutgers.edu;
quinnj1719@gmail.com
20
are effective techniques for lumbar interbody fusion via a posterior-only approach, and each technique has distinct advantages and disadvan­tages [3, 4, 7]. The purpose of this chapter will be to describe our technique for performing a trans­foraminal lumbar interbody fusion in a step-by­step fashion. We will discuss important technical considerations as well as specific techniques for complication avoidance.
First described by Cloward in 1953, the poste­rior lumbar interbody fusion (PLIF) involves placing two grafts on either side of the interbody space after a wide laminectomy and partial face­tectomy [8]. The pars interarticularis is preserved in the traditional PLIF operation, and graft place­ment is carried out through a direct posterior approach which is limited by the amount the the­cal sac can be retracted to either side. A tradi­tional PLIF requires retraction of the thecal sac and nerve roots to gain sufficient access to the posterior disc space through the spinal canal which increases the risks of incidental durotomy and/or injury to the traversing nerve roots [3].
The transforaminal lumbar interbody fusion (TLIF) is a modification of the PLIF that approaches the disc space from a more lateral-to­medial transforaminal corridor [9] (Fig. 20.1). This lateral trajectory is created by a more exten­sive facetectomy including an osteotomy with complete removal of the pars interarticularis and its subjacent inferior articular facet. The lateral­to- medial trajectory with TLIF has several
© Springer International Publishing AG 2017 L.T. Holly, P.A. Anderson (eds.), Essentials of Spinal Stabilization, DOI 10.1007/978-3-319-59713-3_20
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R.F. Heary and J.C. Quinn
Fig. 20.1 Operative corridor PLIF versus TLIF. An axial T2-weighted MR at the L4–L5 disc space demonstrating the operative corridor for intervertebral disc space access during PLIF and TLIF. (a) The operative corridor during PLIF is more medial due to the intact facet joints and
advantages over the more direct, medial trajectory with PLIF. These advantages include less retrac­tion of the thecal sac and the traversing nerve roots, a decreased in the risk of an incidental durotomy or nerve root injury, and the ability to fit a larger interbody graft compared with the PLIF technique [5, 10]. In the setting of a reop­eration following prior posterior decompression (laminectomy or laminotomy), epidural scar tis­sue may limit the ability to mobilize and retract the neural elements. In these cases a transforami­nal approach may be advantageous as the lateral­to- medial approach allows for avoidance of midline epidural scar tissue. The original descrip­tion of the TLIF procedure involved a unilateral facetectomy for unilateral interspace access for discectomy and unilateral graft placement. The contralateral facet was preserved and can be decorticated and used as a fusion surface. Further modifications of the original TLIF to include bilateral medial facetectomies with removal of the pars interarticularis bilaterally or the poste­rior column osteotomy (chevron or Smith­Petersen osteotomy) have been described. The benefit of the complete posterior column osteot­omy is that it allows for a generous bilateral neural
requires retraction of the thecal sac and traversing nerve root to gain access to the disc space. (b) TLIF allows for a more lateral-to-medial access to the disc space through removal of the inferior facet and pars interarticularis
decompression and facilitates realignment in both the coronal and sagittal planes. With a com­plete posterior column release, segmental dis­traction across the interspace can be applied across the pedicle screws. Distraction across the interspace facilitates an aggressive discectomy and also allows for placement of large lordotic­shaped interbody cages into the anterior half of the disc space. After placement of the interbody cages, posterior compression is applied utilizing the pedicle screws, with the cages acting as ful­crums, allowing for restoration of segmental lor­dosis [5]. The combination of a posterior column osteotomy with bilateral discectomy and bilateral interbody cage placements has been described and has the advantage of being able to perform a more complete discectomy compared to the uni­lateral approach [11].

