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10 Fluids, Blood Substitutes, andNew Tools
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relative hypotension and minimally acceptable degrees of perfusion until denitive hemorrhage control. Rationale for this strategy is rooted in the ATLS guidelines that hemor­rhage control is the most important management strategy and that over-resuscitation leads to further coagulopathy and bleeding. Current EAST guidelines address this strategy with only level III evidence advocating that uid be withheld until active bleeding is managed or titrated with 250 mL boluses to a palpable radial pulse. Currently there is no for­mal denition of what constitutes permissive hypotension as some state systolic blood pressure (SBP) at 90 mmHg or >70mmHg while others advocate for a mean arterial pres­sure (MAP) of 50mmHg. It is important to emphasize that permissive hypotension is appropriate for penetrating trauma but should not be employed for specic subgroups like those with TBI or the elderly.
Bickell completed a landmark trial evaluating delayed uid versus standard uid resuscitation in penetrating torso inju­ries. Patients either received standard IV uid or no IV uid until reaching the operating room. Of the 598 patients, there was signicant improved survival as well as shorter hospital stay in the delayed IV uid group. This study has been criti­cized regarding selection bias as its randomization method of alternate days is suited to the difcult prehospital environment but is not really random. Several later studies have found no difference in mortality based on the volume of prehospital resuscitation. A retrospective analysis from USC/LA County reexamined the question and found no difference in mortality based on the volume of prehospital uids administered. Another series of mixed mechanism patients from Maryland Shock Trauma failed to nd any difference in mortality between a conventional resuscitation and a permissive hypo­tension group. A cost-effectiveness meta-analysis from Britain found no benet or savings to the use of prehospital uids but only examined four clinical trials and found methodological aws in most of them. The body of literature to support delay­ing denitive resuscitation until after source control of hemor­rhage is obtained although most of it is animal models.
10.7 Conclusion
Fluid management in the injured is one the most important and not surprisingly controversial topics in the eld of trau­matology. Mainstream guidelines emphasize the need for rapid, denitive hemorrhage control and a shift toward blood products away from crystalloids early in the resuscitation. The use of blood substitutes may be warranted in austere environments and during blood shortages. The preferred ratio for component therapy is 1:1:1; however, whole blood appears to be emerging as the optimal resuscitation strategy instead of component therapy for massive transfusion.
Important Points
• The cornerstone of treating hemorrhage is to stop the source of bleeding.
• Initial resuscitation with isotonic crystalloids should be considered if blood products are not available or if the patient has class I hemorrhagic shock without ongoing bleeding.
• Hypertonic solutions do not appear to be superior to iso­tonic solutions in terms of overall mortality.
• Only specic blood substitutes provide similar outcomes to the current standard of care.
• Increasing the plasma/platelets/RBC ratio to 1:1:1 is associated with improved lower early deaths due to hemorrhage.
• TEG should be used when available to guide resuscitation during acute traumatic blood loss.
• Whole blood may yield improved early survival in mas­sive transfusion compared to component therapy.
• Tranexamic acid and FFP are useful pre-hospital adjuncts that have been shown to decrease early mortality.
• Autotransfusion devices are an important adjunct to mas­sive transfusion to provide rapid restoration of red cell mass when blood supplies become exhausted.
10.6.1 Elderly Population
Traditionally the trauma population is younger, particularly those involved in penetrating injuries. Therefore, limited expe­rience is available with permissive hypotension in the elderly. Using the National Trauma Data Bank, Bridges etal. retro­spectively evaluated the interaction between permissive hypo­tension and age. Elderly were 66 ± 0.6 and had a greater overall mortality (35.1–29%) when compared with younger population. Though previous literature has shown increased mortality in elderly patients with SBP less than 110, this study demonstrated no interaction between age and SBP, suggesting that permissive hypotension in the elderly may be safe.
