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Contents
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29 Robotic-Assisted Ovarian Tumor Resection . . . . . . . . . . . . . . . . . 191
Jinhu Wang and Jiabing Cai
30 Robotic-Assisted Resection for Mediastinal Tumors . . . . . . . . . . 195
Zheng Tan and Jian Zhang
31 Complications of Robotic-Assisted Surgery in Children . . . . . . . 205
Qiang Shu and Shuhao Zhang
Editors and Contributors
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About the Editor
QiangShu MD, obtained his bachelor’s degree in 1988 and master’s degree in medicine in 1996 from Zhejiang Medical University (now Zhejiang University School of Medicine), Hangzhou, China. He received his doctoral degree in 1999 at the University of Bonn, Germany. He completed his residency training in pediatric surgery and fellowship training in pediatric cardiothoracic surgery in Children’s Hospital, Zhejiang University School of Medicine, where he became
a chief surgeon in 2004 and professor of pediat­rics in 2006. He is now the dean of School of Pediatrics, Zhejiang University School of Medicine, and the Director of the Heart Center of Children’s Hospital, Zhejiang University School of Medicine. To date, he as the corre­sponding author and coauthor published more than 240 peer-reviewed arti­cles and edited 14 books. He also received many research grants and awards in recognition of his contributions to the advanced development in the eld of pediatrics and surgery.
Qiang Shu is an Editor-in-Chief of World Journal of Pediatrics and World
Journal of Pediatric Surgery; he is also an editorial board member of Chinese Medical Journal, Journal of Clinical Pediatrics, and Chinese Journal of Pediatric Surgery and a regular reviewer of many international leading jour-
nals in pediatrics and surgery. He is the Vice Chairman of Pediatric Surgery Society of Chinese Medical Association, Pediatric Professional Teaching Guidance Sub-committee of Chinese Medical Association, High Education Steering Committee of Ministry of Education, and Chinese Society for the Prevention and Control of Birth Defect. He is also the Vice Director of Cardiothoracic Surgery Group of Paediatric Surgery Society, Chinese Medical Association. Qiang Shu is an active member of Paediatric Surgeons Branch Standing Committee, Chinese Medical Association, Women and Children’s Healthcare Branch Standing Committee, China International Exchange and Promotion Association for Medical and Health Care, Congenital Heart Disease Professional Committee, and National Cardiovascular Expert Committee.
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Associate Editors
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ZhigangGao Department of General Surgery, Children’s Hospital, Zhejiang University School of Medicine, Hangzhou, China
ShaotaoTang Department of Paediatric Surgery, Xiehe Hospital Afliated to Tongji Medical College of Huazhong University of Science & Technology, Wuhan, China
HuixiaZhou Department of Urology, Bayi Children’s Hospital Afliated of the Seventh Medical Center of PLA General Hospital, Beijing, China
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Contributors
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Duote Cai Department of General Surgery, Children’s Hospital, Zhejiang University School of Medicine, Hangzhou, China
JiabinCai Department of Oncology Surgery, Children’s Hospital, Zhejiang University School of Medicine, Hangzhou, China
Guangjie Chen Department of Pediatric Urology, Children’s Hospital, Zhejiang University School of Medicine, Hangzhou, China
KenChen Department of General Surgery, Children’s Hospital, Zhejiang University School of Medicine, Hangzhou, China
Qingjiang Chen Department of General Surgery, Children’s Hospital, Zhejiang University School of Medicine, Hangzhou, China
Yue Gao Department of Thoracic Surgery, Children’s Hospital, Zhejiang University School of Medicine, Hangzhou, China
JinjinHuang Department of Anaesthesiology, Children’s Hospital, Zhejiang University School of Medicine, Hangzhou, China
Shoujiang Huang Department of Neonatal Surgery, Children’s Hospital, Zhejiang University School of Medicine, Hangzhou, China
TingHuang Department of Thoracic Surgery, Children’s Hospital, Zhejiang University School of Medicine, Hangzhou, China
