Crotty S., Cameron C., Andino R. Ribavirin's antiviral mechanism of action: lethal mutagenesis? // J Mol Med (Berl). 2002. V. 80, № 2. P. 86-95.
CH3
O
O |
H3C |
O
HO
CH3 |
OH |
O |
|
Ribavirin inhibits GB virus. Ribavirin (left) but not the IMPDH inhibitor mycophenolic acid (right) exhibits potent antiviral
activity against the RNA virus GB virus B (the closest known relative to HCV) in cell culture. These data indicate that inhibition of IMPDH is not sufficient for antiviral activity against GB virus
Crotty S., Cameron C., Andino R. Ribavirin's antiviral mechanism of action: lethal mutagenesis? // J Mol Med (Berl). 2002. V. 80, № 2. P. 86-95.
Катастрофа ошибок
Hong Z., Cameron C. E. Pleiotropic mechanisms of ribavirin antiviral activities // Progress in Drug Research / Под ред. Seiler N. и др. Basel: -Birkhäuser Basel, 2002. ‒ C. 41-69.
Ribavirin as an RNA virus mutagen
T-helper(CD4+)cell differentiation and polarization
Ферментный каскад кэпирования
Gppp= GTP, S-Ado-Met = S-
Модель сайта связывания GTP метилтрансферазы
NS5 вируса Денге.
А: модель связывания GTP; B: расположение RTP в активном центре по данным рентгеноструктурного анализа.
Shi F., Len Y., Gong Y., Shi R., Yang X., Naren D., Yan T. Ribavirin Inhibits the Activity of mTOR/eIF4E, ERK/Mnk1/eIF4E Signaling Pathway and Synergizes with Tyrosine Kinase Inhibitor Imatinib to Impair Bcr-Abl Mediated Proliferation and Apoptosis in Ph+ Leukemia // PLoS One. 2015. V. 10, № 8. P. e0136746