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Emergency Department Thoracotomy
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SiminGolestani, AustinEagleton, andCarlosV.R.Brown
11
Emergency Department Thoracotomy (EDT), also known as resuscitative thoracotomy, can be used as an adjunct during the resuscitation of penetrating trauma patients who have sustained a cardiac arrest. EDT should be performed liber­ally in penetrating trauma patients who fall into specic cat­egories, particularly those with a suspected cardiac injury or cardiac tamponade. Appropriate preparation of personnel and equipment is required to perform EDT in a safe and ef­cient manner. EDT provides the opportunity to release car­diac tamponade, repair cardiac injuries, cross-clamp the descending thoracic aorta to improve cerebral and coronary perfusion during resuscitation, control hemorrhage within the chest, and perform internal cardiac massage and debril­lation. This chapter will focus on the indications, prepara­tion, equipment, and technique for EDT in penetrating trauma patients, as well as discuss the effects of specic cir­cumstances on the decision to perform an EDT.
11.1 Background
Since its rst application in the late 1800s, there continues to be controversy surrounding the role of EDT in the manage­ment of trauma patients. There are clearly select patients who will benet from liberal use of EDT, particularly in the setting of penetrating trauma with recent loss of pulses.
11.1.1 Safety
Clear indications for the use of EDT are required as resource utilization and health care provider safety are major con­cerns. Injuries from sharp instruments, as well as the higher rate of bloodborne pathogens seen in trauma patients, make this a high-risk procedure that should only be performed by trained personnel.
11.1.2 Training
As EDT is infrequently performed, the opportunities for training are limited, particularly for physicians who are less familiar with thoracic procedures. Training that combines didactic learning with simulation training is necessary to allow trainees the opportunity to walk through the steps of the thoracotomy in a controlled, non-emergent setting. New realistic simulations and focused courses have been found to be effective in preparing trainees for performing thoracot­omy procedures independently when indicated. These simu­lation models can be as simple as a mannequin with plastic internal organs or high-delity simulations with beating hearts. Both of these models have the ability to increase condence and familiarity of physicians with performing EDTs.
S. Golestani (*) General Surgery Residency, Dell Medical School, University of Texas at Austin, Austin, TX, USA e-mail: Simin.Roward@ascension.org
A. Eagleton Department of Surgery, University of Texas at Tyler Health Science Center, Tyler, TX, USA
C. V. R. Brown Division of Acute Care Surgery, Dell Medical School, University of Texas at Austin, Austin, TX, USA e-mail: Carlos.Brown@austin.utexas.edu
© The Author(s), under exclusive license to Springer Nature Switzerland AG 2023 E. Degiannis et al. (eds.), Penetrating Trauma, https://doi.org/10.1007/978-3-031-47006-6_11
11.1.3 Indications
In 2001, the American College of Surgeons—Committee on Trauma developed practice management guidelines for EDT and published several evidence-based Level II recommenda­tions. The indications for patient selection and patient survival have been continually evaluated, and both the Eastern Association for the Surgery of Trauma (EAST) and the Western Trauma Association (WTA) have produced updated recommen­dations on patient selections for EDT based on injury mecha­nism and location and presence of signs of life. Per EAST
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guidelines, pulseless patients with thoracic penetrating trauma and signs of life (pupillary response, spontaneous ventilation, carotid pulse, measurable blood pressure, extremity movement, or cardiac electrical activity) should undergo a thoracotomy. In patients with blunt injuries without any sign of life thoracotomy was recommended against. For all other patients, conditional recommendations were given to proceed with EDT. The Western Trauma Association also concluded that timing of initiation of cardiopulmonary resuscitation is often a guiding factor for whether to proceed with EDT.EDT is considered futile when CPR exceeds 10min for blunt trauma or 15min for penetrating trauma. Penetrating neck or extremity wounds with greater than 15min of CPR also indicates non- salvageability. Other centers have more restrictive practices for blunt mechanisms and pro­ceed with EDT only for patients with CPR ongoing <5min or witnessed cardiac arrest.
Historically, overall survival has been quite poor follow­ing EDT (5–10%). Mortality after EDT is largely dependent on the mechanism and location of injury, as well as evidence of prehospital signs of life. Survival after EDT for blunt trauma was dismal and usually <1% while survival after pen­etrating trauma was improved at about 10% and higher for stab wounds (~15%) than for gunshot wounds (~5%). Furthermore, while patients with injuries to multiple body regions had a survival close to zero, patients with isolated abdominal, thoracic, and particularly cardiac injuries had reasonable survival rates of about 5%, 10%, and 20%, respectively, after EDT.
