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S. Golestani et al.
the chest wall is not amenable to common techniques of
hemostasis. Similarly, bleeding from the thoracic spine can
be quite difcult to control and a bleeding vessel is not usually obvious. In both these circumstances, consider packing
the chest wall with laparotomy pads, the spine wound with
bone wax, using any available topical hemostatic agents, or
inserting a urinary catheter to provide balloon tamponade,
and return to the site of bleeding for denitive hemorrhage
control later in the operation.
Bleeding from the lung parenchyma is not usually signicant due to its low pressure and intrinsic ability to form clot
from a high local concentration of tissue thromboplastin. You
can usually leave lacerations from the pulmonary parenchyma alone until denitive operation or apply a Duval lung
clamp to temporize troublesome bleeding. However, bleeding from the pulmonary vasculature can be torrential and
quickly result in exsanguination. Furthermore, signicant
disruption in the pulmonary venous system can lead to air
embolism to the left-sided cardiac circulation. You can control bleeding from pulmonary vasculature within the substance of the lung parenchyma using suture ligation. If the
bleeding is too heavy to allow visualization or the bleeding is
emanating from the pulmonary hilum, obtain control of the
hilum either manually or with a vascular clamp. Gain control
of the pulmonary hilum by temporarily halting ventilation to
allow adequate visualization. Next, while retracting the lung
posteriorly, bring your hand or a Satinsky clamp from above
and grasp or clamp the entirety of the pulmonary hilum,
including the pulmonary artery, pulmonary veins, and mainstem bronchus (Fig.11.14). It is important that you approach
the hilum from above, as an inferior approach will be
impeded by the inferior pulmonary ligament and may not
allow hilar control. Some authors have advocated dividing
the pulmonary ligament to mobilize the lung, but in our opinion, this is an unnecessary maneuver. Dividing the inferior
pulmonary ligament takes valuable time, may lead to iatro-
Hilum
of left
lung
Fig. 11.14 Cross-clamp of the pulmonary hilum
genic injury of the inferior pulmonary vein, and may be quite
difcult in the emergent setting with ongoing hemorrhage;
and the pulmonary hilum can be easily controlled with a
superior approach while leaving the inferior pulmonary ligament intact. Despite control of the pulmonary hilum, you
may suspect an air embolism (or conrm the diagnosis by
seeing air bubbles in the coronary arteries). In these cases,
aspirate the left ventricle with a needle and syringe in an
attempt to evacuate any intra-ventricular air.
Though you can perform most required maneuvers during
an EDT through a left anterolateral thoracotomy, you may
occasionally be required to convert the left thoracotomy into
a bilateral or clamshell thoracotomy. The right thoracotomy
can be performed through a separate incision or extend the
left thoracotomy onto the right chest via transverse sternotomy. Consider adding a right thoracotomy to the left anterolateral EDT in a few situations. First, if the patient presents
with primarily right-sided wounds, perform the usual EDT
but have an associate start a right thoracotomy simultaneously. A left thoracotomy is still necessary, as access to the
right chest will allow pericardiotomy, control of intrathoracic hemorrhage, and internal cardiac massage, but does not
allow you to cross-clamp the descending aorta. Another
indication for right thoracotomy is based on the output of the
right tube thoracostomy placed concomitant with EDT.If the
initial right chest tube output is more than 500–1000 mL,
hemorrhage in the right pleural cavity will possibly require
control.
The most common reason for extending a left-sided EDT
is to improve visualization of the mediastinum as it allows
access to the heart, great vessels, and both hemithoraces.
In this case, extend your left thoracotomy into a clamshell
thoracotomy via a transverse sternotomy. The right thoracotomy portion of the bilateral or clamshell thoracotomy is a
mirror image of the left thoracotomy already described. The
transverse sternotomy is accomplished with a variety of
techniques. The skin incision is simply a transverse incision
connecting the right and left thoracotomy (Fig.11.15). Carry
this incision through the subcutaneous tissue and thoracic
musculature until you reach the anterior portion of the sternum. Perform the transverse sternotomy with heavy shears,
Lebsche knife, or a Gigli saw, depending on availability and
personal comfort. Assisting staff should be familiar with
setup and operation to prevent delay in this maneuver should
it be required. Once you perform your transverse sternotomy,
adjust the thoracic retractor or add a second retractor to optimize visualization. Next, extend the pericardiotomy across
the anterior pericardium, taking care not to injure the right
phrenic nerve. Keep in mind that during transverse sternotomy, you will divide both internal mammary arteries. This
may not be readily apparent if the patient is pulseless, but
you should ligate or clip both internal mammary arteries as
they will bleed signicantly during cardiac massage or if the

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Fig. 11.15 Skin incision for
clamshell thoracotomy
95
patient regains a pulse. The clamshell incision provides spectacular exposure to both pleural cavities and all mediastinal
structures, which should allow you to perform any and all
maneuvers required during emergency department thoracotomy (Fig.11.16).
