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S. Golestani et al.
the chest wall is not amenable to common techniques of hemostasis. Similarly, bleeding from the thoracic spine can be quite difcult to control and a bleeding vessel is not usu­ally obvious. In both these circumstances, consider packing the chest wall with laparotomy pads, the spine wound with bone wax, using any available topical hemostatic agents, or inserting a urinary catheter to provide balloon tamponade, and return to the site of bleeding for denitive hemorrhage control later in the operation.
Bleeding from the lung parenchyma is not usually signi­cant due to its low pressure and intrinsic ability to form clot from a high local concentration of tissue thromboplastin. You can usually leave lacerations from the pulmonary paren­chyma alone until denitive operation or apply a Duval lung clamp to temporize troublesome bleeding. However, bleed­ing from the pulmonary vasculature can be torrential and quickly result in exsanguination. Furthermore, signicant disruption in the pulmonary venous system can lead to air embolism to the left-sided cardiac circulation. You can con­trol bleeding from pulmonary vasculature within the sub­stance of the lung parenchyma using suture ligation. If the bleeding is too heavy to allow visualization or the bleeding is emanating from the pulmonary hilum, obtain control of the hilum either manually or with a vascular clamp. Gain control of the pulmonary hilum by temporarily halting ventilation to allow adequate visualization. Next, while retracting the lung posteriorly, bring your hand or a Satinsky clamp from above and grasp or clamp the entirety of the pulmonary hilum, including the pulmonary artery, pulmonary veins, and main­stem bronchus (Fig.11.14). It is important that you approach the hilum from above, as an inferior approach will be impeded by the inferior pulmonary ligament and may not allow hilar control. Some authors have advocated dividing the pulmonary ligament to mobilize the lung, but in our opin­ion, this is an unnecessary maneuver. Dividing the inferior pulmonary ligament takes valuable time, may lead to iatro-
Hilum of left
lung
Fig. 11.14 Cross-clamp of the pulmonary hilum
genic injury of the inferior pulmonary vein, and may be quite difcult in the emergent setting with ongoing hemorrhage; and the pulmonary hilum can be easily controlled with a superior approach while leaving the inferior pulmonary liga­ment intact. Despite control of the pulmonary hilum, you may suspect an air embolism (or conrm the diagnosis by seeing air bubbles in the coronary arteries). In these cases, aspirate the left ventricle with a needle and syringe in an attempt to evacuate any intra-ventricular air.
Though you can perform most required maneuvers during an EDT through a left anterolateral thoracotomy, you may occasionally be required to convert the left thoracotomy into a bilateral or clamshell thoracotomy. The right thoracotomy can be performed through a separate incision or extend the left thoracotomy onto the right chest via transverse sternot­omy. Consider adding a right thoracotomy to the left antero­lateral EDT in a few situations. First, if the patient presents with primarily right-sided wounds, perform the usual EDT but have an associate start a right thoracotomy simultane­ously. A left thoracotomy is still necessary, as access to the right chest will allow pericardiotomy, control of intratho­racic hemorrhage, and internal cardiac massage, but does not allow you to cross-clamp the descending aorta. Another indication for right thoracotomy is based on the output of the right tube thoracostomy placed concomitant with EDT.If the initial right chest tube output is more than 500–1000 mL, hemorrhage in the right pleural cavity will possibly require control.
The most common reason for extending a left-sided EDT is to improve visualization of the mediastinum as it allows access to the heart, great vessels, and both hemithoraces. In this case, extend your left thoracotomy into a clamshell thoracotomy via a transverse sternotomy. The right thora­cotomy portion of the bilateral or clamshell thoracotomy is a mirror image of the left thoracotomy already described. The transverse sternotomy is accomplished with a variety of techniques. The skin incision is simply a transverse incision connecting the right and left thoracotomy (Fig.11.15). Carry this incision through the subcutaneous tissue and thoracic musculature until you reach the anterior portion of the ster­num. Perform the transverse sternotomy with heavy shears, Lebsche knife, or a Gigli saw, depending on availability and personal comfort. Assisting staff should be familiar with setup and operation to prevent delay in this maneuver should it be required. Once you perform your transverse sternotomy, adjust the thoracic retractor or add a second retractor to opti­mize visualization. Next, extend the pericardiotomy across the anterior pericardium, taking care not to injure the right phrenic nerve. Keep in mind that during transverse sternot­omy, you will divide both internal mammary arteries. This may not be readily apparent if the patient is pulseless, but you should ligate or clip both internal mammary arteries as they will bleed signicantly during cardiac massage or if the
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Fig. 11.15 Skin incision for clamshell thoracotomy
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patient regains a pulse. The clamshell incision provides spec­tacular exposure to both pleural cavities and all mediastinal structures, which should allow you to perform any and all maneuvers required during emergency department thoracot­omy (Fig.11.16).