Indications and Patient Selection

Surgical intervention may be indicated for patients with degenerative disc disease that is refractory to conservative management. Previous studies have demonstrated that lumbar fusion
20 Transforaminal Lumbar Interbody Fusion
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surgery is superior to nonoperative treatment in patients with debilitating low back pain and/or radiculopathy that have failed conservative treat­ment [1]. Fusion is also indicated in patients with lumbar instability and for correction of spi­nal deformity including symptomatic spondylo­listhesis, degenerative scoliosis, and spinal stenosis associated with instability [1, 2, 12]. Circumferential fusions with interbody graft placement have several advantages over postero­lateral or intertransverse fusions. These advan­tages include greater surface area for fusion, restoration of disc space height for additional indirect decompression, and restoration of and/ or preservation of segmental lordosis. Recent evidence from the spine deformity literature demonstrates the importance of global and regional alignment on patient outcomes. Inadequate restoration of lordosis or loss of lor­dosis through these segments can have a dra­matic effect on the overall lumbar lordosis, which can impact sagittal alignment, patient out­comes, and need for revision surgery. Not restor­ing adequate lumbar lordosis during lumbar fusion may result in mechanical low back pain, sagittal malalignment, and increased risk of adjacent segment degeneration. Several short­term studies comparing posterolateral fusions to interbody techniques including TLIF have not reported a dramatic difference in short term out­comes. The ability to restore segmental lordosis with TLIF is a distinct advantage over PLF and may result in more durable long-term outcomes.
When an interbody fusion is considered, it is mandatory that an extensive trial of nonoperative treatment has been attempted. At a minimum, we encourage a trial of physical therapy as well as the use of epidural injections. The great majority of patients can benefit from optimizing their body weight (which frequently involves an attempt at dieting) as well as attempting to strengthen mid­sections using core strengthening exercise pro­grams. In addition, alternative approaches, which may include chiropractic treatment, acupuncture, and biofeedback, can be attempted. Only after failure of nonoperative treatment attempts for a minimum period of 6 months should an inter­body fusion surgery be considered or offered to the patient. It is noteworthy that the majority of
patients can avoid surgical intervention with a comprehensive conservative treatment regimen. Advanced radiographic imaging studies are reserved for those patients who have failed con­servative treatments. If the imaging studies con­cur with the clinical scenario, then an interbody fusion surgery may be considered.

Preoperative Considerations

Preoperative planning should include preopera­tive anteroposterior (AP) and lateral standing 36-in. radiographs and flexion/extension lateral radiographs of the lumbosacral spine. A mag­netic resonance imaging (MRI) or a computed tomography (CT) myelogram is routinely obtained to assist with understanding, comple­menting, and comparing the anatomy reflected on the radiographs and to assess the severity and anatomic location of stenosis. These studies will serve to better plan the surgical approach regard­ing side, pedicle size and orientation, nerve root location, and disc space height. If unilateral fac­etectomy is planned, this should always be per­formed on the most symptomatic side unless contraindicated. In very specific cases of disco­genic pain, discography may be useful in deter­mining the level of the pain generator; the clinician ordering this study must follow very selective criteria due to its controversial utility.
Relative contraindications include severe osteoporosis and active infections. Anatomic variations encountered during surgery including conjoined nerve roots or the presence of a high takeoff of the traversing nerve root may limit access to the disc space from the transforaminal approach. If a safe corridor cannot be created with mobilization of the neural elements, a con­tralateral approach should be considered.

Surgical Technique

Patient Positioning

Under general anesthesia, the patient is placed on a radiolucent Jackson table in the prone position. It is essential to extend the hips fully to allow the
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lumbar spine to achieve maximum lordosis [13]. Any hip flexion can be associated with kyphotic angulation of the lumbar spine and may predis­pose to the development of flat-back syndrome and adjacent segment disease [14]. Care is taken to position the arms in a 90° extension–90° flex­ion orientation to prevent any stretch or compres­sion injuries to the peripheral nerves, which can occur during prolonged surgery in the prone posi­tion. It is essential to pad all osseous prominences and take precautions to protect the eyes. Placing a soft foam cushion around the periphery of the face avoids any direct pressure on the eyes, and a 10° reverse Trendelenburg position can reduce the risk of postoperative blindness, a rare but debilitating complication. A radiolucent table is used to aid in intraoperative fluoroscopic imaging in both the coronal and sagittal planes.