Before patient arrival and throughout performing EDT,
consider what the plan will be if the patient has a return of
organized cardiac activity or if cardiac arrest persists despite
all resuscitative efforts. If at any time during EDT, the patient
has a return of a sustained pulse and blood pressure, transport the patient to the operating room for denitive operative
procedures. Furthermore, try to remove the aortic crossclamp as soon as possible if the patient’s physiology will
tolerate it. If cardiac arrest persists during EDT, then determine if ongoing resuscitative efforts should be continued or
if the care is futile. Futility in the setting of EDT for
penetrating trauma is dependent on several factors including
patient age and comorbidities, location of injuries identied
during EDT, and local resources including personnel and
blood bank availability.
Fig. 11.16 Exposure obtained to both pleural cavities and mediastinum via a clamshell thoracotomy

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S. Golestani et al.
Important Points
• An emergent thoracotomy tray with all necessary instru-
ments and retractors needs to be prepared and quickly
available in the emergency department.
• FAST exam may be applied to evaluate for tamponade. If
no cardiac activity or tamponade, care may be futile.
• As you perform the EDT, the remainder of the trauma
team should concomitantly secure a denitive airway
with endotracheal intubation, establish large bore intrave-
nous access for uid and blood resuscitation, and place a
right tube thoracostomy to better evaluate for hemorrhage
in the right chest.
• In a female, retract the breast superiorly. The incision
should follow the inframammary crease. In a male, the
incision should be centered over the fourth or fth inter-
costal space by positioning the curvilinear incision just
inferior to the left nipple–areolar complex.
• Make the initial pericardiotomy with a small stab incision
using a scalpel if a tense tamponade is encountered.
Grasping the pericardium will be challenging if not
impossible in a tamponade.
• Before cross-clamping the aorta, incise the parietal pleura
that covers the descending thoracic aorta.
• The descending aorta should not be circumferentially
mobilized to apply a cross-clamp.
• Bleeding from the chest wall or spine may require pack-
ing, topical hemostatic agents, or balloon tamponade to
temporarily control hemorrhage.
• The pulmonary hilum can be easily controlled with a
superior approach while leaving the inferior pulmonary
ligament intact.
• During transverse sternotomy, ligate or clip both inter-
nal mammary arteries as they will bleed significantly
during cardiac massage or if the patient regains a
pulse.
• Removal of the aortic cross-clamp or replacement of the
clamp below the renal vessel should be performed within
30min to limit ischemia time.
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Intensive Care: Principles andTherapy
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ZacharyM.Bauman andTerenceO’Keee
12
Critical care management principles remain an extremely
important aspect in the care of penetrating trauma patients.
As trauma care continues to evolve and become more sophisticated, the management of penetrating trauma necessitates
all those involved in patient care be as current as possible in
order to provide optimal care. The goal of this chapter is to
provide a summary of important critical care principles
allowing the reader to be successful in the management of
penetrating trauma patients.
12.1 Metabolic Response toTrauma
The body’s response to a traumatic or surgical insult is basically the same. This involves an activation of the sympathetic
nervous system and an increase in circulating catecholamines. Furthermore, endocrine stress hormones are released
from the pituitary gland, as well as changes in the immune
system, including production of inammatory cytokines in
addition to leucocytosis.
These neurohormonal changes cause tachycardia and
fever, which taken together with tachypnea and leucocytosis
form the systemic inammatory response syndrome (SIRS).
Metabolic changes lead to the retention of sodium and water,
in addition to hyperglycemia that is compounded by insulin
resistance, proteolysis of skeletal muscle, lipolysis of fat
stores, and cytokine release, all of which contribute to a catabolic state.
