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Introduction
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It does not take much strength to do things, but it requires great strength to decide on
what to do.
Elbert Hubbard
The Clinical Challenge: Reasoning, Decision-Making,
andAction
One day in the not-so-distant future, all clinical decisions will be aided by articial
intelligence. This will undoubtedly improve patient care, limit mistakes in judgment, and reduce errors of omission. For the time being, however, we, as clinicians,
must continue to do all the work to arrive to the best decisions for our patients.
Surgeons make complex, high-stakes, and time-sensitive decisions when diagnosing a patient, assessing risk factors, selecting and performing an operation, and
managing complications. Surgical decision-making is primarily based on hypothetical deductive reasoning and individual judgment. In the most straightforward clinical scenarios, the surgeon may recognize a pattern and base their decision on prior
experience or knowledge. In cases where the diagnosis is not clear or the clinical
information is limited, the clinician might rely on intuition by integrating blocks of
knowledge and previous experience to arrive at the decision. This is further inuenced by the patient’s values and emotions, patient–surgeon interactions, decisionmaking volume and complexity, time constraints, and uncertainty.
Patient-centered care does not allow for a one-size-ts-all guideline of optimal
decision-making. Clinical decisions are ultimately informed by patients and caregivers’ goals for care and what they value most in life. Decision-making based on
patients’ values can improve patient satisfaction and compliance. However, surgeons’ decision-making may also be negatively inuenced by patients’ and caregivers’ apprehension about surgical diseases or complications. Patients’ emotions can
inuence a surgeon’s perception of risks and benets and may create pressure to
perform unnecessary operations.
Further, surgical decision-making is often affected by uncertainty due to missing
or incomplete data. This occurs when decisions regarding an urgent condition must
be made before all relevant data can be gathered and analyzed. Non-urgent decisions, too, may be hindered by time constraints and uncertainty owing to sheer
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Table 1 Bias in surgical decision-making
Source of bias Example
Framing effect A hospital medicine provider presents a clinical scenario to a surgeon in
different context than the surgeon would have perceived during an
independent assessment
Overcondence
bias
Commission
bias
Anchoring bias Patients are informed of expected outcomes using data from aggregate
Recall bias Recent experiences, particularly negative, with a certain patient population
Conrmation
bias
Adapted from: Loftus etal. [1]
A surgeon falsely believes that weaknesses and failures disproportionately
affect their peers
A surgeon tends toward surgical intervention when non-operative
management may be preferable, especially in the context of overcondence
bias
patient populations without adjusting for their personalized risk prole
or operation disproportionately affect surgical decision-making relative to
remote experiences
Excessive reliance on personal experience. Outcomes are predicted using a
set of beliefs rather than evidence-based guidelines
Introduction
decision-making volume, the time-consuming nature of data acquisition, and complex team dynamics. Even when data collection and analysis are complete, high
decision-making volume begets decision fatigue, manifesting as procrastination,
frustration when facing adversity, decreased physical stamina, and lower quality
and quantity of diagnostic and clinical output [1].
Under the increased pressure of time constraints and uncertainty, decisionmaking may be affected by heuristics or cognitive shortcuts. Heuristics may lead to
bias or predictable and systematic cognitive lapses, as described in Table1.
There is a wealth of clinical-decision support tools, risk calculators, clinical
guidelines, and evidence-based scientic publications to aid surgeons with clinical
decision-making. The challenge of seeking answers in available resources, however,
is identifying what is true and what is not. In recent years, our traditional trusted
source of “truth” (published peer-reviewed literature) has come under increased
scrutiny. Although we hope that scientic misconduct is uncommon, its actual incidence is unknown. “Mistakes,” ranging from benign errors to outright fraud, are
detected with alarming frequency. Methodological aws and interpretive shortcomings compromise much of the biomedical literature. False-positive research ndings
are ubiquitous, reecting awed treatment effect size, underpowered studies,
improper statistical analysis, agrant data-mining, overtting, and a lack of conrmatory studies. These issues are exacerbated by publication bias and an archaic
system of editorial peer review process. Even when based on thoroughly vetted
evidence, a typical textbook merely lists the outcomes of surgical trials that focus on
conventional variables, such as perioperative mortality or disease-free survival, but
these may not directly inform clinical decisions [2].
The Difcult Decisions in Surgery: An Evidence-Based Approach Series, and
this textbook in particular, provides clinicians with an expert appraisal of available
literature, augmented by an assessment of the quality of the evidence and personal

Introduction
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xiii
recommendations by the authors. A unique feature of this series is the focus on
individual author’s perspectives to a series of specic clinical scenarios the surgeons face in their practice.
