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H. J. Welkoborsky
Fig. 10.24 Transcranial Doppler (TCD) sonography to estimate cross
ow in the medial cerebral artery in cases with occlusion of the ipsilateral internal carotid artery. (a) Stenosis of the common carotid artery on the right side with blood ow prestenotically (longitudinal plane). (b) Blood ow in the ipsilateral external carotid artery by duplex and Doppler. (c) Blood ow in the common carotid artery is prestenotically normal. (d) Internal carotid artery on the right side is distally occluded, and distal to the carotid bifurcation, there is a complete obstruction of the vessel. (e) Duplex sonography reveals normal blood ow in the contralateral (left-
sided) internal carotid artery. Only some at, brotic plaques occur in the vessel. In this case, blood ow in the medial cerebral artery on the left side is normal (f), and a moderately good cross ow with collateration of the median cerebral artery (MCA) on the left side (g) that occurs via the left anterior communicating artery (or ramus) (ACA) can be detected (h), which retrogradely lls the right ACA (i) (Courtesy of Dr. Silke Hörnschemeyer-Decker, Dept. of Neurology, Nordstadt Clinic, Hannover, Germany). (j) and (k) MRI shows the occluded carotid artery on the right side in axial view and with vessel reconstruction
jk
10 Sonography oftheLarge Neck Vessels andofTumors withSuspected Inltration oftheLarge Neck Vessels
229
g
h
i
Fig. 10.24 (continued)
230
Fig. 10.25 Ultrasound of the
neck following radiation therapy. Note the increase of scar tissue and brosis. The internal jugular vein is missing, as it has been removed during a neck dissection. The common carotid artery is seen with an increased intima-media thickness and a calcied plaque
H. J. Welkoborsky
IMT and plaque formation. Therefore it is important to keep in mind that after radiation therapy of the neck, patients have a higher risk of carotid artery disease, especially accelerated atherosclerosis, so they need intensive follow-up and surveil­lance. Parallel to changes in the carotid artery wall and decrease of vessel diameter, hemodynamic changes occur, with a decrease of blood ow volume following radiotherapy [70]. If the carotid artery was spared by using intensity-mod­ulated radiotherapy, these pathologic conditions can be sig­nicantly decreased, with both better blood ow volume and decreased risk of progressive atherosclerosis [71]. Carotid IMT has been proven to be a strong biomarker for early diag­nosis of vascular changes and risk of cerebrovascular events after radiation therapy of the neck. In these patients, long­term follow-up including B-mode and duplex sonography is required for early detection and surveillance of vessel disease.
10.8 Examination ofVessels Prior toMicrovascular Flap Surgery
Another indication for vessel ultrasound is the identica­tion of the afferent and efferent vessels prior to intended microvascular tissue transfer. An example is the microvas­cular forehand ap, which has the radial artery as its feeder vessel. This is the microvascular ap that is currently most
often used for reconstruction of larger defects in the head and neck, so it is very common. The examination can be performed preoperatively and intraoperatively. With this test, which is called the Allen test, the existence and patency of the anastomosis between the supercial palmar arterial arch and the profound palmar arterial arch in the ipsilateral hand is assessed (Fig.10.26; Video 10.8). The existence of an anastomosis between the radial and ulnar artery is required before the ap (which is usually pedicled at the radial artery) can be harvested. The profound palmar arte­rial arch is a prolongation of the radial artery and courses beneath the long exor strings. It is identied on the ultra­sound screen, and then the radial artery is compressed under continuous observation of the blood ow in the pal­mar arch. The test is positive if there is signicant blood ow during compression. It is advantageous to perform pulse oximetry with a sensor at the index nger during the test, because this provides additional information about the pulsation, oxygen saturation, and perfusion of the nail bed during compression of the radial artery. It is very likely that the blood supply of the second and third nger is sufcient and the anastomosis is intact when no signicant decrease of the pulsation curve occurs. The ap can then be harvested.
Postoperatively, duplex sonography helps to evaluate the blood supply of an incorporated ap and assess the patency of the ap’s vessels.
10 Sonography oftheLarge Neck Vessels andofTumors withSuspected Inltration oftheLarge Neck Vessels
Fig. 10.26 (a) Before
harvesting a forehand ap, the Allen test is performed to assess the profound palmar artery arch for collateral blood supply of the rst three ngers during compression of the radial artery. (b) Duplex sonography reveals a good blood ow in the profound palmar arterial arch
a
231

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Sonography ofMajor Salivary Glands
AndreasKnopf
11
Major salivary glands represent a melting pot of inamma­tory, neoplastic, and dysontogenetic diseases. Diagnostic approaches are of major clinical impact to achieve both suf­cient radicality of epithelial malignancy and a minimum of functional loss in benign lesions. Whereas B-mode ultra­sound demonstrates high sensitivity and specicity in the identication of sialolithiasis, B-mode ultrasound and color­coded duplex sonography fail to reliably distinguish inam­matory and neoplastic conditions. Recent advances in elastography increased precision of diagnostic regimens in inammatory conditions but require great personal expertise. Modern diagnostic algorithms including elastography and contrast-enhanced ultrasound result in signicantly higher precision in the identication of glandular malignancy. However, complex algorithms are not part of the daily ultra­sonographic routine, and detailed anamnesis and clinical examination remain mandatory in these cases.