Incision and Exposure

Before the initial skin incision, the operative site, including both the lumbar spine and the iliac crest regions, is prepared and draped. A preoper­ative dose of 2 g of cefazolin is administered intravenously, and repeat antibiotic dosing of 1 g every 2 h is given over the course of the surgery. Vancomycin is used in patients with hypersensi­tivity to penicillin or cephalosporins or those known to be carriers of methicillin-resistant Staphylococcus aureus. A standard midline approach is used. After radiographic confirma­tion of the correct operative level, the deep lum­bodorsal fascia is identified and a subperiosteal dissection of the posterior elements is performed. Care is taken to avoid cauterization of the facet joint capsules of the adjacent levels, which will not be included in the fusion procedure. The lat­eral extent of the exposure includes the transverse processes at each operative level and the sacral alae in cases that extend to the sacrum. When fus­ing to the sacrum, adequate exposure of the sacral alae is essential as the L5–S1 space is the most difficult level to achieve successful arthrodesis in the lumbar spine. This exposure may require sig­nificant retraction of the paraspinal muscles in
larger patients. Large Gelpi self-retaining retrac­tors are placed to limit compressive forces on the paraspinal muscles. In addition, these Gelpi retractors work well to allow correct placement of pedicle screws by permitting proper medial and cranial-caudal orientation of instruments during screw placement owing to their smaller footprint within the operative field relative to other retractors commonly used in the posterior lumbar surgery. On an hourly basis, the retractors are released for 90 s; during which time the wound is irrigated with a pulse lavage irrigation system. The retractors are then replaced and the procedure is continued. This maneuver of releas­ing the retractors and irrigating hourly prevents excessive ischemia of the paraspinal musculature and removes any mechanical debris during pro­longed operative procedures.

Decompression

Decompression is undertaken with bilateral removal of the spinous processes, laminae, pars interarticularis, and the inferior facets of the operative levels. In addition, resection of the medial and superior portions of the subjacent superior facets is helpful in limiting neural retrac­tion later in the operation when intervertebral struts are placed. Importantly, a wide foraminot­omy is also accomplished by this maneuver. All resected bones are cleaned of soft tissue and mor­selized and saved for use later in the operation as autologous local bone graft. This aggressive bony decompression provides a generous amount of bone graft material. The exposed ligamentum fla­vum is completely resected. After decompres­sion, the thecal sac and the exiting and traversing nerve roots are well visualized and widely exposed.

Instrumentation

After decompression, pedicle screws are placed. The superior, medial, and inferior margins of the pedicles are readily palpable at this point
20 Transforaminal Lumbar Interbody Fusion
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which makes placement of the screws easier. Lateral fluoroscopy can be used if any concern exists regarding the optimal entry site or trajec­tory for the screw placement. The technique for screw placement involves use of a high-speed burr to decorticate the entry site. A pedicle probe or a drill is then placed to help localize the pedicle. After localization of the pedicle, a small tap is used to access the pedicle. A ball­tipped probe is used to confirm that the tapped track has not deviated out of the pedicle or that it has not violated the far vertebral cortex. Based on the preoperative imaging studies, sequentially larger diameter taps can be inserted with a ball-tipped probe used to confirm the adequacy of each tapped track after the larger tap is utilized. Routinely, the largest tap used is one size, or approximately 0.5–1.0 mm, smaller than the screw to be placed. In so doing, the screw purchase and insertional torque are improved [15].

