История одного препарата
Sidwell R. W., Huffman J. H., Khare L. G. P., Allen B., Witkowski
R. J. T., Robins K. Broad-Spectrum Antiviral Activity of Virazole: 1-b-D-Ribofuranosyl-1,2,4-triazole-3-carboxamide // Science.
1972. V. 177, № 4050. P. 705-706.
Miller J. P., Kigwana L. J., Streeter D. G., Robins R. K., Simon L. N., Roboz J. The Relationship Between The Metabolism Of Ribavirin And Its Proposed Mechanism Of Action // Annals of the New York Academy of Sciences. 1977. V. 284, № 1. P. 211-229.
Miller J. P., Kigwana L. J., Streeter D. G., Robins R. K., Simon L. N., Roboz J. The Relationship Between The Metabolism Of Ribavirin And Its Proposed Mechanism Of Action // Annals of the New York Academy of Sciences. 1977. V. 284, № 1. P. 211-229.
Метаболизм рибавирина
HO
1
HO
NH2
O
N
N N
O
OH OH
C
OH
O
N N N
O
OH 6 OH
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O |
NH2 |
N |
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N |
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A |
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HO |
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P |
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O |
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O |
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OH 3 |
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OH |
OH |
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E |
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NH2 |
F O |
N |
C O |
N |
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N |
N |
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N N |
8 |
H |
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7 H |
O O
BHO P O P O
OH 4 OH
B
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O |
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O |
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O |
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HO |
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P |
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O |
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P |
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O |
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P |
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O |
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OH |
OH |
OH |
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5 |
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NH2
O
N
N N
O
OH OH
NH2
O
N
N N
O
OH OH
А- hADK; B - различные киназы; С- ADA; D - PNP; E - инозинтрифосфат пирофосфатаза; F - различные нуклеозидазы.
Биосинтез пуриновых оснований
Streeter D. G., Miller J. P., Robins R. K., Simon L. N. The enzymic conversion of 1,2,4-triazole-3-carboxamide to ribavirin-5'-phosphate and its relationship to the proposed mechanism of action // Ann N Y Acad Sci. 1977. V. 284, № 1. P. 201-10.