We would like to extend our sincere gratitude to the authors for their invaluable
contributions to this publication. Your time, expertise, and thoughtful advice will
help many of your colleagues to provide better care for their patients. Thank you!
References
1. Loftus TJ, et al. Articial intelligence and surgical decision-making. JAMA
Surg. 2020;155(2):148–58.
2. Matthews JB.Truth and truthiness: evidence, experience and clinical judgement
in surgery. Br J Surg. 2021;108(7):742–4.
KonstantinUmanskyUniversity of Chicago
Chicago, IL, USA

Contents
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1 Evaluating Evidence . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1
Zhaomin Xu and Bradford Sklow
Part I Inammatory Bowel Disease
2 Surgical vs Medical Management of Symptomatic Anal
Fistulas in Patients with Crohn’s Disease . . . . . . . . . . . . . . . . . . . . . . . . 13
Megan Obi and Amy L. Lightner
3 What Are the Treatment Options for Painful Anal Fissure in Patients
with Crohn’s Disease? . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 39
Michael A. Valente
4 Elective Surgical Management in Patients with Ulcerative
Colitis: How Many Stages? . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 45
Roger D. Hurst
5 Which Patients with Ulcerative Colitis Benefit from Ileal
Pouch-Anal Anastomosis? . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 57
Rodrigo Areán-Sanz and Evangelos Messaris
6 Persistent Posterior Sinus After Ileal Pouch-Anal Anastomosis . . . . . . 69
Kathryn E. Chuquin and Brian L. Bello
7 How to Manage Pouch-Perineal and Pouch-Vaginal Fistula
After Ileal Pouch–Anal Anastomosis . . . . . . . . . . . . . . . . . . . . . . . . . . . . 75
Melinda E. Stack and Monika A. Krezalek
8 Ileal Pouch–Anal Anastomosis Failure: What to Do? . . . . . . . . . . . . . . 87
Wyeth Alexander and Samuel Eisenstein
9 Perioperative Steroid Management in IBD Patients Undergoing
Colorectal Surgery . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 99
Evan D. Adams and Karen Zaghiyan
10 Colonic Dysplasia in Patients with Ulcerative Colitis:
Endoscopic or Surgical Management? . . . . . . . . . . . . . . . . . . . . . . . . . . 113
Linda Ferrari and Alessandro Fichera
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Contents
11 Which Patients Benefit from Biologic Agents to Prevent Disease
Recurrence After Resection in Crohn’s Disease? . . . . . . . . . . . . . . . . . . 127
Yusuke Miyatani and Atsushi Sakuraba
Part II Colon Cancer
12 Is Intensive Surveillance Necessary After Curative Resection
for Colon Cancer? . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 141
Terrah J. Paul Olson
13 Surgical Versus Endoscopic Options for Management of
Malignant Large Bowel Obstruction. . . . . . . . . . . . . . . . . . . . . . . . . . . . 151
Marco Bertucci Zoccali and Athanasios Angistriotis
14 Metastatic Colorectal Cancer in the Asymptomatic Patient:
Is There a Benefit in Resection of Primary Tumor? . . . . . . . . . . . . . . . 171
Paolo Goffredo and Martin R. Weiser
15 What Are the Options for Management of Large Colonic Polyps? . . . 179
Sumeyye Yilmaz and Emre Gorgun
16 Management of the Malignant Colon Polyp: Resection
or Surveillance? . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 191
Ahmed A. Eltahir and Radhika K. Smith
17 Stage II Colon Cancer: Towards an Individualized
Treatment Approach . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 201
Gideon Dosunmu and Chih-Yi Liao
18 Is There a Benefit in Cytoreduction and Hyperthermic
Intraperitoneal Chemotherapy in Colorectal Cancer? . . . . . . . . . . . . . 211
Arsha Ostowari and Oliver S. Eng
19 Colorectal Cancer Management in Older Adults: Use of
Geriatric Assessment to Guide Patient-Centered Care . . . . . . . . . . . . . 223
Jeffrey L. Roberson and Nicole M. Saur
20 Colon Cancer in the Splenic Flexure: Which Operation? . . . . . . . . . . . 231
Himani Bhatt and Kellie Mathis
Part III Rectal Cancer
21 Management of T1 Rectal Cancer . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 243
Maggie L. Westfal and Matthew G. Mutch
22 Can Total Mesorectal Excision Be Avoided in T2 Rectal Cancer? . . . . 257
Anthony Loria and Fergal J. Fleming
23 Watch and Wait Versus Conventional Surgical Treatment in Rectal
Cancer . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 269
Felipe F. Quezada-Diaz and J. Joshua Smith

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24 Which Patients Are the Right Candidates for Total
Neoadjuvant Therapy (TNT)? . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 281