It is presumed that this proinammatory response is of
overall benet to the body as it responds to the insult and aids
in recovery. However, in some patients, the degree of trauma
Z. M. Bauman (*)
Division of Trauma/Critical Care and Emergency Surgery,
University of Nebraska Medical Center, Omaha, NE, USA
e-mail: zachary.bauman@unmc.edu
T. O’Keeffe
Division of Trauma/Critical Care and General Surgery, Augusta
University Medical Center, Augusta, GA, USA
e-mail: TOKEEFFE@augusta.edu
is so great that despite adequate resuscitation, it overwhelms
the capacity for recovery and severe SIRS develops. A second “activating” event may also occur after the initial injury,
which leads to a rapid downward spiral into multiorgan failure. The majority of modern critical care is designed to
decrease the likelihood of this second event and/or to abrogate its effects on the patient.
12.2 ICU Monitoring
As critical care medicine continues to evolve and become
more sophisticated, so do the means by which we monitor
the critically ill. There continues to be a trend for noninvasive or minimally invasive monitoring for patients in the
ICU.Numerous new devices are emerging which aid the clinician in making real-time decisions about the status and
direction of patient physiology.
Arterial catheterization is still standard practice in most
ICUs, not only to monitor arterial blood pressure but also to
facilitate blood gas monitoring in ventilated patients.
Complication rates are low, but thrombosis, pseudoaneurysm
formation, and infection may still occur. The radial or femoral routes are preferred for ease of placement and minimal
degree of complications. There are now several types of
monitors that can be directly attached to the arterial line, giving real-time estimates of the cardiac output and index,
stroke volume, systemic vascular resistance, etc.
Pulmonary arterial (PA) catheters have become extremely
uncommon in the ICU setting given their perceived high
complication rate and the fact that not many healthcare providers are trained to place them any longer. We do believe,
however, there is still a small and specic patient population
that will benet from their use. This patient population
includes those who are refractory to adequate volume resuscitation without obvious cause, or who have cardiac dysfunction, either acute or chronic, where monitoring of cardiac
output is necessary to guide clinical care. It should be advised
that not only does the physician caring for these specic
© The Author(s), under exclusive license to Springer Nature Switzerland AG 2023
E. Degiannis et al. (eds.), Penetrating Trauma, https://doi.org/10.1007/978-3-031-47006-6_12
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Z. M. Bauman and T. O’Keee
patients need to be competent in the placement of this device,
and also have a strong working knowledge of how to interpret the data provided, but the entire care team should also
possess this knowledge.
Point of care ultrasonography (POCUS) has become
extremely popular as a monitoring modality in the ICU over
the past few years and is relatively inexpensive. It is a skill
set that is now being taught routinely in both surgical residencies and critical care fellowships. The diagnostic impact
of POCUS has been shown to be as high as 85% whether that
be conrming an expected diagnosis or resulting in a change
of diagnosis and therefore a change in patient management.
The ability to observe directly the heart, lungs, inferior vena
cava, aorta, etc., with the ultrasound at bedside greatly
improves the decision-making ability of the clinician, especially from a hemodynamics standpoint. Lung ultrasonography has really come into popular use over the last several
years, demonstrating a higher reliability diagnosing a pneumothorax than standard chest X-ray. Furthermore, lung
ultrasound has proven very useful in the assessment of adequacy of intubation, to aid with ventilatory changes and
assess weaning strategies. Ultrasonography has also allowed
for improvements in bedside procedures, resulting in a lower
complication rate, especially when it comes to the cannulation of vascular structures. Transesophageal ultrasonography
has also gained popularity in the monitoring of volume status; however, this modality is more invasive and requires the
patient to be intubated. Although the disadvantage of ultrasonography is that it is operator dependent, the application of
this technology is vast and has demonstrated both reliability
and reproducibility.
The future of hemodynamic monitoring in the ICU is very
exciting. Two current concepts coming to the forefront in this
arena include microcirculation monitoring and optimization
as well as the use of articial intelligence to predict hemodynamic changes before they occur. Microcirculation monitoring utilizes a hand-held vital microscope to assess sublingual
circulation, guiding the clinician on uid/therapy choice to
optimize the microcirculation. Articial intelligence theoretically requires machine learning of big data to obtain predictive analysis for hemodynamic collapse before it actually
occurs, therefore allowing the clinician to intervene early.
Although not quite ready for real-time application, research
and development in this eld is rapidly expanding as the
potential use for this technology is limitless.