11.1 Introduction

Major salivary glands represent a melting pot of inamma­tory, neoplastic, and dysontogenetic diseases [13]. Final treatment regimens range from wait and scan concepts to ablative surgery and subsequent facial reconstruction. The close relation of major salivary glands to vascular and neu­ronal structures—particularly the facial, hypoglossal, and lingual nerves—gives rise to the necessity of a reliable preoperative lesional estimation to manage the balancing
A. Knopf (*) Department of Otorhinolaryngology–Head and Neck Surgery, University of Freiburg, Freiburg, Germany
act between sufcient radicality and a minimum of func­tional loss. High-resolution ultrasound provides detailed information about the lesional localization, size, shape, homogeneity, and pattern of vascularity [4]. More recently, modern ultrasound techniques including strain and shear­wave elastography or contrast-enhanced ultrasound (CEUS) have been applied to increase diagnostic sensitiv­ity and specicity, but these techniques are not part of today’s routine in major salivary gland ultrasound. MRI represents an appropriate alternative to head and neck ultrasound [46] and is the diagnostic technique of choice when complete ultrasonographic visualization fails [5]. CT scans are indicated when a growing tumor is suspi­cious for osseous destruction. The diagnostic impact of other imaging techniques (such as glandular scintigraphy in Sjögren’s syndrome) has decreased in the past decades, owing to the increased sensitivity and specicity of high­resolution B-mode ultrasound [7, 8]. Nevertheless, no imaging technique is currently able to reliably distinguish among the variety of salivary gland diseases, so it is vital to associate salivary gland imaging with the patient’s detailed history and clinical examination [9, 10].
11.2 Inammatory Diseases
Inammatory diseases of major salivary glands can be divided into infectious and autoimmune conditions. Other diseases become clinically apparent as inammation, but their etiopathogenesis is poorly understood. Traditionally, the clinical course of salivary gland inammation differenti­ates between acute and chronic disease, but a substantial pro­portion of autoimmune diseases that are summarized as chronic sialadenitis show an acute and self-limiting early disease stage referring to acute sialadenitis. Therefore, clas­sication in this chapter will reect etiopathogenetic considerations.
© Springer Nature Switzerland AG 2019 H. J. Welkoborsky, P. Jecker (eds.), Ultrasonography of the Head and Neck, https://doi.org/10.1007/978-3-030-12641-4_11
235
236
A. Knopf