Before patient arrival and throughout performing EDT, consider what the plan will be if the patient has a return of organized cardiac activity or if cardiac arrest persists despite all resuscitative efforts. If at any time during EDT, the patient has a return of a sustained pulse and blood pressure, trans­port the patient to the operating room for denitive operative procedures. Furthermore, try to remove the aortic cross­clamp as soon as possible if the patient’s physiology will tolerate it. If cardiac arrest persists during EDT, then deter­mine if ongoing resuscitative efforts should be continued or if the care is futile. Futility in the setting of EDT for penetrating trauma is dependent on several factors including patient age and comorbidities, location of injuries identied during EDT, and local resources including personnel and blood bank availability.
Fig. 11.16 Exposure obtained to both pleural cavities and mediasti­num via a clamshell thoracotomy
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Important Points
• An emergent thoracotomy tray with all necessary instru-
ments and retractors needs to be prepared and quickly
available in the emergency department.
• FAST exam may be applied to evaluate for tamponade. If
no cardiac activity or tamponade, care may be futile.
• As you perform the EDT, the remainder of the trauma
team should concomitantly secure a denitive airway
with endotracheal intubation, establish large bore intrave-
nous access for uid and blood resuscitation, and place a
right tube thoracostomy to better evaluate for hemorrhage
in the right chest.
• In a female, retract the breast superiorly. The incision
should follow the inframammary crease. In a male, the
incision should be centered over the fourth or fth inter-
costal space by positioning the curvilinear incision just
inferior to the left nipple–areolar complex.
• Make the initial pericardiotomy with a small stab incision
using a scalpel if a tense tamponade is encountered.
Grasping the pericardium will be challenging if not
impossible in a tamponade.
• Before cross-clamping the aorta, incise the parietal pleura
that covers the descending thoracic aorta.
• The descending aorta should not be circumferentially
mobilized to apply a cross-clamp.
• Bleeding from the chest wall or spine may require pack-
ing, topical hemostatic agents, or balloon tamponade to
temporarily control hemorrhage.
• The pulmonary hilum can be easily controlled with a
superior approach while leaving the inferior pulmonary
ligament intact.
• During transverse sternotomy, ligate or clip both inter-
nal mammary arteries as they will bleed significantly
during cardiac massage or if the patient regains a
pulse.
• Removal of the aortic cross-clamp or replacement of the
clamp below the renal vessel should be performed within
30min to limit ischemia time.
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Intensive Care: Principles andTherapy
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ZacharyM.Bauman andTerenceO’Keee
12
Critical care management principles remain an extremely important aspect in the care of penetrating trauma patients. As trauma care continues to evolve and become more sophis­ticated, the management of penetrating trauma necessitates all those involved in patient care be as current as possible in order to provide optimal care. The goal of this chapter is to provide a summary of important critical care principles allowing the reader to be successful in the management of penetrating trauma patients.
12.1 Metabolic Response toTrauma
The body’s response to a traumatic or surgical insult is basi­cally the same. This involves an activation of the sympathetic nervous system and an increase in circulating catechol­amines. Furthermore, endocrine stress hormones are released from the pituitary gland, as well as changes in the immune system, including production of inammatory cytokines in addition to leucocytosis.
These neurohormonal changes cause tachycardia and fever, which taken together with tachypnea and leucocytosis form the systemic inammatory response syndrome (SIRS). Metabolic changes lead to the retention of sodium and water, in addition to hyperglycemia that is compounded by insulin resistance, proteolysis of skeletal muscle, lipolysis of fat stores, and cytokine release, all of which contribute to a cata­bolic state.