12.3 Neurological System, Pain Control,
andTraumatic Brain Injury
One of the biggest challenges in the ICU is appropriately
managing pain and agitation in critically ill patients. There
are a number of considerations when choosing medications,
not least of which are comorbidities that may affect the pharmacokinetics of the various agents. The Society of Critical
Care Medicine recently published an in-depth set of guidelines for the management of pain, agitation, and delirium.
Although pain and sedation management needs to be tailored
to the individual patient, these guidelines have shown better
outcomes for all critically ill patients and should be implemented in all ICUs.
1. Optimize pain management rst. This will allow for the
use of less sedation and reduce the development of
delirium. It is always preferable to use short-acting
intravenous narcotic analgesics as infusions for initial
pain control. Furthermore, early transition of patients to
oral analgesia (e.g., Oxycodone) via the enteral route is
recommended as soon as the GI tract is available for
use.
2. Make light sedation the norm. Patients should be sedated
to the point of comfort, especially if they are on the ventilator, but should be alert enough to participate in their
care. Over sedation only worsens the potential for delirium and can lengthen ventilation and ICU days. No matter which sedation medication is used, a sedation scale
should be implemented with a specic target range so the
patient does not become over-sedated.
3. Move away from routinely using benzodiazepines, espe-
cially in ICU patients who are at risk for or those who
already have delirium. The choice of a benzodiazepine
or other agents such as propofol as a sedative depends
on the preference of the treating physician, as well as
the patient’s hemodynamic stability. Both propofol and
dexmetomidine infusions, although short acting and
more preferred than benzodiazepines, have deleterious
effects on blood pressure requiring close monitoring.
Conversely, benzodiazepine infusions have long halflives and should be avoided for maintenance sedation
over many days.
4. Implement effective delirium prevention and treatment
strategies, using both nonpharmacologic and pharmacologic approaches. The development of delirium worsens
overall mortality and should be avoided if possible. All
ventilated patients should undergo daily “sedation vacations” to allow medication to wear off, which will allow
more accurate assessment of the patient’s level of consciousness and further decrease delirium development.
Regular re-orientation, sunlight, providing familiarity in
the patient room, appropriate sleep patterns, timely extubation, and early ambulation all assist in helping prevent
delirium.
5. Use antipsychotics judiciously. The more medications a
patient receives, the more it can cloud their senses and
judgment. Avoid additional medications, especially ones
that affect the brain, as much as possible.

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Traumatic brain injury is another major problem that
often requires ICU admission. Historically, the prognosis of
most penetrating brain injuries was usually poor, especially
if it is due to a missile that crosses the midline, resulting in
the utilization of only a few resources to save the patient.
Recent literature, however, has taken a more aggressive
approach to patients with penetrating traumatic brain injury,
especially those patients experiencing gunshot wounds to the
head. Aggressive resuscitation with blood products and
hypertonic saline has been shown to be independently associated with improvement in survival rates, even for those
patients suffering bi-hemispheric missile trauma. The use of
these aggressive resuscitative measures combined with rapid
correction of coagulopathy as well as essential collaboration
between the trauma, neurosurgery, emergency medicine, and
nursing services has resulted in increased survival rates for
gunshot wounds to the head from 10% to 46%. Furthermore,
the use of thyroid hormonal replacement therapy (the “T4
protocol,” which comprises 1 ampule of 50% dextrose, 2g of
methylprednisolone, 20U regular insulin, and 20mg levothyroxine) has been shown to signicantly improve rates of
organ procurement from those patients with fatal gunshot
wounds to the head. With new literature showing increasing
survival and organ procurement rates, the bias of resource
use can no longer be used to preclude trauma surgeons from
abandoning aggressive attempts to save patients with gunshot wounds to the brain.
12.4 Respiratory Failure, Acute Lung
Injury, andARDS
Many trauma patients suffer respiratory failure following
injury and need to be maintained on invasive ventilation.
Daily sedation vacations and spontaneous breathing trials
have both been shown to facilitate earlier extubation. Weaning
protocols that directly involve the nursing staff and respiratory therapists are highly effective. Computer-driven weaning
protocols have also been developed and may be directly
incorporated into ventilators in the future. Extubating patients
as soon as possible is extremely important as it minimizes the
risk of ventilator-associated pneumonia, one of the more serious nosocomial infections that patients develop in the
ICU.These infections are associated with signicant morbidity, mortality, and cost. Noninvasive ventilation may also have
a role either as a means to avoid intubation while still providing ventilatory support or as a bridge following extubation to
allow more time for the respiratory function to improve.