Recent metanalyses have shown that although still low, the survival rate for thoracotomy patients is now higher than previously reported. Overall rates are now closer to 19.9– 29%, with stab wounds again showing a higher likelihood of survival than gunshot wounds (stab wounds 45.6% vs. gun­shot wounds 18.7%). Blunt trauma continues to have low survival at 7.6% and almost no return of spontaneous circu­lation in the emergency department.
11.1.4 Focused Assessment withSonography
forTrauma (FAST)
The FAST exam contributes important information to the decision to perform an EDT, and as such the ability to per­form an accurate and rapid cardiac FAST is an important skill. In patients who present with no signs of life, if the FAST exam shows no cardiac activity, it conrms that the patient will have no survival benet with the performance of an EDT.The cardiac view of the FAST exam will also show the presence of cardiac tamponade, which can be relieved with an EDT with potential life-saving outcomes. Despite the information the cardiac FAST exam can provide, it does not necessarily predict survival in those ultimately undergo­ing EDT, regardless of cardiac wall motion. Following an
EDT, there is still a role for an abdominal fast exam, which can determine the need for an exploratory laparotomy with high sensitivity.
11.1.5 Resuscitative Endovascular Balloon Occlusion oftheAorta (REBOA)
The recent development and increased use of REBOA for aortic occlusion has brought into question the use of EDT solely for the purpose of aortic occlusion. For select groups of hypotensive patients with blunt or penetrating trauma without cardiac tamponade, REBOA may be a useful tool. In non-thoracic penetrating trauma patients specically, REBOA has the possibility of being benecial in 38.6% of patients. REBOA is contraindicated in the setting of a pene­trating chest injury or when an obvious cardiac or thoracic injury is suspected. Although more research is indicated, some studies have evaluated EDT in comparison to REBOA in abdominal hemorrhage and have found REBOA to be associated with lower mortality. Additionally, in a small group of patients receiving REBOA, the rate of spontaneous circulation was higher in comparison to those receiving open chest cardiac massage. The bias in patient selection between REBOA and EDT patients brings the validity of any research result into question. The role of the REBOA in the manage­ment of trauma patients in cardiac arrest continues to evolve. The decision to perform an EDT or place a REBOA must be made based on individual patient characteristics and injuries.
11.1.6 Organ Donation
Even if a patient does not survive to discharge post EDT, occasionally they are able to become organ donors and save the lives of many patients on the transplant list. The rate of organ donation in trauma patients has historically been low. In patients who undergo an EDT, 2–4% of them have the potential to become organ donors. Any decision to perform an EDT should be done with the goal of resuscitating the patient while following all institutional algorithms, so that once the stage of organ procurement is reached, it is done ethically and without any conict of interest. The most com­mon organs donated by patients post EDT are kidneys, fol­lowed by livers. Depending on the nature of the injuries, heart and lung transplants are also possible.
11.1.7 Special Considerations
Both pediatric and geriatric patients warrant special consider­ation for EDT.For all adult patients, liberal use of EDT should
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be undertaken in patients who meet criteria. The effect of advanced age on outcomes of EDT is varied, a multicenter analysis has found that age is not a predictor of mortality. However, previous studies have shown that age is an indepen­dent predictor of mortality in patients over 60, and that there is 100% futility in patients over the age of 57. Pediatric patients between the ages of 15 and 18 should undergo similar treat­ment algorithm to that of adults. Patients between the ages of 0 and 14 who have suffered a blunt thoracic injury have been shown to have extremely low rates of survival, even with wit­nessed loss of pulses. In these cases, withholding EDT should be considered due to lack of benet.
The indications for an EDT remain the same in a pregnant patient, as the primary goal should be resuscitation of the mother. If the fetus is viable, a concurrent EDT and Cesarian section can be performed, as perimortem C sections should be performed within 4min of cardiac arrest. Although there is high mortality and low survival of the fetus with these pro­cedures, survival of both the mother and the fetus have been described in limited case reports.
