Заключение

Становится все более очевидным, что адаптация мышечной ткани к значительным физическим нагрузкам, как и ее реакция на повреждения, вызванные сократительными процессами, происходит на локальном уровне с участием факторов роста и репарации, которые образуется здесь же, в периферических тканях. Семейство ИФР-I включает представителей, которые выполняют в процессах роста и восстановления различные функции. Образование различных изоформ ИФР-I, обладающих разными биологическими функциями, из одного и того же гена происходит с помощью сложного механизма — альтернативного синтеза. Изучение функций этих изоформ ИФР-I, а также их возможного взаимодействия с другими регуляторными процессами, протекающими в мышечной ткани (например, с участием тестостерона, миостатина, убиквитина и др.) поможет оптимизировать тренировочный режим спортсменов. Более того, понимание сигнальных процессов, которые запускаются под воздействием физической тренировки, также предоставит нам средства для разработки более эффективных методов тестирования экзогенных стимуляторов, применяемых в качестве допинга.

Благодарности

Работа была выполнена при поддержке фантов Фонда “Wellcome Trust”, Всемирного антидопингового агентства (WADA) и гранта ЕС (PENAM) для изучения влияния физических упражнений, включая травмы мышечной ткани.

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