Acute respiratory distress syndrome (ARDS) is dened as
acute hypoxemic respiratory failure with bilateral pulmonary
inltrates that is associated with both pulmonary and nonpulmonary risk factors. There are two main processes that
contribute signicantly to the development of ARDS: high
permeability pulmonary edema and alveolar instability from
the repetitive expansion and collapse of alveoli with tidal ventilation causing atelectrauma. In recent years, the denition of
ARDS has changed to exclude the term “acute lung injury.” It
is now referred to as “mild” ARDS.Furthermore, ARDS has
been subcategorized into “moderate” and “severe” dened by
the PaO2:FiO2 (200–300, 100–200 and <100 respectively).
As we have come to better understand the physiology
behind ARDS, multiple modalities have been developed to
better manage these patients. Prevention of ARDS development is most important through more judicious intravenous
uid resuscitation with better monitoring and the use of a
“low tidal volume” strategy for ventilation. When ARDS
does develop, airway pressure release ventilation (APRV)
appears to be effective in reversing atelectasis and improving
oxygenation without requiring the deep sedation or paralysis
that is usually necessary in the other forms of ventilation.
Furthermore, a recent study demonstarted a 16% decrease in
mortality for those patients who develop severe ARDS who
are placed in the prone position. Although proning a patient
is not always easy, it requires minimal resources that should
allow it to be performed in most ICUs.
Over the past few years, extracorporeal membrane oxygenation (ECMO) has gained popularity in the management
of patients with respiratory and/or cardiac failure, specically when these patients have failed conventional medical
therapy and mechanical ventilation. Whether it is venovenous (VV) or veno-arterial (VA) ECMO, the goal of this
therapy is the drainage of deoxygenated blood from the
venous system, moving it across a membrane oxygenator
that removes carbon dioxide, replenishes oxygen, and returns
oxygenated blood back to the patient’s venous or arterial
side. More often used in ARDS, VV-ECMO promotes lung
rest via lung-protective ventilation, minimizing further
ventilator- induced lung injury. Patient selection is important
with this therapy as these patients require signicant anticoagulation as well as the cannula are rather large and distal
perfusion can be an issue. Continuous monitoring of the system and patient is critical for these patients.
12.5 Cardiac Failure
Cardiogenic shock is a relatively rare complication following penetrating trauma and is usually due to direct lacerations of the heart itself or secondary to underlying baseline
cardiac disease. In cases of direct trauma to the heart, take
care to avoid damage to the coronary arteries and veins if at
all possible during surgical repair, as this will lead to infarction of the cardiac muscle distal to the injury. Pay attention to
the possibility of damage to the cardiac valves, papillary
muscles, and septae following penetrating injury, which is
best evaluated by echocardiography, either via the trans-

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esophageal route during the initial operation or via the transthoracic method once the patient is in the ICU. It is
recommended to routinely perform echocardiography postoperatively following cardiac stab wounds, and this should
be done urgently if there are signs of cardiac dysfunction.
It is very common for trauma surgeons to care for a high
number of elderly patients who have multiple cardiac comorbidities such as coronary artery disease, valvular problems,
or arrhythmias. Patients frequently have stents in place and
are on clopidogrel and aspirin or are anticoagulated with
warfarin, apixaban, dabigatran, or rivaroxaban. The risk of
thromboses in these patients needs to be carefully weighed
against the risk of ongoing hemorrhage if the anticoagulation
is maintained. Furthermore, if there is ongoing bleeding,
these medications may need to be reversed. Unfortunately,
for many of these newer agents, reversal can be very challenging as there are not many agents to reverse them and the
agents that are currently available are very expensive. The
reversal of warfarin has been fairly consistent for years utilizing vitamin K and fresh frozen plasma, although the prothrombin complex concentrates have recently become
available and are more effective in reversing the effect of
Warfarin. However, for the factor Xa inhibitors (apixaban,
rivaroxban), prothrombin complex concentrate (PCC) is routinely used but not always successful. The thrombin inhibitors (dabigatran) can undergo hemodialysis to remove the
effects of the anticoagulant as well as a recent medication
(idarucizumab) was developed to specically reverse the
effects of dabigatran. Unfortunately, the factor Xa inhibitors
are resistant to hemodialysis; however, new medications are
currently being developed and researched as potential reversal agents for this group of anticoagulation medications.