It is presumed that this proinammatory response is of overall benet to the body as it responds to the insult and aids in recovery. However, in some patients, the degree of trauma
Z. M. Bauman (*) Division of Trauma/Critical Care and Emergency Surgery, University of Nebraska Medical Center, Omaha, NE, USA e-mail: zachary.bauman@unmc.edu
T. O’Keeffe Division of Trauma/Critical Care and General Surgery, Augusta University Medical Center, Augusta, GA, USA e-mail: TOKEEFFE@augusta.edu
is so great that despite adequate resuscitation, it overwhelms the capacity for recovery and severe SIRS develops. A sec­ond “activating” event may also occur after the initial injury, which leads to a rapid downward spiral into multiorgan fail­ure. The majority of modern critical care is designed to decrease the likelihood of this second event and/or to abro­gate its effects on the patient.
12.2 ICU Monitoring
As critical care medicine continues to evolve and become more sophisticated, so do the means by which we monitor the critically ill. There continues to be a trend for non­invasive or minimally invasive monitoring for patients in the ICU.Numerous new devices are emerging which aid the cli­nician in making real-time decisions about the status and direction of patient physiology.
Arterial catheterization is still standard practice in most ICUs, not only to monitor arterial blood pressure but also to facilitate blood gas monitoring in ventilated patients. Complication rates are low, but thrombosis, pseudoaneurysm formation, and infection may still occur. The radial or femo­ral routes are preferred for ease of placement and minimal degree of complications. There are now several types of monitors that can be directly attached to the arterial line, giv­ing real-time estimates of the cardiac output and index, stroke volume, systemic vascular resistance, etc.
Pulmonary arterial (PA) catheters have become extremely uncommon in the ICU setting given their perceived high complication rate and the fact that not many healthcare pro­viders are trained to place them any longer. We do believe, however, there is still a small and specic patient population that will benet from their use. This patient population includes those who are refractory to adequate volume resus­citation without obvious cause, or who have cardiac dysfunc­tion, either acute or chronic, where monitoring of cardiac output is necessary to guide clinical care. It should be advised that not only does the physician caring for these specic
© The Author(s), under exclusive license to Springer Nature Switzerland AG 2023 E. Degiannis et al. (eds.), Penetrating Trauma, https://doi.org/10.1007/978-3-031-47006-6_12
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patients need to be competent in the placement of this device, and also have a strong working knowledge of how to inter­pret the data provided, but the entire care team should also possess this knowledge.
Point of care ultrasonography (POCUS) has become extremely popular as a monitoring modality in the ICU over the past few years and is relatively inexpensive. It is a skill set that is now being taught routinely in both surgical resi­dencies and critical care fellowships. The diagnostic impact of POCUS has been shown to be as high as 85% whether that be conrming an expected diagnosis or resulting in a change of diagnosis and therefore a change in patient management. The ability to observe directly the heart, lungs, inferior vena cava, aorta, etc., with the ultrasound at bedside greatly improves the decision-making ability of the clinician, espe­cially from a hemodynamics standpoint. Lung ultrasonogra­phy has really come into popular use over the last several years, demonstrating a higher reliability diagnosing a pneu­mothorax than standard chest X-ray. Furthermore, lung ultrasound has proven very useful in the assessment of ade­quacy of intubation, to aid with ventilatory changes and assess weaning strategies. Ultrasonography has also allowed for improvements in bedside procedures, resulting in a lower complication rate, especially when it comes to the cannula­tion of vascular structures. Transesophageal ultrasonography has also gained popularity in the monitoring of volume sta­tus; however, this modality is more invasive and requires the patient to be intubated. Although the disadvantage of ultraso­nography is that it is operator dependent, the application of this technology is vast and has demonstrated both reliability and reproducibility.
The future of hemodynamic monitoring in the ICU is very exciting. Two current concepts coming to the forefront in this arena include microcirculation monitoring and optimization as well as the use of articial intelligence to predict hemody­namic changes before they occur. Microcirculation monitor­ing utilizes a hand-held vital microscope to assess sublingual circulation, guiding the clinician on uid/therapy choice to optimize the microcirculation. Articial intelligence theo­retically requires machine learning of big data to obtain pre­dictive analysis for hemodynamic collapse before it actually occurs, therefore allowing the clinician to intervene early. Although not quite ready for real-time application, research and development in this eld is rapidly expanding as the potential use for this technology is limitless.