11.2.1 Infectious Sialadenitis

Bacterial Sialadenitis
There are different mechanisms resulting in a bacterial infection of major salivary glands. Bacteria ascending via salivary ducts represent one of the most important mecha­nisms. Dysfunctional saliva drainage and irrigation due to obstructive sialadenitis, duct ectasia, duct cysts, dehydra­tion, and Sjögren’s syndrome are preconditions in bacte­rial sialadenitis [11]. Usually, patients present reddened, enlarged, and painful salivary glands. Pus can be expressed at the ductal oricium after palpation. However, in parotid gland sialadenitis, purulent drainage fails if bacterial infection primarily affects intra-parotideal lymph nodes. Cutaneous foci frequently result in the affection of the lymphatic basin of the parotid gland. Hematogenous and lymphatic spread in salivary glands can be diagnosed in mycobacteria and mycobacteria other than tuberculosis (MOTT). Both mycobacteria and MOTT often demon­strate severe resistance to common antibiotics, sometimes with organ stulation. Abscess formation complicates bacterial sialadenitis in all pathomechanisms. Bacterial smear usually identies Staphylococcus aureus and spe­cies of the oral ora [12].
B-mode ultrasound visualizes uncomplicated sialade­nitis as diffuse and inhomogeneous enlargement of the glandular tissue [12]. Strand-like hypoechogenicity refers to congested lymphatic septa (Fig. 11.1). Echo-free strands referring to congested Wharton’s and Stenson’s duct can be identied in obstructive sialadenitis. Peripheral concrements show cortical reex and acoustic shadow
with subsequent proximal duct dilatation (see Sect. 11.4.1) [13]. Color-coded duplex sonography (CDS) shows glan­dular hypervascularity (Fig.11.2). Intraglandular abscess shows irregular borders and marked hypoechogenicity (Fig.11.3). Inhomogeneity is due to different amounts of purulent areas. CDS demonstrates peripheral vascularity and an avascular core (Fig. 11.4). Cold abscesses with intraglandular stula often occur in mycobacterial/MOTT sialadenitis (Fig. 11.5). Usually, bacterial sialadenitis is completed by reactive intra- parotideal and/or cervical lymphadenopathy.
Fig. 11.2 Color-coded duplex sonography of bacterial sialadenitis
shows marked hypervascularity of the entire left parotid gland, with hypoechoic lymphatic septa. JA jaw angle
Fig. 11.1 B-mode ultrasound of bacterial sialadenitis shows diffuse
enlargement of the entire left parotid gland with hypoechoic lymphatic septa. JA jaw angle
Fig. 11.3 B-mode ultrasound of left parotid gland abscesses visualizes
hypoechoic or echo-free lesions with irregular borders. JA jaw angle, MM masseter muscle
11 Sonography ofMajor Salivary Glands
237
Viral Sialadenitis
Various viruses may infect the major salivary glands. Epstein­Barr virus (EBV), cytomegalovirus (CMV), HIV, and mumps viruses are the most frequent pathogens [14, 15]. CMV, EBV, and mumps infections result in acute sialadenitis, but HIV­induced sialadenitis usually presents a chronic clinical course [14]. In contrast to bacterial sialadenitis, viral infection usu­ally demonstrates oligo-sialadenitis. B-mode ultrasound and CDS can visualize diffuse and inhomogeneous enlargement of the glandular tissue with strand-like hypoechogenicity with marked hypervascularity, comparable to bacterial sialadenitis (Fig.11.6). However, CMV and EBV demonstrate a predilec-
tion for cervical lymph nodes and therefore parotid gland infection referring intra- parotideal lymph nodes (Fig. 11.7). Interestingly, the sonographic appearance of HIV infection differs signicantly from the other viral infections, demon­strating echo-free areas referring to lymphoepithelial lesions (Fig. 11.8). CDS and CEUS validate cystic areas without macro- or micro- perfusion (Fig.11.9). Cystic areas were visu­alized soft in strain elastography (Fig.11.10). Sonography in HIV-induced sialadenitis cannot be distinguished from Sjögren’s syndrome or mucosa-associated lymphoid tissue (MALT) lymphoma; differential diagnosis is mandatory in these cases [11, 1618].
Fig. 11.4 Color-coded duplex sonography (CDS) of left parotid gland
abscesses demonstrates peripheral hypervascularity of avascular echo­free areas. JA jaw angle, MM masseter muscle
Fig. 11.5 B-mode sonography of parotid gland tuberculosis shows
echo-free stulae in central glandular parts. CM collum mandibulae
Fig. 11.6 Oligo-sialadenitis of the parotid gland (PG) and subman-
dibular gland (SMG) in mumps infection. B-mode ultrasound shows hypoechoic lymphatic septa of the parotid gland and hypoechogenicity of the submandibular gland
Fig. 11.7 Color-coded duplex sonography of intra-parotideal lymph
node EBV infection. Hypoechoic lymph nodes show hilus hypervascu­larity. JA jaw angle
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A. Knopf

11.2.2 Autoimmune Sialadenitis

Sjögren’s Syndrome
Sjögren’s syndrome represents the most important rheumatic disorder affecting the head and neck, with a prevalence of 1–2% in the adult population, a female predominance of approximately 8:1, and a mean age of onset usually in the fourth to fth decade of life [11, 19, 20]. Sjögren’s syndrome can be present without another underlying inammatory condition (primary Sjögren’s syndrome), or it may be cou­pled with an underlying inammatory disease (secondary
Sjögren’s syndrome). Autoantibodies induce chronic epithe­lialitis, particularly of serous salivary glands. Therefore, the parotid and lacrimal glands are predominantly affected, but sialadenitis also includes submandibular, sublingual, and minor salivary glands [11, 17]. Chronic glandular inamma­tion results in an insidious destruction of salivary gland tis­sue and progressive sicca symptoms. Acute and self-limiting enlargements of major salivary glands, particularly of the parotid gland, represent typical symptoms of early disease stages, but they are dramatically underdiagnosed [11, 17]. Bilateral, hypoechoic lesions of the submandibular and
Fig. 11.8 B-mode ultrasound of lymphoepithelial lesions in HIV
infection demonstrates multiple intra-parotideal echo-free areas. JA jaw angle
Fig. 11.9 Color-coded duplex sonography of lymphoepithelial lesions
in HIV shows peripheral hypervascularity and avascular echo-free areas. JA jaw angle
Fig. 11.10 Strain elastography of lymphoepithelial lesions in HIV infection. Echo-free areas are visualized soft (blue) in contrast to hardened
parotid gland tissue (red). Red areas in the lymphoepithelial lesion refer to compression phenomenon to incompressible liquids