The choice of vasopressor in cardiogenic shock will
depend on the exact cause of the shock, dopamine being
most benecial in those patients needing inotropic support
that are not tachycardic. Dobutamine is a better choice for
patients with a history of congestive cardiac failure. Rarely,
agents such as epinephrine or milrinone are utilized for right
heart failure. In the most severe cases of cardiogenic shock,
intra-aortic balloon pump placement may be required to
maintain left ventricular function. Furthermore, as mentioned above, ECMO (specically VA-ECMO) has become
an option for patients in refractory cardiogenic shock, but
again careful consideration must be utilized as the associated
mortality with VA-ECMO is still in the range of 50–60%.
12.6 Surgical Nutrition
Early enteral feeding is one of the most important aspects of
critical care for the trauma patient, demonstrating signicant
benets, especially in the brain injured patient. As soon as
possible after admission, the patient should be placed on
enteral feeding to minimize the catabolic effects of their
trauma and/or surgery. There is little data to support the timehonored practice of transitioning patients from sips to clears
to soft to regular diet, in those patients who can take diet by
mouth, and unless there are obvious contraindications, a regular diet should be established as soon as possible.
For those patients who are intubated or unable to tolerate
an oral diet, enteral feeding access should be obtained, preferably post-pyloric, to initiate tube feeds. Calculation of the
metabolic requirements of the patient using the various nutrition formulas (e.g., Ireton-Jones energy expenditure) has
been shown to be accurate; therefore, a detailed metabolic
cart assessment is usually not required. Tube feeds can be
given continuously or as bolus feeds, with the later approach
being slightly more effective at meeting the daily nutritional
goals. Unless the patient has specic indications (e.g.,
ARDS, sepsis, renal, or hepatic failure), the use of simple
enteral formulas is encouraged. The immune-enhancing or
specialty formulas should be reserved for those cases where
there is likely to be maximal benet. Intolerance to enteral
feeds can usually be successfully managed with promotility
agents, such as erythromycin, which is somewhat more
effective than metoclopramide. Both agents can also be used
together for a synergistic effect, but it should be remembered
that tachyphylaxis often develops within a week, independent of the agent used.
Total parenteral nutrition (TPN) retains a place in surgical
nutrition, specically in those patients who cannot tolerate
enteral feeds or who have enterocutaneous stulas. Use of a
PICC line for administration rather than a central line
decreases some of the mechanical complications, but patients
are still at risk for metabolic and infectious problems. Close
monitoring of electrolytes is mandatory with TPN.Transition
to enteral feeding should be established as soon as possible
as this will help maintain bowel integrity and provide benets with regard to healing, hepatic protein synthesis, hormonal function of the gut, and immune function. TPN should
only be used in cases where the patient will be unable to
tolerate enteral feeds for at least 7days.
12.7 Fluid, Electrolytes, andRenal Failure
Trauma patients often require the administration of signicant amounts of intravenous uids following injury due to
blood loss, shifts of sodium and water from the interstitium,
and/or uid losses from wounds. Although there is no perfect
measure for assessing the adequacy of resuscitation, a combination of base decit, serum lactate, and urine output
works well (although none of these measures are adequate
independently). As mentioned before, trauma patients
require close monitoring for the end points of resuscitation
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Both normal saline and lactated Ringer’s solution are usually used in the acute phase of resuscitation. The proinammatory effects of excessive crystalloid use have been well
documented, and in this new era of “hemostatic resuscitation,” the goal is to minimize careless use. Care should be
taken to monitor for hyperchloremic acidosis if normal saline
is used as the primary resuscitation uid; lactated Ringer’s
solution may therefore be preferable to eliminate this potential complication.
Hypertonic saline has recently emerged as a potential
resuscitation uid for the hypovolemic patient given its theoretical ability to expand the intravenous volume with a smaller
overall volume administered. Although the benets remain
clear that hypertonic saline improves intracranial pressures
for traumatic brain injured patients when compared to mannitol, a recent study was unable to elicit an improvement in
mortality outcomes when hypertonic saline was administered. Hypertonic saline has its place in the resuscitation of
the injured patient and its use should be reserved for traumatic brain injured patients with close monitoring.
Many hospitals have protocols for electrolyte replacement on standard order sets, although in the asymptomatic
patient who is tolerating a diet, most of these electrolyte
abnormalities are of little consequence. In contrast, the intubated patient in the ICU with arrhythmias should have electrolyte levels closely monitored and aggressively corrected.