12.3 Neurological System, Pain Control,
andTraumatic Brain Injury
One of the biggest challenges in the ICU is appropriately managing pain and agitation in critically ill patients. There are a number of considerations when choosing medications,
not least of which are comorbidities that may affect the phar­macokinetics of the various agents. The Society of Critical Care Medicine recently published an in-depth set of guide­lines for the management of pain, agitation, and delirium. Although pain and sedation management needs to be tailored to the individual patient, these guidelines have shown better outcomes for all critically ill patients and should be imple­mented in all ICUs.
1. Optimize pain management rst. This will allow for the use of less sedation and reduce the development of delirium. It is always preferable to use short-acting intravenous narcotic analgesics as infusions for initial pain control. Furthermore, early transition of patients to oral analgesia (e.g., Oxycodone) via the enteral route is recommended as soon as the GI tract is available for use.
2. Make light sedation the norm. Patients should be sedated to the point of comfort, especially if they are on the ven­tilator, but should be alert enough to participate in their care. Over sedation only worsens the potential for delir­ium and can lengthen ventilation and ICU days. No mat­ter which sedation medication is used, a sedation scale should be implemented with a specic target range so the patient does not become over-sedated.
3. Move away from routinely using benzodiazepines, espe-
cially in ICU patients who are at risk for or those who already have delirium. The choice of a benzodiazepine
or other agents such as propofol as a sedative depends on the preference of the treating physician, as well as the patient’s hemodynamic stability. Both propofol and dexmetomidine infusions, although short acting and more preferred than benzodiazepines, have deleterious effects on blood pressure requiring close monitoring. Conversely, benzodiazepine infusions have long half­lives and should be avoided for maintenance sedation over many days.
4. Implement effective delirium prevention and treatment
strategies, using both nonpharmacologic and pharmaco­logic approaches. The development of delirium worsens
overall mortality and should be avoided if possible. All ventilated patients should undergo daily “sedation vaca­tions” to allow medication to wear off, which will allow more accurate assessment of the patient’s level of con­sciousness and further decrease delirium development. Regular re-orientation, sunlight, providing familiarity in the patient room, appropriate sleep patterns, timely extu­bation, and early ambulation all assist in helping prevent delirium.
5. Use antipsychotics judiciously. The more medications a patient receives, the more it can cloud their senses and judgment. Avoid additional medications, especially ones that affect the brain, as much as possible.
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Traumatic brain injury is another major problem that often requires ICU admission. Historically, the prognosis of most penetrating brain injuries was usually poor, especially if it is due to a missile that crosses the midline, resulting in the utilization of only a few resources to save the patient. Recent literature, however, has taken a more aggressive approach to patients with penetrating traumatic brain injury, especially those patients experiencing gunshot wounds to the head. Aggressive resuscitation with blood products and hypertonic saline has been shown to be independently asso­ciated with improvement in survival rates, even for those patients suffering bi-hemispheric missile trauma. The use of these aggressive resuscitative measures combined with rapid correction of coagulopathy as well as essential collaboration between the trauma, neurosurgery, emergency medicine, and nursing services has resulted in increased survival rates for gunshot wounds to the head from 10% to 46%. Furthermore, the use of thyroid hormonal replacement therapy (the “T4 protocol,” which comprises 1 ampule of 50% dextrose, 2g of methylprednisolone, 20U regular insulin, and 20mg levo­thyroxine) has been shown to signicantly improve rates of organ procurement from those patients with fatal gunshot wounds to the head. With new literature showing increasing survival and organ procurement rates, the bias of resource use can no longer be used to preclude trauma surgeons from abandoning aggressive attempts to save patients with gun­shot wounds to the brain.
12.4 Respiratory Failure, Acute Lung
Injury, andARDS
Many trauma patients suffer respiratory failure following injury and need to be maintained on invasive ventilation. Daily sedation vacations and spontaneous breathing trials have both been shown to facilitate earlier extubation. Weaning protocols that directly involve the nursing staff and respira­tory therapists are highly effective. Computer-driven weaning protocols have also been developed and may be directly incorporated into ventilators in the future. Extubating patients as soon as possible is extremely important as it minimizes the risk of ventilator-associated pneumonia, one of the more seri­ous nosocomial infections that patients develop in the ICU.These infections are associated with signicant morbid­ity, mortality, and cost. Noninvasive ventilation may also have a role either as a means to avoid intubation while still provid­ing ventilatory support or as a bridge following extubation to allow more time for the respiratory function to improve.