11.2 Preparation
EDT requires preparation of both personnel and equipment and requires a team approach to be carried out in an orga­nized and efcient manner. All health care providers (techni­cians, nurses, emergency medicine physicians, and surgeons) involved in the care of a patient requiring an EDT need to be familiar with the basic maneuvers before and during the pro­cedure. This preparation may come in the form of didactic education, patient simulations, or potentially with experi­ence during previous EDTs. Keeping all physicians and staff safe during the procedure is important, and all non- essential personnel should be advised to stay away from sharps and blood exposure. Furthermore, the individual performing the EDT must be prepared to identify and repair injuries within the chest as well as provide resuscitative maneuvers during EDT. If personnel and resources are not available, and/or there is no individual willing or able to perform maneuvers required during EDT, then this procedure should not be part of the resuscitative plan.
11.3 Equipment
If the personnel are available and capable of performing an EDT, then the necessary equipment should be readily acces­sible in the trauma resuscitation room. Equipment for EDT should be stored within a single operative tray and all instru­ments should be loose within the tray for easy handling. Though a standard thoracotomy tray would sufce to per­form EDT, a scaled-down version should be prepared to
remove unnecessary instruments. An EDT tray should be stocked with a #10 scalpel blade (already secured to a han­dle), a pre-assembled retractor (Finochietto or Balfour retractor), curved Mayo scissors (short and long), several forceps (short and long, toothed and smooth), needle drivers (short and long), a variety of large clamps (Satinsky clamps, Debakey aortic aneurysm clamps, Duval lung clamps), and an instrument to perform a transverse sternotomy (heavy shears, Lebsche knife, Gigli saw). Consideration should be given to having at least one additional EDT tray available should a right thoracotomy be required during resuscitation. Suture should be readily available for cardiac or vascular repair; the author prefers a 2–0 Prolene suture on a large tapered needle. The resuscitation room should be equipped with adequate lighting, laparotomy pads or towels, and wall suction, all to allow adequate visualization during the procedure.
11.4 Technique
Prior to patient arrival, the trauma team should be assembled and don universal precautions for personal protection. Once the decision to perform an EDT has been made, quickly eval­uate the location of penetrating wounds, as right-sided tho­racic wounds may prompt a simultaneous right thoracotomy during EDT (discussed later). As you perform the EDT, the remainder of the trauma team should concomitantly secure a denitive airway with endotracheal intubation, establish large bore intravenous access for uid and blood resuscita­tion, and place a right tube thoracostomy to better evaluate for a potential source of hemorrhage in the right chest. Though most operative procedures require sterile technique, the life-saving and emergent nature of EDT does not allow time to perform a sterile procedure. Splashing iodine onto the chest prior to incision provides no antimicrobial efcacy and merely makes the instruments wet and slippery, making the procedure more difcult. As time is crucial and the patient cannot be prepared in the usual sterile fashion, EDT should be performed without preoperative antibiotics, com­plete surgical skin prep, or standard wound draping (Fig.11.1).
To begin the EDT, place the patient in the supine position with the left arm abducted, widening the rib spaces and allowing optimal access via a left anterolateral thoracotomy. Begin the procedure with a generous curvilinear skin inci­sion over the left chest, extending from the left lateral edge of the sternum medially to the anterior edge of the latissi­mus dorsi laterally. In a female, retract the breast superiorly and the incision should follow the inframammary crease. In a male (Fig.11.2), center the incision over the fourth or fth intercostal space by positioning the curvilinear incision just inferior to the left nipple–areolar complex. Make the initial
90
Steps of an Emergency Department Thoracotomy
1.
2.
3.
4.
5.
6. internal cardiac massage.
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entering the thoracic cavity