Discectomy

In order to facilitate the discectomy and inter­body placement, a temporary rod is placed oppo­site the side of the planned discectomy and distraction is applied. Use of an offset distraction device on the ipsilateral side may improve access to the disc space while maintaining distraction. With the disc space under distraction, the thecal sac and exiting nerve roots are identified and pro­tected, the disc space is identified, and discec­tomy is performed. First, the outer annulus fibrosis of the intervertebral disc is incised lateral to the traversing nerve root. If the medial aspect of the subjacent superior facet has been ade­quately resected, the discectomy can be accom­plished with minimal or no retraction of the exiting or the traversing nerve roots. Pituitary rongeurs and bone rasps are used to remove the great majority of disc material from the inter­space. Care is taken to preserve the ventral and lateral margins of the annulus to allow the graft material, both structural and morselized, to be contained.

Interbody Graft Placement

In all cases, we use generous amounts of autolo­gous bone graft for both the intervertebral space and the posterolateral gutters. Autogenous iliac crest graft is combined with the previously pre­pared local autograft bone. Corticocancellous iliac crest autograft may be obtained, through either the same incision or a separate incision, using bone gouges. Recently, we have modified our technique and have started using bone marrow aspirates from the iliac crest. Using a large bore trocar, the bone marrow is aspirated and no inci­sion is necessary. A total of 20 mL of combined blood/bone marrow is removed for processing. This technology allows for concentration of the osteogenic precursor cells which are isolated from the bone marrow. These cells are combined with the previously obtained local bone graft to pro­duce a generous amount of fusion substrate bone for later grafting. The fusion substrate bone is packed within radiolucent, carbon- fiber rein­forced PEEK cages (CFRP cages; DePuy Synthes Spine). In our current technique, after a thorough discectomy, autologous morselized graft is packed into the ventral aspect of the disc space.
A custom-made funnel is positioned through the discectomy defect into the ventral disc space. The morselized graft material is then introduced through this funnel into the ventral disc space. After this is completed, two carbon fiber cages are packed with the morselized graft material. These cages are radiolucent except for tantalum beads which are embedded in the extremes of the cage and allow fluoroscopic confirmation of cage placement. The cages have a lordotic sagittal contour with the anterior surface at least 2 mm taller than the posterior surface. These cages are designed to be inserted straight or in a slight oblique manner to allow for lordosis restoration when posterior compression is applied. A variety of cage heights, lengths, and widths are available, and the appropriate sizing is based on the preop­erative neuroimaging studies and the intraopera­tive clinical impression. The cages are impacted bilaterally so that the dorsal most aspect of each cage is countersunk 2 mm ventral to the dorsal
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R.F. Heary and J.C. Quinn
Fig. 20.2 Techniques for graft placement during TLIF. An axial T2-weighted MR at the L4–L5 disc space dem­onstrating different approaches for placement of interver­tebral cages when performing a TLIF. Straight cages may be placed in a diagonal fashion across the disc space to maximize disc space height restoration (a). Alternatively
margin of the vertebral bodies above and below (Fig. 20.2). In cases of spondylolisthesis, a cage of shorter depth is used. Additional morselized graft is placed between the cages if there is space available. By resecting the medial aspects of the subjacent superior facets, manipulation of the thecal sac and nerve roots is kept to a minimum. A nerve root retractor may be used to protect the thecal sac, though, often, there is no need to retract neural structures. Throughout the cage impaction process, all neural structures are directly visualized and gently protected.
After placement of the interbody struts has been completed, the epidural space is inspected to assure that no bone fragments have been deposited into the spinal canal inadvertently. At this point, we copiously irrigate the wound with 3 L of warm normal saline to remove mechanical debris and assist with hemostasis.
cages may be placed horizontally across the anterior 1/3 of the disc space which when combined with segmental compression acts as a fulcrum for restoration of segmental lordosis (b). Bilateral TLIF cages may be placed after bilateral facetectomies (c)

Rod Placement

After placement of the lateral fusion bone, the screws are connected to each other with either plates or rods. When possible, plates are prefer­entially used for shorter constructs. The plates or rods are contoured in the sagittal plane to achieve a lumbar lordosis. When rods are used, cross­connectors may be attached to each rod to aid in achieving rotational stability. If necessary for alignment and if the bone is of adequate density, compression of the screws posteriorly can be per­formed to improve the extent of lordosis able to be obtained. Following placement of the instru­mentation, biplanar radiographs are obtained using fluoroscopy.