Acute respiratory distress syndrome (ARDS) is dened as acute hypoxemic respiratory failure with bilateral pulmonary inltrates that is associated with both pulmonary and non­pulmonary risk factors. There are two main processes that contribute signicantly to the development of ARDS: high
permeability pulmonary edema and alveolar instability from the repetitive expansion and collapse of alveoli with tidal ven­tilation causing atelectrauma. In recent years, the denition of ARDS has changed to exclude the term “acute lung injury.” It is now referred to as “mild” ARDS.Furthermore, ARDS has been subcategorized into “moderate” and “severe” dened by the PaO2:FiO2 (200–300, 100–200 and <100 respectively).
As we have come to better understand the physiology behind ARDS, multiple modalities have been developed to better manage these patients. Prevention of ARDS develop­ment is most important through more judicious intravenous uid resuscitation with better monitoring and the use of a “low tidal volume” strategy for ventilation. When ARDS does develop, airway pressure release ventilation (APRV) appears to be effective in reversing atelectasis and improving oxygenation without requiring the deep sedation or paralysis that is usually necessary in the other forms of ventilation. Furthermore, a recent study demonstarted a 16% decrease in mortality for those patients who develop severe ARDS who are placed in the prone position. Although proning a patient is not always easy, it requires minimal resources that should allow it to be performed in most ICUs.
Over the past few years, extracorporeal membrane oxy­genation (ECMO) has gained popularity in the management of patients with respiratory and/or cardiac failure, speci­cally when these patients have failed conventional medical therapy and mechanical ventilation. Whether it is veno­venous (VV) or veno-arterial (VA) ECMO, the goal of this therapy is the drainage of deoxygenated blood from the venous system, moving it across a membrane oxygenator that removes carbon dioxide, replenishes oxygen, and returns oxygenated blood back to the patient’s venous or arterial side. More often used in ARDS, VV-ECMO promotes lung rest via lung-protective ventilation, minimizing further ventilator- induced lung injury. Patient selection is important with this therapy as these patients require signicant antico­agulation as well as the cannula are rather large and distal perfusion can be an issue. Continuous monitoring of the sys­tem and patient is critical for these patients.
12.5 Cardiac Failure
Cardiogenic shock is a relatively rare complication follow­ing penetrating trauma and is usually due to direct lacera­tions of the heart itself or secondary to underlying baseline cardiac disease. In cases of direct trauma to the heart, take care to avoid damage to the coronary arteries and veins if at all possible during surgical repair, as this will lead to infarc­tion of the cardiac muscle distal to the injury. Pay attention to the possibility of damage to the cardiac valves, papillary muscles, and septae following penetrating injury, which is best evaluated by echocardiography, either via the trans-
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esophageal route during the initial operation or via the trans­thoracic method once the patient is in the ICU. It is recommended to routinely perform echocardiography post­operatively following cardiac stab wounds, and this should be done urgently if there are signs of cardiac dysfunction.
It is very common for trauma surgeons to care for a high number of elderly patients who have multiple cardiac comor­bidities such as coronary artery disease, valvular problems, or arrhythmias. Patients frequently have stents in place and are on clopidogrel and aspirin or are anticoagulated with warfarin, apixaban, dabigatran, or rivaroxaban. The risk of thromboses in these patients needs to be carefully weighed against the risk of ongoing hemorrhage if the anticoagulation is maintained. Furthermore, if there is ongoing bleeding, these medications may need to be reversed. Unfortunately, for many of these newer agents, reversal can be very chal­lenging as there are not many agents to reverse them and the agents that are currently available are very expensive. The reversal of warfarin has been fairly consistent for years uti­lizing vitamin K and fresh frozen plasma, although the pro­thrombin complex concentrates have recently become available and are more effective in reversing the effect of Warfarin. However, for the factor Xa inhibitors (apixaban, rivaroxban), prothrombin complex concentrate (PCC) is rou­tinely used but not always successful. The thrombin inhibi­tors (dabigatran) can undergo hemodialysis to remove the effects of the anticoagulant as well as a recent medication (idarucizumab) was developed to specically reverse the effects of dabigatran. Unfortunately, the factor Xa inhibitors are resistant to hemodialysis; however, new medications are currently being developed and researched as potential rever­sal agents for this group of anticoagulation medications.