Hypo- or hypernatremia may be the result of an underlying
serious disease such as the syndrome of inappropriate ADH
or diabetes insipidus and needs to be appropriately investigated and treated. Hypophosphatemia and hypomagnesemia
are two other conditions that are common in the ICU setting
and should be treated aggressively due to the serious consequences that can arise, especially prolonged ventilation.
Renal failure is not uncommon in the trauma ICU for a
number of reasons; it may be related to underlying disease, age,
nephrotoxin exposure (i.e., intravenous contrast), or shock.
Prevention through early and adequate resuscitation is ideal
because once renal failure is established, there are few effective
treatment options. The most likely type of renal failure in the
trauma patient is prerenal, but intrinsic and postrenal causes
still need to be excluded. A fractional excretion of sodium (or
fractional excretion of urea when a patient is taking diuretics)
should be calculated, and the Foley catheter must be carefully
examined for evidence of obstruction. Central venous pressure
monitoring is warranted to assess volume status. Although
dopamine will increase urine output temporarily, it will not
inuence the need for dialysis or mortality and has therefore
been abandoned due to deleterious side effects. Similarly, the
administration of loop diuretics has not been shown to improve
outcomes and should not be used in the trauma setting. In those
cases where renal failure becomes established, nephrology
consultation for dialysis (either continuous renal replacement
therapy or hemodialysis) will be necessary.
12.8 Endocrine: Glucose Control
andSteroids
In recent years, the controversy over glucose control in the
ICU has subsided, especially for surgical patients. Most
recent studies have demonstrated the tight target range of
80–110 mg/dL increases mortality, whereas a more liberal
target of less than 180 has shown to improve it. Glucose
monitoring and control in the ICU is denitely important for
healing, etc.; therefore, a target of 150–180mg/dL is currently recommended and is more achievable without the
morbidity associated with hypoglycemia.
Another area of controversy has been the use of steroids in
sepsis and still remains so today. Despite all the studies that
have been conducted over the years about the use of steroids
in septic shock, there still is very limited prospective evidence
that they are benecial. In the most recent Surviving Sepsis
Campaign Guidelines, a few recommendations were made
about the use of corticosteroids in septic shock. First and foremost, corticosteroids should be implemented only in patients
who are in septic shock and do not respond to intravenous
uids or vasopressors at a dose of 200 mg/day. An ACTH
stimulation test should not be performed prior to administration of corticosteroids given its inaccuracy identifying those
patients who may benet from steroids. Finally, the steroids
should be tapered off once the patient is off vasopressors.
Although these are the recommendations from the Surviving
Sepsis Campaign, use of steroids needs to be tailored to each
patient individually at the discretion of the treating clinician.
12.9 Transfusions andBlood Products
Injury is the still the leading cause of death for patients
44 years of age or less. Twenty to forty percent of trauma
deaths occurring after hospital admission involve massive
hemorrhage from truncal injury and are potentially preventable with rapid hemorrhage control and improved resuscitation techniques. Damage control resuscitation, dened as
rapid hemorrhage control through early administration of
blood products in a balanced ratio (1:1:1 for units of plasma to
platelets to red blood cells; a ratio that is the closest approximation to reconstituted whole blood), has emerged as the standard of care for traumatic resuscitation through prevention and
immediate correction of coagulopathy, as well as minimization of crystalloid uids. A recent large, prospective trial demonstrated the efcacy of a 1:1:1 ratio of traumatic transfusion
when compared to a 1:1:2 ratio. Although there was no signicant difference in mortality, the group receiving blood product
transfusions in a 1:1:1 ratio achieved hemostasis faster and
fewer patients experienced death by exsanguination in 24h.
Whole blood resuscitation has also been gaining traction in
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ity in military experiences, whole blood has been shown to be
safe without worse complications or mortality when compared
to component transfusion in the civilian population. Given
these ndings, studies are suggesting the use of whole blood
for resuscitation, especially in severely injured patients.
Multiple studies, however, are currently underway to explore
this resuscitation modality in greater detail.
