- •Contents:
- •Introduction
- •Structure, functions and methods of research of biological membranes The general structure of cell
- •Ultrastrucrure and function of function of biological membrane
- •Kinds of passive transport
- •Methods of research of structure and functions of biological membranes
- •Method of a dark field.
- •Phase - contrast method.
- •Ultramicroscopy.
- •Electronic microscopy.
- •Method of diffraction of X-rays radiation.
- •Luminescent methods of research of membranes.
- •Method of ultrachemistry.
- •Nuclear magnetic resonance research and electronic paramagnetic resonance research.
- •Research of forces of a superficial tension Properties of liquids
- •Superficial tension.
- •Physical properties of biological membranes.
- •Molecular mechanisms of electrochemical potentials of membranes and distribution of a nervous impulse along excitability fibre.
- •Principles of transformation of biological and not electric signals in electric. Designs of sensors and electrodes, their basic characteristics
- •Application of sensors
- •Analog registering devices
- •Rhythm of heart. Parameters of cardiac activity.
- •External displays of activity of heart.
- •Activity of heart
- •Electric activity of cells of a myocardium
- •Functions of conductive system of heart
- •The electrocardiogram
- •Change of a rhythm of cardiac activity.
- •The device and main principles of work of electrocardiograph
- •Imposing of electrodes
- •The device, a principle of work of electroencephalograph. Basic rhythms of eeg. Registration of eeg and principles of the analysis
- •Introduction
- •Essence of a method
- •Technique of record of electroencephalogram.
- •Principles of analyses of electroencephalogram
- •Definition of a photoeffect
- •Types of photoeffects.
- •Einstein equation
- •Application of a photo effect in medicine.
- •The device, principle of work spectrophotometer. Application spectrophometrical methods of research for definition of concentration of substances in biological liquids
- •Method of the calibre graph.
- •Method of comparison.
- •Polarization of light by biosystems. Polarimeter. Light natural and polarized. Polaroids.
- •Research of microstructures in polarizing light
- •Rotation of a plane of fluctuations of polarized light. Saccharimetry.
- •Design of the device
- •Principle of action
- •Special receptions of microscopy of biological objects Special methods of light microscopy (illumination and supervision). Method of a dark field.
- •Method of ultramicroscopy
- •Method of a light field and its version
- •Method of phase contrast
- •Polarizing microscopy
- •The method interference contrast
- •Method of research in a view of a luminescence
- •Device of a microscope. Measurement of value of microscoping object.
- •Model of sliding strings. Biomechanics of a muscle. The equation of Hill. Modeling of muscular reduction Biophysics of muscular reduction
- •Structure of a cross-section-striped muscle. Model of sliding strands.
- •Biomechanics of a muscle
- •The equation of Hill. Power of single reduction.
- •Modelling of muscular reduction
- •Electromechanical interface in muscles
- •Devices for measurement of function of external breath. The device and a principle of work. Registration and the analysis of the given functional researches
- •Change of saturation by gases of an organism at differences of external pressure.
- •Biomechanics of external breath
- •Devices for measurement of function of external breath
- •Viscosity of a liquid
- •Current of a liquid on a horizontal pipe. Puazal’s law.
- •Current of a liquid on a pipe of variable section and branched out
- •Definition of speed of blood-groove
- •Full resistance (impedance) of tissues of the organism Physical bases of rheography
- •Measurement of factor of viscosity.
- •Physical bases of hemodynamic. Laws of movement of blood in an arterial and venous channel
- •Measurement of pressure of blood
- •Systolic and minute volume of a blood-groove
- •Change of minute volume of a blood-groove at work.
- •Biophysical features of an aorta.
- •Biophysical features of arterioles of the big circle of blood circulation.
- •Tomographic methods
- •Classification of kinds of a tomography.
- •Interposition of a source of probing radiation, bject and the detector.
- •Echosounding
- •Computer tomograph.
- •Magnetic-resonant tomography.
- •Three-dimensional ultrasonic
- •ElastoScan-flexography
- •Modes of an acoustic transparency of three-dimensional ultrasonic.
- •Methods of physiotherapeutic influence
- •The therapeutic techniques based on application of a direct current. Electrophoresis and galvanizing in a medical practice. Mobility of ions.
- •Medicinal electrophoresis.
- •Galvanizing.
- •Electrosecurity
- •The basic requirements to an electrosecurity of electromedical devices and devices.
- •Modelling of biophysical processes.
- •The basic stages of modelling
- •The basic stages of modelling
- •4. Creation of model, its research.
- •Classification of models:
- •Mathematical models of growth of number of a population.
- •Pharmacokinetic model.
- •Sources of X-ray radiation.
- •Artificial sources of radiation.