The choice of vasopressor in cardiogenic shock will depend on the exact cause of the shock, dopamine being most benecial in those patients needing inotropic support that are not tachycardic. Dobutamine is a better choice for patients with a history of congestive cardiac failure. Rarely, agents such as epinephrine or milrinone are utilized for right heart failure. In the most severe cases of cardiogenic shock, intra-aortic balloon pump placement may be required to maintain left ventricular function. Furthermore, as men­tioned above, ECMO (specically VA-ECMO) has become an option for patients in refractory cardiogenic shock, but again careful consideration must be utilized as the associated mortality with VA-ECMO is still in the range of 50–60%.
12.6 Surgical Nutrition
Early enteral feeding is one of the most important aspects of critical care for the trauma patient, demonstrating signicant benets, especially in the brain injured patient. As soon as possible after admission, the patient should be placed on
enteral feeding to minimize the catabolic effects of their trauma and/or surgery. There is little data to support the time­honored practice of transitioning patients from sips to clears to soft to regular diet, in those patients who can take diet by mouth, and unless there are obvious contraindications, a reg­ular diet should be established as soon as possible.
For those patients who are intubated or unable to tolerate an oral diet, enteral feeding access should be obtained, pref­erably post-pyloric, to initiate tube feeds. Calculation of the metabolic requirements of the patient using the various nutri­tion formulas (e.g., Ireton-Jones energy expenditure) has been shown to be accurate; therefore, a detailed metabolic cart assessment is usually not required. Tube feeds can be given continuously or as bolus feeds, with the later approach being slightly more effective at meeting the daily nutritional goals. Unless the patient has specic indications (e.g., ARDS, sepsis, renal, or hepatic failure), the use of simple enteral formulas is encouraged. The immune-enhancing or specialty formulas should be reserved for those cases where there is likely to be maximal benet. Intolerance to enteral feeds can usually be successfully managed with promotility agents, such as erythromycin, which is somewhat more effective than metoclopramide. Both agents can also be used together for a synergistic effect, but it should be remembered that tachyphylaxis often develops within a week, indepen­dent of the agent used.
Total parenteral nutrition (TPN) retains a place in surgical nutrition, specically in those patients who cannot tolerate enteral feeds or who have enterocutaneous stulas. Use of a PICC line for administration rather than a central line decreases some of the mechanical complications, but patients are still at risk for metabolic and infectious problems. Close monitoring of electrolytes is mandatory with TPN.Transition to enteral feeding should be established as soon as possible as this will help maintain bowel integrity and provide bene­ts with regard to healing, hepatic protein synthesis, hor­monal function of the gut, and immune function. TPN should only be used in cases where the patient will be unable to tolerate enteral feeds for at least 7days.
12.7 Fluid, Electrolytes, andRenal Failure
Trauma patients often require the administration of signi­cant amounts of intravenous uids following injury due to blood loss, shifts of sodium and water from the interstitium, and/or uid losses from wounds. Although there is no perfect measure for assessing the adequacy of resuscitation, a com­bination of base decit, serum lactate, and urine output works well (although none of these measures are adequate independently). As mentioned before, trauma patients require close monitoring for the end points of resuscitation given the deleterious effects of over-resuscitation.
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Both normal saline and lactated Ringer’s solution are usu­ally used in the acute phase of resuscitation. The proinam­matory effects of excessive crystalloid use have been well documented, and in this new era of “hemostatic resuscita­tion,” the goal is to minimize careless use. Care should be taken to monitor for hyperchloremic acidosis if normal saline is used as the primary resuscitation uid; lactated Ringer’s solution may therefore be preferable to eliminate this poten­tial complication.
Hypertonic saline has recently emerged as a potential resuscitation uid for the hypovolemic patient given its theo­retical ability to expand the intravenous volume with a smaller overall volume administered. Although the benets remain clear that hypertonic saline improves intracranial pressures for traumatic brain injured patients when compared to man­nitol, a recent study was unable to elicit an improvement in mortality outcomes when hypertonic saline was adminis­tered. Hypertonic saline has its place in the resuscitation of the injured patient and its use should be reserved for trau­matic brain injured patients with close monitoring.
