Ординатура / Хирургия / Библиотека им академика М.И. Перельмана / Книга_5578_Библиотеки_им_академика_М_И_Перельмана

constituents of the fruit pulp and seeds are considered to be responsible for this prop­erty (Lal et al., 2011; Kushawaha et al., 2016; Mahmoodpoor et al., 2018). A clinical trial conducted on diabetic critically ill patients who were admitted to the intensive care unit (ICU) demonstrated the efficacy of C. max- ima pulp in decreasing blood glucose level. In that study, the powder of C. maxima (5 g) was administrated twice daily for 3 days. During the time period, the average glucose level and insulin dose were decreased signifi­cantly (Lal et al., 2011). In an in vitro study, the aqueous extract of C. maxima seeds pre­sented inhibitory action on carbohydrate­hydrolyzing enzymes like α-amylase and α-glucosidase (Kushawaha et al., 2016). Furthermore, pumpkin seeds demonstrated hypoglycemic and hypolipidemic effects in a rat model (Farid et al., 2015). In an in vitro study, the hypoglycemic activity of fruit juice and hydroalcoholic extract of C. max- ima was evaluated. Oral dose of both fruit juice and extract (200 mg/kg) for 28 days could decrease hyperglycemia in streptozotocin­induced diabetic rats, significantly. The results showed that the extract was more potent than the control group (Lal et al., 2011).