Zongwei Huang Department of General Surgery, Children’s Hospital, Zhejiang University School of Medicine, Hangzhou, China
Di Hu Department of General Surgery, Children’s Hospital, Zhejiang University School of Medicine, Hangzhou, China
YaoqinHu Department of Anaesthesiology, Children’s Hospital, Zhejiang University School of Medicine, Hangzhou, China
Yi Jin Department of General Surgery, Children’s Hospital, Zhejiang University School of Medicine, Hangzhou, China
Dengming Lai Department of Neonatal Surgery, Children’s Hospital, Zhejiang University School of Medicine, Hangzhou, China
LiangLiang Department of Thoracic Surgery, Children’s Hospital, Zhejiang University School of Medicine, Hangzhou, China
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ZhongkuanLin Department of Clinical Engineering, Children’s Hospital, Zhejiang University School of Medicine, Hangzhou, China
Xiwang Liu Department of Cardiovascular Surgery, Children’s Hospital, Zhejiang University School of Medicine, Hangzhou, China
Wenjuan Luo Department of General Surgery, Children’s Hospital, Zhejiang University School of Medicine, Hangzhou, China
ChengjieLv Department of Neonatal Surgery, Children’s Hospital, Zhejiang University School of Medicine, Hangzhou, China
LongSun Department of Pediatric Urology, Children’s Hospital, Zhejiang University School of Medicine, Hangzhou, China
ZhengTan Department of Thoracic Surgery, Children’s Hospital, Zhejiang University School of Medicine, Hangzhou, China
ChangTao Department of Pediatric Urology, Children’s Hospital, Zhejiang University School of Medicine, HangzhouChina
JinfaTou Department of Neonatal Surgery, Children’s Hospital, Zhejiang University School of Medicine, Hangzhou, China
Jinhu Wang Department of Oncology Surgery, Children’s Hospital, Zhejiang University School of Medicine, Hangzhou, China
Contributors
Zheming Xu Department of Pediatric Urology, Children’s Hospital, Zhejiang University School of Medicine, Hangzhou, China
Liyang Ying Department of Cardiovascular Surgery, Children’s Hospital, Zhejiang University School of Medicine, Hangzhou, China
JiangenYu Department of Thoracic Surgery, Children’s Hospital, Zhejiang University School of Medicine, Hangzhou, China
ChunyanZhan Department of Pediatric Surgery Room, Children’s Hospital, Zhejiang University School of Medicine, HangzhouChina
JianZhang Department of Thoracic Surgery, Children’s Hospital, Zhejiang University School of Medicine, ,Hangzhou China
Shuhao Zhang Department of General Surgery, Children’s Hospital, Zhejiang University School of Medicine, Hangzhou, China
Yuebin Zhang Department of General Surgery, Children’s Hospital, Zhejiang University School of Medicine, Hangzhou, China
HangyanZhao Department of Pediatric Surgery Room, Children’s Hospital, Zhejiang University School of Medicine, Hangzhou, China
Kun Zheng Department of Clinical Engineering, Children’s Hospital, Zhejiang University School of Medicine, Hangzhou, China
Robotic-assisted Surgery in
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Pediatrics: Current Applications, Limitations and Prospects
QiangShu
1
Robot surgical system is currently widely used all over the world. The use of robotic-assisted surgery has also been increasingly introduced in pediatric surgery. Comparing with conventional minimally invasive techniques, the main advantages of robotic-assisted surgery are its dexterity and 3D visualization leading advance to more complex technical areas [1].
Da Vinci robot system is the most successful and widely used surgical system. To date, this da Vinci robot system has undergone four genera­tions. The rst generation (da Vinci Standard Surgical System) was commercialized in 1999, the second (da Vinci S Surgical System) and the third generations (da Vinci Si Surgical System) were commercialized in 2006 and 2009, respec­tively. The fourth generation is the da Vinci Xi Surgical System, which came into the market in
2014. Up to 2019, there are 5582 da Vinci surgi­cal system worldwide and 81 of those are in China. In terms of the number of da Vinci robotic surgeries, gynecological surgery ranks followed by urological surgery and general surgery. In China, urological surgery accounts for about 43% of the total number of da Vinci robotic sur­geries and general surgery accounts for about
33%, followed by gynecological surgery and car­diothoracic surgery.