Many hospitals have protocols for electrolyte replace­ment on standard order sets, although in the asymptomatic patient who is tolerating a diet, most of these electrolyte abnormalities are of little consequence. In contrast, the intu­bated patient in the ICU with arrhythmias should have elec­trolyte levels closely monitored and aggressively corrected. Hypo- or hypernatremia may be the result of an underlying serious disease such as the syndrome of inappropriate ADH or diabetes insipidus and needs to be appropriately investi­gated and treated. Hypophosphatemia and hypomagnesemia are two other conditions that are common in the ICU setting and should be treated aggressively due to the serious conse­quences that can arise, especially prolonged ventilation.
Renal failure is not uncommon in the trauma ICU for a number of reasons; it may be related to underlying disease, age, nephrotoxin exposure (i.e., intravenous contrast), or shock. Prevention through early and adequate resuscitation is ideal because once renal failure is established, there are few effective treatment options. The most likely type of renal failure in the trauma patient is prerenal, but intrinsic and postrenal causes still need to be excluded. A fractional excretion of sodium (or fractional excretion of urea when a patient is taking diuretics) should be calculated, and the Foley catheter must be carefully examined for evidence of obstruction. Central venous pressure monitoring is warranted to assess volume status. Although dopamine will increase urine output temporarily, it will not inuence the need for dialysis or mortality and has therefore been abandoned due to deleterious side effects. Similarly, the administration of loop diuretics has not been shown to improve outcomes and should not be used in the trauma setting. In those cases where renal failure becomes established, nephrology consultation for dialysis (either continuous renal replacement therapy or hemodialysis) will be necessary.
12.8 Endocrine: Glucose Control andSteroids
In recent years, the controversy over glucose control in the ICU has subsided, especially for surgical patients. Most recent studies have demonstrated the tight target range of 80–110 mg/dL increases mortality, whereas a more liberal target of less than 180 has shown to improve it. Glucose monitoring and control in the ICU is denitely important for healing, etc.; therefore, a target of 150–180mg/dL is cur­rently recommended and is more achievable without the morbidity associated with hypoglycemia.
Another area of controversy has been the use of steroids in sepsis and still remains so today. Despite all the studies that have been conducted over the years about the use of steroids in septic shock, there still is very limited prospective evidence that they are benecial. In the most recent Surviving Sepsis Campaign Guidelines, a few recommendations were made about the use of corticosteroids in septic shock. First and fore­most, corticosteroids should be implemented only in patients who are in septic shock and do not respond to intravenous uids or vasopressors at a dose of 200 mg/day. An ACTH stimulation test should not be performed prior to administra­tion of corticosteroids given its inaccuracy identifying those patients who may benet from steroids. Finally, the steroids should be tapered off once the patient is off vasopressors. Although these are the recommendations from the Surviving Sepsis Campaign, use of steroids needs to be tailored to each patient individually at the discretion of the treating clinician.
12.9 Transfusions andBlood Products
Injury is the still the leading cause of death for patients 44 years of age or less. Twenty to forty percent of trauma deaths occurring after hospital admission involve massive hemorrhage from truncal injury and are potentially prevent­able with rapid hemorrhage control and improved resuscita­tion techniques. Damage control resuscitation, dened as rapid hemorrhage control through early administration of blood products in a balanced ratio (1:1:1 for units of plasma to platelets to red blood cells; a ratio that is the closest approxi­mation to reconstituted whole blood), has emerged as the stan­dard of care for traumatic resuscitation through prevention and immediate correction of coagulopathy, as well as minimiza­tion of crystalloid uids. A recent large, prospective trial dem­onstrated the efcacy of a 1:1:1 ratio of traumatic transfusion when compared to a 1:1:2 ratio. Although there was no signi­cant difference in mortality, the group receiving blood product transfusions in a 1:1:1 ratio achieved hemostasis faster and fewer patients experienced death by exsanguination in 24h. Whole blood resuscitation has also been gaining traction in civilian trauma resuscitation. Already demonstrating superior-
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ity in military experiences, whole blood has been shown to be safe without worse complications or mortality when compared to component transfusion in the civilian population. Given these ndings, studies are suggesting the use of whole blood for resuscitation, especially in severely injured patients. Multiple studies, however, are currently underway to explore this resuscitation modality in greater detail.