Maxwell D. Mirande and Scott R. Kelley
25 Management of the Patient with Rectal Cancer Presenting with
Synchronous Liver Metastases . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 293
Cimarron E. Sharon and Joshua I. S. Bleier
26 Who Needs a Loop Ileostomy After Low Anterior Resection
for Rectal Cancer? . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 307
L. Cunningham and E. Huang
27 Reoperative Surgery for Locally Recurrent Rectal Cancer . . . . . . . . . 317
Nicholas P. McKenna and Robert R. Cima
Part IV Anal Dysplasia/Cancer
28 Intensive vs Conservative Management of Patients with
Low Grade Squamous Intraepithelial Lesions . . . . . . . . . . . . . . . . . . . . 331
Ray Ramirez, Nell Maloney Patel, and Joseph Terlizzi
29 How Aggressive Should We Be in Management of Patients
with High Grade Squamous Intraepithelial Lesion? . . . . . . . . . . . . . . . 337
Kinga S. Olortegui
30 Observation Versus Chemoradiotherapy for Management
of Superficial Anal Cancer . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 345
Martin Uwah, Cory Nonnemacher, Erin King-Mullins,
and Valentine N. Nfonsam
31 Is High Resolution Anoscopy Superior to Direct
Evaluation of Anal Dysplasia? . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 351
Maria Abou Khalil and Sender Liberman
Part V Benign Colon Disease
32 Surgical Management Options in Severe C Difficile Colitis . . . . . . . . . 363
Allison M. Ammann and Ian M. Paquette
33 Are Antibiotics Needed for the Management of Uncomplicated
Diverticulitis? . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 371
Nathan Kohrman and Glenn T. Ault
34 Do We Need to Operate on Patients After Successful
Percutaneous Drainage of a Diverticular Abscess? . . . . . . . . . . . . . . . . 379
Tobi J. Reidy and Scott C. Dolejs
35 How to Manage Diverticular Abscess Not Amenable to
Percutaneous Drainage? . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 387
Bhuwan Giri and Gustavo A. Rubio

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Contents
36 Hartmann Procedure vs Primary Anastomosis for Acute
Complicated Diverticulitis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 397
Susanna S. Hill and Aneel Damle
37 Deciding on an IRA vs. IPAA for FAP . . . . . . . . . . . . . . . . . . . . . . . . . . 409
Samuel H. Lai and Jon D. Vogel
38 Rectal Prolapse: Rectopexy vs Perineal Proctosigmoidectomy . . . . . . 423
Sarah A. Vogler and Kristen A. Ban
39 Optimal Management of the Transsphincteric Anal Fistula . . . . . . . . . 437
Shahrose Rahman and Vassiliki Liana Tsikitis
40 Chronic and Refractory Anal Fissure: What Are the Treatment
Options? . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 451
Ga-ram Han and Nitin Mishra
41 Benign Anal Disease: Third Degree Hemorrhoids—Who
Really Needs Surgery? . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 471
Ernie Soto and Jonathan Laryea
42 Management Options for Bleeding Hemorrhoids in Patients
on Anticoagulation . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 483
John Konen and Karim Alavi
43 Sacral Nerve Stimulation: Choices vs Non-surgical Care
for Fecal Incontinence. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 491
William Allen, Alexandra Jones, Hillary Simon, and Russ Farmer
44 Surgical Management Options for Rectourethral Fistula . . . . . . . . . . . 509
Jennifer A. Leinicke and Sean J. Langenfeld
45 Operative vs Non-operative Management of Outlet Obstruction . . . . 521
Thomas M. Ward and Liliana G. Bordeiano
Part VI Quality Improvement
46 Is Bowel Prep Necessary for Patients Undergoing Colon Resection? . 531
Kayla Polcari and Benjamin D. Shogan
47 Enhanced Recovery vs. Conventional Perioperative Management . . . 547
Alison Althans and Jennifer Holder-Murray
48 Quality Improvement: Is There a Benefit in Opioid-Sparing
Strategies for Management of Postoperative Pain? . . . . . . . . . . . . . . . . 555
Allen T. Yu, Alex L. Huang, and Sergey Khaitov
49 What Can Be Done to Prevent Readmission After Ileostomy
Formation? . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 563
Sonja Boatman, Julia Kohn, and Elliot Arsoniadis

Contents
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50 Do Bundles Help to Reduce Surgical Site Infections
and Improve Safety? . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 575
Traci L. Hedrick
Part VII Technique
51 Total Mesorectal Excision for Rectal Cancer: Top Down
or Bottom Up? . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 583
Natalie F. Berger and Patricia Sylla
52 Intracorporeal vs Extracorporeal Anastomosis for Right