posterior retraction of the lung
exploration/repair of cardiac injuries
anterior retraction of lung
aortic cross-clamping
Fig. 11.1 Steps of an EDT
S. Golestani et al.
Fig. 11.3 Incision extended through skin, subcutaneous tissue, and most thoracic musculature
Fig. 11.2 Skin incision for emergency department thoracotomy in a male patient
incision through the skin, subcutaneous fat, much of the tho­racic musculature (Fig. 11.3), and should be down to the intercostal space and ribs with the rst (or at the most sec­ond) pass of the scalpel. Once you reach the intercostal space, use the curved Mayo scissors to puncture the inter­costal muscles and parietal pleural, just superior to a rib as you would for a tube thoracostomy, then spread the scissors widely. Once you have created a large pleural opening, use the scissors to enlarge the incision medially and laterally, taking care to avoid the neurovascular bundle and allowing enough space to place a thoracic retractor. Place your tho­racic retractor and open widely (Fig.11.4). Keep in mind this is an emergent procedure done relatively quickly, so fracturing ribs while opening the retractor may be unavoid­able. While fractured ribs should not alter the course of your EDT, make sure to protect yourself and your assistant from sustaining injury from the sharp edges of the fractured ribs. Once you place and spread the retractor, extend your inci­sion with Mayo scissors through all muscular layers and parietal pleura medially and laterally, to include the full length of your skin incision. Now you should be able to fully open the retractor and adequately visualize the left pleural cavity.
Fig. 11.4 Left anterolateral thoracotomy with retractor in place and opened widely
Once you have completed positioning your retractor and adequately lengthening the incision, you should rst turn your attention to the pericardium. Complete the remainder of the exploration in a systematic manner. Your assistant should retract the left lung posteriorly, allowing visualization of the anterior mediastinum and pericardium. Locate the phrenic nerve following its cranio-caudal path along the lateral aspect of the pericardium (Fig.11.5). While taking care not to injure the phrenic nerve, use forceps to grasp the pericar­dium 1cm anterior to the nerve and make an incision with scissors. The initial incision should allow you to conrm the presence of pericardial blood. Occasionally, a tense cardiac tamponade will be present, making it difcult to grasp the pericardium with forceps. In these cases, you may make the initial pericardiotomy with a small stab incision using a scal-
Phrenic
Tamponade
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phrenic nerve
Fig. 11.5 The phrenic nerve following its cranio-caudal path along the lateral aspect of the pericardium
nerve
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Fig. 11.6 Extension of pericardiotomy with scissors
pel. Next, lengthen the pericardiotomy cranially and cau­dally with scissors, about 1cm anterior and parallel to the path of the phrenic nerve (Fig.11.6). By enlarging the peri­cardial incision, you can evacuate pericardial tamponade and deliver the heart into the wound. This will allow you to repair any cardiac injury that may be present.
If the heart is in asystole, then repair is obviously quite easy. However, if there is an organized cardiac rhythm, you will need to gently stabilize the heart in order to perform the repair. You should be able to x most cardiac injuries with a simple interrupted suture repair; the author usually uses a 2–0 polypropelene suture on a tapered needle. You do not need to use pledgets during the initial repair, but if the tissue tears during repair, you may consider adding pledgets to reinforce the repair. You may also use a running stitch, gure-
Fig. 11.7 Horizontal mattress repair of laceration adjacent to a coro­nary artery
of- eight, or horizontal mattress. If the cardiac wound is in close proximity to a coronary artery, you may need to alter your approach. If the injury is near a distal coronary artery, then a repair that ligates the artery distally should be well tolerated by the myocardium. However, if the injury is near the proximal portion of a coronary artery (particularly the left anterior descending artery), the ligation will surely lead to a massive myocardial infarction and death. In these cases, you should perform a horizontal mattress suture around the laceration and the coronary artery, so as not to ligate the myocardial blood supply (Fig.11.7).
If the repair proves difcult or you are not accustomed to performing cardiac repairs, a few optional approaches exist. You may temporize bleeding from a cardiac wound by plac­ing a urinary catheter through the laceration and inating the balloon (Fig.11.8), then applying gentle traction after mak­ing sure to clamp the proximal part of the catheter. Rather than placing sutures, you may be able to repair the laceration with a skin stapler and perform the denitive suture repair in a delayed fashion in the operating room. You may also con-
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S. Golestani et al.
Right atrial appendagte
Foley catheter
Fig. 11.9 Temporary control of right atrial laceration with a Satinsky clamp
Fig. 11.8 Temporary control of cardiac laceration using a urinary catheter
trol the bleeding from a cardiac laceration using a Satinsky clamp, particularly for right atrial lacerations (Fig. 11.9). Finally, if the wound is on the posterior surface of the heart, you can elevate the heart by grasping the apex with a Duval lung clamp to allow visualization (Fig.11.10). If the heart is beating while elevating the apex, venous return to the heart may be impeded and lead to cardiac arrest, so you should perform this maneuver gently and only elevate enough to complete the repair. After cardiac repair, or if no cardiac wound is identied, attention should be turned to the descending thoracic aorta.