Although blood product transfusion is often started in the trauma bay or operating room, the resuscitative process often carries over to the ICU.Continuing this ratio of blood product transfusion is important but still may not result in the correction of the coagulopathy. In such situations, administration of addi­tion products such as Factor VIIa, tranexamic acid, cryopre­cipitate, or a prothrombin complex concentrate may be required. Furthermore, severe tissue damage can result in such phenomena as disseminated intravascular coagulopathy, fur­ther exacerbating the hemorrhage. The authors also highly encourage the use of thromboelastography (TEG) or rotational thromboelastometry (ROTEM) when available to help guide the patient’s resuscitation efforts from bleeding to help mini­mize transfusion related complications. The main concern with any penetrating trauma is to stop the hemorrhage rst, as this is the most critical reason the patient will die in the acute setting.
12.10 Infectious Disease andNosocomial
Infections
Sepsis in the ICU remains a signicant problem with mortal­ity rates ranging from 25% to 40% despite advances in anti­biotics and critical care. The reader is referred to the 2021 Surviving Sepsis Campaign Guidelines for a full breakdown of ICU measures designed to minimize mortality from severe sepsis and septic shock.
Multiple protocols (i.e., ventilator bundles) have been established as part of ICU sepsis preventive care and should be established in all intensive care units regardless of size, location, resources, etc., as these protocols will provide better patient care and decrease overall hospital costs. Unfortunately, even with strong preventative measures, infections do occur. Source control remains an important part of the ght against infection in the trauma patient, which may require surgical drainage, aggressive debridement of soft tissue infections, and multiple operations to obtain nal control of the infec­tion. Although the tissue defects created may be large, an aggressive initial debridement will serve the patient much better than leaving a continued source of sepsis behind.
A guiding principle for antibiotic use in the ICU should be the early use of empiric antibiotics in suspected cases of infection. Although at times challenging, early implementa­tion of empiric antibiotics has been shown to decrease over­all mortality. Furthermore, all attempts should be made to cover likely bacteria within the given infected tissue and de­escalation opportunities for antibiotic coverage should be assessed daily to prevent the development of resistant bacte-
ria. It is also highly recommended that difcult-to-treat, mul­tidrug resistant organisms be covered with combination (usually two) antibiotic therapy.
Nosocomial infections remain a serious problem in ICU care, with ventilator-associated pneumonia (VAP), catheter­related bloodstream infections (CRBSIs), and urinary tract infections (UTIs) being the most serious and difcult to treat. Nursing measures, such as head of bed elevation, routine oral care, and light sedation, can help prevent VAP.Furthermore, providing appropriate GI prophylaxis for patients on the ven­tilator longer than 48h has been shown to help reduce the rate of VAPs. Modications to the endotracheal tube to allow for subglottic suctioning, and/or impregnation with silver ions, have also shown promise in reducing the development of VAP.Ultimately, the sooner a patient can be extubated, the less chance they have to develop a VAP.
In a recent study on CRBSIs, ve simple measures were found to drastically reduce the incidence of this nosocomial infection: hand-washing prior to line insertion, use of a chlorhexidine skin prep, full barrier precautions including full body sterile draping, avoidance of the femoral and inter­nal jugular routes, and daily assessment for line removal. Using this approach, the investigators showed a 66% drop in CRBSI rates, which was maintained for at least 18months following the intervention.
Prevention of UTIs also remains a problem, with many patients requiring indwelling Foley catheters due to the sever­ity of illness, the need for accurate urine output monitoring, or an inability to spontaneously void. UTIs are the second most common nosocomial infection and can prolong length of stay as well as lead to unnecessary morbidity. As the risk for devel­opment of an UTI linearly increases with length of time the catheter remains in place, patients should have their need for an indwelling catheter assessed daily, and it should be removed as soon as possible. Early removal of the catheter is the only proven intervention to reduce the risk of UTI.Of note, the presence of an epidural for analgesia is not an indication to keep a Foley catheter in place and can be safely removed with less than a 10% occurrence of urinary retention.
12.11 Prophylaxis intheICU: DVT andUlcer
Prophylaxis
Trauma patients should receive both mechanical and chemi­cal thromboprophylaxis as soon as feasible after injury, although this will have to be tempered by the patient’s inju­ries, e.g., brain injury and liver laceration. The weight of evi­dence suggests that low molecular weight heparin in the form of Lovenox at a dose of 30mg every 12h is a more effective agent than unfractionated heparin. There is also more data emerging that low molecular weight heparin dosage should be tailored to an individual patient’s body mass index. This often requires checking anti-Xa levels, but should be consid­ered in order to adequately prevent DVTs. Despite the aggres-