Colectomy . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 605
Henry J. Lujan and Victor Maciel
53 Anastomotic Leak Management Following Low Anterior
Resections . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 617
Sarah Choi and Kyle G. Cologne
54 Colorectal Anastomosis Construction: Is there a Benefit
to a Reservoir? . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 625
Matthew Z. Wilson and David B. Stewart
55 Management of the Unhealed Perineal Wound After
Proctectomy . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 629
Vitaliy Poylin and Mohammad Abbass
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56 Gender Affirmation Procedure: What Are the Reconstructive
Options? . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 641
Paulo Vitor Barreto Guimaraes, Omer Raheem, and Ervin Kocjancic
Index . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 653

Contributors
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MohammadAbbass Division of Gastrointestinal Surgery Northwestern Medicine,
Feinberg School of Medicine, Chicago, IL, USA
MariaAbouKhalil McGill University Health Center, Montreal, QC, Canada
Evan D. Adams Department of General Surgery, Cedars-Sinai Medical Center,
Los Angeles, CA, USA
KarimAlavi UMass Chan Medical School, Department of Surgery, Division of
Colon & Rectal Surgery, Worcester, MA, USA
WyethAlexander Department of Surgery, Division of Colon and Rectal Surgery,
UC San Diego Health, La Jolla, CA, USA
WilliamAllen Department of Surgery, University of Louisville, Louisville, KY, USA
AlisonAlthans Department of Surgery, University of Pittsburgh Medical Center,
Pittsburgh, PA, USA
Allison M. Ammann University of Cincinnati College of Medicine, Surgery,
Cincinnati, OH, USA
AthanasiosAngistriotis,MD Division of Colorectal Surgery, Columbia University
Irving Medical Center-New York Presbyterian Hospital, New York, NY, USA
RodrigoAreán-Sanz,MD Division of Colon and Rectal Surgery, Department of
Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School,
Boston, MA, USA
ElliotArsoniadis Division of Colon and Rectal Surgery, University of Minnesota,
Minneapolis, MN, USA
GlennT.Ault Keck School of Medicine of USC, Los Angeles, CA, USA
Division of Colon and Rectal Surgery, Keck School of Medicine, Los
Angeles, CA, USA
KristenA.Ban Cleveland Clinic Foundation, Cleveland, OH, USA
PauloVitorBarretoGuimaraes Department of Urology, University of Chicago,
Chicago, IL, USA
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Contributors
BrianL.Bello Medstar Medical Center, Washington, DC, USA
Natalie F. Berger Department of Surgery, NYU Langone Hospital, New
York, NY, USA
MarcoBertucci Zoccali,MD, FACSa Division of Colorectal Surgery, Columbia
University Irving Medical Center-New York Presbyterian Hospital, New
York, NY, USA
HimaniBhatt Department of Surgery, Mayo Clinic, Rochester, MN, USA
Joshua I. S. Bleier Division of Colorectal Surgery, Department of Surgery,
University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA, USA
SonjaBoatman Division of Colon and Rectal Surgery, University of Minnesota,
Minneapolis, MN, USA
LilianaG.Bordeiano Section of Colon and Rectal Surgery, Division of General
and Gastrointestinal Surgery, Department of Surgery, Massachusetts General
Hospital, Boston, MA, USA
SarahChoi Division of Colon and Rectal Surgery, Department of Surgery, Keck
School of Medicine, University of Southern California, Los Angeles, CA, USA
KathrynE.Chuquin Washington, DC, USA
Robert R. Cima Mayo Clinic, Division of Colon and Rectal Surgery,
Rochester, MN, USA
KyleG.Cologne Division of Colon and Rectal Surgery, Department of Surgery,
Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
L. Cunningham Department of Surgery, The Ohio State University College of
Medicine, Columbus, OH, USA
Aneel Damle Colon and Rectal Surgery Associates, University of Minnesota
School of Medicine, Minneapolis, MN, USA
ScottC.Dolejs Indiana Colon and Rectal Specialists, Indianapolis, IN, USA
Gideon Dosunmu Section of Hematology/Oncology, Department of Medicine,
University of Chicago, Chicago, IL, USA
SamuelEisenstein Department of Surgery, Division of Colon and Rectal Surgery,
UC San Diego Health, La Jolla, CA, USA
AhmedA.Eltahir Washington University St. Louis, St. Louis, MO, USA
OliverS.Eng Division of Surgical Oncology, Department of Surgery, University
of California, Orange, CA, USA
Russ Farmer Division of Colon and Rectal Surgery, Department of Surgery,
University of Louisville, Louisville, KY, USA
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