With successive optimization and improve­ment of robotic surgical instruments and deepen­ing of understanding of complex congenital malformations in children, the use of robotic­assisted surgery has achieved great success in complex reconstructive surgeries such as radical choledochal cyst resection and ureteral replanta­tion. However, the large surgical instruments, high costs, and special pathophysiological status of pediatric patients have limited its wide appli­cation in young patients. The main reason of lim­ited use in children may be smaller volume of pediatric patients eligible for robotic procedures which may lead to increased costs for children’s hospitals [2, 3]. Therefore, the use of robotic­assisted surgery has been increased more slowly in pediatrics than in the adult population [4].
Herein, we review the current applications, limitations and prospects of da Vinci robot sys­tem in pediatric surgery.
1.1 Current Applications
ofRobot Surgical System in Pediatric Surgery
Q. Shu (*) Department of Cardiac and Thoracic Surgery, Children’s Hospital, Zhejiang University School of Medicine, Hangzhou, China e-mail: shuqiang@zju.edu.cn
© The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd. 2023 Q. Shu (ed.), Pediatric Robotic Surgery, https://doi.org/10.1007/978-981-19-9693-1_1
Robot surgical system has been widely used in pediatric surgery, including urinary, general, cardiothoracic and oncological surgery. Procedures in pediatric robotic urology mainly include pyeloplasty, complete or partial nephrec-
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tomy, ureteral reimplantation, and cystoplasty. Among them, robotic-assisted pyeloplasty is the most commonly. Its feasibility, safety and effec­tiveness have been demonstrated to be compa­rable to open or laparoscopic robotic surgery for children [46]. The number of robot-assisted ureteral reimplantation has been increased from less than 1% in 2000–2012 to 6% in 2016 [7]. In addition, the surgical success rate was increased and even reached 100% in hospitals in China. The robot-assisted nephroureterectomy, ranks third in urological surgery volume, although the operation time is increased signicantly due to the robotic installation time. However, with the assistance of the amplication of the da Vinci 3D surgical eld and exible robotic arms, it is still advantageous in reducing postoperative complications and increasing surgical success rate.
In pediatric general surgery, the application of robotic surgery is not popular yet when compared to pediatric urology. Among applications, robot­assisted fundoplication is the most common gen­eral surgery in children, especially for children with a history of gastrostomy, adhesions caused by previous abdominal surgery, initial fundopli­cation failure and combined neurological impair­ment [8]. Due to the high cost of robotic surgery, the rationality of its application in simple fundo­plication remains to be questioned. However, for choledochal cyst radical surgery, which requires ne anatomy and a large number of sutures in a narrow anatomical space, robotic surgery has its own advantages in cyst dissection and choledo­chojejunostomy. A large number of cases under robotic treatment of choledochal cysts have been reported, and the incidence of surgical complica­tions and postoperative recovery time are signi­cantly decreased compared to traditional laparoscopic surgery. In addition, robot-assisted treatment of Hirschsprung’s disease and anal atresia has also been carried out. Owe to robotic 3D surgical eld with exible robotic arms, sur­geon’s satisfaction has been signicantly improved. Nevertheless, the long-term follow-up study on intestinal function for patients with both megacolon and anal atresia is still lacking. Therefore, the effectiveness, safety, and repeat­ability of robotic-assisted surgery for compli-
cated intestinal malformation require further investigation.