The left lung should now be retracted anteriorly by your assistant. You should evacuate any signicant hemothorax to allow visualization of the descending thoracic aorta. The descending thoracic aorta lies posterior and medial in the left chest, running along the left, anterior thoracic spine. With the left lung retracted anteriorly and the left chest evacuated of blood, you should recognize the thick, white, muscular descending aorta (Fig.11.11). Remember, the esophagus lies anterior and medial to the descending thoracic aorta and you should keep its position in mind when cross-clamping the thoracic aorta in order to avoid iatrogenic esophageal injury. Before you can reliably apply a cross-clamp, you must incise the parietal pleura that covers the descending thoracic aorta. In order to avoid injury to the intercostal arteries, you should incise the parietal pleura just anterior to the aorta, taking care
Fig. 11.10 Elevation of the tear with a Duval clamp grasping the apex in order to repair a posterior cardiac laceration
not to injure the esophagus. You should grasp the parietal pleura with forceps and make the initial incision with scis­sors. You can perform the remainder of the exposure bluntly with nger dissection of the parietal pleura off of the aorta, both in cranial and caudal directions. Keep in mind you do not need to circumferentially mobilize the descending aorta, as this wastes precious time and may cause iatrogenic injury to intercostal branches. Once you have swept away the pari­etal pleura, you should cross-clamp the descending aorta with a Debakey aortic aneurysm clamp or Satinsky clamp (Fig.11.12).
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Fig. 11.11 Cross-clamp of the descending thoracic aorta with a Satinsky clamp
Fig. 11.12 Internal cardiac massage
Cross-clamping the descending thoracic aorta during EDT improves resuscitation via three mechanisms. First, when you begin internal cardiac massage, having the tho­racic aorta cross-clamped will improve cerebral blood ow and perfusion pressure during systole. Similarly, the coro­nary arteries, which ll during diastole, will receive better perfusion during internal cardiac massage. Finally, aortic cross-clamping will slow down intra-abdominal hemorrhage until a denitive abdominal operation can be performed. You should cross-clamp the thoracic aorta as distally as possible to maintain adequate perfusion to the spinal cord during the cross-clamp time. Furthermore, you should remove the aor­tic cross-clamp as soon as possible, and preferably within 30min. Once you have successfully applied the aortic cross-
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Fig. 11.13 Internal debrillation paddles
clamp, you can turn your attention to internal cardiac massage.
With the pericardium already opened widely and the heart delivered into the wound (with or without a previous cardiac repair), you should be able to easily evaluate the heart’s rhythm and contractility. Patients with an organized rhythm and adequate contractility do not need internal cardiac mas­sage but may require intravenous drugs such as atropine and epinephrine to support heart rate and blood pressure. Patients with asystole should receive internal cardiac massage. To begin, cup your hands and place one anterior and one poste­rior to the heart. Using the palm of each hand, begin internal cardiac compression at a rate of about 100 beats/min, com­pressing the heart from its apex to its base. Take care to use only your palms, to avoid iatrogenic injury from point pressure on the heart from your ngers or thumbs. Simultaneously, the patient should receive intravenous ACLS drugs, providing at least 1min of internal cardiac massage to assist with resuscitation. If the patient develops ventricular brillation, use internal paddles and debrillate with an ini­tial setting of 10–15J.The internal paddles should be posi­tioned with one paddle anterior and one paddle posterior to the apex of the heart (Fig.11.13). Continue with internal car­diac massage, debrillation, and ACLS protocols until the patient has a return of spontaneous cardiac activity or you decide the care is futile.
At any point during the EDT, you may be required to con­trol hemorrhage from a variety of sources, including the chest wall, spine, heart, lungs, or pulmonary vasculature. Repair of cardiac injuries has been previously described in this chapter. Bleeding from the chest wall or its associated vessels (intercostal, internal mammary) can usually be con­trolled with simple clamping and ligation using nonabsorb­able sutures or vascular clips. Occasionally, bleeding from