Although blood product transfusion is often started in the
trauma bay or operating room, the resuscitative process often
carries over to the ICU.Continuing this ratio of blood product
transfusion is important but still may not result in the correction
of the coagulopathy. In such situations, administration of addition products such as Factor VIIa, tranexamic acid, cryoprecipitate, or a prothrombin complex concentrate may be
required. Furthermore, severe tissue damage can result in such
phenomena as disseminated intravascular coagulopathy, further exacerbating the hemorrhage. The authors also highly
encourage the use of thromboelastography (TEG) or rotational
thromboelastometry (ROTEM) when available to help guide
the patient’s resuscitation efforts from bleeding to help minimize transfusion related complications. The main concern with
any penetrating trauma is to stop the hemorrhage rst, as this is
the most critical reason the patient will die in the acute setting.
12.10 Infectious Disease andNosocomial
Infections
Sepsis in the ICU remains a signicant problem with mortality rates ranging from 25% to 40% despite advances in antibiotics and critical care. The reader is referred to the 2021
Surviving Sepsis Campaign Guidelines for a full breakdown
of ICU measures designed to minimize mortality from severe
sepsis and septic shock.
Multiple protocols (i.e., ventilator bundles) have been
established as part of ICU sepsis preventive care and should
be established in all intensive care units regardless of size,
location, resources, etc., as these protocols will provide better
patient care and decrease overall hospital costs. Unfortunately,
even with strong preventative measures, infections do occur.
Source control remains an important part of the ght against
infection in the trauma patient, which may require surgical
drainage, aggressive debridement of soft tissue infections,
and multiple operations to obtain nal control of the infection. Although the tissue defects created may be large, an
aggressive initial debridement will serve the patient much
better than leaving a continued source of sepsis behind.
A guiding principle for antibiotic use in the ICU should
be the early use of empiric antibiotics in suspected cases of
infection. Although at times challenging, early implementation of empiric antibiotics has been shown to decrease overall mortality. Furthermore, all attempts should be made to
cover likely bacteria within the given infected tissue and deescalation opportunities for antibiotic coverage should be
assessed daily to prevent the development of resistant bacte-
ria. It is also highly recommended that difcult-to-treat, multidrug resistant organisms be covered with combination
(usually two) antibiotic therapy.
Nosocomial infections remain a serious problem in ICU
care, with ventilator-associated pneumonia (VAP), catheterrelated bloodstream infections (CRBSIs), and urinary tract
infections (UTIs) being the most serious and difcult to treat.
Nursing measures, such as head of bed elevation, routine oral
care, and light sedation, can help prevent VAP.Furthermore,
providing appropriate GI prophylaxis for patients on the ventilator longer than 48h has been shown to help reduce the
rate of VAPs. Modications to the endotracheal tube to allow
for subglottic suctioning, and/or impregnation with silver
ions, have also shown promise in reducing the development
of VAP.Ultimately, the sooner a patient can be extubated, the
less chance they have to develop a VAP.
In a recent study on CRBSIs, ve simple measures were
found to drastically reduce the incidence of this nosocomial
infection: hand-washing prior to line insertion, use of a
chlorhexidine skin prep, full barrier precautions including
full body sterile draping, avoidance of the femoral and internal jugular routes, and daily assessment for line removal.
Using this approach, the investigators showed a 66% drop in
CRBSI rates, which was maintained for at least 18months
following the intervention.
Prevention of UTIs also remains a problem, with many
patients requiring indwelling Foley catheters due to the severity of illness, the need for accurate urine output monitoring, or
an inability to spontaneously void. UTIs are the second most
common nosocomial infection and can prolong length of stay
as well as lead to unnecessary morbidity. As the risk for development of an UTI linearly increases with length of time the
catheter remains in place, patients should have their need for
an indwelling catheter assessed daily, and it should be removed
as soon as possible. Early removal of the catheter is the only
proven intervention to reduce the risk of UTI.Of note, the
presence of an epidural for analgesia is not an indication to
keep a Foley catheter in place and can be safely removed with
less than a 10% occurrence of urinary retention.
12.11 Prophylaxis intheICU: DVT andUlcer
Prophylaxis
Trauma patients should receive both mechanical and chemical thromboprophylaxis as soon as feasible after injury,
although this will have to be tempered by the patient’s injuries, e.g., brain injury and liver laceration. The weight of evidence suggests that low molecular weight heparin in the form
of Lovenox at a dose of 30mg every 12h is a more effective
agent than unfractionated heparin. There is also more data
emerging that low molecular weight heparin dosage should
be tailored to an individual patient’s body mass index. This
often requires checking anti-Xa levels, but should be considered in order to adequately prevent DVTs. Despite the aggres-
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