There are many complications and trauma after thoracotomy in children, including scolio­sis, shoulder muscle weakness, and chest wall deformity. Thus, minimally invasive surgery may become inevitable for cardiothoracic surgery. However, robotic cardiothoracic surgery started relatively late. The following factors may limit the extensive development of robotic-assisted cardiothoracic surgery: small thoracic with “concentrated” large vessels and vital organs, less cardiothoracic reconstruction surgery, needs and less well trained cardiothoracic surgeons [9]. At present, robotic-assisted cardiothoracic surgery mainly includes lobectomy, mediastinal tumor resection, and patent ductus arteriosus (PDA) ligation. Though the surgical duration of robotic surgery for pediatric PDA was signi­cantly increased. However, intraoperative manipulation around the aorta, subclavian artery, ductus arteriosu, or ligaments become more deli­cate and safe [10]. Tang et al. completed the rst robotic-assisted surgery for type I esophageal atresia correction in China, the young patient recovered well postoperatively (not published case). Overall, the conversion of robotic surgery was signicantly lower than conventional thora­coscopic surgery, with technical and safety advantages, it is likely that more and more robotic-assisted precise surgeries will be per­formed for the lung, heart tissues and large ves­sels in the young. Indeed, many scholars believe that it is safe and feasible for robot- assisted pul­monary surgery, and even superior to thoraco­scopic surgery. However, the long-term efcacy of robotic-assisted pulmonary surgery over tra­ditional thoracotomy and thoracoscopic surgery still needs to be determined through multicenter, large sample and prospective study [11].
1.2 Limitations of Using Robot
Surgical System in Pediatric Surgery
With the introduction of robot surgical system into more and more children’s hospitals, robotic surgery has gradually broken barriers for its
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more applications. However, the special patho­physiological status of children compared with adults also limits the extensive development of robotic surgery. First, the narrow lacunar operat­ing space of children is its greatest limitation. Robot surgical instruments are large, and the 8-mm-diameter trocar is too large for children’s intercostal space and thorax, especially for infants younger than 1year old. The size of the trocar, in turn, directly affects the size of the sur­gical instrument, resulting in a very limited choice of 5 mm instruments. In addition to dimensional differences, there are many differ­ences in design of 5mm and 8mm instruments. Devices in size of 5 mm are smaller with their joint motion mechanism different from that of 8mm devices; and a larger curve radius is needed to make a motion similar to that of an 8 mm instrument. In addition, the 5mm device options are limited and the mechanical motion is less precise. Second, the da Vinci robot instructions for two trocar distances are at least 5cm to avoid robotic arm collisions. But due to the small body surface area of the child, da Vinci surgery of tro­car location in children is more special. We should ensure that no collision occurs when the smaller thoracic or abdominal cavity simultane­ously accommodates the lens, robotic arms, and trocar. Meanwhile, the use of the fourth arm is limited. Third, infant airways are more vulnera­ble to pneumoperitoneum than adults, with reduced airway compliance and increased air­way pressure. Especially for infants weighing less than 10 kg, pressures exceeding 9 mmHg have signicant effects on respiratory mechanics and hemodynamics [12]. While insufcient clin­ical experience can signicantly prolong robotic surgery time, which further aggravates the nega­tive physiological effects of CO2. In addition, ination can increase vagal tone, leading to bra­dycardia and reducing ventricular preload, thus endangering infants whose cardiac system is not yet mature [13]. Fourth, children have limited abdominal ination and pressure, and children weighing 10kg have abdominal ination of less than 1 L, which reduces the operable space of robotic devices to some extent, and the propor-
tion of spleen and liver in the abdominal cavity of infants is relative bigger to that of adults, thus further limiting the working space [14].
1.3 Prospects of Robot Surgical
System in Pediatric Surgery
1.3.1 Robotic Surgery Under
the5GEra
The maturity of robotic surgery technology and the renement of robotic surgical instruments make it increasingly used in pediatric surgery; and the comprehensive coverage of 5G network lays a solid foundation for robotic telemedicine. Studies have shown that delays of around 200ms can be fatal for complex and delicate procedures. But the peak theoretical transmission speed of 5G network is 10Gb per second, which is faster than the transmission speed of the 4G network hundred times, fast 5G network, therefore, sig­nicantly promote the development of telemedi­cine showcase. The design of da Vinci robot system is on the basis of the concept of remote operation. Thus, telemedicine will be performed in the 5G era. The remote operation with a low delay will break through the space and geograph­ical restrictions to the greatest extent and will facilitate the subsidence of robotic surgical tech­niques and operating experience as high-end non- material medical resources to primary hospi­tals [15]. In 2019, Beijing Jishuitan Hospital took the lead in conducting spinal internal xation surgery for ve cases through remote manipula­tion of robots with the help of 5G network, which makes patients from low socioeconomic regions who access the top medical resources in China. The impact of 5G technology on medical care is enormous and far-reaching, and with the help of 5G medical care, medical resources can be shared and used by more people. With the establishment of two children’s national medical centers and ve children’s regional medical centers in China, more children in remote areas can access to high­quality medical care and will get more benets from robotic surgery technology.