- •Interaction of X-ray radiation with substance.
- •1. Coherent dispersion;
- •2. Photoeffect
- •3. Kompton - effect
- •Radioactivity radiation Radioactive disintegration Structure of a nucleus
- •A radioactive disintegration. Kinds of radioactive radiation
- •It is thrown out and a nucleus has more stability complex of nucleons. Positron β-disintegration is described by the equation:
- •The basic law of radioactive disintegration in the differential form. A constant of disintegration.
- •The basic law of radioactive disintegration in the differential form.
- •A half-life period.
- •Activity. A unit of measure.
- •Radioactive elements in the nature.
- •Ionizing radioactive radiation and its biological action.
- •The absorbed and exposition doze. Power of a doze. Units of measure.
- •Relative biological efficiency.
- •Mehanisms of action of laser radiation on biological tissues.
- •Mechanisms of action of laser radiation on biological tissues
- •Список использованной литературы :
- •Educational handout on medical biophysics kovaleva larissa valentinovna
Application of sensors
Application of microelectronic devices in medicine allows not only to reduce the sizes of devices and devices, but also to create devices and sensors to them, very small sizes. Such small sensors can safely be entered inside of cavities of various bodies, and even to be implanted in a fabric of an organism. In this connection new diagnostic methods have appeared. They is called endoradiometry.
For example, the tiny electric manometer is applied, for measurement of pressure in cavities of heart. It becomes stronger on the end of cordial catheter. Silicone resistance connected to a membrane, perceiving external pressure serves in it as the sensor. The new method endoradiometry is developed for research of a gastroenteric path. Research of temperature, pressure and acidity of environment is made during all paths by means of endoradioprobe, having the form of a pill which the investigated patient swallows. The microradiogenerator is in a pill. It contains the power supply, the transistor, details of contours and on the open end - the sensor influencing frequency of generated fluctuations, radiated in the form of electromagnetic waves.
Semi-conductor sensor serves as the sensor of temperature in endoradioprobe, the sensor of pressure - the coil of inductance of an oscillatory contour of the generator connected with a membrane, the sensor of acidity of environment - two platinum electrodes. The alkaline microaccumulator is the power supply depending on the energy, being a data carrier, distinguishes mechanical, acoustic (sound), temperature, electric, optical and other sensors.
In some cases sensors name on the measured size: so, for example the sensor of pressure.
Sensors are characterized by function of transformation, sensitivity and the time characteristic (inertia).
Function of
transformation - functional dependence of target size Y
from
entrance X,
which is described by analytical expression Y=
f (Х)
or it is represented in the form of the schedule. The most simple and
an opportunity is directly proportional dependence Y
=
kХ.
Sensitivity of the sensor shows, in what measure the target size
reacts to change entrance size
.
It is expressed in Ohms on millimeter (Ohm/mm), millivolts on Kelvin
in depending on a kind of the sensor.
Sensitivity of consecutive set of sensors is equal to product sensitivity all sensors.
Time characteristics of sensors are essential. The physical processes in sensors do not occur instantly, it leads to delay of change of target size in comparison with change entrance. Analytically such feature, inertness, leads to dependence of sensitivity of the sensor on speed of change of entrance size dx/dt or from frequency at change х under the harmonious law dx/dω. At work with the sensor it is necessary to consider possible errors specific to them. To the reasons of errors can be:
1) temperature dependence of function of transformation;
2) hysteresis - delays Y or X even at slow change of entrance size, as a result of irreversible processes in the sensor;
3) inconstancy of function of transformation in time;
4) return influence of the sensor on the biological system, leading change of indications;
5) inercia the sensor (its neglect time characteristics).
Transfer of a signal. Radiotelemetry.
Communication between the device of removal and the registering device on wires, or by radio is called radiotelemetry. Such measurements concern to telemetry or to biotelemetry. The radiotelemetry is applied also for endoradio researches of digestive tract. The very small capsule with a radio transmitter (endoradio probe) is swallowed by patients.
On change of frequency of the transmitter by the receiver located near to the patient, it is possible to measure pressure, degree of acidities or alkalinity, temperature and other parameters in the location of a capsule (look fig.4).
Fig. 4.
The scheme of endoradio probe for definition of activity of digestive enzymes.
It consists from three basic parts: 1 - the source of a voltage; 2 - a disk pressed from a ferromagnetic powder and particles, dissolved enzyme; 3 - the transistor and other elements of the radioscheme. The disk is located in demountable element. It can be replaced by another after the unitary use. The disk is pressed to the inductance coil 4 and forms with it the closed contour. In process of dissolution of a disk by digestive enzymes inductance L of a circuit decreases and frequency of the generator increases. On perceived frequency it is possible to judge about activity of enzymes.