Closure

Posterolateral Fusion

Attention is now directed to the lateral gutters. Generous amounts of morselized autograft are placed over the decorticated transverse processes and sacral alae. This is performed before con­necting the pedicle screws together to allow for the bone to be in direct apposition to the exposed donor sites.
At this point, care is taken to achieve meticulous hemostasis. Particular attention is directed to the epidural venous structures to confirm control of any bleeding sites. Depending on surgeon pref­erence, suction drains may be placed at this time. For single-level fusions, closure is most often performed without drain placement; in multi­level cases, drains are used routinely. When used, the drains are routinely brought out through two separate stab wounds in the skin. Drains
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remain in place until output decreases to less than 50 mL over a 24-h period. Vancomycin powder (1 gm or 2 gms) can be placed into the lateral gutters covering the graft material and the metallic instrumentation in an attempt to limit the likelihood of developing a postoperative wound infection. Standard wound closure is per­formed in layers.

Illustrative Case

History

A 59-year-old male with a history of progressive mechanical back pain, lumbar stenosis with neu­rogenic claudication, and bilateral L5 radiculopa­thies. Extensive conservative management had been attempted without improvement. These therapies included multiple epidural steroid injections and several courses of both land-based physical therapy and aquatic physical therapy.

Treatment

Given the significant disc height loss causing severe foraminal stenosis, as well as the degen­erative spondylolisthesis at L4–L5, a two-level TLIF was offered to decompress the nerve roots, stabilize the L4–L5 and L5–S1 interspaces, restore the disc space heights, and attempt to restore the segmental lordosis across the L4–S1 segments (Figs.
20.3 and 20.4).

Outcome

The patient tolerated the procedure well with an immediate improvement in his radicular leg pain. At 6-month follow-up, the patient reported a dra­matic improvement in his back and leg pain and was able to ambulate over a mile pain free. His motor strength improved to 5/5 in all muscle groups with mild residual paresthesias in the right L5 distribution.

Physical Examination

On physical examination the patient demon­strated normal posture and gait. He was able to toe and heel walk without difficulty. His lower extremity motor strength exam was symmetric; 5/5 in hip flexion, knee extension, ankle dorsi­flexion, and plantar flexion; and 4+/5 in extensor hallucis longus. His sensory exam was notable for paresthesias in an L5 distribution bilaterally, and his lower extremity reflexes were diminished +1 and symmetric.

Imaging

Plain radiographs and magnetic resonance (MR) imaging showed significant disc degeneration which was greatest at the L4–L5 and L5–S1 lev­els with loss of disc height and severe L4–L5 and L5–S1 lateral recess and foraminal stenoses as well as a low-grade degenerative spondylolisthe­sis at L4–L5.

Technical Pearls

• TLIF can be a powerful tool for restoration of segmental lordosis. This can be achieved by performing a posterior column osteotomy (chevron or Smith-Petersen osteotomy) fol­lowed by compression across the segment. This is facilitated by anterior placement of the interbody cages which acts as a fulcrum when compression is applied across the segment.
• Cages with lordotic shapes are used to main­tain or restore sagittal plane alignment. In addition, the large degree of bony decompres­sion allows the application of compressive, lordotic forces if needed to correct or maintain sagittal plane alignment.
• The placement of large bilateral, lordotic interbody grafts is both structurally robust and biomechanically advantageous for posterior column compression and the subsequent res­toration of sagittal plane alignment. In addi­tion, utilizing large quantities of autograft bone in the disc spaces, in and between the