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1.3.2 The Future ofSingle-Port Robotic Surgery inPediatric Surgery
In recent years, increased demands for minimally invasive surgery, prompting surgeons continu­ously explore innovation in pursuing smaller and less incisional surgical methods, such as tran­sumbilical single- port laparoscopic radical resec­tion of intestinal duplication and transaxillary small incision atrial septal defect repair. Due to the limited exibility and eld of view of tradi­tional laparoscopic instruments, after losing the “operation triangle,” device collision is prone to happen in single-port laparoscopic surgery, thus limiting the application of single-port laparo­scopic surgery. The exible robotic arm design of the da Vinci robot system and the better three­dimensional surgical eld will solve this techni­cal barrier.
Robotic-assisted surgery has clear advantages for complex reconstructive surgery in children, such as radical choledochal cyst surgery, ureteral reimplantation, and radical megacolon surgery. However, robotic-assisted laparoscopic surgery has more puncture holes than traditional laparos­copy. With the further pursuit of minimally inva­sive and esthetic by doctors and patients, robotic surgery has gradually moved to a single port. Currently, single-port robotic surgery is primarily used in adults, including gynecology, urology, general surgery and thoracic surgery. Single-port laparoscopic robot-assisted renal transplantation has also been reported [16]. In the eld of pediat­ric surgery, single-port da Vinci surgery has been used gradually. In 2015, 16 cases of single-port robotic-assisted cholecystectomy was reported [17]. Sung and colleagues completed the rst single-port robot-assisted pyeloplasty in who successfully completed anatomy, anastomosis, and antegrade indwelling of a ureteral stent [18]. Therefore, single-port robotic surgery can reduce the difculty of surgery and meet the need for one step minimally invasive and cosmetic sur­gery. For children, single-port robotic surgery is not far off.
1.3.3 Development ofPediatric Surgery Under Articial Intelligence
Thanks to the evolution of information technolo­gies such as the internet, big data, and cloud computing, the rapid development of articial intelligence (AI) technology represented by deep learning has even surpassed humans in terms of images, speech, and text recognition. In recent years, it has gradual penetration into medical care eld. Surgical robot is an important part of clinical adjuvant therapy, of which the da Vinci robot is representative. In addition, there are robotic frameless stereotactic surgical assistive systems (robotized stereotactic assistant, ROSA), robotic surgery system (transoral robotic surgery, TORS) and more. De Benedictis et al. [19] reported surgical treatment of 116 children with ROSA surgery, including epilepsy, brain tumors, and hydrocephalus. The overall procedural success rate was 97.7%. TORS [20] was widely used in head and neck surgery. The treatment of glottic stenosis, laryngeal ssure, cleft palate, thyroglossal duct cyst, and other dis­eases in children with TORS is associated with less trauma, lower recurrence rate, and better outcomes than traditional surgical methods. The application of AI in the medical eld is still in its infancy, and it mainly relies on the surgeon to control the robot on the operating table to com­plete the operation. With the continuous accu­mulation and innovation of technology and the continuous improvement of existing algorithms and instruments, AI can help to solve palliative pediatric surgery status quo of uneven distribu­tion of medical resources and improve childish diagnostic efciency in a simple, low-risk, repeatable, and efcient manner.
In conclusion, robot surgical system is a safe, feasible, and promising new technology in pediatric surgery and has obvious advan­tages for complex gastrointestinal surgery and organ reconstruction surgery. Although robot surgical system still have many defects, including high costs, lack of tactile feedback
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and too relatively larg surgical instruments for children. Therefore, further developments in the robot surgical system are required, and indications for its use in pediatric surgery are still under investigation. Robotic-assisted sur­gery is undoubtedly a promising technology and will be used more widely in future.
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